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L. Murugan resigns as minister and plans to focus on BJP in Tamil Nadu

L. Murugan has resigned as a Union minister and said he will give his full time to strengthening the BJP in Tamil Nadu ahead of the 2029 general election.

“With humility and grateful heart, I therefore request you to relieve me of my responsibility as MoS and permit me to relinquish my membership of the Rajya Sabha, so that I may dedicate full time to strengthening the party in Tamil Nadu”
L. MuruganUnion Minister of State

Protests over voter roll removals spread across India as detentions mount

Demonstrations backing the Cockroach Janta Party’s demand for Chief Election Commissioner Gyanesh Kumar to resign spread across several states. Police detained protesters in Delhi, Mumbai, Pune and Goa.

Petition challenges Form 6 for restoring voters removed in Delhi revision

A Supreme Court petition challenges the use of Form 6 to restore voters removed from Delhi's electoral rolls, arguing that the form requires a false declaration. The court has not ruled on the form's validity.

Journalists condemn Delhi police treatment during protests over election chief

Journalists in New Delhi condemned police actions during weekend protests over Chief Election Commissioner Gyanesh Kumar. MP John Brittas also sought an investigation into his alleged assault.

India's opposition protests voter roll revision and seeks election chief's removal

Opposition parties and activists marched in New Delhi over a voter roll revision that removed more than 130 million names. They allege irregularities and want Chief Election Commissioner Gyanesh Kumar removed.

Supreme Court plea on voter roll revision delayed by filing defects

The Supreme Court registry flagged 14 defects in a petition by Rahul Gandhi and 10 other opposition leaders, delaying a hearing until they are corrected.

Delhi Police registers cases over Opposition march against election roll revision

Delhi Police registered cases over alleged barricade-breaking and graffiti during an INDIA bloc march in New Delhi against voter roll revisions. Opposition leaders also filed a petition in the Supreme Court.

Delhi Police registered cases over an Opposition protest in New Delhi on Monday, October 12.

INDIA bloc leaders and supporters, including Rahul Gandhi, marched towards the Supreme Court to challenge the Election Commission’s Special Intensive Revision of electoral rolls.

The bloc alleges irregularities and voter deletions in the revision overseen by Chief Election Commissioner Gyanesh Kumar.

Police said the march had no permission and alleged that protesters broke barricades; one account also says the cases concern graffiti on roads.

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BJP and JD(U) accuse Congress of undermining institutions after protests

BJP and ally JD(U) accused Congress of challenging electoral institutions and creating disorder through protests after poll defeats. Congress has questioned the Election Commission and the voter-roll revision process.

Congress-led protests took place; The Hindu gives October 11, while the Times of India identifies the day as Monday, October 12.

Piyush Goyal and Rajiv Ranjan Singh held a joint press conference at BJP headquarters and criticised Congress over the protests.

Bengaluru court orders platforms to block videos about Siddaramaiah

A Bengaluru court temporarily barred 42 media organisations and platforms from sharing two videos about Siddaramaiah, and ordered major tech platforms to block their URLs.

Court
19th Additional City Civil and Sessions Court, Bengaluru
Judge
B. Pushpanjali
Media organisations
42
Platforms ordered to block URLs
YouTube, Yahoo, Google and Facebook

Kerala High Court refuses to pause FIR order in CMRL case

A Kerala High Court bench declined to pause an order directing an FIR in the CMRL-Exalogic case and reserved its decision on whether to allow an appeal.

The accused The State

Opportunity to be heard

The accused said they were not given an opportunity to be heard before the order directing an FIR.

The State said it was conducting a preliminary inquiry to determine whether the information from the ED disclosed a cognisable offence.

FIR process

The accused argued that the court order foreclosed options they could have used to challenge an FIR registered by the police or State.

The State said it had discretion to register an FIR or conduct a preliminary inquiry and was seeking a fair investigation.

Karnataka IPS officer S. Ravi seeks voluntary retirement

S. Ravi, an additional director general with Karnataka State Reserve Police, has applied for voluntary retirement, citing personal reasons, with six months left before retirement.

World

Morelos officials freed after authorities release detained gang suspect

Pueblos Unidos kidnapped three officials in Morelos after a suspect was detained. Authorities released him to protect the hostages, who were later freed.

“These are decisions to save lives, that is very important.”
Claudia SheinbaumPresident of Mexico

Simon and Rachel leave five dead and six missing in Mexico

Storms Simon and Rachel caused deaths and flooding along Mexico’s Pacific coast. Simon remained offshore, with heavy rain and possible flooding still forecast.

Magnitude 6.1 earthquake shakes southern Panama; no damage reported

A magnitude 6.1 earthquake struck southern Panama on Monday evening, with no immediate reports of casualties or damage, three days after a damaging quake.

Hurricane Simon weakens to Category 3 but threatens Mexico’s Pacific coast

Simon weakened from Category 4 to Category 3 as it moved parallel to Mexico’s Pacific coast, bringing heavy rain, strong winds and flooding. Authorities issued high alerts and closed Puerto Vallarta’s airport temporarily.

Iguazu Falls access temporarily closed as river levels surge

Authorities closed tourist access to Iguazu Falls in Argentina after heavy rain pushed river flows above six times the average. The park said access would reopen Tuesday as flows declined.

Bus and nine other vehicles involved in crash on Anchieta Highway

A bus and nine other vehicles were involved in a crash on the Anchieta Highway. One headline said more than 10 people were injured and a lane toward the coast was blocked.

Pastor shot dead inside church in São Leopoldo

Cláudio Roberto da Silva, 53, was shot dead inside his church in São Leopoldo, Brazil. Police are investigating and have not arrested anyone.

Pastor Cláudio Roberto da Silva was shot dead inside his church in São Leopoldo, in southern Brazil, on Monday night.

He was 53 and was with his wife when two men entered the church; she escaped to seek help.

The men tried to get him to go with them to another place, saying people there wanted to speak with him, according to his wife’s account to police.

It remains unclear whether they intended to take him hostage or move him before killing him, and police have not established a motive.

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Tourism falls at Mexico’s beach resorts as costs, seaweed and safety concerns weigh

International visitors to Cancun’s airport fell 12% in September from a year earlier. A stronger peso, smelly seaweed and safety concerns are among the factors cited.

Mexican troops killed the leader of the Jalisco New Generation Cartel, after which roads in Puerto Vallarta were blocked.

The Mexican peso rose about 12% against the US dollar.

Cancun’s international airport recorded about 12% fewer international passengers than in the same month a year earlier.

The Financial Times reported on falling visitor numbers and the pressures facing Mexico’s beach resorts.

Fire hits native vegetation reserve at Terra Santa farm in Mato Grosso

A fire reached a legal reserve at Fazenda Iporanga in Nova Maringá, Mato Grosso. Terra Santa says it will assess the damage after the fire is under control.

Property
Fazenda Iporanga
Municipality and state
Nova Maringá, Mato Grosso
Affected land
Legal reserve of native vegetation, not currently leased for agriculture
Company
Terra Santa Propriedades Agrícolas

China sanctions ministers from Paraguay and Belize over Taiwan ties

China imposed sanctions on Paraguay’s communications minister and Belize’s foreign minister for supporting their countries’ diplomatic ties with Taiwan. The measures include asset freezes and entry bans.

China Taiwan government

Taiwan's status

China says Taiwan is one of its provinces and has no right to the trappings of a state.

Taiwan's government strongly rejects China's view.

Diplomatic ties

China sanctioned the ministers over support for Paraguay's and Belize's diplomatic ties with Taiwan.

Paraguay and Belize maintain formal diplomatic relations with Taiwan.

India opens resident diplomatic mission in Costa Rica

India’s new resident mission in San Jose began operating on October 10, with the aim of strengthening ties and expanding its diplomatic presence in Central America.

Business

Starbucks denies plans to buy Chipotle

Starbucks said it is not planning to buy Chipotle, contradicting a Financial Times report that it had been working on a possible offer. Starbucks shares rose after the denial, while Chipotle shares fell.

“Starbucks is not buying Chipotle.”
Starbucks spokespersonCompany spokesperson

Social Security’s 2027 Cost-of-Living Increase Is Due for Announcement

U.S. officials are set to announce the 2027 Social Security cost-of-living adjustment on Oct. 14, after September inflation data is released. Forecasts put the increase at 3.5% or 3.6%.

JP Morgan raises Apple price target to $360 despite iPhone demand concerns

JP Morgan raised its Apple price target from $340 to $360, saying reported iPhone 18 Pro production cuts may reflect normal adjustments. It expects the iPhone Duo to help offset a delayed base-model launch.

Kroger plans to cut about 3,000 corporate roles over three years

Kroger says it will cut about 3,000 corporate roles over three years, citing efforts to simplify operations and adapt to technology. The company says it will invest in frontline workers.

Warner Music sues Ray-Ban owner over alleged use of its music in ads

Warner Music Group sued Luxottica and affiliated companies, alleging they used at least 427 Warner works in social media marketing without licenses or payment.

Apple reportedly cuts iPhone 18 Pro parts orders amid weaker demand

Apple has reportedly asked suppliers to reduce parts production for the iPhone 18 Pro and Pro Max. One account puts October order cuts at 15% to 20%.

Bumble reportedly in advanced talks for a $1bn takeover

Bumble shares rose almost 50% after a report that technology holding company Ithaca is in advanced talks to buy the dating app firm for around $1bn.

Bumble, a dating app company based in Texas, is reportedly in advanced talks to be bought by technology holding company Ithaca for around $1bn.

A deal could be announced as early as this week, according to the report.

Bumble shares rose almost 50% on Monday after the news, giving the company a market value of more than $580m.

That is still far below its value of more than $14bn after it listed on the Nasdaq in 2021.

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Kalshi traders expect US inflation to stay high after a likely 2026 peak

Kalshi traders expect US inflation to remain elevated, with September CPI forecast at 3.6% year over year. They see limited odds of new highs this year.

An unexpectedly hot CPI reading of 3.8% led Kalshi markets to anticipate a possible peak of 4.8% in May.

Year-over-year inflation peaked at 4.2%, according to CNBC.

Year-over-year CPI rose 3.4%, according to CNBC.

Reports said Kalshi traders expected September CPI to rise 3.6% year over year.

UnitedHealth raises its profit forecast again as turnaround efforts advance

UnitedHealth raised its profit forecast again as its turnaround efforts gathered pace. No forecast figure or further details were provided.

Company
UnitedHealth
Forecast
Profit forecast raised again
Publication date
October 13, 2026

Mike Tomlin shares a 12-year Minecraft city project

The former Pittsburgh Steelers coach has launched a YouTube channel to show a sprawling city he built in Minecraft over 12 years.

Admirers of Tomlin’s project Critics of the project

Time spent

They admired his dedication to a project developed over 12 years.

They questioned whether Tomlin devoted too much time to his virtual city.

Sushi-Con 2026 draws crowds to New York expo

More than 60 companies took part in Sushi-Con 2026 in New York, where visitors sampled Japanese foods and watched a bluefin tuna-cutting show.

Science & Tech

SpaceX launches more than 6,300 pounds of cargo to the space station

A SpaceX Dragon spacecraft launched from Florida on Tuesday with science, supplies and the final pair of roll-out solar arrays for the International Space Station. It is due to arrive Thursday.

“It’s been quite the journey. Folks may remember back in 2017 when we launched the ROSA on CRS-11 and that’s really where we demonstrated this innovative approach to deploying a solar array”
Gaurang PatelNASA Low Earth Orbit Program operations integration manager

Hubble data point to a possible second-generation planet around a white dwarf

Researchers found unusually high niobium levels in Hubble data from white dwarf HS 0209+0832, suggesting a planet formed from material shed by a dying star. The finding needs confirmation.

Airbus and Kratos fly Valkyrie combat drone in Europe for the first time

The uncrewed Valkyrie flew in Northern Europe, reaching Mach 0.8 and taking off with rocket assistance. Airbus and Kratos plan further tests ahead of a 2029 target.

NASA astronaut photographs auroras from the ISS with an iPhone

Anil Menon photographed colorful auroras from the International Space Station on Oct. 10 using an iPhone, during a period of strong geomagnetic activity.

Webb traces the most distant fast radio burst to a small galaxy

Astronomers traced the record-distant burst FRB 20240304B to a small, actively star-forming galaxy, using the James Webb Space Telescope to find its otherwise hidden host.

French astronaut Sophie Adenot says space brought a full range of emotions

After eight months in space, Sophie Adenot returned to Earth and spoke publicly in Cologne, Germany, on Saturday about the emotions she experienced.

Varda plans to expand its in-space manufacturing missions

Varda has two spacecraft in orbit and expects to launch a third soon. It plans seven more missions in 2027 as it builds toward regular in-space manufacturing and returns to Earth.

Varda Space Industries has two spacecraft in orbit after they launched together on a SpaceX rideshare mission on Oct.

1.

The Los Angeles-area company says this was the first time two commercial reentry vehicles launched to orbit at once.

Its spacecraft are designed as mini-factories that can make goods such as pharmaceuticals in orbit and bring them back to Earth.

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SpaceX rocket plume creates a glowing ‘jellyfish’ in the dawn sky

A SpaceX Falcon 9 launch from Florida sent a Dragon spacecraft toward the International Space Station and left a sunlit plume visible across parts of the eastern U.S.

FOX 5 Atlanta reported that the launch was scheduled for 6:33 a.m. EDT the following morning.

A SpaceX Falcon 9 launched from Florida with a Dragon spacecraft on an ISS resupply mission.

People reported seeing the sunlit rocket plume across the eastern United States.

ESA’s Hera mission is set to reach the Didymos asteroid pair in November

Hera is due to rendezvous with Didymos and its moonlet Dimorphos, where it will study the effects of NASA’s 2022 impact test. Two small spacecraft will also investigate the pair.

Mission
Hera
Destination
Didymos-Dimorphos binary asteroid pair
Launch
October 7, 2024, from Cape Canaveral
DART impact
2022

Halley's Comet disappointed many viewers in 1986 but advanced astronomy

Halley's Comet was a letdown for many skywatchers in 1986, but spacecraft observations turned its return into a major scientific opportunity.

Public viewers Astronomers

Expectation

Many members of the public expected a “once-in-a-lifetime spectacle.

Comet experts warned in the mid-1970s that it would likely disappoint much of the public.

Outcome

Many viewers found the comet underwhelming or could not see it clearly.

The return was an unprecedented scientific opportunity, and spacecraft revealed secrets of the comet.

Gold nanogap sensor distinguishes amino acid handedness

Researchers at Osaka University tested a gold-wire sensor that identified amino acid types and handedness, offering a possible alternative to bulky methods used to search for signs of life.

Sports

Commanders and Giants tie after Washington fails to stop the clock in overtime

Washington let the clock expire while in field-goal range, ending its chance to beat New York. Coach Dan Quinn and quarterback Jayden Daniels accepted blame for the mistake.

“The sequence of that does not fall on him.”
Dan QuinnCommanders head coach

Penix says he hopes to play next week after rib injury

Atlanta quarterback Michael Penix Jr. left the Falcons’ overtime loss to Baltimore with a rib injury. He said he hopes to return next week, but further tests are planned.

49ers lead Week 6 NFL power rankings as several 0-5 teams struggle

The 49ers remain No. 1 in one Week 6 ranking, while the Vikings rise and the 0-5 Chargers, Titans and Dolphins sit near the bottom.

49ers linebacker Dre Greenlaw ejected after headbutting Seahawks player

Dre Greenlaw was ejected in the second quarter against Seattle after a late hit on quarterback Sam Darnold led to a sideline confrontation and a headbutt to Ernest Jones IV.

Jaguars left tackle Anton Harrison to have knee surgery

Anton Harrison will have arthroscopic surgery on his right knee after an injury against Philadelphia. His absence could last three to five weeks or the rest of the regular season.

Deebo Samuel expected to miss multiple weeks with hamstring injury

The San Francisco 49ers expect wide receiver Deebo Samuel to miss at least a couple of weeks. Nick Bosa could return from a calf injury against Washington in Week 6.

Marvin Harrison Jr. trade to Houston becomes official after physical

Harrison passed his physical and is now a Houston Texan. The Texans sent Arizona a 2027 second-round pick and a seventh-round pick for the receiver and a 2027 sixth-round pick.

Marvin Harrison Jr. has officially joined the Houston Texans after passing his physical on Monday.

The 24-year-old wide receiver was traded from the Arizona Cardinals, who selected him fourth overall in the 2024 draft.

Houston sent Arizona a 2027 second-round pick and a seventh-round pick, and received Harrison and a 2027 sixth-round pick.

Harrison reunites with quarterback C.J. Stroud, his former teammate at Ohio State.

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UCLA quarterback Nico Iamaleava expected to miss season with knee injury

Nico Iamaleava is expected to miss the rest of UCLA's season after injuring his knee against Oregon. Coach Bob Chesney says medical evaluations will determine the final timeline.

Iamaleava landed awkwardly during a scramble against Oregon and was later replaced.

UCLA beat Oregon 17-15, improving to 5-0.

Chesney said medical evaluations would determine the final timeline for Iamaleava’s status.

CBS Sports reported that Iamaleava was expected to miss the remainder of the season.

Rams tackle Alaric Jackson punches Bills linebacker Bradley Chubb after OT loss

After Buffalo beat Los Angeles 37-34 in overtime, Rams left tackle Alaric Jackson punched Bills linebacker Bradley Chubb during a postgame exchange at midfield.

Final score
Bills 37, Rams 34
Game result
Buffalo won in overtime
Jackson's position
Rams left tackle
Chubb's position
Bills outside linebacker

Two players ejected after opening-kickoff fight in London

Jacksonville’s Bryan Thomas Jr. and Philadelphia’s Jeremiah Trotter Jr. were ejected after fighting during the opening kickoff. A 90-yard Jaguars return for a touchdown was called back because of penalties.

NFL playoff projections shift after the season’s first five weeks

Early projections put the Patriots and 49ers among the stronger playoff contenders, while the Cowboys and Chargers face weaker odds. The 14-team postseason begins in January.

Entertainment

Brazilian axé singer Netinho dies at 60

Netinho, whose 1996 hit “Mila” helped make him a leading axé singer, died in Salvador after a return of non-Hodgkin lymphoma.

“Artista extraordinário, talentoso, sensível e inovador, Netinho construiu uma trajetória marcada pela alegria, pela música e por um carisma inconfundível”
Netinho's teamArtist's representatives

Sean Combs Taken From Fort Dix for Treatment of Head Injury

Sean Combs was taken from Fort Dix prison for treatment of a head injury early Saturday and returned before sunrise. How he was injured has not been confirmed.

Epic delays Marvel and Star Wars game amid reported AI-first shift

Epic Games has delayed an unannounced shooter featuring Marvel and Star Wars characters, with developers reportedly told to use AI tools for its production. The game has no new release date.

Paul Panzer says his wife has died after 25 years together

German comedian Paul Panzer has publicly announced his wife's death. He says he will care for their son and is returning to the stage.

Rodrigo Faro says he worked as a child to help support his family

The Brazilian presenter says he and his brother began making commercials at age eight and gave their earnings to help support their mother.

Hillary Clinton and Kara Swisher to host weekly midterms podcast

Clinton and journalist Kara Swisher will launch “High Stakes” on Oct. 14, discussing U.S. political issues ahead of the 2026 midterm elections. The weekly series will run as part of Swisher’s podcast for New York magazine.

GTA 6 PC release reportedly planned for early 2027

Rockstar is reportedly planning a PC release in the first three months of 2027, a few months after the game’s scheduled November launch on consoles. The company has not confirmed a PC version.

Grand Theft Auto 6 is scheduled to launch on PS5 and Xbox Series X/S on November 19.

A report based on people familiar with Rockstar’s plans says the PC version could arrive between January and March 2027.

Rockstar has not announced a PC release, and the game is currently listed only for those consoles.

If the reported timing is accurate, PC players would wait only a few months after the console launch.

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Lucian Piane, ‘RuPaul’s Drag Race’ composer, dies at 46

Lucian Piane, a composer and guest judge on “RuPaul’s Drag Race,” died at 46 after being struck by a vehicle in Glendale, California, according to authorities.

Glendale emergency crews responded to a reported collision involving a vehicle and a pedestrian at San Fernando Road and Harvard Street.

The pedestrian was pronounced dead at the scene.

News outlets reported Piane’s death and his work on “RuPaul’s Drag Race.

Jade Anna says she and Kenneth ended their engagement over future plans

Jade Anna says she and Kenneth made a joint decision to end their relationship because their future plans and careers no longer aligned. She is moving from Rome back to the Netherlands.

Move
Jade moved to Rome in January.
Proposal
Kenneth proposed in May.
Breakup announcement
Jade said the relationship ended about three months after the proposal.
Reason
Jade cited their future plans and careers.

Kacey Musgraves Fires Back at Kristi Noem Over Texas Senate Candidate

After James Talarico appeared at Musgraves’ Dallas concert, Kristi Noem criticized the singer’s support for him. Musgraves replied with a jab about Noem’s account of killing her dog.

Kristi Noem Kacey Musgraves

Political support

Noem said she would take Ken Paxton over James Talarico.

Musgraves welcomed Talarico at her Dallas concert.

Criticism

Noem said she preferred Ella Langley over Musgraves.

Musgraves replied with a reference to Noem’s account of killing her dog.

Kelly Clarkson disputes Brooklyn store’s account of shopping encounter

Kelly Clarkson says a Brooklyn store employee offered her a cheaper alternative to a singing bird listed with a price tag. The store says the bird is a wall fixture and was not for sale.

Health

BioNTech cancer vaccine misses one goal in pivotal trial

BioNTech’s experimental mRNA vaccine for head and neck cancer failed to meet one of two primary goals in a pivotal trial.

“support continued evaluation”
Özlem TüreciBioNTech co-founder and chief medical officer

Suspected cholera cases triple in Yemen amid renewed fighting

Yemen has recorded 8,034 suspected cholera cases and 27 deaths this year. Cases tripled in three weeks as fighting displaced people into unsanitary camps.

Kudumbashree promotes local nutritious foods during Poshan Maah in Kozhikode

Kudumbashree in Kozhikode is holding food festivals and cooking contests to promote nutritious dishes made with local millets, tubers and leaves during Poshan Maah.

Review finds insufficient evidence for medicinal cannabis to treat insomnia

A review of nine trials involving 537 adults found too little reliable evidence to recommend medicinal cannabis for insomnia. The findings do not prove the products are ineffective.

EU regions urge stronger local role in cardiovascular health strategy

The EU Committee of the Regions unanimously adopted recommendations calling for more prevention and greater involvement of local authorities in European cardiovascular health efforts.

Flu season is starting early, raising questions about vaccination

Flu season is kicking off early. The story raises the question of whether people are getting vaccinated but gives no further details.

DEA proposes strict controls on concentrated kratom compounds

The DEA has proposed emergency restrictions on four kratom-linked substances, while Michigan lawmakers consider whether to ban kratom or regulate its sale.

The DEA has proposed emergency restrictions on four kratom-linked substances found in some concentrated products.

The proposal would place the substances in Schedule I, the federal category for drugs considered to have a high potential for abuse and no accepted medical use in the United States.

Kratom comes from a tree native to Southeast Asia and is sold in the United States in products such as powders, capsules and liquids.

It is marketed for pain relief and other uses, but as an herbal supplement it does not face the same safety testing rules as prescription medicines.

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Sixth measles-related death reported in Pennsylvania

A 39-year-old unvaccinated woman in Franklin County is the sixth person reported to have died in Pennsylvania amid the state’s largest measles outbreak in three decades.

Pennsylvania announced the first two measles-related deaths, both infants in Lancaster County.

A 40-year-old woman in Jefferson County and an 18-year-old Mifflin County resident died after measles-related complications.

The Philadelphia Inquirer reported the fifth death, involving a 20-year-old woman with a compromised immune system.

Pennsylvania reported the sixth death, involving a 39-year-old woman in Franklin County.

Higher physical activity linked to slower decline in Parkinson’s study

A study following 294 people with Parkinson’s for up to seven years linked higher activity levels with slower declines in thinking and movement. It does not prove exercise caused the difference.

Participants
294 adults with mild to moderate Parkinson’s disease
Average age
66
Follow-up
Up to seven years
Activity groups
Up to four hours, four to eight hours, and more than eight hours weekly

Muscle and liver cells may retain benefits of past exercise

Research suggests muscle and liver cells retain a memory of exercise after training stops. This may help people regain fitness faster when they return to exercise.

Traditional view of exercise adaptation Exercise-memory research

Effects of a break

Muscle gains and insulin sensitivity can drift back toward their starting levels, often within weeks.

Cells may retain memories of earlier training during a period without exercise.

Regaining fitness

The traditional “use it or lose it” view implies that benefits fade when training stops.

People with a training history may get fit again faster, and previously trained mice grew bigger muscles when they retrained.

Large study finds abrupt shifts in health markers at menopause

A study of more than one million women found sudden changes in several health markers around menopause. Researchers say the findings are observational and need further study.