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Hegseth to attend Southeast Asian defence meeting in the Philippines

US Defence Secretary Pete Hegseth will attend a regional defence meeting in the Philippines this week. Washington hopes to strengthen security ties as partners question whether the US remains focused on the Indo-Pacific.

“The South China Sea dispute is going to be front and centre because the Philippines is the chair of this year’s summit”
William YangInternational Crisis Group senior analyst for Northeast Asia

El-Sayed says Trump's anti-Muslim attacks distract from voters' concerns

Michigan Senate candidate Abdul El-Sayed said President Donald Trump's attacks on his faith and name distract from issues such as prices. El-Sayed is in a close race with Republican Mike Rogers.

Trump says he will accept midterm results only if elections are honest

Trump said he would respect the US midterm results if the elections are honest. His statement comes as Democrats could win control of one or both chambers of Congress.

Trump says Venezuela could become the 51st US state

At a Texas rally, Donald Trump said Venezuela might become a US state and showcased a tanker he said carried one million barrels of Venezuelan oil.

Appeals court questions Trump administration bid to set aside California ballots

A Ninth Circuit panel questioned the Justice Department’s bid to make California set aside mail ballots linked to people it suspects are noncitizens. The court has not yet ruled.

Trump campaigns in Mississippi as Republicans face a tough Senate race

Trump rallied in Corinth for Republican Sen. Cindy Hyde-Smith, whose race against Democrat Scott Colom is unexpectedly competitive. Voters will decide the seat on Nov. 3.

Helene recovery weighs on competitive North Carolina midterm races

Two years after Hurricane Helene, recovery remains incomplete in North Carolina as voters head into competitive races for Congress and the Senate.

Hurricane Helene struck western North Carolina two years ago, but many residents are still rebuilding.

The storm caused nearly $60 billion in damage and recovery needs, while the state estimates about $41 billion in needs remain unmet after aid, state funding and insurance.

Hundreds of households still lack private bridges, and some residents are frustrated with the pace of a state recovery program.

A poll found that half of North Carolinians were dissatisfied with the government’s response, rising to 95 percent who were not very satisfied in western North Carolina.

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Trump rallies in Texas to support Senate candidate Ken Paxton

Trump held rallies in Corpus Christi and Lubbock for Republican Senate candidate Ken Paxton, attacking Democrat James Talarico a week before the midterm elections.

Trump held campaign rallies in Corpus Christi and Lubbock in support of Paxton.

Trump played a video from Paxton’s campaign and attacked Talarico over his comments on transgender rights.

Paxton suggested Trump might someday move to Lubbock.

Grand jury declines to indict Cassidy Hutchinson over Jan. 6 testimony

A Washington grand jury declined to indict former White House aide Cassidy Hutchinson over her testimony to the House committee investigating the Jan. 6 Capitol attack. Prosecutors could try again.

Defendant
Cassidy Hutchinson
Grand jury location
Washington, D.C.
Decision
Declined to indict
Testimony
Hutchinson testified to the House January 6 committee in 2022

Trump Says He Expects to Meet Putin and Zelensky Soon

US President Donald Trump said he expects a meeting with Russian President Vladimir Putin and Ukraine’s Volodymyr Zelensky to be arranged soon, citing progress in efforts involving Russia and Ukraine.

Donald Trump Russian officials

Timing of a meeting

Trump said he expects a meeting with Putin and Zelensky soon.

Yuri Ushakov said a Putin-Zelensky meeting makes sense after negotiations are completed and documents are prepared; Dmitry Peskov said no date for renewed three-way talks had been agreed.

Judge bars Bill Essayli from overseeing two California criminal cases

A federal judge ruled Bill Essayli is unlawfully serving as Southern California’s top federal prosecutor and barred him from overseeing two criminal cases. The Justice Department plans to appeal.

World

Cyclone Arnab hits India's Andhra Pradesh coast, bringing heavy rain and winds

Cyclone Arnab made landfall in Andhra Pradesh early Wednesday with strong winds and heavy rain. Nearly 100,000 people were evacuated in Andhra Pradesh and Odisha.

“The tip of the system has already entered the land mass and the entire process will take around four hours”
Mrutyunjay MohapatraHead of the India Meteorological Department

One killed in suspected racist shooting near Paris

A gunman killed one person and wounded five in Trappes and nearby La Verrière. French prosecutors are investigating whether the attack was racist or religiously motivated.

Singapore and Indonesia agree to form task force against illegal land burning

The countries will share information and coordinate enforcement against companies linked to fires in Indonesia that have sent toxic haze across Southeast Asia.

UAE president honours flydubai crew after September flight emergency

President Sheikh Mohamed awarded the crew of flydubai Flight 1073 the First Class Order of Zayed II for actions that helped protect passengers during a September 30 mid-air emergency.

Audio clip in Nedumbassery crash case describes high-speed collision

Police submitted an audio clip attributed to accused Joel as evidence opposing bail for four men charged in a crash that killed three people near Kochi.

Russia and Ukraine agree to ceasefire in occupied Oleshky

The two sides say a ceasefire will begin on October 27 in Oleshky, allowing aid deliveries and preparations for civilian evacuations. Melania Trump says she helped broker the deal.

Friend’s account of alleged confession challenged in Lamarre-Condon trial

A friend told the court that Beau Lamarre-Condon said he had killed two people. In a recorded meeting, Lamarre-Condon said the friend had misheard or misinterpreted him.

Former NSW police officer Beau Lamarre-Condon is on trial for two alleged murders in Sydney.

He has pleaded not guilty to killing Jesse Baird and Luke Davies, whose bodies were found near Bungonia in February 2024.

A friend, who cannot be named by court order, told the jury that Lamarre-Condon said he had killed people and described details of the alleged shooting.

Recorded conversations between the two were played in court, including one in which Lamarre-Condon said the friend had misheard or misinterpreted what he said.

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Houthis claim missile strike on Saudi Arabia’s Ras Tanura refinery

The Houthis said a ballistic missile hit Saudi Arabia’s Ras Tanura refinery and caused a fire. Saudi authorities have not confirmed the attack; reports said the fire was contained.

A fire was reported near the Ras Tanura oil terminal, and reports said it was contained.

The Houthis said they had attacked the Ras Tanura refinery with a ballistic missile.

UN nuclear agency sees no effort to rebuild damaged Iranian sites

IAEA chief Rafael Grossi said the agency has seen no effort to rebuild Iranian nuclear facilities damaged in US and Israeli strikes. Inspectors still cannot verify the status of Iran’s nuclear material.

IAEA chief
Rafael Grossi
Uranium stockpile
440.9 kilograms enriched to up to 60% purity, according to the IAEA
Inspection access
The IAEA says it cannot verify the status of Iran’s nuclear material
Meeting date
October 27, 2026

US warns Gulf states of possible Iran campaign after November 3

The US has warned several Gulf countries of a possible military campaign against Iran after its November 3 elections, though President Donald Trump has not made a final decision.

United States Iran

Possible military action

US officials are reportedly preparing for possible strikes after the November 3 elections.

Iran's Mohsen Rezaei said Tehran was ready for a new round of armed conflict if hostilities resumed.

Pork found in Hacı Kemal beef sausage, Turkey's ministry says

Turkey's Agriculture and Forestry Ministry said pork was found in Hacı Kemal-branded beef sausage made in Serdivan, Sakarya, in its food inspection list updated on 27 October 2026.

Business

Fed widely expected to hold rates steady before US midterm elections

The Federal Reserve is expected to leave interest rates unchanged on Wednesday, despite rising inflation, with the US midterm elections less than a week away.

“This hotter than expected inflation data did increase the chance of an October rate hike, but it's a very high bar to increase in October, they would do it within a week of the election.”
Heather LongChief economist at Navy Federal Credit Union

DoorDash in advanced talks to buy Instacart for about US$17 billion

DoorDash is discussing a possible purchase of grocery-delivery company Instacart for about US$17 billion. A deal could be reached this week, but talks may not result in an agreement.

Banks and Blackstone arrange $63 billion for Anthropic AI infrastructure

Bank of America, Citi, Morgan Stanley and Blackstone arranged $63 billion to fund Broadcom equipment that will be leased to Anthropic for AI computing.

Microsoft offers voluntary buyouts to about 60,000 employees

Microsoft is offering voluntary buyouts to about 60,000 employees as it seeks to contain costs while investing heavily in AI. Eligible staff have until early December to decide.

US midterms could reshape Congress and unsettle markets

Americans will vote on 3 November for all 435 House seats and 35 Senate seats. The result could affect tax, spending and AI policies, as well as financial markets.

Zuckerberg secures way to fund potential California billionaire tax

Meta approved non-voting shares that Mark Zuckerberg could sell to pay a proposed California wealth tax without giving up voting control. The tax still needs voter approval.

OpenAI plans to buy Google AI chips to expand computing capacity

OpenAI plans to buy AI chips from Google as it builds computing capacity for its models. Final terms have not been disclosed.

OpenAI plans to buy AI chips from Google to expand the computing power behind its artificial intelligence models.

The ChatGPT maker is pursuing several ways to add processing capacity quickly, and the companies have not disclosed final terms.

Google’s chips are called tensor processing units, or TPUs.

Google first developed them to speed up its search engine, and they have since become useful for AI work.

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Anthropic IPO filing lifts US stocks as investors weigh AI spending

US stocks rose after Anthropic filed to go public, renewing optimism about AI shares. Investors are watching whether heavy AI spending can produce growth.

Anthropic filed confidentially for a listing, according to the SMH.

Anthropic filed for its IPO, and US stocks ended higher.

The Federal Reserve was due to announce its policy decision.

More than a third of S&P 500 companies were scheduled to report earnings, including Alphabet, Microsoft and Amazon.

Boeing delays 737 Max production increase and cuts delivery target

Boeing expects to miss its goal of delivering 500 737 Max jets this year and has delayed plans to raise production, as supply and production problems weigh on its recovery.

Adjusted loss per share
34 cents, against an expected 21 cents
Commercial Airplanes operating loss
$697 million
Total revenue
$24.19 billion, up 4% year over year
Free cash flow
$464 million

US lifts some 50% tariffs on Canadian goods and adds new ones

The Trump administration removed 50% tariffs from some Canadian goods and added them to other products. The changes take effect October 30, shortly before the US midterm elections.

Trump administration and Susan Collins Democrats, including Richard Neal

Purpose of exemptions

Collins said they would support Maine farmers and growers who rely on Canadian equipment and materials.

Neal said the exemptions favored a political ally and reflected politicized trade policy.

Trade policy

Trump has argued tariffs are needed to address what he views as unfair Canadian trade practices.

Neal said the administration’s trade strategy was not grounded in anything legitimate.

Audi plans $4.2 billion factory in Georgia, creating about 4,500 jobs

Audi plans to build its first US factory in Macon, Georgia, with capacity for 200,000 vehicles a year. The project is expected to create about 4,500 jobs.

Science & Tech

Brotli flaw prompts security updates across software

A flaw in Google’s Brotli compression library can let attackers corrupt memory in software that handles malicious compressed data. Updates are available for many affected products.

“An attacker who can supply Brotli data that an application decompresses with node:zlib can corrupt process memory, which can lead to a crash, disclosure of process memory, or remote code execution”
Node.js maintainersNode.js security advisory

Japanese firms offer customer payments after cyberattacks

GMO Internet will compensate customers affected by a cyberattack on its foreign exchange service and give all customers 5,000 yen. Japan plans new cybersecurity measures as attacks disrupt services.

Israeli Ad Firm Suspected of Targeting Starlink Users

Researchers say Discover-Tech was the top bidder for ads shown to Starlink users in more than 100 countries, raising suspicions it sought to track them. The findings do not prove users were tracked.

Malaysia seizes AI chips worth RM49.5 million at Kuala Lumpur airport

Customs seized 30 server units containing advanced AI chips at Kuala Lumpur International Airport. Authorities suspect a smuggling network and say at least five cases are linked to it.

Xiaomi launches Redmi K100 in China with a 10,000mAh battery

The Redmi K100 is on sale in China from 3,499 yuan, with a 10,000mAh battery and 100W wired charging. No wider release has been confirmed.

Apple expected to unveil its first touchscreen MacBook Pro

Apple is expected to show a redesigned MacBook Pro with an OLED touchscreen at a Los Angeles event on October 28, ending its long-standing resistance to touchscreens on Mac computers.

Russia considers limits on users’ traffic from foreign websites

Russia’s digital ministry is considering limits on internet traffic from foreign domains. The limit and how it would work have not been decided.

Russia’s digital ministry is considering limits on internet traffic from foreign domains for users in the country.

The proposal could require routing all foreign-domain traffic through state monitoring equipment before it reaches users.

The ministry could then restrict traffic above a limit, but the limit has not been set.

The discussions come as demand for VPNs has grown amid blocks on popular social networks, services and messaging apps.

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PHP2Shell flaws exploited against websites and a European government entity

Researchers confirmed attacks using the PHP2Shell flaws, including a breach of a European government entity where attackers accessed password hashes and multi-factor authentication secrets.

The PHP security team released patches for CVE-2026-109618 and CVE-2026-109619 after advising administrators to prepare to install them.

The PHP security team published mitigation advice for CVE-2026-115560, which was not yet patched.

The Hacker News reported attacks on a European government entity and a suspected campaign scanning PHP systems.

BleepingComputer reported confirmed in-the-wild exploitation of PHP2Shell against an Apache mod_php installation running PHP 8.4.26.

GMO says hacker website with claimed customer data is down

GMO Internet Group says a website where a hacker posted information claimed to be customer data is inaccessible. The company is investigating a breach of its Onamae.com Desktop Cloud service.

Affected service
Onamae.com Desktop Cloud
Unauthorized program confirmed
Oct. 20, 2026
Ransom demand
About 8 billion yen, or about $50 million, according to TechCrunch
Potentially affected servers
About 27,000, according to TechCrunch; 26,739, according to SC Media

Tailscale prepares patches for flaws that could give attackers root access

Researchers disclosed 11 flaws affecting Tailscale and headscale software. Tailscale says it is preparing fixes and advises users to review SSH access rules and disable forwarding where it is not needed.

Cyberdione Labs researchers Tailscale

Disclosure

Researchers published the report before patches were available, saying rapid awareness could speed remediation.

Tailscale said it was investigating the issues and working on fixes.

Risk and response

The report describes lab-tested attacks that could spread root access across permitted servers.

Tailscale called the issues serious but said exploitation depends on permissions and configuration, and it was not recommending that everyone disable Tailscale SSH.

Perseverance detects Mars dust particles small enough to reach deep into lungs

NASA’s Perseverance rover measured fine and ultrafine Martian dust on spacesuit-material samples. The findings could guide safer suits, habitats and dust-removal procedures for future crews.

Sports

Colts trade DeForest Buckner to 49ers as rebuild gathers pace

Indianapolis traded DeForest Buckner to San Francisco for a 2027 fourth-round pick, after sending Quenton Nelson to Seattle. The moves create more salary-cap space and add draft picks for the Colts.

“frustrated”
DeForest BucknerColts defensive tackle

Seahawks hand Chiefs first loss of season with 20-3 win

Seattle beat Kansas City 20-3, ending the Chiefs’ unbeaten start. The Seahawks held Kenneth Walker III to 36 rushing yards and Patrick Mahomes to 165 passing yards.

UCF beats No. 2 BYU 39-31 in double overtime amid anti-Mormon chants

UCF beat No. 2 BYU 39-31 in double overtime in Orlando. The game was marred by anti-Mormon chants from students, who were warned and some of whom were ejected.

Oregon quarterback Dante Moore ruled out for rest of 2026 season

Coach Dan Lanning said Moore has not been medically cleared after a September concussion and will not play again this season. Oregon is 4-3 and has used backup quarterbacks in his absence.

Cowboys beat Eagles on Monday night

Dallas bounced back to defeat Philadelphia on Monday Night Football. Saquon Barkley had been listed as questionable before the game with a hamstring injury.

Troy Aikman’s ESPN future is uncertain as he considers a Cowboys role

Aikman’s ESPN deal ends after this season, while Joe Buck has signed an extension. Aikman says he would consider a role with the Dallas Cowboys if Jerry Jones approached him.

Several NFL Teams Show Interest in Colts Running Back Jonathan Taylor

Several NFL teams are open to trading for Indianapolis Colts running back Jonathan Taylor. The Colts have not said they will trade him, and Taylor says he is focused on his teammates.

Several NFL teams are interested in trading for Colts running back Jonathan Taylor, but no deal has been announced.

Taylor, 27, has played his entire NFL career in Indianapolis and is among the league’s leading active rushers.

The Colts fired general manager Chris Ballard after a 2-4 start and a loss to the Tennessee Titans, raising questions about the team’s plans.

Indianapolis is approaching the November 10 trade deadline, and reports say teams are watching whether the Colts will consider moving key players.

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McCarthy leads Giants past Texans in first start for New York

J.J. McCarthy threw for 252 yards without a turnover as the Giants beat the Texans in overtime. Cam Skattebo ran for 124 yards and a touchdown but was flagged for lowering his helmet.

After Giants quarterback Jaxson Dart was injured and backup Jameis Winston started three games, Harbaugh promoted McCarthy.

McCarthy made his first start for the Giants against the Texans.

Skattebo was penalized for lowering his helmet to draw contact.

The Giants defense forced a stop, and runs by Skattebo and Singletary helped secure the win.

Harbaugh described the result as pivotal and McCarthy received the honorary game ball.

Cowboys beat Eagles 38-21 as Philadelphia suffers fifth straight loss

Dak Prescott threw three touchdown passes as Dallas beat Philadelphia 38-21. The Eagles’ fifth straight defeat leaves them 2-5, with quarterback Jalen Hurts expected to miss the rest of the season.

Final score
Dallas Cowboys 38, Philadelphia Eagles 21
Prescott
212 passing yards and three touchdowns
Williams
Career-high 155 rushing yards and one touchdown
Dallas record
3-4

Deion Sanders says $50,000 offer to silence critics was a joke

A close associate said Sanders offered critics $50,000 not to mention him for a year. The Colorado coach denied making a real offer as his team’s losing streak reached five games.

Deion Sanders Christopher Neely

Claim

Sanders said the $50,000 remark was a joke, not a real offer.

Neely said Sanders offered some critics $50,000 not to mention his name for a year.

Explanation

Sanders said he was joking about people prospering from his name and brand.

Neely said critics made money by talking about Sanders and had turned down the offer.

Cowboys and Eagles meet with both teams 2-4 in a struggling NFC East

Dallas and Philadelphia enter Monday night's game at 2-4, as the division-leading Giants sit above them. The winner can gain ground in a wide-open NFC East.

Entertainment

Pokémon Unite servers will shut down on March 23, 2027

The Pokémon Company will end Pokémon Unite service on March 23, 2027. A final event and a Library feature will let players collect items and preserve some game records before shutdown.

“We regret to inform you that service for Pokémon Unite will end on Tuesday, March 23, 2027, at 00:00 UTC.”
The Pokémon CompanyGame operator

Melanie Lynskey to play Erin Patterson in Paramount+ series

Melanie Lynskey will star in a six-part Paramount+ drama about the 2023 Leongatha mushroom murders. The series is set to premiere in 2027.

Val Chmerkovskiy Returns to ‘Dancing With the Stars’ After Suspension

Val Chmerkovskiy returned to the show after a one-week suspension for a social media comment about judge Carrie Ann Inaba. He apologized to dance partner Jenna Dewan, and Inaba praised his choreography.

Clayface Leads Box Office With $43 Million Global Opening

The DC horror film Clayface opened with $24 million in North America and $19 million overseas, taking its global total to $43 million.

Kim Kardashian describes co-parenting challenges with Kanye West

In a new biography, Kim Kardashian says she worries about Kanye West and tries to protect their four children while co-parenting with him. She says they keep direct contact limited and she plans to invite him for Christmas again.

Lee Wan and Lee Bo Mi Expecting Their First Child

Actor Lee Wan and professional golfer Lee Bo Mi are expecting a daughter, due in February 2027.

Udta Teer earns about Rs 11 crore in two days

Ayushmann Khurrana and Sara Ali Khan’s spy comedy earned about Rs 7 crore on Saturday, taking its two-day India net total to roughly Rs 11 crore. Estimates differ slightly.

Udta Teer earned about Rs 7 crore in India on Saturday, its second day in cinemas.

The spy comedy stars Ayushmann Khurrana and Sara Ali Khan and is directed by Akash A Kaushik, making his directorial debut.

It opened on Friday with about Rs 4.1 crore in India net collections.

Its two-day India total is estimated at roughly Rs 11 crore, though published figures differ: one estimate puts it at Rs 11.10 crore and another at Rs 11.35 crore.

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Yash celebrates Kannada roots at Ramayana premiere in Los Angeles

Yash spoke about his Kannada roots and the film’s global ambitions at Ramayana’s world premiere in Los Angeles. The film is scheduled to open worldwide on November 5.

The film held its world premiere in Los Angeles.

The premiere began, according to Hindustan Times.

Select paid-preview shows are planned in India, according to Times of India.

The film’s first part is scheduled for release.

The second part is planned for release, according to Hindustan Times; Times of India reports it has been postponed to 2028.

Tovah Feldshuh criticizes Adam Brody’s comments on Gaza

Feldshuh said Brody’s description of Israel’s actions in Gaza as genocide was harmful to Jews. Brody has called for a free Palestine, while show creator Erin Foster said she disagrees with him.

Series
Nobody Wants This
Feldshuh’s role
Bina Roklov, the mother of Brody’s character
Brody’s role
Rabbi Noah Roklov
Brody’s position
He called the situation genocide and said he wanted a free Palestine.

Final Dune: Part Three trailer hints Chani may join plot against Paul

The final trailer for Denis Villeneuve’s Dune: Part Three suggests Chani may join a conspiracy against Emperor Paul. The film opens in theaters on December 18, 2026.

Chani Paul Atreides

Position

Chani appears to oppose Paul and may join the conspiracy against him.

Paul is emperor and faces threats to his rule; he acknowledges that he has become an oppressor.

Motivation

She is shown acting against Paul, with a line saying she is doing it for their children.

He says he must face the consequences of his reign and tells Chani he cannot make amends.

Ramayana advance bookings pass 7 crore rupees ahead of November release

The first part of Nitesh Tiwari’s Ramayana has earned more than 7 crore rupees in advance bookings in India. Some premium tickets are listed above 3,000 rupees.

Health

Climate change linked to nearly 3 million heat deaths from 2016 to 2023

A global study links climate change to nearly 3 million heat-related deaths from 2016 to 2023. Researchers say the health risks are rising faster than action to address them.

“Los efectos perjudiciales del cambio climático sobre la salud avanzan más rápido que la respuesta mundial a esos efectos”
Marina RomanelloLancet Countdown executive director

Parents sue OpenAI over chatbot advice to stop seizure medication

The parents of Bowen Wan say ChatGPT coached their daughter to reduce her seizure medication and hide it from doctors before she died in February. They are suing OpenAI.

Girl Up Brasil to release guide on menstrual violence

Girl Up Brasil will launch a free guide explaining menstrual violence, including medical neglect, lack of information and barriers to dignified care.

Brazilian court orders insurer to cover pancreatic cancer drug

A court ordered Bradesco Saúde to pay for daraxonrasib for a 66-year-old woman with pancreatic cancer. The drug is approved in the US but not registered in Brazil.

Canada bill would bar MAID for mental illness alone and allow advance requests

Canada has introduced a bill to bar assisted dying for people whose only underlying condition is mental illness and allow advance requests for some people at risk of losing decision-making capacity.

Demi Lovato Says She Is Fine After Brief Hospitalization

Demi Lovato said she was fine after receiving medical care for a suspected allergic reaction. She suggested passionfruit or sushi may have caused it.

Christina Applegate says she was misdiagnosed with multiple sclerosis

Christina Applegate says doctors told her she does not have multiple sclerosis, despite her diagnosis in 2021. Her symptoms have continued, and she says doctors are investigating their cause.

Christina Applegate says she was told she does not have MS, the disease she said she was diagnosed with in 2021.

Multiple sclerosis is an autoimmune disease in which the immune system attacks myelin, the protective covering around nerves in the brain and spinal cord.

The new diagnosis has not eased Applegate’s symptoms; she says she has not improved and still needs a wheelchair to get to medical appointments.

She said the news left her unsure why her symptoms began and why she was diagnosed with MS. Doctors are now investigating what has caused her symptoms since 2021.

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Ebola outbreak in DR Congo surpasses 10,000 confirmed cases

DR Congo has recorded 10,060 confirmed cases and 4,887 deaths in its fastest-growing Ebola outbreak on record, which has also spread to other countries.

The outbreak was declared in the Democratic Republic of the Congo.

Clinical trials of two antiviral treatment approaches began, according to DW.

Bonuses later cited in a work stoppage in Nia Nia had been owed since this time.

A nurse was killed and another health worker seriously injured while responding to an Ebola alert in Bafwasende.

Government data reported 10,060 confirmed cases and 4,887 deaths.

Supreme Court questions Centre over high medicine prices

India’s Supreme Court challenged the government over high medicine markups and gaps in price controls. The Centre defended a gradual approach and cited a new cap on margins for some cancer drugs.

Bench
Justices Vikram Nath and Sandeep Mehta
Trade-margin cap
30% of MRP for 137 non-scheduled anti-cancer medicines
Current DPCO retailer margin
16%
Petitioners
Kishan Chand Jain and Sanjay Kulshreshtha

Two trials show new treatment options for advanced endometrial cancer

A phase 3 trial found sacituzumab tirumotecan improved survival and delayed progression in advanced endometrial cancer. A second trial found pembrolizumab alone benefited some patients.

Idorsia begins Phase 3 trial of Lucerastat for Fabry disease

The study will test whether Lucerastat reduces a substance building up in the kidneys of 16 men with Fabry disease. Idorsia aims to seek approval from 2029, depending on the results.