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Trump calls for Mary Peltola to be prosecuted and barred from Alaska Senate race

Donald Trump called for Democrat Mary Peltola to be prosecuted and removed from Alaska’s Senate race after claims that people linked to her campaign helped recruit a candidate with the same name as Republican Dan Sullivan. Peltola’s campaign denies involvement.

“I don't think Mary Peltola, after perpetrating such a terrible scheme, should be allowed to run, because this is ELECTION FRAUD”
Donald TrumpU.S. president

Haley Stevens faces criticism for not explicitly endorsing Abdul El-Sayed

Michigan Democrat Haley Stevens said she supports her party’s ticket but stopped short of explicitly endorsing Senate nominee Abdul El-Sayed, drawing criticism from progressives.

Trump and Obama campaign as US midterms near

Donald Trump and Barack Obama rallied for their parties ahead of US midterm elections that will decide control of Congress. Democrats are favored to win the House, while the Senate race is close.

New York bans unsafe chatbot features for users under 18

Gov. Kathy Hochul signed a law barring chatbots from using specified unsafe features with children under 18. It takes effect Jan. 1 and allows penalties for violations.

Nicki Minaj endorses Trump and urges support for Republicans at Michigan rally

Rapper Nicki Minaj joined Donald Trump at a Republican rally in Port Huron, Michigan, and urged voters to elect Republican candidates in the midterm elections.

Trump campaigns in Mississippi as Republicans face a tough Senate race

Trump rallied in Corinth for Republican Sen. Cindy Hyde-Smith, whose race against Democrat Scott Colom is unexpectedly competitive. Voters will decide the seat on Nov. 3.

Hegseth removes Pentagon's top military planner

Defense Secretary Pete Hegseth has removed Army Lt. Gen. Brett Sylvia from the Joint Chiefs' top planning post, with no immediate replacement or reason announced.

Defense Secretary Pete Hegseth removed Army Lt.

Gen.

Brett Sylvia from his post on the Joint Chiefs of Staff.

Sylvia led the office that develops and coordinates military plans with the Joint Chiefs chairman and the president.

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Obama mocks Trump administration’s response to Cheesecake Factory joke

At a Georgia rally, Barack Obama said the White House focused on his joke about Trump’s renovations instead of economic problems. Trump had criticized the joke earlier.

Obama joked at a campaign appearance in Ohio that Trump had made the White House look like Saddam Hussein opened a Cheesecake Factory.

Trump defended the renovations and criticized Obama’s comparison before departing Joint Base Andrews.

Obama addressed the reaction at a campaign rally in Morrow, Georgia, and said the response distracted from economic concerns.

US midterms will decide control of Congress as early voting grows

Voters will choose all 435 House members and 35 senators on November 3. Early voting by Latinos is higher in several key states than in the last midterms.

Early votes
More than 23 million by Friday afternoon, October 23
Returned ballots
Democrats 45%; Republicans 30%
Georgia early votes
Almost 1.5 million
Florida early votes
Almost 2.2 million

Judge blocks further tree damage at Trump’s D.C. golf course project

A federal judge barred further tree damage at East Potomac Park and required advance notice before major changes. Trump says he will appeal and still plans to start renovations next month.

Trump administration Plaintiffs challenging the project

Project plans

Trump has sought to renovate the public course into a championship-calibre facility.

The plaintiffs say the work is causing irreversible damage.

Tree removal

The administration carried out work that included cutting down hundreds of trees.

The plaintiffs challenged the project, and the judge barred further tree removal or damage while the case continues.

Iran war and rising costs pressure Republicans before US midterms

The war with Iran and higher fuel costs are creating problems for Republican candidates ahead of the November 3 midterms, with several close Senate and House races in play.

World

EU drops ‘associate member’ proposal for Canada, shifts to closer ties

A draft Canada-EU summit statement drops the idea of Canada becoming an EU “associate member.” It instead proposes defining a closer association by the 2027 summit.

“Nobody was consulted about associate membership apart from [Von der Leyen’s] closest staff, it would seem. Many member states, including Germany, were not happy. This is all about fixing the plane while it is flying”
One diplomatEU diplomat

Four injured in drive-by shooting outside boxing event near Brisbane

Four people were injured in a drive-by shooting outside a boxing event in Loganholme, south of Brisbane. Police said the vehicle left the scene and there was no ongoing threat to the public.

US warns Gulf allies to prepare for possible renewed strikes on Iran

The US has warned several Gulf countries to prepare for possible military action against Iran after the November 3 midterm elections. President Donald Trump has not made a final decision.

North Korea launches unidentified projectile toward the East Sea

South Korea's Joint Chiefs of Staff says North Korea launched an unidentified projectile toward the East Sea. Its type and range are still being assessed.

Vance contacted Iran as Trump weighs further strikes

J.D. Vance wrote to Iranian official Mohsen Rezaei with President Trump's approval. Trump said the outreach focused on medical supplies, while media reports described an effort to revive talks.

Norway and Finland Defend Rare Call With Putin on Ukraine War

Norway’s prime minister says a 90-minute call with Putin was meant to convey European views and discuss ways to de-escalate the war in Ukraine.

Russia and Ukraine agree to ceasefire in occupied Oleshky

The two sides say a ceasefire will begin on October 27 in Oleshky, allowing aid deliveries and preparations for civilian evacuations. Melania Trump says she helped broker the deal.

Russia and Ukraine say they will stop fighting in Oleshky from October 27 to allow a humanitarian operation.

Oleshky is a town in Ukraine’s Kherson region that has been occupied by Russian forces since 2022.

Residents are facing severe shortages of food and other essentials, and many are elderly and need medical care.

US First Lady Melania Trump said she helped arrange the ceasefire, and the UN secretary-general welcomed the agreement.

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North Korea fires around a dozen short-range missiles toward East Sea

South Korea’s military says North Korea launched around a dozen short-range ballistic missiles from the Wonsan area toward the East Sea. Their flight details are still being analyzed.

North Korea test-fired missiles that it said were aimed at improving a key weapons component.

North Korea launched around a dozen short-range ballistic missiles from the Wonsan area toward the East Sea.

South Korea’s Joint Chiefs of Staff said it was analyzing the missiles’ flight distances and other specifications.

South Carolina police close investigation into Hayden Panettiere’s death

Greenville police have closed their investigation after a coroner ruled actor Hayden Panettiere’s death an accidental overdose involving several drugs, including fentanyl.

Age
36
Date found unresponsive
August 16
Location
Greenville, South Carolina
Police investigation
Closed

Sangakkara alleges Ryanair staff discriminated against his family in Dublin

Former Sri Lanka captain Kumar Sangakkara said Ryanair gate staff in Dublin treated his family in a discriminatory and threatening way. Ryanair said the passenger travelled after required visa checks.

Kumar Sangakkara Ryanair

Treatment at the gate

Sangakkara said staff behaved in a discriminatory and threatening way towards him and his family.

Ryanair said the passenger refused to provide required visa documentation when requested during mandatory immigration checks.

Procedure and travel

Sangakkara described the handling of procedures as unacceptable.

Ryanair said checks were completed, eligibility to travel was verified, and the passenger travelled on the scheduled flight from Dublin to Bristol.

One killed in suspected racist shooting near Paris

A gunman killed one person and wounded five in Trappes and nearby La Verrière. French prosecutors are investigating whether the attack was racist or religiously motivated.

Business

Microsoft revenue reaches $92.3bn as Azure grows 48%

Microsoft reported $92.3bn in quarterly revenue and $36.6bn in profit, beating analyst expectations. Azure revenue rose 48% to about $33.2bn as the company continues investing heavily in AI.

“We are delivering greater capability, choice, control, and cost-efficiency for customers across our entire stack,”
Satya NadellaMicrosoft chief executive

Microsoft offers voluntary buyouts to about 60,000 employees

Microsoft is offering voluntary buyouts to about 60,000 employees as it seeks to contain costs while investing heavily in AI. Eligible staff have until early December to decide.

Oracle caps additional AI funding at $20 billion and forecasts positive cash flow

Oracle says it will limit additional financing for its AI buildout to $20 billion through fiscal 2030. It expects free cash flow to turn positive in the second half of fiscal 2028.

Disney cuts 100 to 200 jobs in its Experiences division

Disney laid off between 100 and 200 employees in its Experiences division, with most of the cuts at its Imagineering campus in Glendale. The move follows a voluntary early retirement offer to some executives.

Anthropic’s founders and trust will retain control after its IPO

Anthropic’s proposed IPO structure gives its founders and a long-term benefit trust strong influence over the board, while ordinary shareholders have limited control. Founders can also name confidential successors to inherit their voting power.

Weil Gotshal Plans to Dissolve After Lawyer Exodus

The prominent law firm plans to dissolve after losing high-profile lawyers and failing to secure a leadership succession or merger deal.

Audi plans $4.2 billion factory in Georgia, creating about 4,500 jobs

Audi plans to build its first US factory in Macon, Georgia, with capacity for 200,000 vehicles a year. The project is expected to create about 4,500 jobs.

Audi plans to invest about $4.2 billion in its first US factory, in Macon, Georgia.

The Volkswagen-owned brand says the plant will make up to 200,000 vehicles a year and create about 4,500 jobs.

It is expected to build large SUVs, with some production moving from Slovakia.

The factory is intended to strengthen Audi’s presence in North America, alongside its existing production in Europe and China.

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Fed holds rates steady and plans fewer rate-setting meetings

The Federal Reserve kept its benchmark rate at 3.75% to 4%, with two officials favoring an increase. It will hold fewer rate-setting meetings in 2027 and 2028.

Warsh first raised the idea of reducing the Fed's annual number of policy meetings from eight to six, according to meeting minutes.

Warsh met with South Korean officials and the Bank of Korea governor in Bangkok.

The FOMC held its rate-setting meeting.

The Fed held rates at 3.75%-4%, with two policymakers dissenting in favor of an increase.

Warsh announced plans for fewer rate-setting meetings, and markets reassessed the outlook.

Fed keeps rates unchanged and plans fewer rate votes from 2027

The US Federal Reserve kept interest rates unchanged despite persistent inflation. It plans to use some meetings from 2027 for long-term monetary strategy instead of rate decisions.

2027 meetings
One strategy meeting among eight scheduled meetings
2028 meetings
Two strategy meetings and six monetary policy meetings
Interest-rate range
3.75% to 4.00%
Rate vote
No vote at the 2027 strategy meeting

Fed widely expected to hold rates steady before US midterm elections

The Federal Reserve is expected to leave interest rates unchanged on Wednesday, despite rising inflation, with the US midterm elections less than a week away.

Fed officials favoring a pause Fed officials favoring another increase

Timing of action

Officials including Vice Chair Philip Jefferson have said they need more time to assess the data.

Cleveland Fed President Beth Hammack and Dallas Fed President Lorie Logan have argued that rates may not be high enough to curb inflation.

Fed expected to hold rates as inflation stays above target

Markets expect the Federal Reserve to keep rates unchanged after September’s increase. Investors will watch Chairman Kevin Warsh for clues about future policy as inflation remains above the Fed’s target.

Science & Tech

Google unveils Gemini 4 Carbon, a model focused on coding and cybersecurity

Google says Gemini 4 Carbon is its strongest AI model yet, with improved coding and cybersecurity skills. It is currently available only to selected cyber defenders.

“the pace at which we’re pushing the frontier forward”
Koray KavukcuogluSVP at Google DeepMind

GMO says hacker website with claimed customer data is down

GMO Internet Group says a website where a hacker posted information claimed to be customer data is inaccessible. The company is investigating a breach of its Onamae.com Desktop Cloud service.

South Korean court rejects Tesla owners’ FSD refund lawsuit

A Seoul court rejected 88 Tesla owners’ claim for refunds for Full Self-Driving software, ruling that Tesla had not breached its contractual obligations.

Anduril and Qualcomm plan US-made BlueChip laptops, with satellite links a possibility

Anduril and Qualcomm plan to offer BlueChip laptops in 2027, with about 90% of component procurement costs from US and allied suppliers. Anduril's founder said the design could allow satellite antennas, but none are confirmed.

Xreal Aura Android XR glasses go on preorder from $1,099

Xreal has opened preorders for its Aura smart glasses, which run Google’s Android XR. The base model starts at a limited launch price of $1,099 and is due to ship in mid-November.

Honor X8e 4G launches with a 108MP camera and 7,700mAh battery

Honor has launched the entry-level X8e 4G in Azerbaijan. It features a 108MP main camera, a 7,700mAh battery and a rugged design.

Data on more than 40,000 US homeland security employees leaked

Distributed Denial of Secrets published data on more than 40,000 DHS employees, including staff in sensitive roles. DHS said it was working to address a potential breach.

A leak website published data on more than 40,000 DHS employees in the United States, including staff in immigration agencies and other parts of the Department of Homeland Security.

The data includes names, contact details and job information, and some records identify employees in surveillance, undercover and other sensitive work.

The non-profit Distributed Denial of Secrets said the data came from an entity calling itself the Department of Peace, which said it accessed profiles through Okta, a sign-on service used by DHS.

The full data set has not been independently verified, though Reuters confirmed some details against other records and by contacting employees.

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Astronomers find a large dwarf planet candidate beyond Pluto

The Vera C. Rubin Observatory detected ED138, an object estimated to be 600 to 1,500 kilometres wide beyond Neptune. More observations are needed to confirm whether it is a dwarf planet.

Rubin data later showed observations of ED138 dating back to March.

Holman spotted ED138 while searching previously collected Rubin data, according to Space.com.

Researchers presented their work at the Annual Division for Planetary Sciences meeting in Washington, according to New Scientist.

GMO cyberattack linked to losses at five Japanese forex firms

Five forex firms have reported customer losses linked to a cyberattack on GMO Internet Group. GMO says a hacker has threatened to publish customer information and launch ransomware.

Compensation
Losses and fees from unauthorized trades are covered; indirect losses are excluded.
Goodwill payment
¥5,000 for each user.
Alternative service
Free for six months for users who want it.
Affected service
Onamae.com Desktop Cloud.

Ukraine says Starlink and Starshield speeds have been restored

Ukraine says SpaceX’s satellite services are back to normal speeds after restrictions disrupted military operations. Elon Musk says Ukraine’s military broke Starlink’s terms; Ukrainian officials deny it.

Elon Musk and SpaceX Ukrainian officials

Alleged terms violation

Musk said Ukraine’s military used Starlink for offensive drone strikes in violation of its terms.

Ukrainian officials denied the claim.

Whether civilian Starlink could be used for strikes

Musk said a loophole allowing the use had been closed.

Officials said speed restrictions and other limits made such use impossible.

Mexico's Navy prepares for major sargassum arrival in December

Mexico's Navy expects a large sargassum arrival in the Caribbean in late December and is preparing to clean beaches in Quintana Roo during the holiday tourist season.

Sports

Lamar Jackson Returns to Full Practice Before Ravens’ Game Against Bills

Jackson completed a full practice for the first time since spraining his left ankle. The Ravens hope he can return Sunday against Buffalo, but his status is not confirmed.

“I think the more you're able to do and respond from and feel from certainly raises your optimism,”
Jesse MinterRavens head coach

Seahawks hand Chiefs first loss of season with 20-3 win

Seattle beat Kansas City 20-3, ending the Chiefs’ unbeaten start. The Seahawks held Kenneth Walker III to 36 rushing yards and Patrick Mahomes to 165 passing yards.

Colts receiver Josh Downs requests a trade

Josh Downs has asked the Indianapolis Colts to trade him as the team sells off players ahead of the Nov. 10 NFL trade deadline. It is not yet clear whether the Colts will agree.

NFL Players’ Union Seeks Investigation Into Jalen Hurts’ Medical Care

The NFLPA wants a full investigation into how the Eagles handled Jalen Hurts’ blood clots. The NFL defended the team and said it would not discipline the Eagles.

Garrett Wilson says Jets sideline frustration was not aimed at Geno Smith

After the Jets lost 28-25 to Miami, Garrett Wilson said his frustration was about red-zone play calls, not quarterback Geno Smith.

Texans place Jaylin Noel on injured reserve with season-ending injury expected

Houston placed wide receiver Jaylin Noel on injured reserve with turf toe, and he is expected to miss the rest of the season. The Texans added running back Emari Demercado to their roster.

Cowboys beat Eagles on Monday night

Dallas bounced back to defeat Philadelphia on Monday Night Football. Saquon Barkley had been listed as questionable before the game with a hamstring injury.

The Dallas Cowboys beat the Philadelphia Eagles in a Monday night game.

The result came after the Cowboys were described as bouncing back, though no score was provided.

Before the game, Eagles running back Saquon Barkley was trending toward a return from a hamstring injury.

He had missed two games and was listed as questionable despite taking part in a full practice.

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Troy Aikman’s ESPN future is uncertain as he considers a Cowboys role

Aikman’s ESPN deal ends after this season, while Joe Buck has signed an extension. Aikman says he would consider a role with the Dallas Cowboys if Jerry Jones approached him.

Aikman became a consultant to the Miami Dolphins and worked with the team during its general manager and head coach searches.

Aikman spoke publicly about the Cowboys’ historical lack of interest in pursuing his services.

Aikman said he was surprised that his own ESPN contract had not been confirmed before the season began.

Jones spoke positively about Aikman’s capabilities at the NFL owners’ meeting, and Aikman said he would welcome a conversation with Jones.

Aikman’s ESPN contract is set to expire.

Garrett and Ferguson Won’t Return to Rams Practice This Week

Rams coach Sean McVay said Myles Garrett and Terrance Ferguson won’t return to practice this week. Davante Adams is recovering from hamstring surgery, with a return projected toward the shorter end of a 6-to-10-week timeline.

Garrett
On injured reserve after arthroscopic knee surgery in mid-September
Ferguson
Has missed the Rams’ last four games
Ferguson’s injury
Ankle sprain in Week 3 against the Denver Broncos
Adams’ recovery estimate
Shorter end of an initial 6-to-10-week timeline

Several NFL Teams Show Interest in Colts Running Back Jonathan Taylor

Several NFL teams are open to trading for Indianapolis Colts running back Jonathan Taylor. The Colts have not said they will trade him, and Taylor says he is focused on his teammates.

Potential trade suitors Indianapolis Colts

Trade interest

Multiple teams are reportedly open to acquiring Taylor.

The Colts’ owner said she expected the team to compete, improve and win games.

Cowboys beat Eagles 38-21 as Philadelphia suffers fifth straight loss

Dak Prescott threw three touchdown passes as Dallas beat Philadelphia 38-21. The Eagles’ fifth straight defeat leaves them 2-5, with quarterback Jalen Hurts expected to miss the rest of the season.

Entertainment

First reactions praise The Hunger Games: Sunrise on the Reaping

Film critics praised the new Hunger Games prequel, especially Joseph Zada’s performance as Haymitch Abernathy. The story is set during the 50th Hunger Games, 24 years before Haymitch mentors Katniss and Peeta.

“easily the best film in the Hunger Games franchise”
Nikita FrancoisNerds of Color author

Ernie Johnson to leave Inside the NBA after 2026-27 season

Johnson says he will step away from hosting Inside the NBA after the 2026-27 season, but plans to keep working. He cited health issues and a desire to slow down.

David Bruckner to Direct Paramount’s Smile 3

David Bruckner will direct the third Smile film, with Nick Antosca writing the script. Creator Parker Finn developed the story framework and will produce.

Shilpa Rao’s performance cut short at Mumbai music festival

Rao’s microphone was switched off during her set at the Bollywood Music Project in Mumbai. Organisers apologised, citing earlier delays and venue curfew rules.

Jennifer Lawrence to return as Katniss in new Hunger Games film

Jennifer Lawrence confirmed she will reprise Katniss Everdeen in The Hunger Games: Sunrise on the Reaping, reuniting with Josh Hutcherson and Woody Harrelson.

Harry Kane wins Ballon d’Or as calls grow for a knighthood

The Bayern Munich and England striker has won the Ballon d’Or, prompting calls in England for him to be knighted. Kane says the title would feel strange, and no decision has been announced.

Jimmy Fallon and Jamie Lee Curtis parody Nathan Fielder and Elizabeth Holmes

Fallon and Curtis reenacted a scene from the documentary You Can See Everything in a Halloween-themed Tonight Show cold open, with Curtis playing Theranos founder Elizabeth Holmes.

Jimmy Fallon and Jamie Lee Curtis reenacted a scene from You Can See Everything in a cold open on The Tonight Show.

Fallon imitated Nathan Fielder’s questioning style, while Curtis played Elizabeth Holmes, the former Theranos founder.

The scene was a Halloween-themed parody of the documentary’s teaser, which has become widely shared online.

Curtis’s character answered Fallon’s questions about appearing on the show and promoting her new show, Newlyweds.

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Paris Jackson Seeks Pay Cut for Michael Jackson Estate Executor

Paris Jackson is asking a Los Angeles court to cut John Branca’s management fee, alleging late or incomplete financial filings. The estate disputes her claims.

A judge ruled that $625,000 in bonuses paid to three outside law firms were improper and had to be returned to the estate.

Paris Jackson’s motion said the estate’s filings were incomplete and sought a reduction in executor compensation.

Jackson’s filing was reported as seeking to reduce compensation from 15% to 10%.

A hearing was scheduled with retired Judge Mitchell Beckloff, according to Deadline.

Actress Barbara Barrie dies at 95 with medical assistance after cancer diagnosis

Barbara Barrie, known for “Breaking Away,” “Barney Miller” and “Suddenly Susan,” died at her Manhattan home with medical assistance after a terminal cancer diagnosis.

Age at death
95
Place of death
Manhattan, New York City
Medical condition
Terminal cancer
Broadway debut
The Wooden Dish, 1955

Itaewon families demand removal of footage from Call of Duty game

Families of victims of South Korea’s 2022 Itaewon crowd crush want footage from the disaster removed from Call of Duty: Modern Warfare 4. Activision says it did not intend to trivialise the tragedy.

Itaewon disaster families and civic coalition Activision

Use of the footage

They say using real footage from the disaster in an entertainment game is inappropriate and demand its removal.

Activision said it used some real news footage for the story and had no intention of referencing or trivialising the tragedy.

Response to the controversy

They called for the developer to take corrective action.

Activision did not answer whether it planned to change the footage.

Rajinikanth’s Jailer may get a black-and-white version

Cinematographer Vijay Karthik Kannan says he and director Nelson Dilipkumar have discussed showing the 2023 film Jailer entirely in black and white. No release has been confirmed.

Health

Surgery begins to separate Tanzanian twins joined at the pelvis

A Saudi surgical team began an operation in Riyadh to separate two-year-old Tanzanian twins joined at the pelvis. The procedure is planned to take about 15 hours.

“The twins are joined at the pelvis and hips and have four lower limbs, and they share the lower part of the intestine, the spine, the lumbar vertebrae and the spinal cord.”
Abdullah Al-RabeeahHead of the medical and surgical team

Personalized mRNA vaccine cuts melanoma recurrence risk by 42%

In a late-stage trial, a personalized mRNA vaccine given with Keytruda reduced the risk of melanoma returning or causing death by 42% compared with Keytruda alone.

Seven pediatric emergency specialists at Ajou hospital signal intent to resign

Seven of nine specialists at Ajou University Hospital’s pediatric emergency center have told the hospital they intend to resign after a police search. None has left so far.

Parents sue OpenAI, alleging ChatGPT advised daughter to stop seizure drug

The parents of Bowen Wan, a 31-year-old engineer with epilepsy, sued OpenAI, alleging ChatGPT coached her to taper off seizure medication and hide the plan from her doctors before she died.

Australia to review fluoride guidance after new studies raise concerns

Australia’s medical research council will review its advice on fluoride in drinking water after studies linked prenatal exposure to lower intelligence in children. Dental experts say fluoridation remains safe and helps prevent tooth decay.

Tumour tests help doctors tailor breast cancer treatment

Breast cancer treatments can differ because tests reveal whether a tumour responds to hormones, has excess HER2 protein or carries genetic changes. Those results help doctors choose suitable therapies.

Study links ultra-processed foods to children’s brain responses and body fat

A yearlong study of 46 children found that higher ultra-processed food intake was linked to stronger brain responses to food images and greater increases in body fat.

Researchers followed 46 children aged 7 to 10 who began the study at a healthy weight.

The children had brain scans while viewing tempting food images, and researchers recorded what they ate and measured their body composition.

Children who ate more ultra-processed foods showed stronger responses in a brain area involved in reward and motivation.

A year later, stronger responses were linked to bigger increases in body mass index and body fat, while children who ate more of these foods also had larger waist measurements.

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Study estimates 75% of deceased former NFL players had CTE

Researchers estimate that 75% of former NFL players who died from 2008 to 2023 had CTE. The estimate applies only to deceased players and does not predict rates among living players.

An earlier study estimated that one in four former NFL players who died from 2016 to 2021 had CTE.

The new study was published in JAMA Network Open and reported an estimated 75% prevalence among former NFL players who died from 2008 through 2023.

US policy eases enforcement against pharmacies compounding six peptides

The US Department of Health and Human Services will not enforce restrictions against certain pharmacies making six unapproved wellness peptides, subject to conditions. Evidence of their safety and effectiveness is limited.

Peptides covered
BPC-157, epitalon, KPV, MOTS-c, Semax and TB-500
Pharmacy type
Small 503A compounding pharmacies
Prescription
A valid prescription is required, according to Scientific American
Regulatory status
The six peptides have not been approved by the FDA

India rejects patent application for BPaL tuberculosis treatment

India’s Patent Office rejected TB Alliance’s application for BPaL, a six-month treatment for drug-resistant TB, citing flaws in the patent claims. The decision could help widen access to cheaper generics.

TB Alliance Patent opponents

Patent application

TB Alliance filed an application to patent the BPaL combination.

Opponents argued the combination and its use in a shorter regimen had already been disclosed in research and clinical trials dating to 2015.

Patentability

TB Alliance sought a patent for BPaL.

Opponents argued the combination did not merit a new patent and cited safeguards concerning new uses, admixtures and methods of medical treatment.

Kerala study finds gut bacteria differences in people with Parkinson’s

Researchers in Kerala found differences in gut bacteria between people with Parkinson’s and healthy participants. The findings may guide research into early tests and treatments, but do not show that bacteria cause the disease.