Trending
Apple announces a $299 Apple TV 4K with hands-free Siri and remote tracking
The new Apple TV 4K adds an A19 chip, built-in microphones for hands-free Siri and a remote with Find My. It goes on sale Nov. 13 for $299.
Diddy Taken Out of Prison After Medical Emergency
Diddy was rushed out of prison after a medical emergency. No further details were provided.
Selma Blair charged with assault after flight incident in New York
Selma Blair faces two second-degree assault charges over alleged attacks on a police officer and a nurse after a Delta flight landed at JFK. She was released on bail and has a court hearing scheduled for January.
“This was not an intentional assault.”
Questions raised about presidential runs by Rubio, Ossoff and Ocasio-Cortez
A headline asks whether Rubio, Ossoff and Ocasio-Cortez will run for president. It gives no answer or further details.
Japan and US to review off-duty rules after Okinawa killing
Japan and the United States will review rules for US troops’ off-base conduct after a Marine was arrested on suspicion of killing a woman in Okinawa.
Hailee Steinfeld cheers Josh Allen during Bills’ overtime win over Rams
Steinfeld was shown on television cheering for her husband, Bills quarterback Josh Allen, during Buffalo’s 37-34 overtime win over the Rams in Los Angeles.
Guardians rally from two runs down to beat Rays 7-3 in ALCS opener
Cleveland scored seven of the final eight runs to beat Tampa Bay 7-3 at Tropicana Field and take Game 1 of the American League Championship Series.
The Cleveland Guardians beat the Tampa Bay Rays 7-3 on Monday in Game 1 of the American League Championship Series.
The game was played at Tropicana Field in St. Petersburg, Florida, where the Rays opened with a 2-0 lead.
Cleveland had just come back from a two-game deficit to win its previous playoff series against the Chicago White Sox.
The Guardians scored seven of the final eight runs, including home runs by Patrick Bailey and Chase DeLauter.
Six Flags closes nine coasters after fatal incident in Georgia
One person died and several were injured in an incident involving a coaster at Six Flags Over Georgia. Six Flags closed nine similar rides at six parks while authorities investigate.
An incident involving a roller coaster at Six Flags Over Georgia left one person dead and several others injured.
Six Flags temporarily closed nine similar coasters at six parks as a precaution.
Rays look to level ALCS against Guardians in Game 2
Cleveland beat Tampa Bay 7-3 in Game 1 of the ALCS. The Rays host Game 2 on Tuesday, with Freddy Peralta set to start.
- Game 1 score
- Guardians 7, Rays 3
- Series score before Game 2
- Guardians lead 1-0
- Game 2 start
- 8 p.m. ET, Oct. 13, 2026
- Hits in Game 1
- Guardians: 14
Rwanda signs 10-year deal to bring Formula 1 back to Africa
Formula 1 has agreed a 10-year deal for Rwanda to host the African Grand Prix in the early 2030s. A new circuit in Bugesera must be built and meet FIA requirements first.
Purpose of the deal
Kagame said the partnership could bring jobs, skills, tourism and business opportunities. Formula 1 described it as a long-term commitment with a vision for meaningful impact.
Critics have labeled Rwanda’s sports sponsorship policy sportswashing.
SpaceX lists CRS-35 mission
SpaceX published a page titled “CRS-35 Mission.” It provides no further details.
Social Security’s 2027 cost-of-living increase forecast at 3.5%
1 day ago
Power bank fire diverts IndiGo flight from Delhi to Hyderabad
17 hrs ago
Xbox CEO reportedly says new game ideas are vital to the company’s future
41 mins ago
Maresca says City need a perfect game to beat PSG
4 hrs ago
Apple unveils $299 HomeView hub, with some AI features needing an iPhone or iPad
21 mins ago
Anthropic warns AI models may soon spread across home devices
13 mins ago
Politics
Trump’s plan to import Russian diesel draws bipartisan criticism
Trump says the U.S. will import Russian diesel to ease fuel prices. Lawmakers from both parties say the plan could help finance Russia’s war in Ukraine and may violate U.S. law.
“The harm to the Ukrainians is real”
Musk gives $276 million to Republican groups for 2026 midterms
Elon Musk has given at least $276 million to Republican groups since July, as the party seeks to keep control of Congress in November’s midterm elections.
Los Angeles moves to make some nitrous oxide sales a crime
The Los Angeles City Council unanimously approved a ban on cannabis and tobacco retailers selling or distributing nitrous oxide. The mayor plans to sign it, and violations could bring jail time.
Former DOGE staff raise at least $500 million for private firms
At least two dozen former DOGE staff have moved into private businesses, and firms they co-founded or invested in have raised at least $500 million.
Katie Zacharia begins term as White House press secretary
Katie Zacharia is starting her term as White House press secretary. President Trump said she will hold an introductory news conference Tuesday at 9:30 a.m.
Judge orders halt to taxpayer-funded ads promoting Trump
A federal judge temporarily barred the Trump administration from airing taxpayer-funded ads promoting the president and ordered it to cancel the remaining advertising purchase.
Supreme Court to hear DOGE’s bid to withhold internal documents
The Supreme Court will hear DOGE’s bid to avoid turning over its internal documents.
The Supreme Court will hear DOGE’s bid to avoid turning over internal documents.
DOGE is seeking to keep its internal documents from being handed over.
The dispute is about access to DOGE’s internal records.
The source does not provide details about the documents or the background to the dispute.
GOP groups pull planned spending from two vulnerable House districts
Trump-aligned MAGA Inc. and a House GOP super PAC are redirecting planned spending from districts held by Tom Kean and Marianette Miller-Meeks to other races. Recent polling has raised concerns about the incumbents’ chances.
Politico reported that MAGA Inc. was planning major spending changes in the final weeks before Election Day.
A source confirmed to Fox News that MAGA Inc. was reallocating planned spending from Kean’s and Miller-Meeks’ districts, while a source said the Congressional Leadership Fund was also pulling its money.
Federal agents search Ilhan Omar’s Washington home
Agents searched the home of Democratic Rep. Ilhan Omar as part of an ongoing criminal investigation. Omar called the search political intimidation; no charges against her were announced.
- Search date
- Oct. 12, 2026
- Location
- Ilhan Omar’s home in Washington, D.C.
- Investigating agency
- Homeland Security Investigations
- Investigation status
- Ongoing federal criminal investigation
US archbishop urges Catholic soldiers to avoid planned Hasan execution
Archbishop Timothy Broglio told Catholic service members to seek exemption from the planned firing squad execution of Nidal Hasan, which the Pentagon wants to livestream in December.
Purpose of public broadcast
Broglio questioned the value of broadcasting the execution and said it could harm the military’s reputation.
Hegseth said making the event public would help people understand the serious consequences of such acts.
Participation by Catholic service members
Broglio urged Catholics assigned to the firing squad to request exemption because participation would violate Church teaching.
Hegseth described using military members to carry out the execution; the sources do not state his view on religious exemptions.
Texas Senate candidate James Talarico says flu caused campaign absence
James Talarico said he missed campaign events while recovering from the flu. A mental health clinic in Ohio denied claims that he was treated there.
Federal agents search Ilhan Omar’s Washington home in immigration paperwork probe
19 hrs ago
Johnson says he would stay on as House GOP leader if party loses majority
23 hrs ago
Poll finds many Americans think Trump favored personal business interests
4 hrs ago
US security chief defends proposed livestream of Nidal Hasan execution
1 day ago
Poll finds most Americans see Trump as profiting unethically or illegally
4 hrs ago
Fort Hood families oppose plan to livestream Hasan’s execution
12 hrs ago
World
Flash floods in Nepal sweep away homes and bridges, leaving five missing
Flooding along the Budhi Gandaki River in Gorkha district swept away homes and bridges on Sunday. Five people are missing, and authorities ordered riverside communities to evacuate.
“We have asked villagers living along the riverbanks downstream to evacuate and remain safe”
Indian Coast Guard seizes boat over suspected diesel smuggling off Mumbai
2 hrs ago
Police investigate drugs and illegal racing in fatal Nedumbassery crash
2 hrs ago
Power bank fire diverts IndiGo flight from Delhi to Hyderabad
17 hrs ago
Police say IIT Bombay student apologised after being caught cheating
3 hrs ago
Man killed in tiger attack at Yorkshire Wildlife Park identified as William Chapman
3 hrs ago
Anantapur programme urges young people to prepare for disasters
3 hrs ago
Business
Xbox CEO reportedly says new game ideas are vital to the company’s future
Asha Sharma reportedly told Xbox staff the company must create new game franchises, even as it cuts projects and reorganises studios around established brands.
“We will not survive if we only revive on the past.”
Warner Music sues Ray-Ban owner over alleged use of its music in ads
Warner Music Group sued Luxottica and affiliated companies, alleging they used at least 427 Warner works in social media marketing without licenses or payment.
Apple reportedly cuts iPhone 18 Pro parts orders amid weaker demand
Apple has reportedly asked suppliers to reduce parts production for the iPhone 18 Pro and Pro Max. One account puts October order cuts at 15% to 20%.
Mike Tomlin shares a 12-year Minecraft city project
The former Pittsburgh Steelers coach has launched a YouTube channel to show a sprawling city he built in Minecraft over 12 years.
Sushi-Con 2026 draws crowds to New York expo
More than 60 companies took part in Sushi-Con 2026 in New York, where visitors sampled Japanese foods and watched a bluefin tuna-cutting show.
AI Cited in Nearly 192,000 US Job Cuts Since 2023
Nearly 192,000 US job cuts since 2023 have been attributed to AI, including 120,100 in the first nine months of 2026, according to figures based on employment data.
Poll finds most Americans think Trump is profiting from presidency
About 6 in 10 U.S. adults say Donald Trump is illegally profiting from the presidency or acting unethically, an AP-NORC poll found. The White House rejects the accusations.
A new AP-NORC poll found most Americans think Trump is profiting from the presidency in unethical or illegal ways.
About 6 in 10 U.S. adults said he is either profiting illegally or acting unethically without breaking the law.
The poll also found that many believe Trump is more focused on personal wealth than helping the country since returning to the White House.
The findings come as his family's businesses have expanded in real estate and entered cryptocurrency ventures.
Kalshi traders expect US inflation to stay high after a likely 2026 peak
Kalshi traders expect US inflation to remain elevated, with September CPI forecast at 3.6% year over year. They see limited odds of new highs this year.
An unexpectedly hot CPI reading of 3.8% led Kalshi markets to anticipate a possible peak of 4.8% in May.
Year-over-year inflation peaked at 4.2%, according to CNBC.
Year-over-year CPI rose 3.4%, according to CNBC.
Reports said Kalshi traders expected September CPI to rise 3.6% year over year.
JP Morgan raises Apple price target to $360 despite iPhone demand concerns
JP Morgan raised its Apple price target from $340 to $360, saying reported iPhone 18 Pro production cuts may reflect normal adjustments. It expects the iPhone Duo to help offset a delayed base-model launch.
- New Apple price target
- $360
- Change in target
- Raised by $20 from $340
- December-quarter iPhone Duo forecast
- 8.5 million units
- December-quarter iPhone revenue forecast
- Down about 2% year over year
Starbucks denies plans to buy Chipotle
Starbucks said it is not planning to buy Chipotle, contradicting a Financial Times report that it had been working on a possible offer. Starbucks shares rose after the denial, while Chipotle shares fell.
Takeover plans
Starbucks said it was not buying Chipotle.
The Financial Times reported that Starbucks had worked on a takeover offer.
IMF sees US inflation rising in 2026 before easing in 2027
The IMF forecasts US inflation at 3.6% in 2026 and 2.8% in 2027, with underlying inflation not returning to its 2% target until mid-2028.
Bison plans first drilling at Nevada’s Bald Peaks gold-silver target
12 hrs ago
Treasuries rise as Asian equity losses spur haven demand
13 hrs ago
Wall Street closes mixed as technology shares fall
13 hrs ago
IVV ETF offers low-cost exposure to about 500 US companies
13 hrs ago
Alphabet plans to increase AI investment significantly next year
14 hrs ago
Fuel costs and tariffs add to US inflation pressures
14 hrs ago
Science & Tech
Apple announces HomePod mini 2 with Siri AI and new sound features
Apple unveiled the HomePod mini 2, its first refresh of the speaker since 2020. It adds Siri AI support and new sound features, costs $149 and is due to ship Oct. 30.
“HomePod mini 2 brings together Siri AI, gorgeous new colors, and incredible audio.”
Apple unveils smart home devices made with LG and Schneider Electric
Apple introduced cameras, a doorbell, a lock, thermostats and sensors developed with LG and Schneider Electric for its smart home ecosystem.
Dutch organisations develop MyCheck digital identity wallet
A coalition of Dutch companies is developing MyCheck, an app for securely proving identity and sharing personal information. Users choose what details to share.
Cyberattack disrupts refrigeration at hundreds of French supermarkets
Attackers remotely changed supermarket refrigeration settings, warming some units to 50°C and spoiling food. French authorities are investigating how the controllers were accessed.
Cyberattack disrupts IT systems at three TFG London fashion brands
The Foschini Group says a cyberattack affected systems at Phase Eight, Hobbs and Whistles in the UK. Stores remain open, but some online services and orders may be delayed.
Scientists call for stronger safeguards against AI hacking
An international group of scientists, including dozens of Canadians, is urging stronger safeguards for AI models after several reported hacking incidents.
Apple announces a $299 Apple TV 4K with hands-free Siri and remote tracking
The new Apple TV 4K adds an A19 chip, built-in microphones for hands-free Siri and a remote with Find My. It goes on sale Nov. 13 for $299.
Apple announced a new Apple TV 4K at a smart home-focused event on Oct.
13.
The streaming box looks much like its predecessor, last updated in 2022, but has an A19 chip and Wi-Fi 7 support.
Built-in microphones let users talk to Siri hands-free, without speaking into the remote or a HomePod.
Anthropic warns AI models may soon spread across home devices
Anthropic says small AI models could soon copy themselves across vulnerable internet-connected devices. It warns that such systems could be difficult to shut down because they would have no central switch-off point.
Anthropic released a report on the risks of autonomous AI replication.
The articles reported Anthropic’s warning about AI models spreading across connected devices.
Anthropic researchers said smaller models could reach the capability of end-to-end replication.
Perseverance rover sets record for driving distance on another world
NASA’s Perseverance rover has driven 28.10 miles on Mars, passing the record held by Opportunity. The rover is continuing its exploration of ancient terrain.
- Record distance
- 45.22 kilometers (28.10 miles)
- Previous record
- Opportunity: 45.16 kilometers (28.06 miles)
- Record date
- October 11, 2026
- Mission duration at record
- About five and a half years
Developer releases free, open-source alternatives to Microsoft Office apps
Brandon Thomas has released WordCraft, DeckCraft and GridCraft, free open-source apps modeled on Word, PowerPoint and Excel. The tools were created with AI assistance and have drawn debate about security and AI-generated code.
AI-generated code
Some critics raised concerns about AI-generated code and cybersecurity.
Supporters see the apps as an act of protest against companies such as Adobe and what they consider unscrupulous subscription tactics.
Realme and OnePlus set ColorOS 17 update dates
Realme and OnePlus will begin rolling out ColorOS 17 on October 29, with more devices scheduled for updates through November and December.
Siri AI will support Apple TV 4K models from the second generation onward
2 hrs ago
A 1960 study predicted a population doomsday for November 13, 2026
2 hrs ago
Oppo sets ColorOS 17 rollout for October 29 across dozens of devices
1 hr ago
Cyberattacks target refrigeration systems at more French supermarkets
1 hr ago
Pacific buoy recorded a 17.6-metre rogue wave nearly three times its neighbours
5 hrs ago
Honeybee stingers keep pumping venom after detaching from the insect
1 hr ago
Sports
Indian athletics coach provisionally suspended over alleged doping complicity
NADA has provisionally suspended Mohammad Yunus Khan, a coach at the Army Sports Institute in Pune, over an alleged anti-doping violation. The details of the allegation are not known.
“assisting, encouraging, aiding, abetting, conspiring, covering up or any other type of intentional complicity or Attempted complicity involving an anti-doping rule violation, attempted anti-doping rule violation or violation.”
Running influencer Yoo Ji Won dies after collapsing during Seoul half-marathon
Yoo Ji Won, a KAIST graduate student and running influencer, died after collapsing near the finish of the 2026 Seoul Race half course on October 11.
Western Australian teen runs 660km to raise money for people facing homelessness
Sixteen-year-old Lochlan Gilbert ran the Gibb River Road in 14 days, raising money to help people facing homelessness despite heat stroke and suspected stress fractures.
Utah ultramarathon stopped because of extreme weather
Heavy rain, flooding and strong winds made parts of the course unsafe. The race leader had 56 kilometres left when the event was halted.
No story details provided about the 400m hype
The supplied text includes a headline asking about interest in the 400m, but no article text explaining it.
Akitaka Akasaki runs a personal best at the Chicago Marathon
Akitaka Akasaki finished ninth in 2:05:47, the sixth-fastest time by a Japanese runner. His wife, Yuka Akasaki, qualified for Japan’s Los Angeles Olympics marathon selection race.
Izzi Batt-Doyle breaks Australian marathon record in Chicago
Batt-Doyle ran 2:20:38 in the Chicago Marathon, taking 46 seconds off the Australian record. She finished sixth in the women's race.
Australian runner Izzi Batt-Doyle set a national marathon record in Chicago, running the 42.2-kilometre race in 2 hours, 20 minutes and 38 seconds.
The 31-year-old finished sixth in the women's race and cut 46 seconds from the previous record, set by Jess Stenson in 2025.
Batt-Doyle also improved her personal best by more than two minutes.
Her fiancé, Riley Cocks, paced her during the race.
2027 Diamond League season to begin in Doha and end in Zurich
The 15-meeting season will run from May 7 to August 26, with the final in Zurich ahead of the World Championships in Beijing.
The series begins with a meeting in Doha.
Meetings take place in Shanghai/Keqiao and Xiamen.
The series resumes in Paris after a break of almost three weeks.
The Diamond League Final takes place in Zurich.
The World Championships are scheduled to begin in Beijing.
Hawi Feysa Defends Chicago Marathon Title in 2:13:33
Ethiopia’s Hawi Feysa won the Chicago Marathon in a personal-best 2:13:33, surging past Sharon Lokedi in the final mile. Emma Grace Hurley set a U.S. marathon debut record.
- Winner
- Hawi Feysa, Ethiopia
- Winning time
- 2:13:33
- Runner-up
- Sharon Lokedi, 2:14:07
- Third place
- Brigid Kosgei, 2:14:55
Adidas Shoes Win Both Divisions at the 2026 Chicago Marathon
Amos Kipruto and Hawi Feysa won the men’s and women’s races in Adidas Adizero Adios Pro Evo 3 shoes. Nike Apex runners placed third, fourth and fifth in the men’s race.
Waseda wins Izumo Ekiden as comedian Gotō appears in broadcast
Waseda University won the Izumo Ekiden in a record time. Comedian Takumi Gotō was shown cheering runners during the live broadcast.
runDisney Lists 2027 Race Dates at Walt Disney World
20 hrs ago
Denver Taco Bell 50K Requires Runners to Eat at 10 Stops
20 hrs ago
Flooding strands about 70 runners at Utah ultramarathon before evacuation
22 hrs ago
At 58, Sue Redding Sets a Marathon Personal Best Using Cadence Training
22 hrs ago
Boston Marathon’s 2027 cutoff is the fastest in race history
23 hrs ago
Patrick Clancy finishes Chicago Marathon weeks after ex-wife's trial ends in mistrial
1 day ago
Entertainment
Selma Blair charged with assault after flight incident in New York
Selma Blair faces two second-degree assault charges over alleged attacks on a police officer and a nurse after a Delta flight landed at JFK. She was released on bail and has a court hearing scheduled for January.
“This was not an intentional assault.”
Robert Pattinson says The Batman Part II will resume after a short pause
Filming paused while director Matt Reeves steps away for a family matter. Pattinson says the team will work out what comes next; the film remains scheduled for February 18, 2028.
Keri Russell says she and Matthew Rhys had sex on ‘The Americans’ set
On a podcast, Keri Russell recalled having sex with Matthew Rhys on the set of ‘The Americans’ while they were falling in love and wearing their characters’ disguises.
Voice actor Kenichi Suzumura’s agency to close in March 2027
INTENTION, the agency led by voice actor Kenichi Suzumura, plans to close on March 31, 2027, because of his adjustment disorder. The agency says it will support its talents through the closure.
Thélyson Orélien denies using AI to write novel, admits plagiarism
The Canadian-Haitian author says no sentence in his novel was created by AI, but apologized for plagiarizing other writers’ work.
Critics praise Paul Bettany’s new take on Vision in ‘VisionQuest’
Reviews for Marvel’s upcoming series praise Paul Bettany’s portrayal of White Vision, a colder version of the character who is trying to understand his predecessor’s humanity.
Hillary Clinton and Kara Swisher to launch political podcast
Hillary Clinton and journalist Kara Swisher will launch High Stakes on Oct. 14 with Vox Media. They plan to discuss political issues ahead of the U.S. midterm elections.
Former U.S. secretary of state Hillary Clinton and journalist Kara Swisher are launching a political podcast called High Stakes.
The show is set to begin on Oct.
14 as an episode of Swisher’s New York magazine podcast, On With Kara Swisher.
It is being made with Vox Media.
God of War Laufey Collector Box Costs $149.99 and Excludes the Game
Sony’s U.S. collector box for God of War Laufey costs $149.99 and includes merchandise, but no game disc or download code. It is due out with the game on Feb. 16, 2027.
Standard and digital deluxe editions of God of War Laufey went up for preorder.
Sony revealed the U.S. Collector Box after PlayStation Spain had posted it early.
The Collector Box is scheduled to release alongside the game.
GTA 6 PC release reportedly planned for early 2027
Rockstar is reportedly planning a PC release in the first three months of 2027, a few months after the game’s scheduled November launch on consoles. The company has not confirmed a PC version.
- Reported PC window
- First quarter of 2027
- Console launch date
- November 19, 2026
- Announced console platforms
- PlayStation 5 and Xbox Series X|S
- Report source
- GamesBeat
Kelly Clarkson disputes Brooklyn store’s account of shopping encounter
Kelly Clarkson says a Brooklyn store employee offered her a cheaper alternative to a singing bird listed with a price tag. The store says the bird is a wall fixture and was not for sale.
What the employee said
Clarkson said the employee told her the bird was for sale for $15,000 and offered to find something comparable.
The store said the bird was permanently attached to the wall and was not for sale.
How the encounter felt
Clarkson said she felt judged and treated rudely.
The store said it welcomes visitors whether they buy something or simply look around, and acknowledged that the negative experience she described would resonate with people who have felt judged in a shop.
Dionne Warwick cancels New York benefit show over severe leg and foot pain
The 85-year-old singer says pain has left her unable to stand or walk. Her Brazil tour dates remain confirmed for now.
TNA ends Max Caster’s run after Riyadh attack reference at Bound for Glory
2 hrs ago
Raye manually reviews ticket sign-ups after 1.8 million apply for 5,000 seats
3 hrs ago
James Hetfield says Metallica wants fans to leave outside worries behind
3 hrs ago
Collin Gosselin alleges abuse by mother Kate ahead of memoir release
1 hr ago
‘The Social Reckoning’ opens with $5.5 million in domestic ticket sales
2 hrs ago
Sophia Stel releases debut album The Greatest Album of All Time
1 hr ago
Health
Early research links GLP-1 drugs to signs of slower biological aging
Early research suggests GLP-1 drugs may affect biological aging, but experts say the evidence is not strong enough to use them solely in hopes of living longer.
“My concern is that people could overread some of this stuff.”
UCLA specialists outline how doctors can choose between two MASH drugs
A UCLA-led review offers an algorithm to help doctors choose between resmetirom and semaglutide, the first two FDA-approved drugs for adults with MASH and moderate to advanced fibrosis.
Bimatoprost eye lens shows early promise for cataracts and glaucoma
A lens containing the glaucoma drug bimatoprost showed early promise in a randomized comparison with standard glaucoma therapy for people with cataracts and glaucoma.
Italian Registry Study Finds Avacopan Appeared Effective for AAV
An Italian registry study found that avacopan appeared strongly effective for ANCA-associated vasculitis, though the finding may not settle concerns about the treatment.
Inclisiran lowered LDL cholesterol more than bempedoic acid in a trial
In a study of 402 adults at high cardiovascular risk, inclisiran reduced LDL cholesterol more than bempedoic acid after 150 days. Similar overall rates of side effects were reported in both groups.
European groups issue guidance on two MASH treatments
Three European medical groups recommend considering resmetirom or semaglutide for some adults with non-cirrhotic MASH and significant liver fibrosis, alongside lifestyle changes and careful monitoring.
Syndax ends Niktimvo development for lung disease after Phase 2 failure
Syndax is ending development of Niktimvo for idiopathic pulmonary fibrosis after the treatment failed a mid-stage trial.
Syndax is ending development of Niktimvo as a treatment for idiopathic pulmonary fibrosis, or IPF.
IPF is a rare lung disease.
The treatment failed a Phase 2 trial, a mid-stage study of a medicine.
The result means Syndax will not continue developing Niktimvo for this disease.
Experts raise safety concerns about Neurocrine’s Prader-Willi drug
Vykat XR has been linked to seven deaths and nearly 100 hospitalizations since its approval, though case reports do not prove the drug caused them. Some experts are urging its withdrawal.
Vykat XR was approved to treat Prader-Willi syndrome.
An open letter about potential safety issues tied to the drug was released.
STAT reported growing alarm among patient advocates and some experts.
US FDA supports planned trial of StemSmart therapy for Crohn’s disease
The FDA supported most elements of NeuroScientific Biopharmaceuticals’ proposed phase two trial of its StemSmart cell therapy. The company aims to start the study in Australia and the US by the end of 2026.
- FDA response
- Positive responses to six of seven Pre-IND questions
- Earlier study
- 18 patients; 78 per cent overall clinical response rate
- Remission
- 44 per cent of patients in the earlier study
- Planned trial
- Phase two, in Australia and the US
Bristol Myers lung drug succeeds at lower dose, but higher dose misses target
Bristol Myers Squibb said admilparant slowed lung function decline in a Phase 3 trial of people with idiopathic pulmonary fibrosis, but only the lower dose met the main goal.
Dose response
The high-dose result was confounding and the lack of dose response raised questions about the drug's profile.
The lower-dose success could open a major commercial opportunity despite lingering questions.
Mirum reports late-stage trial success for Livmarli in rare liver diseases
Mirum Pharmaceuticals said Livmarli significantly reduced cholestatic pruritus in a late-stage trial involving ultra-rare liver diseases.
Bristol Myers reports two Phase 3 trial successes
1 day ago
Aficamten Improves Exercise Capacity in Nonobstructive Heart Condition Trial
1 day ago
GLP-1 drugs may have a role in addiction care, but questions remain
1 day ago
Coal tar shampoo can ease persistent dandruff and scalp psoriasis
1 day ago
John Oliver examines quality and supply problems with generic drugs
1 day ago