Explore

Jump to a category

Politics

Trump’s plan to import Russian diesel draws bipartisan criticism

Trump says the U.S. will import Russian diesel to ease fuel prices. Lawmakers from both parties say the plan could help finance Russia’s war in Ukraine and may violate U.S. law.

“The harm to the Ukrainians is real”
William TaylorFormer US ambassador to Ukraine and Atlantic Council senior fellow

Elon Musk gives more than $276 million to Republican groups since July

Musk has donated more than $276 million to Republican groups since July, making him the biggest known donor of the 2026 midterm elections. The largest share went to a group backing Republican Senate candidates.

Los Angeles moves to make some nitrous oxide sales a crime

The Los Angeles City Council unanimously approved a ban on cannabis and tobacco retailers selling or distributing nitrous oxide. The mayor plans to sign it, and violations could bring jail time.

Former DOGE staff raise at least $500 million for private firms

At least two dozen former DOGE staff have moved into private businesses, and firms they co-founded or invested in have raised at least $500 million.

Katie Zacharia begins term as White House press secretary

Katie Zacharia is starting her term as White House press secretary. President Trump said she will hold an introductory news conference Tuesday at 9:30 a.m.

Supreme Court to hear Trump’s dispute with watchdog group over DOGE

The Supreme Court is set to hear Donald Trump’s dispute with a watchdog group over DOGE. No details of the case or hearing date are provided.

Supreme Court to hear DOGE’s bid to withhold internal documents

The Supreme Court will hear DOGE’s bid to avoid turning over its internal documents.

The Supreme Court will hear DOGE’s bid to avoid turning over internal documents.

DOGE is seeking to keep its internal documents from being handed over.

The dispute is about access to DOGE’s internal records.

The source does not provide details about the documents or the background to the dispute.

Read full story →

GOP groups pull planned spending from two vulnerable House districts

Trump-aligned MAGA Inc. and a House GOP super PAC are redirecting planned spending from districts held by Tom Kean and Marianette Miller-Meeks to other races. Recent polling has raised concerns about the incumbents’ chances.

Politico reported that MAGA Inc. was planning major spending changes in the final weeks before Election Day.

A source confirmed to Fox News that MAGA Inc. was reallocating planned spending from Kean’s and Miller-Meeks’ districts, while a source said the Congressional Leadership Fund was also pulling its money.

Federal agents search Ilhan Omar’s Washington home

Agents searched the home of Democratic Rep. Ilhan Omar as part of an ongoing criminal investigation. Omar called the search political intimidation; no charges against her were announced.

Search date
October 12, 2026
Search location
Omar’s home in the Washington, DC area
Investigative agency
Homeland Security Investigations, according to Fox News
Investigation status
Ongoing federal criminal investigation; officials disclosed no details

US archbishop urges Catholic soldiers to avoid planned Hasan execution

Archbishop Timothy Broglio told Catholic service members to seek exemption from the planned firing squad execution of Nidal Hasan, which the Pentagon wants to livestream in December.

Archbishop Timothy Broglio Defense Secretary Pete Hegseth

Purpose of public broadcast

Broglio questioned the value of broadcasting the execution and said it could harm the military’s reputation.

Hegseth said making the event public would help people understand the serious consequences of such acts.

Participation by Catholic service members

Broglio urged Catholics assigned to the firing squad to request exemption because participation would violate Church teaching.

Hegseth described using military members to carry out the execution; the sources do not state his view on religious exemptions.

Texas Senate candidate James Talarico says flu caused campaign absence

James Talarico said he missed campaign events while recovering from the flu. A mental health clinic in Ohio denied claims that he was treated there.

World

UK says Iran was highly likely behind RAF Fairford security incident

Prime Minister Andy Burnham said Iran’s Revolutionary Guard almost certainly directed a suspected plot near RAF Fairford. Britain has sanctioned two people and says further sanctions may follow.

“I can confirm our assessment that it is highly likely to have been coordinated in Iran, almost certainly directed by Iran’s Islamic Revolutionary Guard (IRGC),”
Andy BurnhamUK prime minister

Israel turns back Ethiopian Airlines cargo flight over Indonesian pilot

Israel denied a cargo flight from Addis Ababa permission to land because one pilot was Indonesian. The plane returned to Ethiopia, changed pilots and later landed in Tel Aviv.

Singapore advises citizens to defer all travel to Saudi Arabia

Singapore’s foreign ministry advised citizens to postpone all travel to Saudi Arabia after missile and drone attacks hit airports and other infrastructure. It urged those already there to avoid high-risk areas.

Iranian man executed hours after marrying imprisoned girlfriend by phone

Alireza Sepahi, 25, married Mahsat Keshani, 22, by phone from prison in Iran. He was executed hours later after being sentenced to death for protesting against the government.

Thirty-one detained in drug operation across 14 Ankara districts

Authorities carried out simultaneous operations in 14 Ankara districts, detaining 31 of 33 suspects and seizing drugs, weapons and ammunition.

Netanyahu seeks probe into anonymous sources for Gaza documentary NAZA

Benjamin Netanyahu has called for an investigation and prosecution of anonymous Israeli military sources in NAZA, a film alleging the army used AI targeting systems in Gaza.

Hezbollah announces housing aid of up to $14,000 for displaced families

Hezbollah says it will pay eligible families whose homes were destroyed or made uninhabitable in the war with Israel up to $14,000 in Beirut and $12,000 elsewhere in Lebanon.

Hezbollah has announced housing aid for families in Lebanon whose homes were destroyed or made uninhabitable during the war with Israel.

The group says eligible families in Beirut and its southern suburbs will receive up to $14,000, while families elsewhere will receive up to $12,000.

The payments include money for furniture and rent; Hezbollah says they will be made in four instalments over a year.

Aid is limited to people whose damaged home was their main residence and who do not own a second home.

Read full story →

Saudi Arabia reports new missile and drone threats as Riyadh airport stays shut

Saudi Arabia reported new incoming drones and missiles on Monday after deadly Houthi attacks. King Khalid International Airport remains closed while authorities check its safety.

A missile strike on the airport killed 13 people, according to The Hindu.

Saudi Media Ministry CCTV footage of the airport strike was released, according to The Hindu.

Saudi authorities extended the suspension of operations at King Khalid International Airport.

Saudi Arabia reported new drone and missile threats, while the coalition said it had intercepted attacks overnight.

The Hindu’s aviation source said flights were expected to remain halted until at least Thursday.

Houthis threaten response to any attack on Sanaa after coalition warning

The Houthis warned of a “painful” response if Sanaa is attacked. The warning came as Saudi Arabia reported intercepting three drones headed for Riyadh.

Evacuation site
Yemeni Oil Company and nearby storage areas in western Sanaa
Houthi spokesman
Brig. Gen. Yahya Saree
Threatened response location
Riyadh
Intercepted drones
Three, north of Riyadh, according to the coalition

Attack on Riyadh airport kills one, injures 11, Saudi authorities say

A projectile struck a domestic terminal at King Khalid International Airport on Sunday, killing a Pakistani resident and injuring 11. The airport has been hit four times in five days.

Saudi-led coalition and Saudi authorities Houthis

Attacks in Yemen

The Saudi-led coalition said it was continuing strikes on Houthi launch sites.

The Houthis said Saudi airspace was a military zone and blamed Saudi Arabia for strikes on Sanaa.

Bus-truck crash in western Turkey kills 11 and injures 27

A tour bus and a timber-laden truck collided near Akhisar in western Turkey on Sunday. Authorities said 11 people died and 27 were injured; the crash is under investigation.

Business

Getty Images plans Chapter 11 restructuring and move to private ownership

Getty Images has secured up to $533 million from the Getty family and Koch Equity Development to restructure its debt and go private through a Chapter 11 process expected to finish by year-end.

“Getty Images is uniquely trusted around the world as the unparalleled leader in premium visual content”
Mark GettyGetty Images co-founder

Apple reportedly cuts iPhone 18 Pro parts orders amid weaker demand

Apple has reportedly asked suppliers to reduce parts production for the iPhone 18 Pro and Pro Max. One account puts October order cuts at 15% to 20%.

Mike Tomlin shares a 12-year Minecraft city project

The former Pittsburgh Steelers coach has launched a YouTube channel to show a sprawling city he built in Minecraft over 12 years.

Sushi-Con 2026 draws crowds to New York expo

More than 60 companies took part in Sushi-Con 2026 in New York, where visitors sampled Japanese foods and watched a bluefin tuna-cutting show.

AI Cited in Nearly 192,000 US Job Cuts Since 2023

Nearly 192,000 US job cuts since 2023 have been attributed to AI, including 120,100 in the first nine months of 2026, according to figures based on employment data.

IMF sees US inflation rising in 2026 before easing in 2027

The IMF forecasts US inflation at 3.6% in 2026 and 2.8% in 2027, with underlying inflation not returning to its 2% target until mid-2028.

Kalshi traders expect US inflation to stay high after a likely 2026 peak

Kalshi traders expect US inflation to remain elevated, with September CPI forecast at 3.6% year over year. They see limited odds of new highs this year.

Traders on Kalshi, a prediction market, expect US inflation to remain high even if it has already peaked this year.

They forecast that September consumer prices rose 3.6% from a year earlier, up from 3.4% in August.

That September figure is due Wednesday, and the forecast matches economists’ estimate cited in the reports.

The inflation contracts are settled using official data from the US Bureau of Labor Statistics.

Read full story →

JP Morgan raises Apple price target to $360 despite iPhone demand concerns

JP Morgan raised its Apple price target from $340 to $360, saying reported iPhone 18 Pro production cuts may reflect normal adjustments. It expects the iPhone Duo to help offset a delayed base-model launch.

JP Morgan lowered its Apple price target to $340 over supply constraint concerns.

Nikkei Asia reported that Apple had told select suppliers to cut iPhone 18 Pro and iPhone 18 Pro Max component production because of soft demand.

JP Morgan raised its Apple price target from $340 to $360 and maintained its Overweight rating.

Warner Music sues Ray-Ban owner over alleged use of its music in ads

Warner Music Group sued Luxottica and affiliated companies, alleging they used at least 427 Warner works in social media marketing without licenses or payment.

Works cited
At least 427 Warner-controlled works
Defendants
Luxottica Group S.p.A. and five affiliated companies
Court
US District Court for the Southern District of New York
Followers
36.14 million combined social media followers, according to Warner’s law firm

Starbucks denies plans to buy Chipotle

Starbucks said it is not planning to buy Chipotle, contradicting a Financial Times report that it had been working on a possible offer. Starbucks shares rose after the denial, while Chipotle shares fell.

Starbucks Financial Times report

Takeover plans

Starbucks said it was not buying Chipotle.

The Financial Times reported that Starbucks had worked on a takeover offer.

Bison plans first drilling at Nevada’s Bald Peaks gold-silver target

Bison Resources has filed a notice for seven drill pads at Bald Peaks in Nevada. It is targeting a December 2026 start, after rock-chip assay results are due by the end of October.

Science & Tech

SpaceX set to send solar arrays and supplies to the space station

A SpaceX Falcon 9 is scheduled to launch the CRS-35 cargo mission from Florida on Oct. 13, carrying 6,300 pounds of supplies, science equipment and the station’s final pair of new solar arrays.

“Additional equipment we’re launching includes a dose pump for our toilet, some pre-treat quality sensors, a robot microcontical tool used for space station maintenance and utilization tasks with external replacement units and impairments”
Bill SpetchNASA Low Earth Orbit Program deputy manager of Commercial

FAA analyst Kayla Bigham works to keep commercial spaceflight safe

Kayla Bigham analyzes rockets and reentry capsules for the FAA, assessing risks to the public as commercial spaceflight grows.

Vast engineer Brianna Clark works on technology for future space living

Brianna Clark, a propulsion engineer at Vast, contributed to a demo that tested technology for future human living in low Earth orbit. She is also set to work on Haven-1, whose launch is planned for no earlier than the first quarter of 2027.

ORBES plans to send robots to the ISS and capture exterior footage

Founded by Anna Shaposhnik, ORBES is developing robots to support work and filming in space. Its first space-station robot is scheduled to travel to the ISS next year.

Gold nanogap sensor distinguishes amino acid handedness

Researchers at Osaka University tested a gold-wire sensor that identified amino acid types and handedness, offering a possible alternative to bulky methods used to search for signs of life.

NASA predicts two solar eclipses in 2027

NASA predicts an annular solar eclipse on Feb. 6, 2027, and a total solar eclipse on Aug. 2. The total eclipse is expected to last 6 minutes 23 seconds.

SpaceX rocket plume creates a glowing ‘jellyfish’ in the dawn sky

A SpaceX Falcon 9 launch from Florida sent a Dragon spacecraft toward the International Space Station and left a sunlit plume visible across parts of the eastern U.S.

A SpaceX Falcon 9 launched from Florida before dawn on October 13, carrying a Dragon spacecraft toward the International Space Station.

The flight was an ISS resupply mission, sending supplies to the orbiting station.

As the rocket climbed, its exhaust spread high in the atmosphere and formed a broad plume.

Early sunlight lit the plume, creating a shape that many people called a space jellyfish.

Read full story →

NASA astronaut photographs auroras from the ISS with an iPhone

Anil Menon photographed colorful auroras from the International Space Station on Oct. 10 using an iPhone, during a period of strong geomagnetic activity.

Menon photographed auroras from the ISS using an iPhone camera.

Menon posted a video of the aurora to X.

Space.com featured the photograph as its space photo of the day.

Hubble data point to a possible second-generation planet around a white dwarf

Researchers found unusually high niobium levels in Hubble data from white dwarf HS 0209+0832, suggesting a planet formed from material shed by a dying star. The finding needs confirmation.

System
HS 0209+0832
First Hubble observations
1999
Unidentified chemical features
Roughly 100
Niobium level
1,000 times the Sun's level, according to Engadget

Halley's Comet disappointed many viewers in 1986 but advanced astronomy

Halley's Comet was a letdown for many skywatchers in 1986, but spacecraft observations turned its return into a major scientific opportunity.

Public viewers Astronomers

Expectation

Many members of the public expected a “once-in-a-lifetime spectacle.

Comet experts warned in the mid-1970s that it would likely disappoint much of the public.

Outcome

Many viewers found the comet underwhelming or could not see it clearly.

The return was an unprecedented scientific opportunity, and spacecraft revealed secrets of the comet.

Landsat 9 captures a mosaic of farms around Taiwan’s longest river

A Landsat 9 image shows tens of thousands of small farms around the Zhuoshui River in Yunlin County, western Taiwan.

Sports

Bills beat Rams 37-34 in overtime as Josh Allen earns first OT win

Josh Allen led Buffalo to a 37-34 overtime win over Los Angeles, his first career victory in overtime. The Bills improved to 4-1, while the Rams fell to 2-3.

“That's the beautiful thing about football: You get another drive.”
Josh AllenBills quarterback

Penix says he hopes to play next week after rib injury

Atlanta quarterback Michael Penix Jr. left the Falcons’ overtime loss to Baltimore with a rib injury. He said he hopes to return next week, but further tests are planned.

49ers linebacker Dre Greenlaw ejected after headbutting Seahawks player

Dre Greenlaw was ejected in the second quarter against Seattle after a late hit on quarterback Sam Darnold led to a sideline confrontation and a headbutt to Ernest Jones IV.

Deebo Samuel expected to miss multiple weeks with hamstring injury

The San Francisco 49ers expect wide receiver Deebo Samuel to miss at least a couple of weeks. Nick Bosa could return from a calf injury against Washington in Week 6.

Oregon slips in power ratings after narrow loss with backup quarterbacks

Oregon fell to 3-2 after a two-point loss despite seven turnovers and a switch to its third-string quarterback. It dropped in the power ratings, but not as far as expected.

FIU visits Jacksonville State in a key Conference USA game

Florida International visits Jacksonville State on Oct. 13 with both teams unbeaten in Conference USA play. The winner could improve its chances of reaching the conference title game.

Marvin Harrison Jr. trade to Houston becomes official after physical

Harrison passed his physical and is now a Houston Texan. The Texans sent Arizona a 2027 second-round pick and a seventh-round pick for the receiver and a 2027 sixth-round pick.

Marvin Harrison Jr. has officially joined the Houston Texans after passing his physical on Monday.

The 24-year-old wide receiver was traded from the Arizona Cardinals, who selected him fourth overall in the 2024 draft.

Houston sent Arizona a 2027 second-round pick and a seventh-round pick, and received Harrison and a 2027 sixth-round pick.

Harrison reunites with quarterback C.J. Stroud, his former teammate at Ohio State.

Read full story →

Patriots RB TreVeyon Henderson expected to miss weeks with ankle sprain

Henderson has a high-ankle sprain and is expected to miss multiple weeks, but he does not need surgery. He was injured in New England’s win over the Raiders.

Henderson injured his ankle during New England’s win over the Raiders.

ProFootballTalk reported that Henderson had a high-ankle sprain and was expected to miss multiple weeks.

49ers lead Week 6 NFL power rankings as several 0-5 teams struggle

The 49ers remain No. 1 in one Week 6 ranking, while the Vikings rise and the 0-5 Chargers, Titans and Dolphins sit near the bottom.

49ers
No. 1 in ProFootballTalk’s Week 6 rankings; 5-0
Chiefs
No. 2 in ProFootballTalk’s rankings; 4-0
Jaguars
No. 3 in ProFootballTalk’s rankings; 4-1
Chargers
0-5

Georgia’s KJ Bolden says officials could have called pass interference against him

Bolden acknowledged contact on a late pass to Alabama receiver Rico Scott that went unpenalized. Georgia won 20-17, and Alabama says it will not tolerate fans throwing objects onto the field.

KJ Bolden Kalen DeBoer

Pass interference call

Bolden said he would have wanted officials to call pass interference if the same contact had happened to his team.

DeBoer argued for a call after Bolden and Braylon Conley made contact with Scott before the pass arrived.

Two players ejected after opening-kickoff fight in London

Jacksonville’s Bryan Thomas Jr. and Philadelphia’s Jeremiah Trotter Jr. were ejected after fighting during the opening kickoff. A 90-yard Jaguars return for a touchdown was called back because of penalties.

Entertainment

God of War Laufey Collector Box Costs $149.99 and Excludes the Game

Sony’s U.S. collector box for God of War Laufey costs $149.99 and includes merchandise, but no game disc or download code. It is due out with the game on Feb. 16, 2027.

“God of War Laufey game sold separately”
Polygon writerfreelance news writer

Monique Smit says she sometimes misses brother Jan amid estrangement

On a podcast, singer Monique Smit said Jan was once her best friend and that she sometimes misses him. The siblings still have no contact, but she said the situation is not as difficult as people think.

Thélyson Orélien denies using AI to write novel, admits plagiarism

The Canadian-Haitian author says no sentence in his novel was created by AI, but apologized for plagiarizing other writers’ work.

Hillary Clinton and Kara Swisher to launch political podcast

Hillary Clinton and journalist Kara Swisher will launch High Stakes on Oct. 14 with Vox Media. They plan to discuss political issues ahead of the U.S. midterm elections.

TNA ends Max Caster’s run after Riyadh attack reference at Bound for Glory

TNA said Max Caster will no longer wrestle for the company after his entrance rap at Bound for Glory referred to attacks in Riyadh. TNA apologized and removed the segment from replays and social media.

Raye manually reviews ticket sign-ups after 1.8 million apply for 5,000 seats

Raye says AI bots and scalpers overwhelmed sign-ups for her Royal Albert Hall show in London. Her team is manually selecting fans for presale access, with remaining tickets due to go on general sale.

GTA 6 PC release reportedly planned for early 2027

Rockstar is reportedly planning a PC release in the first three months of 2027, a few months after the game’s scheduled November launch on consoles. The company has not confirmed a PC version.

Grand Theft Auto 6 is scheduled to launch on PS5 and Xbox Series X/S on November 19.

A report based on people familiar with Rockstar’s plans says the PC version could arrive between January and March 2027.

Rockstar has not announced a PC release, and the game is currently listed only for those consoles.

If the reported timing is accurate, PC players would wait only a few months after the console launch.

Read full story →

Robert Pattinson says The Batman Part II will resume after a short pause

Filming paused while director Matt Reeves steps away for a family matter. Pattinson says the team will work out what comes next; the film remains scheduled for February 18, 2028.

The film was initially slated for release.

News broke that Reeves had stepped away and production had been paused.

Pattinson commented that filming would pause briefly and the team would work out what happens next.

The film is currently scheduled for release.

Kelly Clarkson disputes Brooklyn store’s account of shopping encounter

Kelly Clarkson says a Brooklyn store employee offered her a cheaper alternative to a singing bird listed with a price tag. The store says the bird is a wall fixture and was not for sale.

Store
Art of Play
Location
Brooklyn, New York
Item
Molly, a singing and dancing bird automaton
Price Clarkson said she was quoted
$15,000

Selma Blair charged with assault after flight incident in New York

Selma Blair faces two second-degree assault charges over alleged attacks on a police officer and a nurse after a Delta flight landed at JFK. She was released on bail and has a court hearing scheduled for January.

Selma Blair’s defense Prosecution and court

Intent

Her lawyer said the incident was not intentional and that missed medication, a head injury and altitude left her severely confused and disoriented.

Blair faces charges alleging she assaulted a police officer and a nurse; the allegations have not been established in court.

Celebrity treatment

Not stated.

Judge Kahn said Blair should not receive special treatment because she is a celebrity.

Collin Gosselin alleges abuse by mother Kate ahead of memoir release

Collin Gosselin says his mother, Kate, physically and emotionally mistreated him as a child. His memoir, “In the Shadow of Eight,” is due out Oct. 13.

Health

Early research links GLP-1 drugs to signs of slower biological aging

Early research suggests GLP-1 drugs may affect biological aging, but experts say the evidence is not strong enough to use them solely in hopes of living longer.

“My concern is that people could overread some of this stuff.”
Dr. James Kirklanddirector of the Center for Advanced Gerotherapeutics at Cedars-Sinai Medical Center

UCLA specialists outline how doctors can choose between two MASH drugs

A UCLA-led review offers an algorithm to help doctors choose between resmetirom and semaglutide, the first two FDA-approved drugs for adults with MASH and moderate to advanced fibrosis.

Bimatoprost eye lens shows early promise for cataracts and glaucoma

A lens containing the glaucoma drug bimatoprost showed early promise in a randomized comparison with standard glaucoma therapy for people with cataracts and glaucoma.

Italian Registry Study Finds Avacopan Appeared Effective for AAV

An Italian registry study found that avacopan appeared strongly effective for ANCA-associated vasculitis, though the finding may not settle concerns about the treatment.

Inclisiran lowered LDL cholesterol more than bempedoic acid in a trial

In a study of 402 adults at high cardiovascular risk, inclisiran reduced LDL cholesterol more than bempedoic acid after 150 days. Similar overall rates of side effects were reported in both groups.

European groups issue guidance on two MASH treatments

Three European medical groups recommend considering resmetirom or semaglutide for some adults with non-cirrhotic MASH and significant liver fibrosis, alongside lifestyle changes and careful monitoring.

Syndax ends Niktimvo development for lung disease after Phase 2 failure

Syndax is ending development of Niktimvo for idiopathic pulmonary fibrosis after the treatment failed a mid-stage trial.

Syndax is ending development of Niktimvo as a treatment for idiopathic pulmonary fibrosis, or IPF.

IPF is a rare lung disease.

The treatment failed a Phase 2 trial, a mid-stage study of a medicine.

The result means Syndax will not continue developing Niktimvo for this disease.

Read full story →

Experts raise safety concerns about Neurocrine’s Prader-Willi drug

Vykat XR has been linked to seven deaths and nearly 100 hospitalizations since its approval, though case reports do not prove the drug caused them. Some experts are urging its withdrawal.

Vykat XR was approved to treat Prader-Willi syndrome.

An open letter about potential safety issues tied to the drug was released.

STAT reported growing alarm among patient advocates and some experts.

US FDA supports planned trial of StemSmart therapy for Crohn’s disease

The FDA supported most elements of NeuroScientific Biopharmaceuticals’ proposed phase two trial of its StemSmart cell therapy. The company aims to start the study in Australia and the US by the end of 2026.

FDA response
Positive responses to six of seven Pre-IND questions
Earlier study
18 patients; 78 per cent overall clinical response rate
Remission
44 per cent of patients in the earlier study
Planned trial
Phase two, in Australia and the US

Bristol Myers lung drug succeeds at lower dose, but higher dose misses target

Bristol Myers Squibb said admilparant slowed lung function decline in a Phase 3 trial of people with idiopathic pulmonary fibrosis, but only the lower dose met the main goal.

Analysts questioning admilparant's prospects Analysts more positive about the drug's prospects

Dose response

The high-dose result was confounding and the lack of dose response raised questions about the drug's profile.

The lower-dose success could open a major commercial opportunity despite lingering questions.

Mirum reports late-stage trial success for Livmarli in rare liver diseases

Mirum Pharmaceuticals said Livmarli significantly reduced cholestatic pruritus in a late-stage trial involving ultra-rare liver diseases.