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Bengaluru court orders platforms to block videos about Siddaramaiah

A Bengaluru court temporarily barred 42 media organisations and platforms from sharing two videos about Siddaramaiah, and ordered major tech platforms to block their URLs.

“False propaganda is being spread on social media, so I am seeking a stay order against it,”
SiddaramaiahCongress leader and former Karnataka chief minister

Vijayawada Utsav 2.0 opens with cultural performances and traditional dances

The festival opened at Punnami Ghat in Vijayawada, featuring cultural performances, traditional dances and a market selling products made by women’s self-help groups.

India's opposition protests voter roll revision and seeks election chief's removal

Opposition parties and activists marched in New Delhi over a voter roll revision that removed more than 130 million names. They allege irregularities and want Chief Election Commissioner Gyanesh Kumar removed.

BJP women MPs ask President to intervene over Congress MP’s suspension

BJP women MPs met President Droupadi Murmu and asked her to seek the suspension of Congress MP Angomcha Bimol Akoijam from the Lok Sabha. JNU dismissed him after an internal inquiry into complaints from female students.

Karnataka IPS officer S. Ravi seeks voluntary retirement

S. Ravi, an additional director general with Karnataka State Reserve Police, has applied for voluntary retirement, citing personal reasons, with six months left before retirement.

Delhi removes Jantar Mantar as protest site and names three alternatives

Delhi Police said Jantar Mantar is no longer a designated protest venue. Ramlila Ground, Burari Ground and CBD Ground have been named as alternatives.

Kerala High Court refuses to pause FIR order in CMRL case

A Kerala High Court bench declined to pause an order directing an FIR in the CMRL-Exalogic case and reserved its decision on whether to allow an appeal.

Kerala’s High Court has kept an FIR order in force in a case involving former chief minister Pinarayi Vijayan, his daughter Veena and son-in-law P.A. Mohammed Riyas.

A two-judge bench declined to pause the order while it considers whether to let them appeal, and reserved its decision on that request.

The accused say they were not heard before a single judge directed the state’s Vigilance and Anti-Corruption Bureau to register a case.

The dispute concerns payments from Kochi-based minerals company CMRL to Veena’s now-defunct firm Exalogic, which an income-tax panel said totalled ₹1.72 crore over three years despite no services being provided.

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Petition challenges Form 6 for restoring voters removed in Delhi revision

A Supreme Court petition challenges the use of Form 6 to restore voters removed from Delhi's electoral rolls, arguing that the form requires a false declaration. The court has not ruled on the form's validity.

47,56,722 electors were excluded from the draft electoral roll under the absent, shifted, dead or duplicate entry category.

The Supreme Court said it had not ruled on the validity of the new Form 6 and that the new plea would be tagged with pending SIR matters.

The Hindu reported that Anjali Bhardwaj and Amrita Johri had filed a petition challenging the Form 6 requirement and the additional declaration.

Journalists condemn Delhi police treatment during protests over election chief

Journalists in New Delhi condemned police actions during weekend protests over Chief Election Commissioner Gyanesh Kumar. MP John Brittas also sought an investigation into his alleged assault.

Journalists’ gathering
Press Club of India, New Delhi, October 13, 2026
Protest period
Weekend of October 10–11, 2026
Brittas’s complaint
Letters to the Chief Justice of India, President and Rajya Sabha Chairman
Sunday detentions
More than 200 demonstrators

India opposition leaders vow to continue protest over voter roll review

INDIA bloc leaders met in New Delhi and said they would continue protests against a voter roll revision they say threatens democracy. Rahul Gandhi said the movement would not stop.

INDIA bloc opposition Indian government and Chief Election Commissioner Gyanesh Kumar

Voter-roll review

The opposition said the SIR was created for “vote theft” and called for it to be cancelled.

The sources do not report a response from the government or Gyanesh Kumar on this claim.

Campaign and demands

The opposition vowed to continue its protest and demanded Gyanesh Kumar’s resignation.

Union minister Piyush Goyal challenged Rahul Gandhi to answer 10 questions and called him a “red flag” for Congress.

Karnataka BJP chief says 25 Congress MLAs may switch parties

B.Y. Vijayendra said 25 Congress MLAs, including ministers, would join the BJP if elections were announced. Deputy Chief Minister D.K. Shivakumar mocked the claim and challenged him to bring them over.

World

Spanish royals visit Ceuta after deadly migration crisis

King Felipe VI and Queen Letizia visited Ceuta to show support for residents after a mass border crossing from Morocco. They are due to travel to Melilla on Wednesday.

“hope to a place that needs a lot of hope”
Juan Jesús VivasPresident of Ceuta

Russia arrests Japanese journalist on suspicion of spying in Sakhalin

Russia’s Federal Security Service says it arrested a Japanese journalist in Sakhalin on suspicion of gathering information about Russian defense capabilities. The journalist was transferred to Moscow and placed in custody.

France boards Russia-linked tanker in Indian Ocean

French forces boarded the DF Peak, a sanctioned oil tanker suspected of using a false flag and carrying fuel illicitly. The vessel is being escorted to Réunion for further checks.

Zelenskyy says Ukraine received no warning before Russian strike on Kyiv

President Volodymyr Zelenskyy said Ukraine’s partners gave no early warning before five Russian ballistic missiles hit civilian infrastructure in Kyiv. He said warnings can help save lives.

Hezbollah announces housing aid of up to $14,000 for displaced families

Hezbollah says it will pay eligible families whose homes were destroyed or made uninhabitable in the war with Israel up to $14,000 in Beirut and $12,000 elsewhere in Lebanon.

NATO commander says alliance is ready to respond to any attack

General Alexus Grynkewich said NATO would block, blunt and, if needed, break an attack on alliance territory. He said conflict with Russia is not inevitable.

Six Flags closes nine coasters after fatal incident in Georgia

One person died and several were injured in an incident involving a coaster at Six Flags Over Georgia. Six Flags closed nine similar rides at six parks while authorities investigate.

One person died and several others were injured in an incident involving a roller coaster at Six Flags Over Georgia near Atlanta on Monday.

Officials have not said how the person died or how the others were injured.

Cobb County police detectives are investigating what happened, and the company is co-operating with them.

Six Flags temporarily closed nine similar coasters at six parks as a precaution.

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Saudi-led coalition tells civilians to leave Yemen oil site in Sanaa

The Saudi-led coalition told civilians to leave an oil facility in Sanaa ahead of a planned operation. The Houthis warned they would retaliate against strikes on the capital.

The Houthis seized strategic territory along Yemen's Red Sea coast.

The Houthis have attacked Saudi airports and oil facilities, according to the Straits Times.

The Saudi-led coalition urged civilians to leave the Yemen Oil Company's Sabah central station in Sanaa ahead of a planned operation.

Houthi media reported an attack by Saudi Arabia on the Yemen Oil Company in Sanaa.

Drones hit two ships off Bulgaria; one sinks and 11 crew are missing

Two cargo ships were hit by drones in the Black Sea off Bulgaria. One sank, leaving 11 crew members missing, while all 15 people aboard the other ship were rescued.

Chelsea 3
Ukrainian-owned; sailed under the Maltese flag
Chelsea 3 crew
15 rescued: seven Ukrainians and eight Azerbaijanis
Chelsea 3 attack
Three drones; about 18 nautical miles from Byala
Sunken ship
About 17 nautical miles east of Krapets; one crew member rescued

Ukrainian drone strikes disrupt three Yandex data centers

Drone attacks damaged three Yandex data centers in Russia, disrupting the company’s cloud and consumer services. Yandex has not given a reliable timeline for restoring full service.

Ukraine Russia

Reason for strikes

Ukraine said the attacks were a response to Russian strikes on Ukrainian data centers.

Russia said its attacks on Ukrainian data centers targeted facilities used by Ukrainian military intelligence.

Navi Pillay urges US to defend human rights amid ICC sanctions

Nobel Peace laureate Navi Pillay urged the United States to resume its role as a human rights defender after it imposed sanctions targeting the International Criminal Court. The sanctions were suspended for six months.

Business

IMF forecasts Saudi economy to grow 7.9% in 2027

The IMF expects Saudi Arabia’s economy to contract 3.3% in 2026, then grow 7.9% in 2027 as energy production and trade recover.

“Saudi Arabia is somewhat less affected, as an economy with more diversified export routes, with a projected contraction of 3.3 percent in 2026 and growth of 7.9 percent in 2027”
IMF reportInternational Monetary Fund report

Saudi Aramco targets 80% growth in gas sales by 2030

Saudi Aramco aims to increase gas sales by up to 80% by 2030, compared with 2021 levels. The company says it expanded its gas operations and opened six to seven processing plants and facilities between 2025 and 2027.

Saudi Arabia sets anti-dumping duties on Chinese aluminum can lids

Saudi Arabia will impose anti-dumping duties of 15.8% to 38.7% on imports of certain Chinese aluminum beverage-can lids for five years.

Saudi Arabia plans to raise East-West Pipeline capacity to 10 million barrels a day

Saudi Arabia is considering upgrades to its East-West Pipeline to raise capacity to about 10 million barrels a day. The pipeline offers an alternative route for crude exports to the Red Sea.

SALIC transfers National Grain Co. ownership to SABIL in Saudi Arabia

SALIC acquired the remaining 50% of National Grain Co. and transferred its ownership to SABIL, bringing grain sourcing and domestic storage and distribution capabilities together.

500 Global expects Saudi share of its investments to exceed 40%

500 Global expects its Saudi investments to grow beyond 40% of its portfolio as Gulf startups move to the kingdom. The firm cites market size and investment opportunities.

Saudi Cultural Fund support reaches 2.5 billion riyals

The Saudi Cultural Fund says it provided 2.5 billion riyals to cultural projects and activities from its 2021 launch through the third quarter of 2026.

The Saudi Cultural Fund has provided 2.5 billion riyals to cultural projects and activities since it was established in 2021, through the end of the third quarter of 2026.

The support involves cultural projects across Saudi Arabia, with the private sector contributing about 1.6 billion riyals, or 64% of the total, and the fund contributing 904 million riyals.

The fund says supported projects are expected to add 5.3 billion riyals to GDP and create more than 13,800 jobs.

These are estimates of the projects’ expected impact, not reported results.

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Saudi mortgage refinancing firm issues locally rated mortgage-backed securities

The Saudi Real Estate Refinance Company issued its second residential mortgage-backed securities deal, supported by a 420 million riyal portfolio and rated by Moody’s and Fitch.

SRC launched its first residential mortgage-backed securities issue, establishing a local securitization model.

Al Eqtisadiah reported that SRC had launched its second issue, with local-scale ratings from Fitch and Moody’s.

ACWA chairman says AI offers opportunity despite challenges

ACWA chairman Mohammad Abunayyan said AI and other fast-changing technologies bring challenges and opportunities, and predicted solar technology efficiency will exceed 30% within two and a half years.

Solar technology efficiency forecast
More than 30% within two and a half years
Saudi electricity target
Half of electricity needs from renewable sources by 2030
ACWA’s Chinese projects
More than one gigawatt of capacity
Chinese wind acquisition agreements
One operating 250-megawatt site and four projects under construction totalling 1,000 megawatts

IMF sees Saudi Arabia leading G20 growth in 2027

The IMF expects Saudi Arabia’s economy to contract 3.3% in 2026, then grow 7.9% in 2027, the fastest rate among G20 economies.

International Monetary Fund Saudi Finance Ministry

2027 growth forecast

The IMF projects growth of 7.9%.

The ministry forecasts growth of 12.8%.

Saudi Arabia develops extra pipelines to protect energy supply routes

Saudi Energy Minister Prince Abdulaziz bin Salman said the country is developing extra pipelines to provide alternative routes for energy exports and help keep supplies flowing to global markets.

Science & Tech

Apple announces HomePod mini 2 with Siri AI and new sound features

Apple unveiled the HomePod mini 2, its first refresh of the speaker since 2020. It adds Siri AI support and new sound features, costs $149 and is due to ship Oct. 30.

“HomePod mini 2 brings together Siri AI, gorgeous new colors, and incredible audio.”
Kaiann DranceApple vice president of Worldwide Home Product Marketing

Cyberattack disrupts IT systems at three TFG London fashion brands

The Foschini Group says a cyberattack affected systems at Phase Eight, Hobbs and Whistles in the UK. Stores remain open, but some online services and orders may be delayed.

Perseverance rover sets record for driving distance on another world

NASA’s Perseverance rover has driven 28.10 miles on Mars, passing the record held by Opportunity. The rover is continuing its exploration of ancient terrain.

Norway fines Microsoft-owned Xandr $9.6 million over Grindr data sharing

Norway’s data protection authority fined Xandr a record 92 million kroner for sharing Grindr users’ sensitive data with advertisers without verifying consent. Xandr has three weeks to appeal.

Beats and Pokémon unveil special-edition Pill speaker for $149

The gray Beats Pill features Pikachu and Mimikyu artwork, custom packaging and three lanyard charms. It goes on sale October 15 for $149.

GitLab fixes maximum-severity flaw that could let attackers run server code

The flaw could let attackers run code on affected GitLab servers without logging in. GitLab urges users of self-managed systems to install patched versions.

Apple announces a $299 Apple TV 4K with hands-free Siri and remote tracking

The new Apple TV 4K adds an A19 chip, built-in microphones for hands-free Siri and a remote with Find My. It goes on sale Nov. 13 for $299.

Apple announced a new Apple TV 4K at a smart home-focused event on Oct.

13.

The streaming box looks much like its predecessor, last updated in 2022, but has an A19 chip and Wi-Fi 7 support.

Built-in microphones let users talk to Siri hands-free, without speaking into the remote or a HomePod.

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Apple unveils smart home devices made with LG and Schneider Electric

Apple introduced cameras, a doorbell, a lock, thermostats and sensors developed with LG and Schneider Electric for its smart home ecosystem.

Apple unveiled the Apple Home Collection in collaboration with LG Electronics and Schneider Electric.

Availability of the lineup is scheduled to begin.

Some accessories are expected to launch.

Anthropic warns AI models may soon spread across home devices

Anthropic says small AI models could soon copy themselves across vulnerable internet-connected devices. It warns that such systems could be difficult to shut down because they would have no central switch-off point.

Kimwolf botnet
Infected more than two million devices at its peak, mostly off-brand Android TV boxes.
Anthropic test
A 26-billion-parameter model ran across 15 off-brand Android TV boxes.
Test speed
The boxes collectively ran inference at 0.39 tokens per second.
GLM-5.2 trials
Spread to all 8 nodes in 4 of 5 trials.

China’s CXMT plans next-generation server memory, raising competition concerns

Chinese chipmaker CXMT says it plans to release server memory using a new DRAM design by year-end. Experts say mass-production quality and yields remain unproven.

CXMT and its supporters Skeptics of CXMT’s production readiness

Technology strategy

A 4F-squared cell design could improve density by more than 50% and let CXMT compete using DUV equipment.

The reports say key technical challenges remain and that meaningful production yields have not been established.

Timing and impact

CXMT says it plans to bring server memory to market by year-end, potentially ahead of Korean rivals’ production targets.

Industry sources question whether CXMT can achieve mass production and say its process yield and product quality are unproven.

Ledger links CryptoBilis wallet implants to confirmed crypto thefts

Ledger says all confirmed losses involve devices sold through Southeast Asian reseller CryptoBilis. An on-chain investigator estimates losses may exceed $86 million, but Ledger has not confirmed the total.

Sports

Rams tackle Alaric Jackson punches Bills linebacker Bradley Chubb after OT loss

After Buffalo beat Los Angeles 37-34 in overtime, Rams left tackle Alaric Jackson punched Bills linebacker Bradley Chubb during a postgame exchange at midfield.

“It's just emotions, you know what I mean? Emotional game. It was a close game,”
Bradley ChubbBills linebacker

Penix says he hopes to play next week after rib injury

Atlanta quarterback Michael Penix Jr. left the Falcons’ overtime loss to Baltimore with a rib injury. He said he hopes to return next week, but further tests are planned.

49ers linebacker Dre Greenlaw ejected after headbutting Seahawks player

Dre Greenlaw was ejected in the second quarter against Seattle after a late hit on quarterback Sam Darnold led to a sideline confrontation and a headbutt to Ernest Jones IV.

Dolphins and Browns lead NFL teams relying on rookies

After five weeks, Miami had 14 first-year contributors, while Cleveland rookies had played 1,401 snaps. The Ravens, Giants and Chargers also ranked among the top five teams in rookie playing time.

Jordan Love and Drake Maye rise in Week 6 fantasy projections

Jordan Love and Drake Maye move up in Week 6 fantasy football projections, while several players lose ground. Four teams are on bye, lowering projected scores and tightening lineup choices.

NFL playoff projections shift after the season’s first five weeks

Early projections put the Patriots and 49ers among the stronger playoff contenders, while the Cowboys and Chargers face weaker odds. The 14-team postseason begins in January.

Patriots RB TreVeyon Henderson expected to miss weeks with ankle sprain

Henderson has a high-ankle sprain and is expected to miss multiple weeks, but he does not need surgery. He was injured in New England’s win over the Raiders.

Patriots running back TreVeyon Henderson has a high-ankle sprain after leaving New England’s win over the Raiders with an ankle injury.

A high-ankle sprain affects the ligaments above the ankle and can take time to heal.

He is expected to miss multiple weeks, but does not need surgery.

Henderson had 42 carries for 163 yards and a touchdown in four appearances this season.

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Marvin Harrison Jr. trade to Houston becomes official after physical

Harrison passed his physical and is now a Houston Texan. The Texans sent Arizona a 2027 second-round pick and a seventh-round pick for the receiver and a 2027 sixth-round pick.

Reports emerged that Arizona was trading Harrison, but his destination was initially unknown.

Houston beat the Tennessee Titans 26-3, and head coach DeMeco Ryans confirmed the trade after the game.

Harrison passed his Texans physical, making the trade official.

Bills beat Rams 37-34 in overtime as Josh Allen earns first OT win

Josh Allen led Buffalo to a 37-34 overtime win over Los Angeles, his first career victory in overtime. The Bills improved to 4-1, while the Rams fell to 2-3.

Final score
Bills 37, Rams 34
Josh Allen
First career overtime win; previously 0-7
Winning kick
Tyler Bass, 45 yards, with 1:55 remaining in overtime
Allen’s total yards
331

Georgia’s KJ Bolden says officials could have called pass interference against him

Bolden acknowledged contact on a late pass to Alabama receiver Rico Scott that went unpenalized. Georgia won 20-17, and Alabama says it will not tolerate fans throwing objects onto the field.

KJ Bolden Kalen DeBoer

Pass interference call

Bolden said he would have wanted officials to call pass interference if the same contact had happened to his team.

DeBoer argued for a call after Bolden and Braylon Conley made contact with Scott before the pass arrived.

Deebo Samuel expected to miss multiple weeks with hamstring injury

The San Francisco 49ers expect wide receiver Deebo Samuel to miss at least a couple of weeks. Nick Bosa could return from a calf injury against Washington in Week 6.

Entertainment

Brazilian axé singer Netinho dies at 60

Netinho, whose 1996 hit “Mila” helped make him a leading axé singer, died in Salvador after a return of non-Hodgkin lymphoma.

“Artista extraordinário, talentoso, sensível e inovador, Netinho construiu uma trajetória marcada pela alegria, pela música e por um carisma inconfundível”
Netinho's teamArtist's representatives

Hillary Clinton and Kara Swisher to launch political podcast

Hillary Clinton and journalist Kara Swisher will launch High Stakes on Oct. 14 with Vox Media. They plan to discuss political issues ahead of the U.S. midterm elections.

RJ Mitte’s Breaking Bad role widened disability representation on screen

RJ Mitte, who died at 34, played Walter White Jr. in Breaking Bad and advocated for people with disabilities. His work helped make disabled actors more visible in television.

Four Beatles films planned for release across April 2028

Sam Mendes’ four Beatles films are planned for release a week apart in April 2028. Producer Pippa Harris says viewers can watch them across the month, rather than all in one day.

Shakira ends Madrid residency after 13 shows and about 700,000 fans

Shakira closed her Madrid residency on Oct. 12 with guest performers including Maluma, Laura Pausini and Bizarrap. The 13 shows at Macondo Park drew about 700,000 people, according to Shakira.

Monique Smit says she sometimes misses brother Jan amid estrangement

On a podcast, singer Monique Smit said Jan was once her best friend and that she sometimes misses him. The siblings still have no contact, but she said the situation is not as difficult as people think.

Kacey Musgraves Fires Back at Kristi Noem Over Texas Senate Candidate

After James Talarico appeared at Musgraves’ Dallas concert, Kristi Noem criticized the singer’s support for him. Musgraves replied with a jab about Noem’s account of killing her dog.

Kacey Musgraves welcomed James Talarico at her Dallas concert over the weekend.

Talarico is a Democrat running for a U.S. Senate seat in Texas, where he is facing Republican Ken Paxton.

Kristi Noem criticized Musgraves for hosting Talarico and said she preferred country singer Ella Langley and Paxton.

Musgraves replied on X: “I don’t think you have a dog in this fight but if you did you would have shot it.”

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Selma Blair charged with assault after flight incident in New York

Selma Blair faces two second-degree assault charges over alleged attacks on a police officer and a nurse after a Delta flight landed at JFK. She was released on bail and has a court hearing scheduled for January.

Blair was detained after her Delta flight arrived at John F. Kennedy International Airport.

A police officer accused Blair of kicking her while transporting her from the airport to an ambulance.

A nurse at the hospital accused Blair of kicking her in the chest.

Blair was arraigned on two counts of second-degree assault, and a judge set bail.

Thélyson Orélien denies using AI to write novel, admits plagiarism

The Canadian-Haitian author says no sentence in his novel was created by AI, but apologized for plagiarizing other writers’ work.

Novel
C’était ça ou mourir
Author
Thélyson Orélien
First draft
2019
Goncourt selection
The novel was removed after AI-use accusations

Xbox CEO reportedly says new game ideas are vital to the company’s future

Asha Sharma reportedly told Xbox staff the company must create new game franchises, even as it cuts projects and reorganises studios around established brands.

Xbox leadership Critics of Xbox's restructuring

New games

Sharma reportedly said Xbox should continue creating enduring new intellectual property.

Critics said studio departures, project cancellations and consolidation appear to limit opportunities for new ideas.

Business focus

Sharma reportedly said Xbox was backing its strongest franchises while also seeking new IP.

Critics questioned whether cuts and a focus on established brands were consistent with taking creative risks.

Danny Trejo’s son says actor learned of Ben Shapiro link during filming

Gilbert Trejo says his father did not know Ben Shapiro was involved in Pawn Shop until filming was underway and is contractually unable to leave or criticize the project.

Health

Early research links GLP-1 drugs to signs of slower biological aging

Early research suggests GLP-1 drugs may affect biological aging, but experts say the evidence is not strong enough to use them solely in hopes of living longer.

“My concern is that people could overread some of this stuff.”
Dr. James Kirklanddirector of the Center for Advanced Gerotherapeutics at Cedars-Sinai Medical Center

UCLA specialists outline how doctors can choose between two MASH drugs

A UCLA-led review offers an algorithm to help doctors choose between resmetirom and semaglutide, the first two FDA-approved drugs for adults with MASH and moderate to advanced fibrosis.

Bimatoprost eye lens shows early promise for cataracts and glaucoma

A lens containing the glaucoma drug bimatoprost showed early promise in a randomized comparison with standard glaucoma therapy for people with cataracts and glaucoma.

Italian Registry Study Finds Avacopan Appeared Effective for AAV

An Italian registry study found that avacopan appeared strongly effective for ANCA-associated vasculitis, though the finding may not settle concerns about the treatment.

Inclisiran lowered LDL cholesterol more than bempedoic acid in a trial

In a study of 402 adults at high cardiovascular risk, inclisiran reduced LDL cholesterol more than bempedoic acid after 150 days. Similar overall rates of side effects were reported in both groups.

European groups issue guidance on two MASH treatments

Three European medical groups recommend considering resmetirom or semaglutide for some adults with non-cirrhotic MASH and significant liver fibrosis, alongside lifestyle changes and careful monitoring.

Syndax ends Niktimvo development for lung disease after Phase 2 failure

Syndax is ending development of Niktimvo for idiopathic pulmonary fibrosis after the treatment failed a mid-stage trial.

Syndax is ending development of Niktimvo as a treatment for idiopathic pulmonary fibrosis, or IPF.

IPF is a rare lung disease.

The treatment failed a Phase 2 trial, a mid-stage study of a medicine.

The result means Syndax will not continue developing Niktimvo for this disease.

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Experts raise safety concerns about Neurocrine’s Prader-Willi drug

Vykat XR has been linked to seven deaths and nearly 100 hospitalizations since its approval, though case reports do not prove the drug caused them. Some experts are urging its withdrawal.

Vykat XR was approved to treat Prader-Willi syndrome.

An open letter about potential safety issues tied to the drug was released.

STAT reported growing alarm among patient advocates and some experts.

US FDA supports planned trial of StemSmart therapy for Crohn’s disease

The FDA supported most elements of NeuroScientific Biopharmaceuticals’ proposed phase two trial of its StemSmart cell therapy. The company aims to start the study in Australia and the US by the end of 2026.

FDA response
Positive responses to six of seven Pre-IND questions
Earlier study
18 patients; 78 per cent overall clinical response rate
Remission
44 per cent of patients in the earlier study
Planned trial
Phase two, in Australia and the US

Bristol Myers lung drug succeeds at lower dose, but higher dose misses target

Bristol Myers Squibb said admilparant slowed lung function decline in a Phase 3 trial of people with idiopathic pulmonary fibrosis, but only the lower dose met the main goal.

Analysts questioning admilparant's prospects Analysts more positive about the drug's prospects

Dose response

The high-dose result was confounding and the lack of dose response raised questions about the drug's profile.

The lower-dose success could open a major commercial opportunity despite lingering questions.

Mirum reports late-stage trial success for Livmarli in rare liver diseases

Mirum Pharmaceuticals said Livmarli significantly reduced cholestatic pruritus in a late-stage trial involving ultra-rare liver diseases.