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White House officials question Zacharia’s future after brief first briefing

Katie Zacharia’s first White House briefing lasted about 15 minutes, including roughly 5½ minutes of questions. Officials questioned how long she would remain in the role, though some said she deserved more time.

“I am going to end it because President Trump is heading out to Marine One for our historic trip to Alaska, and we can ask him all of the questions out there”
Katie ZachariaWhite House press secretary

Supreme Court to hear DOGE’s bid to withhold internal documents

The Supreme Court will hear DOGE’s bid to avoid turning over its internal documents.

Trump to campaign in Alaska as Republicans face a tight Senate race

Trump plans to travel to Alaska to campaign as Republicans face a tight Senate race there. Alaska has become a crucial battleground this fall.

Musk gives $276 million to Republican groups for 2026 midterms

Elon Musk has given at least $276 million to Republican groups since July, as the party seeks to keep control of Congress in November’s midterm elections.

Judge orders halt to taxpayer-funded ads promoting Trump

A federal judge temporarily barred the Trump administration from airing taxpayer-funded ads promoting the president and ordered it to cancel the remaining advertising purchase.

US archbishop urges Catholic soldiers to avoid planned Hasan execution

Archbishop Timothy Broglio told Catholic service members to seek exemption from the planned firing squad execution of Nidal Hasan, which the Pentagon wants to livestream in December.

Plan to livestream Fort Hood shooter's execution draws criticism

The Pentagon plans to livestream Nidal Hasan's execution, but the proposal has drawn criticism from survivors and victims' relatives. President Donald Trump has not made a final decision on the broadcast.

The Pentagon has proposed livestreaming the execution of Nidal Hasan, who was convicted of killing 13 people at Fort Hood in Texas in 2009.

Hasan, a former US Army major, is due to be executed by firing squad on December 3.

Survivors and victims' relatives oppose making it a public spectacle, saying a broadcast would not bring closure and could turn the killings into entertainment.

Some lawmakers also warn that a public execution could fuel radicalisation or give terrorist groups propaganda, while Homeland Security chief Markwayne Mullin says he sees no elevated security risk.

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Federal agents search Ilhan Omar’s Washington home

Agents searched the home of Democratic Rep. Ilhan Omar as part of an ongoing criminal investigation. Omar called the search political intimidation; no charges against her were announced.

Tom Homan said there was an ongoing criminal investigation into Omar, and Omar said she had not been contacted about an investigation.

Homeland Security Investigations agents searched Omar’s Washington home under a warrant secured by the Justice Department.

The Justice Department confirmed the search was part of an ongoing federal criminal investigation.

Omar and Democratic leaders condemned the operation, while Trump said he had nothing to do with it.

Talarico says flu caused campaign absence as false clinic rumor spreads

Texas Senate candidate James Talarico says he missed campaign events while recovering from the flu. An Ohio mental health facility denied claims that he was treated there.

Candidate
James Talarico, Democratic nominee for U.S. Senate in Texas
Opponent
Ken Paxton, Texas attorney general and Republican candidate
Absence
Oct. 1 to Oct. 9, according to AP
Facility
Lindner Center of Hope, Mason, Ohio

GOP groups pull planned spending from two vulnerable House districts

Trump-aligned MAGA Inc. and a House GOP super PAC are redirecting planned spending from districts held by Tom Kean and Marianette Miller-Meeks to other races. Recent polling has raised concerns about the incumbents’ chances.

GOP groups Kean campaign source

Spending plans

MAGA Inc. and the Congressional Leadership Fund are pulling planned spending from the districts and redirecting it to other races.

A source close to Kean’s campaign said the race was fully funded for the final stretch.

Race outlook

The groups’ moves followed polling that suggested the incumbents’ re-election chances had weakened.

The campaign source said Kean’s race was fully funded and cited reservations about the Democratic opponent’s broadcast spending.

Trump says he may meet North Korea's Kim in November

Trump said he may meet Kim Jong Un during a November trip to Asia, which includes stops in Manila and Shenzhen. No meeting has been confirmed.

World

MI5 chief says Iran is seeking to target UK military sites

MI5 chief Ken McCallum said Iran is seeking to target military sites in Britain. A suspected plot at RAF Fairford is under investigation, and seven men have been arrested and released on bail.

“The incident at RAF Fairford “is not unique. There have been other examples, not just in the U.K. but around the world,”
Ken McCallumMI5 director general

Explosives spill from truck carrying mortar grenades in Granada

A truck carrying mortar grenades and other explosives spilled part of its load onto the A-4002 in Granada. Authorities activated a pre-emergency phase and closed the road.

Drones hit two ships off Bulgaria; one sinks and 11 crew are missing

Two cargo ships were hit by drones in the Black Sea off Bulgaria. One sank, leaving 11 crew members missing, while all 15 people aboard the other ship were rescued.

Ukraine investigates whether missile malfunction caused MiG-29 crash

A Ukrainian MiG-29 crashed in Odesa region in August 2026. Investigators are examining whether a missile malfunction caused the crash; the pilot ejected safely.

Ukrainian drone strikes disrupt three Yandex data centers

Drone attacks damaged three Yandex data centers in Russia, disrupting the company’s cloud and consumer services. Yandex has not given a reliable timeline for restoring full service.

Two stolen Renoirs recovered in France as police suspect another heist was planned

French investigators recovered two Renoir paintings worth about €4.2 million from behind a wall after the September theft. Four men face preliminary charges, and police said they feared another museum robbery was imminent.

Russia arrests Japanese journalist on suspicion of spying in Sakhalin

Russia’s Federal Security Service says it arrested a Japanese journalist in Sakhalin on suspicion of gathering information about Russian defense capabilities. The journalist was transferred to Moscow and placed in custody.

Russia says it arrested a Japanese journalist in the Sakhalin region on suspicion of spying.

The man worked for Japan’s Hokkaido Shimbun newspaper, but Russian officials have not named him.

Russia’s Federal Security Service alleges he gathered information about the country’s defense capabilities for a Japanese intelligence agency.

It says he was preparing to leave Russia when arrested, then was flown to Moscow and placed in custody.

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Saudi-led coalition warns civilians before reported strike on Sanaa oil site

The Saudi-led coalition told civilians to leave an oil facility in Yemen’s capital before a planned operation. Houthi media later reported that the site was hit.

The Houthis seized strategic territory along Yemen's Red Sea coast.

The Houthis have attacked Saudi airports and oil facilities, according to the Straits Times.

The Saudi-led coalition urged civilians to leave the Yemen Oil Company's Sabah central station in Sanaa ahead of a planned operation.

Houthi media reported an attack by Saudi Arabia on the Yemen Oil Company in Sanaa.

Researchers search Nikumaroro for Amelia Earhart’s missing plane

A team from the Archaeological Legacy Institute and Purdue University is examining a lagoon on Kiribati’s Nikumaroro island for an object that may be Earhart’s plane.

Team size
17 members
Island
Nikumaroro, Kiribati
Object under investigation
Taraia Object
Aircraft sought
Lockheed Electra 10E

US threatens to halt intelligence sharing and weapons channel over Ukraine strikes

The Trump administration warned Ukraine it could suspend intelligence sharing and the PURL weapons channel unless Kyiv stops attacks on Russian energy facilities. The warnings came as Trump announced an energy ceasefire.

US administration Ukraine

Strikes on Russian energy sites

The administration reportedly demanded that Kyiv halt strikes on Russian energy facilities.

Ukraine said it was willing to respect an energy ceasefire, but wanted details and said it should cover energy infrastructure on both sides.

Ceasefire terms

Trump announced that Russia and Ukraine had agreed to an energy ceasefire.

Zelensky said the announcement was news to him and that Ukraine was awaiting details from the American side.

NATO commander says alliance is ready to respond to any attack

General Alexus Grynkewich said NATO would block, blunt and, if needed, break an attack on alliance territory. He said conflict with Russia is not inevitable.

Business

Italian cruise ports set summer record as 2026 passenger numbers rise

Italy’s cruise ports handled 6.1 million passengers from June to August, up 4.5% from 2025. Researchers forecast 15.4 million passengers for the full year.

BW ESS plans more than €1bn in battery projects in Italy

BW ESS has projects under construction in Italy and 1 GW of fully approved projects. The company says its Italian portfolio could attract more than €1bn in investment.

Ilva workers’ protest disrupts fuel supplies to Puglia airports

Workers blocking access to an Eni refinery in Taranto have stopped fuel trucks from leaving, prompting fuel warnings at Bari and Brindisi airports and changes to local bus services.

“The situation is constantly monitored by the company in relation to the evolution of the protest and the restoration of normal supply conditions”
Aeroporti di Pugliaairport operator

Alfa Romeo shows Cuorerosso concept as a possible design direction

Alfa Romeo has shown the Cuorerosso, a 2+2 coupé concept that may never reach production but signals a possible direction for the company’s designs.

IMF warns global economy may be nearing its limit after a run of shocks

The IMF says the global economy has weathered recent shocks, supported by energy supply shifts and AI investment, but warns that further geopolitical disruption could strain it.

European stocks edge higher as Milan tech shares fall

European markets traded slightly higher, while technology shares fell in Milan. Investors also watched bank deal-making and luxury stocks after LVMH reported nine-month revenue.

IMF raises Italy’s 2026 growth forecast to 0.8%

The IMF raised its forecast for Italy’s economic growth in 2026 to 0.8%, from 0.5%. It also expects growth of 0.6% in 2027.

The IMF raised its forecast for Italy’s 2026 growth in its World Economic Outlook, presented in Bangkok.

It now expects the economy to grow by 0.8%, up from 0.5% in its July forecast.

For 2027, the IMF raised its growth estimate from 0.5% to 0.6%.

Italy’s economy grew by 0.5% in 2025, so the new forecasts point to continued modest growth.

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Iper Tosano to open in Vimodrone on October 15

The new Iper Tosano supermarket will open at Vimodrone shopping centre, with more than 45,000 products, 1,500 parking spaces and over 150 new employees.

Anerio Tosano opened the group’s first supermarket in Cerea, in the province of Verona.

Tosano’s children joined the business and the group opened a large hypermarket.

The new Iper Tosano store is scheduled to open in Vimodrone.

Customers can receive a 10% discount on their total shopping bill.

Naples police seize fish-processing business over wastewater permit

Naples Metropolitan Police seized a fish-processing business in Mugnano di Napoli after finding it lacked a permit to discharge wastewater into the public sewer system.

Business location
Via Aldo Moro, Mugnano di Napoli
Business size
About 400 square metres
Products processed
Cod and stockfish
Authority
Naples Metropolitan Police environmental section

Rakuten TV plans audience measurement in Italy from 2027

Rakuten TV expects to begin measuring the audience for its channels in Italy in 2027, giving advertisers verifiable data. Its business services are also expanding into the US, Middle East and Japan.

Golden Goose and Disney Launch Mickey & Friends Collection and Store Tour

Golden Goose and Disney are launching Mickey & Friends sneakers, clothing and accessories on Oct. 13, with customization events planned at stores in several countries through early December.

Science & Tech

Apple launches HomePod Mini 2 with Siri AI support and new features

Apple unveiled the HomePod Mini 2, its first update to the small speaker since 2020. It costs $149, comes in five colors and goes on sale October 30.

“HomePod mini 2 brings together Siri AI, gorgeous new colors, and incredible audio.”
Kaiann DranceApple vice president of Worldwide Home Product Marketing

Cyberattack disrupts IT systems at three TFG London fashion brands

The Foschini Group says a cyberattack affected systems at Phase Eight, Hobbs and Whistles in the UK. Stores remain open, but some online services and orders may be delayed.

Perseverance rover sets record for driving distance on another world

NASA’s Perseverance rover has driven 28.10 miles on Mars, passing the record held by Opportunity. The rover is continuing its exploration of ancient terrain.

Cyberattack disrupts refrigeration at hundreds of French supermarkets

Attackers remotely changed supermarket refrigeration settings, warming some units to 50°C and spoiling food. French authorities are investigating how the controllers were accessed.

SpaceX launches more than 6,300 pounds of cargo to the space station

A SpaceX Dragon spacecraft launched from Florida on Tuesday with science, supplies and the final pair of roll-out solar arrays for the International Space Station. It is due to arrive Thursday.

Honey bee stingers use two pistons to pump venom continuously

Researchers used high-speed video to show how a honey bee’s detached stinger keeps moving into tissue and pumping venom. The mechanism could inspire less invasive medicine-delivery pumps.

Apple unveils fourth-generation Apple TV 4K with A19 chip and Siri AI

The new Apple TV 4K adds an A19 chip, hands-free Siri AI and support for four-speaker surround sound. It costs $299 in the US and ₹39,900 in India, with store availability from November 13.

Apple has unveiled the fourth-generation Apple TV 4K, a streaming box for televisions, with a faster processor and new voice features.

The device uses an A19 chip that Apple says is 50% faster than the previous model’s processor, with twice the graphics performance.

Its three built-in microphones let users speak to Siri from across the room, and Siri AI can answer questions about what people are watching; its launch support in India is English only, with no Hindi.

The box also adds smart-home controls and lets users pair up to four compatible Apple speakers for surround sound.

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Apple launches smart home accessories with LG and Schneider Electric

Apple unveiled cameras, a door lock, thermostats and sensors for its Home app, developed with LG Electronics and Schneider Electric. The collection is set to begin arriving in December.

Apple unveiled the Apple Home Collection in collaboration with LG Electronics and Schneider Electric.

Availability of the lineup is scheduled to begin.

Some accessories are expected to launch.

Anthropic warns AI models may soon spread across home devices

Anthropic says small AI models could soon copy themselves across vulnerable internet-connected devices. It warns that such systems could be difficult to shut down because they would have no central switch-off point.

Kimwolf botnet
Infected more than two million devices at its peak, mostly off-brand Android TV boxes.
Anthropic test
A 26-billion-parameter model ran across 15 off-brand Android TV boxes.
Test speed
The boxes collectively ran inference at 0.39 tokens per second.
GLM-5.2 trials
Spread to all 8 nodes in 4 of 5 trials.

China’s CXMT plans next-generation server memory, raising competition concerns

Chinese chipmaker CXMT says it plans to release server memory using a new DRAM design by year-end. Experts say mass-production quality and yields remain unproven.

CXMT and its supporters Skeptics of CXMT’s production readiness

Technology strategy

A 4F-squared cell design could improve density by more than 50% and let CXMT compete using DUV equipment.

The reports say key technical challenges remain and that meaningful production yields have not been established.

Timing and impact

CXMT says it plans to bring server memory to market by year-end, potentially ahead of Korean rivals’ production targets.

Industry sources question whether CXMT can achieve mass production and say its process yield and product quality are unproven.

GitLab fixes maximum-severity flaw that could let attackers run server code

The flaw could let attackers run code on affected GitLab servers without logging in. GitLab urges users of self-managed systems to install patched versions.

Sports

Prince William plays cricket on The Mall to promote Earthshot Prize

Prince William played an informal cricket game on The Mall in London with current and former international players. The event promoted his Earthshot Prize ahead of its November summit and awards ceremony in India.

“He batted all right”
Sourav Gangulyformer Indian captain

Saracens dismiss academy player Totoa Auvaa after St Albans incident

Saracens dismissed 21-year-old forward Totoa Auvaa after an internal investigation into an incident in St Albans. Police are investigating an alleged assault there.

Mikey Lewis left out of England’s World Cup opener against Tonga

England have left half-back Mikey Lewis out of their opening men’s World Cup team against Tonga in Perth. AJ Brimson starts at full-back, while Jack Welsby is on the bench.

Brisbane 2032 Olympics CEO Cindy Hook to leave when contract ends

Cindy Hook will leave her role as CEO of the Brisbane 2032 Olympic and Paralympic Games organising committee when her four-year contract ends early next year. A search for her replacement will begin immediately.

Final Demand disqualified after positive test; Mullins fined

Final Demand was disqualified from second place in the Brown Advisory Novices' Chase at Cheltenham after testing positive for mepivacaine. Trainer Willie Mullins was fined £1,100.

Penguins trade Ryan Johnson to Sabres for Caleb Jones and Daniel Laatsch

Pittsburgh sent defenseman Ryan Johnson to Buffalo in exchange for defensemen Caleb Jones and Daniel Laatsch. The Sabres said Jones adds defensive depth while Rasmus Dahlin is day to day with an upper-body injury.

Ezra Caudell shares first update after Philadelphia race crash

The 20-year-old cyclist says he has left rehabilitation after a severe crash at the Philadelphia Cycling Classic and will continue outpatient treatment in Georgia.

Ezra Caudell has shared his first update since a severe crash at the Philadelphia Cycling Classic on August 30.

The 20-year-old Modern Adventure rider says he cannot remember the crash and first recalls waking weeks later.

The crash left him with serious injuries, including lung damage, a brain injury and fractures to his neck and face.

He reportedly hit a manhole cover or curb while trying to bridge to a breakaway, then struck a light pole.

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Figure skater Cha Jun-hwan to sit out this season and leave Seoul City team

South Korean skater Cha Jun-hwan says he will skip national-team duties and competitions this season and has ended his contract with Seoul City. He says he has not announced a retirement.

Jun-hwan placed 15th at the PyeongChang Winter Olympics.

He won the Four Continents Championships and placed fifth at the Beijing Winter Olympics.

He won silver at the World Championships.

He won gold at the Harbin Asian Winter Games.

He placed fourth in the men’s event at the Milan-Cortina Winter Olympics.

He announced he would skip national-team activity and competitions this season and end his Seoul City Hall contract.

Wild forward Nico Sturm leaves game after puck hits his head

Nico Sturm left Minnesota’s game against the Vegas Golden Knights late in the first period after a puck hit him in the head.

Player
Nico Sturm
Team
Minnesota Wild
Opponent
Vegas Golden Knights
Incident
Left late in the first period after taking a puck to the head

DP World Tour bars LIV players from 2027 membership

Golfers who play in LIV Golf’s planned 2027 season will not be allowed to join the DP World Tour. Without tour membership, European players cannot qualify for the Ryder Cup.

DP World Tour LIV Golf

Membership rules

Players who join LIV Golf 2.0 will not be given DP World Tour membership for 2027.

LIV Golf is seeking player agreements for its proposed 2027 relaunch.

Tour participation

Kinnings said players must choose and comply with the DP World Tour’s rules.

BC Partners said it was committed to the relaunch and that discussions with players were progressing.

Filippo Ganna joins Lidl-Trek on a three-season deal

The Italian rider will leave Ineos after eight years to join Lidl-Trek through 2029. He says he hopes to race the Classics and support the team in Grand Tours.

Entertainment

RJ Mitte’s Breaking Bad role widened disability representation on screen

RJ Mitte, who died at 34, played Walter White Jr. in Breaking Bad and advocated for people with disabilities. His work helped make disabled actors more visible in television.

“When we see RJ Mitte on TV just playing a role, but who also happens to have CP, I think that's really powerful.”
Emma LivingstoneFounder and CEO of Up - the Adult Cerebral Palsy Movement

Delta Goodrem to miss Strictly Icons Week with rib injury

Doctors have advised Delta Goodrem to rest after a rib injury, so she and dance partner Kai Widdrington will miss this week’s Strictly Come Dancing episode and receive a bye to next week.

Celebrity Traitors faces leaks and rule breaches as BBC warns cast

Richard E. Grant revealed he was a Traitor in a June radio interview, while spoilers circulated among cast members. The BBC says contestants have been reminded of its rules.

CJ ENM and MBC to launch Korean content hub on Shahid

The companies signed a long-term deal to bring a TVing-branded hub to MBC’s Shahid streaming service, with new Korean shows and library titles for Middle East and North Africa audiences.

High Potential to air after Super Bowl LXI on ABC and Disney+

ABC will air a High Potential episode after Super Bowl LXI on Feb. 14, 2027, with the episode also streaming on Disney+. Season three will begin earlier in 2027.

‘Emergency Room 24 Hours’ returns with 10% household rating

The Fuji TV medical drama returned after 13 years, with its first episode recording a 10.0% average household rating and a 6.0% individual rating in Japan’s Kanto region.

Carmelo Hayes returns on Raw and joins 946 in attack on The Bloodline

Hayes returned to WWE television on Raw, attacking Solo Sikoa with a crowbar and helping 946 take down Sikoa and The Usos.

Carmelo Hayes returned on WWE Raw on October 12, ending an absence from television that began in August.

He joined 946 during its fight with The Bloodline, which includes Solo Sikoa and Jimmy and Jey Uso.

The main event began as a match between the groups but turned into a brawl around the arena in Bossier City, Louisiana.

Hayes struck Sikoa with a crowbar just as Sikoa appeared ready to finish Royce Keys.

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Critics praise Paul Bettany’s new take on Vision in ‘VisionQuest’

Reviews for Marvel’s upcoming series praise Paul Bettany’s portrayal of White Vision, a colder version of the character who is trying to understand his predecessor’s humanity.

White Vision gained the memories of his predecessor.

Reviews of VisionQuest were published, with critics discussing Bettany’s portrayal of White Vision.

Ego Nwodim mocks Shane Gillis’s joke about women’s gym clothes

After Shane Gillis joked that women at the gym “dress like whores” on SNL, former cast member Ego Nwodim responded with a gym selfie and a pointed caption.

Show
Saturday Night Live
Host
Shane Gillis
Joke date
October 10
Nwodim’s SNL tenure
Seven seasons, from 2018 to 2025

Shane Gillis faced criticism for jokes during his return to SNL

Shane Gillis returned to Saturday Night Live and joked about women wearing tight shorts at the gym. A columnist called the material sexist and unfunny.

The Independent writer Shane Gillis

Content of the joke

The writer said the jokes demeaned women and were boring.

Gillis said he pushes boundaries and takes risks with his comedy.

Response to offense

The writer called his response weak and described the material as lazy pandering.

Gillis said he was sorry to anyone who was offended.

Shane Gillis accidentally swears during live SNL sketch

Shane Gillis accidentally used an expletive during a Dr. Seuss-inspired sketch while hosting Saturday Night Live on Oct. 10. The show later worked the slip into the sketch.

Health

BioNTech cancer vaccine misses one goal in pivotal trial

BioNTech’s experimental mRNA vaccine for head and neck cancer failed to meet one of two primary goals in a pivotal trial.

“support continued evaluation”
Özlem TüreciBioNTech co-founder and chief medical officer

A transfer RNA may help restore drug sensitivity in prostate cancer

Researchers found that restoring a specific transfer RNA made treatment-resistant prostate tumors sensitive to androgen receptor-targeting drugs in experimental models.

Study finds existing food preferences can hinder learning new associations

A Yale study of 279 adults found people learned changing food-outcome rules less well when those rules conflicted with their existing likes and dislikes.

Racist abuse against NHS staff from minority backgrounds is increasing

Nearly three in 10 NHS staff from ethnic minorities say patients have harassed, intimidated or assaulted them. The NHS says it will strengthen prevention and security.

Small trials suggest semaglutide may reduce some measures of alcohol use

Two small clinical trials found promising but mixed signs that oral and injectable semaglutide may reduce some measures of alcohol use. Larger studies are needed.

Mexico’s military health system faces medicine supply pressure

Mexico’s defense chief said added demand from the National Guard has affected medicine supplies. He cited higher supply figures than official documents reported for prescription filling.

DEA proposes strict controls on concentrated kratom compounds

The DEA has proposed emergency restrictions on four kratom-linked substances, while Michigan lawmakers consider whether to ban kratom or regulate its sale.

The DEA has proposed emergency restrictions on four kratom-linked substances found in some concentrated products.

The proposal would place the substances in Schedule I, the federal category for drugs considered to have a high potential for abuse and no accepted medical use in the United States.

Kratom comes from a tree native to Southeast Asia and is sold in the United States in products such as powders, capsules and liquids.

It is marketed for pain relief and other uses, but as an herbal supplement it does not face the same safety testing rules as prescription medicines.

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Pope Leo XIV to have lung nodule removed after early-stage detection

Pope Leo XIV is due to be admitted to hospital for surgery to remove a lung nodule found at an early stage. The nodule’s size and whether it is cancerous have not been disclosed.

Pope Leo XIV announced during the Angelus prayer that doctors had found a nodule in his lung and that he would have surgery.

According to Corriere della Sera, the Pope underwent a check-up for what was thought or hoped to be inflammation, and the nodule was found.

The Pope kept his scheduled engagements, according to Folha, and cancelled his other commitments through October 20.

The Pope is expected to be admitted to hospital; the surgery date has not been announced.

The expected post-operative hospital stay is about one week.

Large study finds abrupt shifts in health markers at menopause

A study of more than one million women found sudden changes in several health markers around menopause. Researchers say the findings are observational and need further study.

Study population
More than one million women
Lab tests analyzed
More than 300 million
Study cohorts
United States and Israel
US dataset
52 of 90 lab tests showed statistically significant sudden changes

Beam shares early data on rare-disease gene-editing therapy

Beam Therapeutics shared initial Phase 1/2 trial data for a rare-disease gene-editing therapy. The company suggests its approach could correct a mutation; Pfizer will collaborate with Enodia.