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Trump’s plan to import Russian diesel draws bipartisan criticism

Trump says the U.S. will import Russian diesel to ease fuel prices. Lawmakers from both parties say the plan could help finance Russia’s war in Ukraine and may violate U.S. law.

“The harm to the Ukrainians is real”
William TaylorFormer US ambassador to Ukraine and Atlantic Council senior fellow

Elon Musk gives more than $276 million to Republican groups since July

Musk has donated more than $276 million to Republican groups since July, making him the biggest known donor of the 2026 midterm elections. The largest share went to a group backing Republican Senate candidates.

Los Angeles moves to make some nitrous oxide sales a crime

The Los Angeles City Council unanimously approved a ban on cannabis and tobacco retailers selling or distributing nitrous oxide. The mayor plans to sign it, and violations could bring jail time.

Former DOGE staff raise at least $500 million for private firms

At least two dozen former DOGE staff have moved into private businesses, and firms they co-founded or invested in have raised at least $500 million.

Katie Zacharia begins term as White House press secretary

Katie Zacharia is starting her term as White House press secretary. President Trump said she will hold an introductory news conference Tuesday at 9:30 a.m.

Supreme Court to hear Trump’s dispute with watchdog group over DOGE

The Supreme Court is set to hear Donald Trump’s dispute with a watchdog group over DOGE. No details of the case or hearing date are provided.

Supreme Court to hear DOGE’s bid to withhold internal documents

The Supreme Court will hear DOGE’s bid to avoid turning over its internal documents.

The Supreme Court will hear DOGE’s bid to avoid turning over internal documents.

DOGE is seeking to keep its internal documents from being handed over.

The dispute is about access to DOGE’s internal records.

The source does not provide details about the documents or the background to the dispute.

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GOP groups pull planned spending from two vulnerable House districts

Trump-aligned MAGA Inc. and a House GOP super PAC are redirecting planned spending from districts held by Tom Kean and Marianette Miller-Meeks to other races. Recent polling has raised concerns about the incumbents’ chances.

Politico reported that MAGA Inc. was planning major spending changes in the final weeks before Election Day.

A source confirmed to Fox News that MAGA Inc. was reallocating planned spending from Kean’s and Miller-Meeks’ districts, while a source said the Congressional Leadership Fund was also pulling its money.

Federal agents search Ilhan Omar’s Washington home

Agents searched the home of Democratic Rep. Ilhan Omar as part of an ongoing criminal investigation. Omar called the search political intimidation; no charges against her were announced.

Search date
October 12, 2026
Search location
Omar’s home in the Washington, DC area
Investigative agency
Homeland Security Investigations, according to Fox News
Investigation status
Ongoing federal criminal investigation; officials disclosed no details

US archbishop urges Catholic soldiers to avoid planned Hasan execution

Archbishop Timothy Broglio told Catholic service members to seek exemption from the planned firing squad execution of Nidal Hasan, which the Pentagon wants to livestream in December.

Archbishop Timothy Broglio Defense Secretary Pete Hegseth

Purpose of public broadcast

Broglio questioned the value of broadcasting the execution and said it could harm the military’s reputation.

Hegseth said making the event public would help people understand the serious consequences of such acts.

Participation by Catholic service members

Broglio urged Catholics assigned to the firing squad to request exemption because participation would violate Church teaching.

Hegseth described using military members to carry out the execution; the sources do not state his view on religious exemptions.

Texas Senate candidate James Talarico says flu caused campaign absence

James Talarico said he missed campaign events while recovering from the flu. A mental health clinic in Ohio denied claims that he was treated there.

World

Drones hit two ships off Bulgaria; one sinks and 11 crew are missing

Two cargo ships were hit by drones in the Black Sea off Bulgaria. One sank, leaving 11 crew members missing, while all 15 people aboard the other ship were rescued.

“This is absolutely unacceptable: yet another attack in close proximity to Bulgaria’s territorial waters”
Rumen RadevBulgarian prime minister

Break-in reported at business building in Drensteinfurt-Walstedde

Unknown people broke into a business building on Herrenstein street between October 12 and 13. Police are asking witnesses to come forward.

France boards Russia-linked tanker in Indian Ocean

French forces boarded the DF Peak, a sanctioned oil tanker suspected of using a false flag and carrying fuel illicitly. The vessel is being escorted to Réunion for further checks.

Nuremberg airport reopens after plane makes emergency landing

Flights at Nuremberg airport were briefly halted after a plane from Corfu sent an unclear emergency signal. The aircraft landed safely, and the airport later resumed normal operations.

Two Turkish citizens detained in Germany over fire at Polish Starlink station

German police detained two Turkish citizens suspected of setting fire to a Starlink station in central Poland. Polish officials say they will face sabotage charges in Poland.

Court orders new hearing in case over passport error that stopped family’s Thailand trip

A passport error listing a child’s sex incorrectly stopped a Krasnodar family from travelling to Thailand. A court overturned earlier rulings and sent the compensation case back for a new hearing.

Eight people injured in stabbing at Incheon supermarket

A man stabbed eight people at a supermarket in Incheon, South Korea. Police detained the suspect and are investigating the attack.

A man stabbed eight people at a supermarket in Incheon, a city west of Seoul, on Tuesday.

Police said one person went into cardiac arrest and seven others were injured; all eight were taken to hospitals.

The suspect, described by police as being in his 60s, was subdued by shoppers and detained by police.

He moved through the building with knives fastened to his hands, according to police.

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Truck ends up on Merwedebrug cycle path despite heavy-vehicle ban

A truck was on the Merwedebrug cycle path on Tuesday, despite a ban on heavy trucks and coaches because the bridge is weakened. Rijkswaterstaat inspectors were on their way.

The Merwedebrug was closed to heavy trucks and coaches because of its weakened structure.

A truck ended up on the bridge’s cycle path.

The truck was still on the cycle path, and Rijkswaterstaat road inspectors were on their way to guide the driver.

MI5 chief warns Iran and Russia are stepping up threats to Britain

MI5 chief Ken McCallum said Iran is seeking to target harder sites, including military locations, while Russia is increasing hybrid operations against Ukraine’s allies. He also warned that AI could help terrorists develop biological weapons.

MI5 chief
Ken McCallum
Suspected plot site
RAF Fairford, western England
Arrests
Seven men were arrested and released on bail under investigation.
Iran-linked operations
More than 50 arrests over the past year, according to McCallum.

UK says Iran was highly likely behind RAF Fairford security incident

Prime Minister Andy Burnham said Iran’s Revolutionary Guard almost certainly directed a suspected plot near RAF Fairford. Britain has sanctioned two people and says further sanctions may follow.

UK government Iranian government

Responsibility

Burnham said the incident was highly likely to have been coordinated in Iran and almost certainly directed by the IRGC.

Iran rejected any suggestion it was involved and called the accusation unfounded and malicious speculation.

Evidence

British authorities cited their assessment and said investigators found accelerants but no viable explosives in vans.

Iran called on Britain to present evidence supporting its allegations.

Polish foreign minister says a European army could form by 2030

Radosław Sikorski said a joint European force could be formed by 2030, possibly limited to the Baltic states and the eastern flank.

Business

IMF forecasts Saudi economy to grow 7.9% in 2027

The IMF expects Saudi Arabia’s economy to contract 3.3% in 2026, then grow 7.9% in 2027 as energy production and trade recover.

“Saudi Arabia is somewhat less affected, as an economy with more diversified export routes, with a projected contraction of 3.3 percent in 2026 and growth of 7.9 percent in 2027”
IMF reportInternational Monetary Fund report

Saudi Aramco targets 80% growth in gas sales by 2030

Saudi Aramco aims to increase gas sales by up to 80% by 2030, compared with 2021 levels. The company says it expanded its gas operations and opened six to seven processing plants and facilities between 2025 and 2027.

Saudi Arabia sets anti-dumping duties on Chinese aluminum can lids

Saudi Arabia will impose anti-dumping duties of 15.8% to 38.7% on imports of certain Chinese aluminum beverage-can lids for five years.

Saudi Arabia says foreign investment in emerging sectors rose 162%

Investment Minister Fahad Al-Saif said foreign direct investment in emerging economic sectors rose 162% over five years. He said Saudi Arabia will now focus on investment quality and productivity.

US corporate bond spreads narrowed as Treasury yields rose

The 10-year US Treasury yield climbed from 3.96% in February to 5.31% on October 5, while investment-grade corporate bond spreads edged down from 86 to 84 basis points between February and September.

Saudi Arabia plans to raise East-West Pipeline capacity to 10 million barrels a day

Saudi Arabia is considering upgrades to its East-West Pipeline to raise capacity to about 10 million barrels a day. The pipeline offers an alternative route for crude exports to the Red Sea.

Saudi Cultural Fund support reaches 2.5 billion riyals

The Saudi Cultural Fund says it provided 2.5 billion riyals to cultural projects and activities from its 2021 launch through the third quarter of 2026.

The Saudi Cultural Fund has provided 2.5 billion riyals to cultural projects and activities since it was established in 2021, through the end of the third quarter of 2026.

The support involves cultural projects across Saudi Arabia, with the private sector contributing about 1.6 billion riyals, or 64% of the total, and the fund contributing 904 million riyals.

The fund says supported projects are expected to add 5.3 billion riyals to GDP and create more than 13,800 jobs.

These are estimates of the projects’ expected impact, not reported results.

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Saudi mortgage refinancing firm issues locally rated mortgage-backed securities

The Saudi Real Estate Refinance Company issued its second residential mortgage-backed securities deal, supported by a 420 million riyal portfolio and rated by Moody’s and Fitch.

SRC launched its first residential mortgage-backed securities issue, establishing a local securitization model.

Al Eqtisadiah reported that SRC had launched its second issue, with local-scale ratings from Fitch and Moody’s.

ACWA chairman says AI offers opportunity despite challenges

ACWA chairman Mohammad Abunayyan said AI and other fast-changing technologies bring challenges and opportunities, and predicted solar technology efficiency will exceed 30% within two and a half years.

Solar technology efficiency forecast
More than 30% within two and a half years
Saudi electricity target
Half of electricity needs from renewable sources by 2030
ACWA’s Chinese projects
More than one gigawatt of capacity
Chinese wind acquisition agreements
One operating 250-megawatt site and four projects under construction totalling 1,000 megawatts

IMF sees Saudi Arabia leading G20 growth in 2027

The IMF expects Saudi Arabia’s economy to contract 3.3% in 2026, then grow 7.9% in 2027, the fastest rate among G20 economies.

International Monetary Fund Saudi Finance Ministry

2027 growth forecast

The IMF projects growth of 7.9%.

The ministry forecasts growth of 12.8%.

SALIC transfers National Grain Co. ownership to SABIL in Saudi Arabia

SALIC acquired the remaining 50% of National Grain Co. and transferred its ownership to SABIL, bringing grain sourcing and domestic storage and distribution capabilities together.

Science & Tech

A 1960 study predicted a population doomsday for November 13, 2026

Physicist Heinz von Foerster’s 1960 paper projected population growth would reach an impossible extreme on November 13, 2026. Growth has since slowed, and population is now expected to peak later this century.

“Our great—great—grandchildren will not starve to death”
Heinz von Foerster and co-authorsPhysicist and researchers

International timekeepers set to vote on ending leap seconds

The 69 member states of an international standards body are due to vote on a proposal to end leap seconds, which keep atomic time aligned with Earth’s uneven rotation.

Amazon fires and a strong El Niño threaten regional rainfall

Rising fires in Amazonas and a potentially record-strength El Niño could worsen drying in parts of the Amazon, weakening rainfall that supports farming, reservoirs and cities across Brazil.

Researchers try to restore California kelp forests by reintroducing sunflower sea stars

Researchers off Monterey are placing sunflower sea stars on the seafloor to help control purple sea urchins, which have consumed much of California’s kelp forests.

Mining pressures protected areas as wildlife populations decline in Africa

WWF’s Congo Basin director says mining has no place in protected areas as new analyses highlight industrial pressures and steep wildlife declines.

Maynooth Researchers Build a DNA Computer That Needs No Continuous Power

Researchers at Maynooth University built a DNA-based computer that can perform calculations without continuous electricity. It can be reused for up to 25 calculations, though it is slower than silicon computers.

Honeybee stingers keep pumping venom after detaching from the insect

Researchers at Macquarie University filmed detached honeybee stingers pumping venom into a gel that mimics skin. Their findings reveal how the stinger’s tiny valves and lancets keep the venom flowing.

Researchers at Macquarie University filmed honeybee stingers pumping venom after they detach from the bee’s body.

They used high-speed cameras to record detached stingers working in a clear gel designed to mimic human skin.

The two-millimetre stinger keeps moving into its target and injecting venom even after the bee has flown away.

Its two sharp parts move back and forth to push the stinger deeper, while tiny valves work like pistons to keep venom flowing.

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Rain may ease heat in Telangana over the next four days

A Bay of Bengal trough is expected to bring light rain to Telangana over the next four days, helping temperatures return closer to normal after a dry, hot spell.

The Hindu reported that a Bay of Bengal trough and easterly winds may bring rainfall to Telangana over the next four days.

Telangana received 61.6 cm of rain, compared with a normal 78.9 cm.

Land carbon storage rebounded in 2025 after two years of decline

Preliminary research estimates that land ecosystems absorbed more carbon in 2025 as tropical forests recovered. Scientists warn that another drop may follow as a powerful El Niño brings heat and drought.

Land carbon uptake in 2025
2.36 gigatonnes of carbon
Difference from 2015–2022 average
0.71 gigatonnes more
Main driver of recovery
Renewed growth in tropical forests
Land sink reduction
25 per cent smaller than it would have been without climate change and natural variability

Political identity shapes trust in science in Brazil, columnist argues

The column links political views in Brazil to trust in scientists and examines the Bolsonaro camp’s approach to Covid-19, climate change and research funding.

Mainstream science Bolsonaro-aligned “patriotic science

Who can produce trusted science

The article says Bolsonaro-aligned groups describe their own doctors and studies as “patriotic science” and oppose what they regard as corrupted mainstream science.

The article describes mainstream science as the approach those groups challenge.

What science should do

The columnist says scientists’ loyalty is to method and evidence, not to those who trust or distrust them.

The article says Flávio Bolsonaro favors funding areas such as technology, innovation and artificial intelligence, and tying research funding to productive impact.

Cape Town plans to relocate two baboon troops from Simon’s Town

Cape Town authorities plan to capture two baboon troops near Simon’s Town and move them to enclosures for the rest of their lives, as part of a wider change to baboon management.

Sports

Bills beat Rams 37-34 in overtime as Josh Allen earns first OT win

Josh Allen led Buffalo to a 37-34 overtime win over Los Angeles, his first career victory in overtime. The Bills improved to 4-1, while the Rams fell to 2-3.

“That's the beautiful thing about football: You get another drive.”
Josh AllenBills quarterback

Penix says he hopes to play next week after rib injury

Atlanta quarterback Michael Penix Jr. left the Falcons’ overtime loss to Baltimore with a rib injury. He said he hopes to return next week, but further tests are planned.

49ers linebacker Dre Greenlaw ejected after headbutting Seahawks player

Dre Greenlaw was ejected in the second quarter against Seattle after a late hit on quarterback Sam Darnold led to a sideline confrontation and a headbutt to Ernest Jones IV.

Deebo Samuel expected to miss multiple weeks with hamstring injury

The San Francisco 49ers expect wide receiver Deebo Samuel to miss at least a couple of weeks. Nick Bosa could return from a calf injury against Washington in Week 6.

Oregon slips in power ratings after narrow loss with backup quarterbacks

Oregon fell to 3-2 after a two-point loss despite seven turnovers and a switch to its third-string quarterback. It dropped in the power ratings, but not as far as expected.

FIU visits Jacksonville State in a key Conference USA game

Florida International visits Jacksonville State on Oct. 13 with both teams unbeaten in Conference USA play. The winner could improve its chances of reaching the conference title game.

Marvin Harrison Jr. trade to Houston becomes official after physical

Harrison passed his physical and is now a Houston Texan. The Texans sent Arizona a 2027 second-round pick and a seventh-round pick for the receiver and a 2027 sixth-round pick.

Marvin Harrison Jr. has officially joined the Houston Texans after passing his physical on Monday.

The 24-year-old wide receiver was traded from the Arizona Cardinals, who selected him fourth overall in the 2024 draft.

Houston sent Arizona a 2027 second-round pick and a seventh-round pick, and received Harrison and a 2027 sixth-round pick.

Harrison reunites with quarterback C.J. Stroud, his former teammate at Ohio State.

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Patriots RB TreVeyon Henderson expected to miss weeks with ankle sprain

Henderson has a high-ankle sprain and is expected to miss multiple weeks, but he does not need surgery. He was injured in New England’s win over the Raiders.

Henderson injured his ankle during New England’s win over the Raiders.

ProFootballTalk reported that Henderson had a high-ankle sprain and was expected to miss multiple weeks.

49ers lead Week 6 NFL power rankings as several 0-5 teams struggle

The 49ers remain No. 1 in one Week 6 ranking, while the Vikings rise and the 0-5 Chargers, Titans and Dolphins sit near the bottom.

49ers
No. 1 in ProFootballTalk’s Week 6 rankings; 5-0
Chiefs
No. 2 in ProFootballTalk’s rankings; 4-0
Jaguars
No. 3 in ProFootballTalk’s rankings; 4-1
Chargers
0-5

Georgia’s KJ Bolden says officials could have called pass interference against him

Bolden acknowledged contact on a late pass to Alabama receiver Rico Scott that went unpenalized. Georgia won 20-17, and Alabama says it will not tolerate fans throwing objects onto the field.

KJ Bolden Kalen DeBoer

Pass interference call

Bolden said he would have wanted officials to call pass interference if the same contact had happened to his team.

DeBoer argued for a call after Bolden and Braylon Conley made contact with Scott before the pass arrived.

Two players ejected after opening-kickoff fight in London

Jacksonville’s Bryan Thomas Jr. and Philadelphia’s Jeremiah Trotter Jr. were ejected after fighting during the opening kickoff. A 90-yard Jaguars return for a touchdown was called back because of penalties.

Entertainment

God of War Laufey Collector Box Costs $149.99 and Excludes the Game

Sony’s U.S. collector box for God of War Laufey costs $149.99 and includes merchandise, but no game disc or download code. It is due out with the game on Feb. 16, 2027.

“God of War Laufey game sold separately”
Polygon writerfreelance news writer

Monique Smit says she sometimes misses brother Jan amid estrangement

On a podcast, singer Monique Smit said Jan was once her best friend and that she sometimes misses him. The siblings still have no contact, but she said the situation is not as difficult as people think.

Thélyson Orélien denies using AI to write novel, admits plagiarism

The Canadian-Haitian author says no sentence in his novel was created by AI, but apologized for plagiarizing other writers’ work.

Hillary Clinton and Kara Swisher to launch political podcast

Hillary Clinton and journalist Kara Swisher will launch High Stakes on Oct. 14 with Vox Media. They plan to discuss political issues ahead of the U.S. midterm elections.

TNA ends Max Caster’s run after Riyadh attack reference at Bound for Glory

TNA said Max Caster will no longer wrestle for the company after his entrance rap at Bound for Glory referred to attacks in Riyadh. TNA apologized and removed the segment from replays and social media.

Raye manually reviews ticket sign-ups after 1.8 million apply for 5,000 seats

Raye says AI bots and scalpers overwhelmed sign-ups for her Royal Albert Hall show in London. Her team is manually selecting fans for presale access, with remaining tickets due to go on general sale.

GTA 6 PC release reportedly planned for early 2027

Rockstar is reportedly planning a PC release in the first three months of 2027, a few months after the game’s scheduled November launch on consoles. The company has not confirmed a PC version.

Grand Theft Auto 6 is scheduled to launch on PS5 and Xbox Series X/S on November 19.

A report based on people familiar with Rockstar’s plans says the PC version could arrive between January and March 2027.

Rockstar has not announced a PC release, and the game is currently listed only for those consoles.

If the reported timing is accurate, PC players would wait only a few months after the console launch.

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Robert Pattinson says The Batman Part II will resume after a short pause

Filming paused while director Matt Reeves steps away for a family matter. Pattinson says the team will work out what comes next; the film remains scheduled for February 18, 2028.

The film was initially slated for release.

News broke that Reeves had stepped away and production had been paused.

Pattinson commented that filming would pause briefly and the team would work out what happens next.

The film is currently scheduled for release.

Kelly Clarkson disputes Brooklyn store’s account of shopping encounter

Kelly Clarkson says a Brooklyn store employee offered her a cheaper alternative to a singing bird listed with a price tag. The store says the bird is a wall fixture and was not for sale.

Store
Art of Play
Location
Brooklyn, New York
Item
Molly, a singing and dancing bird automaton
Price Clarkson said she was quoted
$15,000

Selma Blair charged with assault after flight incident in New York

Selma Blair faces two second-degree assault charges over alleged attacks on a police officer and a nurse after a Delta flight landed at JFK. She was released on bail and has a court hearing scheduled for January.

Selma Blair’s defense Prosecution and court

Intent

Her lawyer said the incident was not intentional and that missed medication, a head injury and altitude left her severely confused and disoriented.

Blair faces charges alleging she assaulted a police officer and a nurse; the allegations have not been established in court.

Celebrity treatment

Not stated.

Judge Kahn said Blair should not receive special treatment because she is a celebrity.

Collin Gosselin alleges abuse by mother Kate ahead of memoir release

Collin Gosselin says his mother, Kate, physically and emotionally mistreated him as a child. His memoir, “In the Shadow of Eight,” is due out Oct. 13.

Health

Early research links GLP-1 drugs to signs of slower biological aging

Early research suggests GLP-1 drugs may affect biological aging, but experts say the evidence is not strong enough to use them solely in hopes of living longer.

“My concern is that people could overread some of this stuff.”
Dr. James Kirklanddirector of the Center for Advanced Gerotherapeutics at Cedars-Sinai Medical Center

UCLA specialists outline how doctors can choose between two MASH drugs

A UCLA-led review offers an algorithm to help doctors choose between resmetirom and semaglutide, the first two FDA-approved drugs for adults with MASH and moderate to advanced fibrosis.

Bimatoprost eye lens shows early promise for cataracts and glaucoma

A lens containing the glaucoma drug bimatoprost showed early promise in a randomized comparison with standard glaucoma therapy for people with cataracts and glaucoma.

Italian Registry Study Finds Avacopan Appeared Effective for AAV

An Italian registry study found that avacopan appeared strongly effective for ANCA-associated vasculitis, though the finding may not settle concerns about the treatment.

Inclisiran lowered LDL cholesterol more than bempedoic acid in a trial

In a study of 402 adults at high cardiovascular risk, inclisiran reduced LDL cholesterol more than bempedoic acid after 150 days. Similar overall rates of side effects were reported in both groups.

European groups issue guidance on two MASH treatments

Three European medical groups recommend considering resmetirom or semaglutide for some adults with non-cirrhotic MASH and significant liver fibrosis, alongside lifestyle changes and careful monitoring.

Syndax ends Niktimvo development for lung disease after Phase 2 failure

Syndax is ending development of Niktimvo for idiopathic pulmonary fibrosis after the treatment failed a mid-stage trial.

Syndax is ending development of Niktimvo as a treatment for idiopathic pulmonary fibrosis, or IPF.

IPF is a rare lung disease.

The treatment failed a Phase 2 trial, a mid-stage study of a medicine.

The result means Syndax will not continue developing Niktimvo for this disease.

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Experts raise safety concerns about Neurocrine’s Prader-Willi drug

Vykat XR has been linked to seven deaths and nearly 100 hospitalizations since its approval, though case reports do not prove the drug caused them. Some experts are urging its withdrawal.

Vykat XR was approved to treat Prader-Willi syndrome.

An open letter about potential safety issues tied to the drug was released.

STAT reported growing alarm among patient advocates and some experts.

US FDA supports planned trial of StemSmart therapy for Crohn’s disease

The FDA supported most elements of NeuroScientific Biopharmaceuticals’ proposed phase two trial of its StemSmart cell therapy. The company aims to start the study in Australia and the US by the end of 2026.

FDA response
Positive responses to six of seven Pre-IND questions
Earlier study
18 patients; 78 per cent overall clinical response rate
Remission
44 per cent of patients in the earlier study
Planned trial
Phase two, in Australia and the US

Bristol Myers lung drug succeeds at lower dose, but higher dose misses target

Bristol Myers Squibb said admilparant slowed lung function decline in a Phase 3 trial of people with idiopathic pulmonary fibrosis, but only the lower dose met the main goal.

Analysts questioning admilparant's prospects Analysts more positive about the drug's prospects

Dose response

The high-dose result was confounding and the lack of dose response raised questions about the drug's profile.

The lower-dose success could open a major commercial opportunity despite lingering questions.

Mirum reports late-stage trial success for Livmarli in rare liver diseases

Mirum Pharmaceuticals said Livmarli significantly reduced cholestatic pruritus in a late-stage trial involving ultra-rare liver diseases.