Science & Tech · Science & Environment · 2 hrs ago

Researchers create fertile female clones from male mice

Researchers create fertile female clones from male mice

Researchers made fertile female clones from male mice in a laboratory experiment.

The team used a CRISPR-based method called Y-CUT to remove the Y chromosome from cloned male mouse embryos, leaving them with a single X chromosome.

The embryos were carried by surrogate mothers, and the female clones later had offspring with male clones.

This means one male donor could provide both sexes for breeding, a possible aid for endangered species with very few individuals left.

The work is an early step, and the study has not yet been peer-reviewed.

The method may not work for many mammals because females with a single X chromosome cannot reproduce in some species.

The researchers say future technologies that add an X chromosome could help address this limitation.

What people are saying

Ben Novaklead scientist at Revive and Restore
I think it’s a really neat foundational breakthrough in reproductive science
via Scientific American
Being able to manipulate chromosome counts and chromosome makeup will open up a new avenue of functional genomic science
via Scientific American
It certainly can have long-term future applications for extreme cases of species revival
via Scientific American

Sources

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