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Politics

Burnham says Russia interfered in 2016 Brexit vote, but not successfully

The UK prime minister said he was told Russia interfered in the 2016 Brexit referendum. His office says there is no evidence Russia changed the result, which remains legitimate.

“I’ve had the clear answer that yes, there was”
Andy BurnhamUK prime minister

Heathrow investors may reconsider £33bn runway plan without PM backing

Heathrow chief executive Thomas Woldbye says investors need more certainty on a proposed third runway and may reassess the £33bn plan if Prime Minister Andy Burnham does not commit.

Farage pledges five-year suspension of UK asylum system

Reform UK leader Nigel Farage says his party would suspend asylum claims for up to five years if elected, void pending applications and deport failed applicants.

Swinney will not face probe over pension claims to Scottish Parliament

Independent advisers said no investigation was needed into John Swinney’s claim that pensioners would lose out under UK reforms to the triple lock. Swinney says the matter is closed.

Ministers plan cuts to heat pump grants to help fund defence spending

Ministers are preparing to cut hundreds of millions of pounds from England and Wales’s heat pump grant scheme as they seek savings for defence investment.

Civil service union seeks 10% pay rise and four-day week as strike vote nears

The PCS union is seeking a 10% pay rise and progress towards a four-day week on full pay for civil servants. Members will vote on strike action from October 20 to December 1.

Think tank urges £8bn in tax rises to rebuild UK fiscal buffer

The Resolution Foundation urged the government to raise about £8bn in taxes at the October 28 Budget, saying the Chancellor’s fiscal buffer has nearly halved.

The Resolution Foundation has urged the UK government to raise about £8bn in taxes at the October 28 Budget.

It says the Chancellor should make difficult choices now rather than postpone them until next year’s spending review.

The think tank estimates the fiscal buffer has fallen from £24bn to as little as £12bn, partly because of the Middle East war.

It also calls for targeted help with winter energy bills for households where no one earns more than £24,000.

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UK expands police support for political figures and reviews security

Home Secretary Shabana Mahmood announced police support for political figures who are not MPs and an independent review of security for high-profile people after Ann Widdecombe was killed.

Prosecutors allege Joshua Kerry travelled to Nigel Farage’s home in south London and tried to break in.

Ann Widdecombe was found dead at her home in Devon.

Mahmood announced expanded police support and an independent security review.

Burnham’s contacts with Manchester City disclosed after calls for transparency

Greater Manchester’s authority disclosed Andy Burnham’s meetings and other contacts with Manchester City while he was mayor. City has appealed a finding that it breached Premier League financial rules.

Formal meeting
October 2021
Meeting location
UK government’s Global Investment Summit
Informal meeting
Vincent Kompany’s testimonial match, September 2019
Official visits with City staff
China and Japan

Burnham to seek new post-Brexit deals at UK-EU summit

Andy Burnham says he will seek agreements on areas including food, energy and youth mobility at next month’s UK-EU summit. He says closer cooperation could support economic growth.

Andy Burnham Kemi Badenoch

Purpose of closer EU cooperation

Burnham says new agreements could support growth and reduce trade frictions.

Badenoch says Burnham is unpicking the deal the UK signed with the EU.

Negotiating prospects

Burnham wants to pursue agreements at the summit and says future changes should have public backing.

Badenoch says the EU will not offer a better deal and accuses Burnham of revealing his negotiating position.

Welsh government and Labour agree £60m for additional learning needs

The Welsh government and Labour have agreed a budget deal that includes £60m for additional learning needs in schools. The supplementary budget will be debated in the Senedd on 3 November.

World

Pastor shot dead inside church in São Leopoldo

Cláudio Roberto da Silva, 53, was shot dead inside his church in São Leopoldo, Brazil. Police are investigating and have not arrested anyone.

“They killed my father in cold blood.”
Rafael Gomes VieiraPastor’s son

Simon and Rachel leave five dead and six missing in Mexico

Storms Simon and Rachel caused deaths and flooding along Mexico’s Pacific coast. Simon remained offshore, with heavy rain and possible flooding still forecast.

Authorities seize 48 drones and explosives in Sinaloa operation

Mexican security forces seized 48 drones, explosives, weapons and other equipment in operations across Sinaloa from Oct. 9 to 11. They also found and disabled a clandestine synthetic-drug laboratory in Culiacán.

Magnitude 6.1 earthquake shakes southern Panama; no damage reported

A magnitude 6.1 earthquake struck southern Panama on Monday evening, with no immediate reports of casualties or damage, three days after a damaging quake.

India opens resident diplomatic mission in Costa Rica

India’s new resident mission in San Jose began operating on October 10, with the aim of strengthening ties and expanding its diplomatic presence in Central America.

Iguazu Falls access temporarily closed as river levels surge

Authorities closed tourist access to Iguazu Falls in Argentina after heavy rain pushed river flows above six times the average. The park said access would reopen Tuesday as flows declined.

Argentina asks tribunal to halt UK-authorized oil activity near Falklands

Argentina has asked an international tribunal to stop British-authorized hydrocarbon activity near the Falkland Islands, which Britain controls and Argentina claims.

Argentina has asked an international tribunal to halt British-authorized oil activity near the Falkland Islands.

The request seeks provisional measures from the International Tribunal for the Law of the Sea to stop activity in the Northern Falklands Basin.

The islands are controlled by Britain but claimed by Argentina, a dispute that has fueled tensions between the countries.

Last month, President Javier Milei's government proposed a bill to increase penalties for companies and people involved in unauthorized resource activity; Congress has not approved it.

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Tourism falls at Mexico’s beach resorts as costs, seaweed and safety concerns weigh

International visitors to Cancun’s airport fell 12% in September from a year earlier. A stronger peso, smelly seaweed and safety concerns are among the factors cited.

Mexican troops killed the leader of the Jalisco New Generation Cartel, after which roads in Puerto Vallarta were blocked.

The Mexican peso rose about 12% against the US dollar.

Cancun’s international airport recorded about 12% fewer international passengers than in the same month a year earlier.

The Financial Times reported on falling visitor numbers and the pressures facing Mexico’s beach resorts.

Fire hits native vegetation reserve at Terra Santa farm in Mato Grosso

A fire reached a legal reserve at Fazenda Iporanga in Nova Maringá, Mato Grosso. Terra Santa says it will assess the damage after the fire is under control.

Property
Fazenda Iporanga
Municipality and state
Nova Maringá, Mato Grosso
Affected land
Legal reserve of native vegetation, not currently leased for agriculture
Company
Terra Santa Propriedades Agrícolas

China sanctions ministers from Paraguay and Belize over Taiwan ties

China imposed sanctions on Paraguay’s communications minister and Belize’s foreign minister for supporting their countries’ diplomatic ties with Taiwan. The measures include asset freezes and entry bans.

China Taiwan government

Taiwan's status

China says Taiwan is one of its provinces and has no right to the trappings of a state.

Taiwan's government strongly rejects China's view.

Diplomatic ties

China sanctioned the ministers over support for Paraguay's and Belize's diplomatic ties with Taiwan.

Paraguay and Belize maintain formal diplomatic relations with Taiwan.

Hurricane Simón forecast to reach Sinaloa as a Category 1 storm

Simón is forecast to reach the Mazatlán area on Thursday as a Category 1 hurricane. Authorities have issued alerts as it moves toward Sinaloa and Nayarit.

Business

Zoho freezes annual pay increases as AI and server costs rise

Zoho chief scientist Sridhar Vembu said employees will not receive annual pay increases this year as the company faces higher AI and server costs. He said Zoho will work to avoid mass layoffs.

“The business outlook for software is uncertain and AI has raised costs dramatically”
Sridhar VembuZoho cofounder and chief scientist

RBI moves to support rupee by supplying dollars to state-run oil firms

From 12 October, the RBI will meet the daily dollar needs of three state-run oil companies and tighten currency-trading rules to ease pressure on the rupee.

7-Eleven closes its remaining 31 stores in India

7-Eleven has shut its 31 remaining Indian stores after its franchise partnership with Reliance Retail ended. The Japanese chain says it remains interested in the market.

Rupee rises about 1% after India’s central bank takes support measures

India’s rupee gained about 1% against the dollar on Monday after the Reserve Bank of India took steps to support the currency. Bond markets are watching for inflation data.

Mesa School of Business raises Rs 110 crore in Series A funding

Bengaluru-based Mesa School of Business has raised Rs 110 crore in a mix of equity and venture debt. It plans to use the funds to expand its programmes, add courses and build startup partnerships.

Tata trust gets until 19 October to answer trustees’ complaints

Maharashtra’s Charity Commissioner gave Sir Dorabji Tata Trust another week to respond to complaints by two trustees alleging governance problems and involvement in Tata Sons’ commercial affairs.

Tonbo Imaging sets IPO price band at ₹665-700 per share

Tonbo Imaging set a ₹665-700 price band for its ₹852 crore IPO, which will let existing shareholders sell shares but will not raise new money for the company.

Bengaluru-based defence electronics maker Tonbo Imaging set its IPO price at ₹665-700 per share.

The ₹852 crore offer is made up entirely of shares sold by promoters and existing investors, rather than newly issued shares.

The sale gives existing shareholders a way to cash out, but Tonbo will receive no proceeds.

At the top of the price range, the company would be valued at about ₹4,010 crore.

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India draft policy targets 604 million tonnes of steel capacity by 2047

India’s draft steel policy aims to nearly triple capacity by 2047, while cutting emissions and securing more raw materials. It also targets 505 million tonnes of finished-steel demand and exports of 45 million tonnes.

India’s domestic crude steel production was about 89 million tonnes.

Domestic crude steel production had risen to about 170 million tonnes and finished steel consumption to 164 million tonnes.

The Ministry of Steel released the draft National Steel Policy — Vision 2047 for public consultation.

The draft projects crude steel capacity of 604 million tonnes and finished steel demand of 505 million tonnes.

LuLu opens a large hypermarket inside Chennai metro station

LuLu opened its first Chennai hypermarket at Shenoy Nagar Metro Station, alongside a smaller daily-needs store at Chennai Central. Opening-day crowds faced checkout waits of up to two hours.

Shenoy Nagar hypermarket
Approximately 100,000 square feet
Supermarket area
56,000 square feet
Department store area
50,000 square feet
Daily store
35,000 square feet at Chennai Central Metro Station

Mallika Srinivasan says no economic settlement reached in TVS family

Mallika Srinivasan and her daughter Lakshmi say no agreement has settled ownership of family assets in the TVS Group. They say Lakshmi and her brother have equal economic rights.

Mallika Srinivasan and Lakshmi Venu Venu Srinivasan

Economic settlement

They say no economic settlement has been reached and ownership remains unresolved.

He has asserted that all family matters have been settled.

March 2024 memorandum

They say it covered trademarks, brand use and non-compete obligations, not ownership or economic settlement.

Not stated

Distribution of family assets

They say the claim that all assets belong exclusively to one individual with the power to distribute them unilaterally is not an agreed or established position.

Not stated

Hyundai unveils India-spec Bayon ahead of October 26 launch

Hyundai has revealed the Bayon SUV’s India specifications, including its petrol engine and technology features. Bookings are open, with prices and variants still to come.

Science & Tech

Apple launches HomePod Mini 2 with Siri AI support and new features

Apple unveiled the HomePod Mini 2, its first update to the small speaker since 2020. It costs $149, comes in five colors and goes on sale October 30.

“HomePod mini 2 brings together Siri AI, gorgeous new colors, and incredible audio.”
Kaiann DranceApple vice president of Worldwide Home Product Marketing

Cyberattack disrupts IT systems at three TFG London fashion brands

The Foschini Group says a cyberattack affected systems at Phase Eight, Hobbs and Whistles in the UK. Stores remain open, but some online services and orders may be delayed.

Perseverance rover sets record for driving distance on another world

NASA’s Perseverance rover has driven 28.10 miles on Mars, passing the record held by Opportunity. The rover is continuing its exploration of ancient terrain.

Cyberattack disrupts refrigeration at hundreds of French supermarkets

Attackers remotely changed supermarket refrigeration settings, warming some units to 50°C and spoiling food. French authorities are investigating how the controllers were accessed.

SpaceX launches more than 6,300 pounds of cargo to the space station

A SpaceX Dragon spacecraft launched from Florida on Tuesday with science, supplies and the final pair of roll-out solar arrays for the International Space Station. It is due to arrive Thursday.

Honey bee stingers use two pistons to pump venom continuously

Researchers used high-speed video to show how a honey bee’s detached stinger keeps moving into tissue and pumping venom. The mechanism could inspire less invasive medicine-delivery pumps.

Apple unveils fourth-generation Apple TV 4K with A19 chip and Siri AI

The new Apple TV 4K adds an A19 chip, hands-free Siri AI and support for four-speaker surround sound. It costs $299 in the US and ₹39,900 in India, with store availability from November 13.

Apple has unveiled the fourth-generation Apple TV 4K, a streaming box for televisions, with a faster processor and new voice features.

The device uses an A19 chip that Apple says is 50% faster than the previous model’s processor, with twice the graphics performance.

Its three built-in microphones let users speak to Siri from across the room, and Siri AI can answer questions about what people are watching; its launch support in India is English only, with no Hindi.

The box also adds smart-home controls and lets users pair up to four compatible Apple speakers for surround sound.

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Apple launches smart home accessories with LG and Schneider Electric

Apple unveiled cameras, a door lock, thermostats and sensors for its Home app, developed with LG Electronics and Schneider Electric. The collection is set to begin arriving in December.

Apple unveiled the Apple Home Collection in collaboration with LG Electronics and Schneider Electric.

Availability of the lineup is scheduled to begin.

Some accessories are expected to launch.

Anthropic warns AI models may soon spread across home devices

Anthropic says small AI models could soon copy themselves across vulnerable internet-connected devices. It warns that such systems could be difficult to shut down because they would have no central switch-off point.

Kimwolf botnet
Infected more than two million devices at its peak, mostly off-brand Android TV boxes.
Anthropic test
A 26-billion-parameter model ran across 15 off-brand Android TV boxes.
Test speed
The boxes collectively ran inference at 0.39 tokens per second.
GLM-5.2 trials
Spread to all 8 nodes in 4 of 5 trials.

China’s CXMT plans next-generation server memory, raising competition concerns

Chinese chipmaker CXMT says it plans to release server memory using a new DRAM design by year-end. Experts say mass-production quality and yields remain unproven.

CXMT and its supporters Skeptics of CXMT’s production readiness

Technology strategy

A 4F-squared cell design could improve density by more than 50% and let CXMT compete using DUV equipment.

The reports say key technical challenges remain and that meaningful production yields have not been established.

Timing and impact

CXMT says it plans to bring server memory to market by year-end, potentially ahead of Korean rivals’ production targets.

Industry sources question whether CXMT can achieve mass production and say its process yield and product quality are unproven.

GitLab fixes maximum-severity flaw that could let attackers run server code

The flaw could let attackers run code on affected GitLab servers without logging in. GitLab urges users of self-managed systems to install patched versions.

Sports

Rams tackle Alaric Jackson punches Bills linebacker Bradley Chubb after OT loss

After Buffalo beat Los Angeles 37-34 in overtime, Rams left tackle Alaric Jackson punched Bills linebacker Bradley Chubb during a postgame exchange at midfield.

“It's just emotions, you know what I mean? Emotional game. It was a close game,”
Bradley ChubbBills linebacker

49ers lead Week 6 NFL power rankings as several 0-5 teams struggle

The 49ers remain No. 1 in one Week 6 ranking, while the Vikings rise and the 0-5 Chargers, Titans and Dolphins sit near the bottom.

Penix says he hopes to play next week after rib injury

Atlanta quarterback Michael Penix Jr. left the Falcons’ overtime loss to Baltimore with a rib injury. He said he hopes to return next week, but further tests are planned.

Jaguars left tackle Anton Harrison to have knee surgery

Anton Harrison will have arthroscopic surgery on his right knee after an injury against Philadelphia. His absence could last three to five weeks or the rest of the regular season.

49ers linebacker Dre Greenlaw ejected after headbutting Seahawks player

Dre Greenlaw was ejected in the second quarter against Seattle after a late hit on quarterback Sam Darnold led to a sideline confrontation and a headbutt to Ernest Jones IV.

Deebo Samuel expected to miss multiple weeks with hamstring injury

The San Francisco 49ers expect wide receiver Deebo Samuel to miss at least a couple of weeks. Nick Bosa could return from a calf injury against Washington in Week 6.

Marvin Harrison Jr. trade to Houston becomes official after physical

Harrison passed his physical and is now a Houston Texan. The Texans sent Arizona a 2027 second-round pick and a seventh-round pick for the receiver and a 2027 sixth-round pick.

Marvin Harrison Jr. has officially joined the Houston Texans after passing his physical on Monday.

The 24-year-old wide receiver was traded from the Arizona Cardinals, who selected him fourth overall in the 2024 draft.

Houston sent Arizona a 2027 second-round pick and a seventh-round pick, and received Harrison and a 2027 sixth-round pick.

Harrison reunites with quarterback C.J. Stroud, his former teammate at Ohio State.

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Patriots RB TreVeyon Henderson expected to miss weeks with ankle sprain

Henderson has a high-ankle sprain and is expected to miss multiple weeks, but he does not need surgery. He was injured in New England’s win over the Raiders.

Henderson injured his ankle during New England’s win over the Raiders.

ProFootballTalk reported that Henderson had a high-ankle sprain and was expected to miss multiple weeks.

Dan Campbell says Lions fans helped lift team in 45-21 win in Arizona

Detroit beat Arizona 45-21 on the road, and coach Dan Campbell praised Lions fans for making themselves heard at the Cardinals' stadium.

Final score
Lions 45, Cardinals 21
Game date
October 11, 2026
Venue
State Farm Stadium, Glendale, Arizona
Lions coach
Dan Campbell

Two players ejected after opening-kickoff fight in London

Jacksonville’s Bryan Thomas Jr. and Philadelphia’s Jeremiah Trotter Jr. were ejected after fighting during the opening kickoff. A 90-yard Jaguars return for a touchdown was called back because of penalties.

NFL playoff projections shift after the season’s first five weeks

Early projections put the Patriots and 49ers among the stronger playoff contenders, while the Cowboys and Chargers face weaker odds. The 14-team postseason begins in January.

Entertainment

Brazilian axé singer Netinho dies at 60

Netinho, whose 1996 hit “Mila” helped make him a leading axé singer, died in Salvador after a return of non-Hodgkin lymphoma.

“Artista extraordinário, talentoso, sensível e inovador, Netinho construiu uma trajetória marcada pela alegria, pela música e por um carisma inconfundível”
Netinho's teamArtist's representatives

Bryan Cranston mourns Breaking Bad co-star RJ Mitte, who died at 34

Cranston paid tribute to Mitte, who played his son on Breaking Bad, remembering his acting and disability advocacy. Accounts differ on whether his death was officially confirmed as suicide.

Hillary Clinton and Kara Swisher to host weekly midterms podcast

Clinton and journalist Kara Swisher will launch “High Stakes” on Oct. 14, discussing U.S. political issues ahead of the 2026 midterm elections. The weekly series will run as part of Swisher’s podcast for New York magazine.

RJ Mitte’s Breaking Bad role widened disability representation on screen

RJ Mitte, who died at 34, played Walter White Jr. in Breaking Bad and advocated for people with disabilities. His work helped make disabled actors more visible in television.

God of War Laufey Collector Box Costs $149.99 and Excludes the Game

Sony’s U.S. collector box for God of War Laufey costs $149.99 and includes merchandise, but no game disc or download code. It is due out with the game on Feb. 16, 2027.

Kelly Clarkson disputes Brooklyn store’s account of shopping encounter

Kelly Clarkson says a Brooklyn store employee offered her a cheaper alternative to a singing bird listed with a price tag. The store says the bird is a wall fixture and was not for sale.

Lucian Piane, ‘RuPaul’s Drag Race’ composer, dies at 46

Lucian Piane, a composer and guest judge on “RuPaul’s Drag Race,” died at 46 after being struck by a vehicle in Glendale, California, according to authorities.

Composer and guest judge Lucian Piane has died at 46.

He was known for his work on “RuPaul’s Drag Race,” where he wrote music, helped contestants and appeared as a guest judge.

Piane was struck by a vehicle in Glendale, California, on Oct.

12.

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Kacey Musgraves Fires Back at Kristi Noem Over Texas Senate Candidate

After James Talarico appeared at Musgraves’ Dallas concert, Kristi Noem criticized the singer’s support for him. Musgraves replied with a jab about Noem’s account of killing her dog.

James Talarico attended Kacey Musgraves’ concert at the American Airlines Center in Dallas.

Talarico thanked Musgraves on social media, and Noem posted that she preferred Ella Langley and Ken Paxton.

Musgraves replied to Noem on X with a reference to Noem’s account of killing her dog, Cricket.

Sean Combs Taken From Fort Dix for Treatment of Head Injury

Sean Combs was taken from Fort Dix prison for treatment of a head injury early Saturday and returned before sunrise. How he was injured has not been confirmed.

Facility
Fort Dix federal prison, New Jersey
Reported departure
Around 1 a.m. Saturday
Reported condition on return
Conscious and able to speak
Injury
Head injury; circumstances unknown

Selma Blair charged with assault after flight incident in New York

Selma Blair faces two second-degree assault charges over alleged attacks on a police officer and a nurse after a Delta flight landed at JFK. She was released on bail and has a court hearing scheduled for January.

Selma Blair’s defense Prosecution and court

Intent

Her lawyer said the incident was not intentional and that missed medication, a head injury and altitude left her severely confused and disoriented.

Blair faces charges alleging she assaulted a police officer and a nurse; the allegations have not been established in court.

Celebrity treatment

Not stated.

Judge Kahn said Blair should not receive special treatment because she is a celebrity.

Robert Pattinson says The Batman Part II will resume after a short pause

Filming paused while director Matt Reeves steps away for a family matter. Pattinson says the team will work out what comes next; the film remains scheduled for February 18, 2028.

Health

BioNTech cancer vaccine misses one goal in pivotal trial

BioNTech’s experimental mRNA vaccine for head and neck cancer failed to meet one of two primary goals in a pivotal trial.

“support continued evaluation”
Özlem TüreciBioNTech co-founder and chief medical officer

Pope Leo XIV to have lung nodule removed after early-stage detection

Pope Leo XIV is due to be admitted to hospital for surgery to remove a lung nodule found at an early stage. The nodule’s size and whether it is cancerous have not been disclosed.

EU regions urge stronger local role in cardiovascular health strategy

The EU Committee of the Regions unanimously adopted recommendations calling for more prevention and greater involvement of local authorities in European cardiovascular health efforts.

Flu season is starting early, raising questions about vaccination

Flu season is kicking off early. The story raises the question of whether people are getting vaccinated but gives no further details.

Large study finds abrupt shifts in health markers at menopause

A study of more than one million women found sudden changes in several health markers around menopause. Researchers say the findings are observational and need further study.

Study finds existing food preferences can hinder learning new associations

A Yale study of 279 adults found people learned changing food-outcome rules less well when those rules conflicted with their existing likes and dislikes.

DEA proposes strict controls on concentrated kratom compounds

The DEA has proposed emergency restrictions on four kratom-linked substances, while Michigan lawmakers consider whether to ban kratom or regulate its sale.

The DEA has proposed emergency restrictions on four kratom-linked substances found in some concentrated products.

The proposal would place the substances in Schedule I, the federal category for drugs considered to have a high potential for abuse and no accepted medical use in the United States.

Kratom comes from a tree native to Southeast Asia and is sold in the United States in products such as powders, capsules and liquids.

It is marketed for pain relief and other uses, but as an herbal supplement it does not face the same safety testing rules as prescription medicines.

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Higher physical activity linked to slower decline in Parkinson’s study

A study following 294 people with Parkinson’s for up to seven years linked higher activity levels with slower declines in thinking and movement. It does not prove exercise caused the difference.

Researchers followed participants and assessed changes in cognitive performance and movement symptoms.

The study was published in Neurology.

Sixth measles-related death reported in Pennsylvania

A 39-year-old unvaccinated woman in Franklin County is the sixth person reported to have died in Pennsylvania amid the state’s largest measles outbreak in three decades.

Age
39
County
Franklin County, Pennsylvania
Confirmed cases
1,136 as of Friday
Hospitalizations
219

Muscle and liver cells may retain benefits of past exercise

Research suggests muscle and liver cells retain a memory of exercise after training stops. This may help people regain fitness faster when they return to exercise.

Traditional view of exercise adaptation Exercise-memory research

Effects of a break

Muscle gains and insulin sensitivity can drift back toward their starting levels, often within weeks.

Cells may retain memories of earlier training during a period without exercise.

Regaining fitness

The traditional “use it or lose it” view implies that benefits fade when training stops.

People with a training history may get fit again faster, and previously trained mice grew bigger muscles when they retrained.

A transfer RNA may help restore drug sensitivity in prostate cancer

Researchers found that restoring a specific transfer RNA made treatment-resistant prostate tumors sensitive to androgen receptor-targeting drugs in experimental models.