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White House officials question Zacharia’s future after brief first briefing

Katie Zacharia’s first White House briefing lasted about 15 minutes, including roughly 5½ minutes of questions. Officials questioned how long she would remain in the role, though some said she deserved more time.

“I am going to end it because President Trump is heading out to Marine One for our historic trip to Alaska, and we can ask him all of the questions out there”
Katie ZachariaWhite House press secretary

Talarico says flu caused campaign absence as false clinic rumor spreads

Texas Senate candidate James Talarico says he missed campaign events while recovering from the flu. An Ohio mental health facility denied claims that he was treated there.

Trump to campaign in Alaska as Republicans face a tight Senate race

Trump plans to travel to Alaska to campaign as Republicans face a tight Senate race there. Alaska has become a crucial battleground this fall.

Musk gives $276 million to Republican groups for 2026 midterms

Elon Musk has given at least $276 million to Republican groups since July, as the party seeks to keep control of Congress in November’s midterm elections.

Los Angeles moves to make some nitrous oxide sales a crime

The Los Angeles City Council unanimously approved a ban on cannabis and tobacco retailers selling or distributing nitrous oxide. The mayor plans to sign it, and violations could bring jail time.

Former DOGE staff raise at least $500 million for private firms

At least two dozen former DOGE staff have moved into private businesses, and firms they co-founded or invested in have raised at least $500 million.

Federal agents search Ilhan Omar’s Washington home

Agents searched the home of Democratic Rep. Ilhan Omar as part of an ongoing criminal investigation. Omar called the search political intimidation; no charges against her were announced.

Federal agents searched the Washington home of Ilhan Omar, a Democratic member of Congress from Minnesota.

The Justice Department said the search was carried out under a court-authorised warrant as part of an ongoing criminal investigation, but did not name Omar or explain the investigation.

News reports linked the search to a fraud inquiry about immigration paperwork filed by Omar’s late father when she was a child; officials have not confirmed that link.

Omar, who came to the United States from Somalia as a child, said the search was an attempt to target political opponents.

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GOP groups pull planned spending from two vulnerable House districts

Trump-aligned MAGA Inc. and a House GOP super PAC are redirecting planned spending from districts held by Tom Kean and Marianette Miller-Meeks to other races. Recent polling has raised concerns about the incumbents’ chances.

Politico reported that MAGA Inc. was planning major spending changes in the final weeks before Election Day.

A source confirmed to Fox News that MAGA Inc. was reallocating planned spending from Kean’s and Miller-Meeks’ districts, while a source said the Congressional Leadership Fund was also pulling its money.

Supreme Court to hear DOGE’s bid to withhold internal documents

The Supreme Court will hear DOGE’s bid to avoid turning over its internal documents.

Court
Supreme Court
Agency
Department of Government Efficiency (DOGE)
Plaintiff
Nonprofit watchdog group
Law
Federal Freedom of Information Act

US archbishop urges Catholic soldiers to avoid planned Hasan execution

Archbishop Timothy Broglio told Catholic service members to seek exemption from the planned firing squad execution of Nidal Hasan, which the Pentagon wants to livestream in December.

Archbishop Timothy Broglio Defense Secretary Pete Hegseth

Purpose of public broadcast

Broglio questioned the value of broadcasting the execution and said it could harm the military’s reputation.

Hegseth said making the event public would help people understand the serious consequences of such acts.

Participation by Catholic service members

Broglio urged Catholics assigned to the firing squad to request exemption because participation would violate Church teaching.

Hegseth described using military members to carry out the execution; the sources do not state his view on religious exemptions.

Kansas Senator Pays Six-Year-Old Campaign Bakery Bill

Sen. Roger Marshall paid $1,300 to a Kansas bakery after its owner said his campaign had left a $678.75 bill unpaid since 2020. The bakery owner confirmed the payment.

World

Spanish royals visit Ceuta after deadly migration crisis

King Felipe VI and Queen Letizia visited Ceuta to show support for residents after a mass border crossing from Morocco. They are due to travel to Melilla on Wednesday.

“hope to a place that needs a lot of hope”
Juan Jesús VivasPresident of Ceuta

Russia arrests Japanese journalist on suspicion of spying in Sakhalin

Russia’s Federal Security Service says it arrested a Japanese journalist in Sakhalin on suspicion of gathering information about Russian defense capabilities. The journalist was transferred to Moscow and placed in custody.

France boards Russia-linked tanker in Indian Ocean

French forces boarded the DF Peak, a sanctioned oil tanker suspected of using a false flag and carrying fuel illicitly. The vessel is being escorted to Réunion for further checks.

Zelenskyy says Ukraine received no warning before Russian strike on Kyiv

President Volodymyr Zelenskyy said Ukraine’s partners gave no early warning before five Russian ballistic missiles hit civilian infrastructure in Kyiv. He said warnings can help save lives.

Hezbollah announces housing aid of up to $14,000 for displaced families

Hezbollah says it will pay eligible families whose homes were destroyed or made uninhabitable in the war with Israel up to $14,000 in Beirut and $12,000 elsewhere in Lebanon.

NATO commander says alliance is ready to respond to any attack

General Alexus Grynkewich said NATO would block, blunt and, if needed, break an attack on alliance territory. He said conflict with Russia is not inevitable.

Six Flags closes nine coasters after fatal incident in Georgia

One person died and several were injured in an incident involving a coaster at Six Flags Over Georgia. Six Flags closed nine similar rides at six parks while authorities investigate.

One person died and several others were injured in an incident involving a roller coaster at Six Flags Over Georgia near Atlanta on Monday.

Officials have not said how the person died or how the others were injured.

Cobb County police detectives are investigating what happened, and the company is co-operating with them.

Six Flags temporarily closed nine similar coasters at six parks as a precaution.

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Saudi-led coalition tells civilians to leave Yemen oil site in Sanaa

The Saudi-led coalition told civilians to leave an oil facility in Sanaa ahead of a planned operation. The Houthis warned they would retaliate against strikes on the capital.

The Houthis seized strategic territory along Yemen's Red Sea coast.

The Houthis have attacked Saudi airports and oil facilities, according to the Straits Times.

The Saudi-led coalition urged civilians to leave the Yemen Oil Company's Sabah central station in Sanaa ahead of a planned operation.

Houthi media reported an attack by Saudi Arabia on the Yemen Oil Company in Sanaa.

Drones hit two ships off Bulgaria; one sinks and 11 crew are missing

Two cargo ships were hit by drones in the Black Sea off Bulgaria. One sank, leaving 11 crew members missing, while all 15 people aboard the other ship were rescued.

Chelsea 3
Ukrainian-owned; sailed under the Maltese flag
Chelsea 3 crew
15 rescued: seven Ukrainians and eight Azerbaijanis
Chelsea 3 attack
Three drones; about 18 nautical miles from Byala
Sunken ship
About 17 nautical miles east of Krapets; one crew member rescued

Ukrainian drone strikes disrupt three Yandex data centers

Drone attacks damaged three Yandex data centers in Russia, disrupting the company’s cloud and consumer services. Yandex has not given a reliable timeline for restoring full service.

Ukraine Russia

Reason for strikes

Ukraine said the attacks were a response to Russian strikes on Ukrainian data centers.

Russia said its attacks on Ukrainian data centers targeted facilities used by Ukrainian military intelligence.

Navi Pillay urges US to defend human rights amid ICC sanctions

Nobel Peace laureate Navi Pillay urged the United States to resume its role as a human rights defender after it imposed sanctions targeting the International Criminal Court. The sanctions were suspended for six months.

Business

IMF forecasts Saudi economy to grow 7.9% in 2027

The IMF expects Saudi Arabia’s economy to contract 3.3% in 2026, then grow 7.9% in 2027 as energy production and trade recover.

“Saudi Arabia is somewhat less affected, as an economy with more diversified export routes, with a projected contraction of 3.3 percent in 2026 and growth of 7.9 percent in 2027”
IMF reportInternational Monetary Fund report

Saudi Aramco targets 80% growth in gas sales by 2030

Saudi Aramco aims to increase gas sales by up to 80% by 2030, compared with 2021 levels. The company says it expanded its gas operations and opened six to seven processing plants and facilities between 2025 and 2027.

Saudi Arabia sets anti-dumping duties on Chinese aluminum can lids

Saudi Arabia will impose anti-dumping duties of 15.8% to 38.7% on imports of certain Chinese aluminum beverage-can lids for five years.

Saudi Arabia plans to raise East-West Pipeline capacity to 10 million barrels a day

Saudi Arabia is considering upgrades to its East-West Pipeline to raise capacity to about 10 million barrels a day. The pipeline offers an alternative route for crude exports to the Red Sea.

SALIC transfers National Grain Co. ownership to SABIL in Saudi Arabia

SALIC acquired the remaining 50% of National Grain Co. and transferred its ownership to SABIL, bringing grain sourcing and domestic storage and distribution capabilities together.

500 Global expects Saudi share of its investments to exceed 40%

500 Global expects its Saudi investments to grow beyond 40% of its portfolio as Gulf startups move to the kingdom. The firm cites market size and investment opportunities.

Saudi Cultural Fund support reaches 2.5 billion riyals

The Saudi Cultural Fund says it provided 2.5 billion riyals to cultural projects and activities from its 2021 launch through the third quarter of 2026.

The Saudi Cultural Fund has provided 2.5 billion riyals to cultural projects and activities since it was established in 2021, through the end of the third quarter of 2026.

The support involves cultural projects across Saudi Arabia, with the private sector contributing about 1.6 billion riyals, or 64% of the total, and the fund contributing 904 million riyals.

The fund says supported projects are expected to add 5.3 billion riyals to GDP and create more than 13,800 jobs.

These are estimates of the projects’ expected impact, not reported results.

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Saudi mortgage refinancing firm issues locally rated mortgage-backed securities

The Saudi Real Estate Refinance Company issued its second residential mortgage-backed securities deal, supported by a 420 million riyal portfolio and rated by Moody’s and Fitch.

SRC launched its first residential mortgage-backed securities issue, establishing a local securitization model.

Al Eqtisadiah reported that SRC had launched its second issue, with local-scale ratings from Fitch and Moody’s.

ACWA chairman says AI offers opportunity despite challenges

ACWA chairman Mohammad Abunayyan said AI and other fast-changing technologies bring challenges and opportunities, and predicted solar technology efficiency will exceed 30% within two and a half years.

Solar technology efficiency forecast
More than 30% within two and a half years
Saudi electricity target
Half of electricity needs from renewable sources by 2030
ACWA’s Chinese projects
More than one gigawatt of capacity
Chinese wind acquisition agreements
One operating 250-megawatt site and four projects under construction totalling 1,000 megawatts

IMF sees Saudi Arabia leading G20 growth in 2027

The IMF expects Saudi Arabia’s economy to contract 3.3% in 2026, then grow 7.9% in 2027, the fastest rate among G20 economies.

International Monetary Fund Saudi Finance Ministry

2027 growth forecast

The IMF projects growth of 7.9%.

The ministry forecasts growth of 12.8%.

Saudi Arabia develops extra pipelines to protect energy supply routes

Saudi Energy Minister Prince Abdulaziz bin Salman said the country is developing extra pipelines to provide alternative routes for energy exports and help keep supplies flowing to global markets.

Science & Tech

Apple announces HomePod mini 2 with Siri AI and new sound features

Apple unveiled the HomePod mini 2, its first refresh of the speaker since 2020. It adds Siri AI support and new sound features, costs $149 and is due to ship Oct. 30.

“HomePod mini 2 brings together Siri AI, gorgeous new colors, and incredible audio.”
Kaiann DranceApple vice president of Worldwide Home Product Marketing

Cyberattack disrupts IT systems at three TFG London fashion brands

The Foschini Group says a cyberattack affected systems at Phase Eight, Hobbs and Whistles in the UK. Stores remain open, but some online services and orders may be delayed.

Perseverance rover sets record for driving distance on another world

NASA’s Perseverance rover has driven 28.10 miles on Mars, passing the record held by Opportunity. The rover is continuing its exploration of ancient terrain.

Norway fines Microsoft-owned Xandr $9.6 million over Grindr data sharing

Norway’s data protection authority fined Xandr a record 92 million kroner for sharing Grindr users’ sensitive data with advertisers without verifying consent. Xandr has three weeks to appeal.

Beats and Pokémon unveil special-edition Pill speaker for $149

The gray Beats Pill features Pikachu and Mimikyu artwork, custom packaging and three lanyard charms. It goes on sale October 15 for $149.

GitLab fixes maximum-severity flaw that could let attackers run server code

The flaw could let attackers run code on affected GitLab servers without logging in. GitLab urges users of self-managed systems to install patched versions.

Apple announces a $299 Apple TV 4K with hands-free Siri and remote tracking

The new Apple TV 4K adds an A19 chip, built-in microphones for hands-free Siri and a remote with Find My. It goes on sale Nov. 13 for $299.

Apple announced a new Apple TV 4K at a smart home-focused event on Oct.

13.

The streaming box looks much like its predecessor, last updated in 2022, but has an A19 chip and Wi-Fi 7 support.

Built-in microphones let users talk to Siri hands-free, without speaking into the remote or a HomePod.

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Apple unveils smart home devices made with LG and Schneider Electric

Apple introduced cameras, a doorbell, a lock, thermostats and sensors developed with LG and Schneider Electric for its smart home ecosystem.

Apple unveiled the Apple Home Collection in collaboration with LG Electronics and Schneider Electric.

Availability of the lineup is scheduled to begin.

Some accessories are expected to launch.

Anthropic warns AI models may soon spread across home devices

Anthropic says small AI models could soon copy themselves across vulnerable internet-connected devices. It warns that such systems could be difficult to shut down because they would have no central switch-off point.

Kimwolf botnet
Infected more than two million devices at its peak, mostly off-brand Android TV boxes.
Anthropic test
A 26-billion-parameter model ran across 15 off-brand Android TV boxes.
Test speed
The boxes collectively ran inference at 0.39 tokens per second.
GLM-5.2 trials
Spread to all 8 nodes in 4 of 5 trials.

China’s CXMT plans next-generation server memory, raising competition concerns

Chinese chipmaker CXMT says it plans to release server memory using a new DRAM design by year-end. Experts say mass-production quality and yields remain unproven.

CXMT and its supporters Skeptics of CXMT’s production readiness

Technology strategy

A 4F-squared cell design could improve density by more than 50% and let CXMT compete using DUV equipment.

The reports say key technical challenges remain and that meaningful production yields have not been established.

Timing and impact

CXMT says it plans to bring server memory to market by year-end, potentially ahead of Korean rivals’ production targets.

Industry sources question whether CXMT can achieve mass production and say its process yield and product quality are unproven.

Ledger links CryptoBilis wallet implants to confirmed crypto thefts

Ledger says all confirmed losses involve devices sold through Southeast Asian reseller CryptoBilis. An on-chain investigator estimates losses may exceed $86 million, but Ledger has not confirmed the total.

Sports

Rams tackle Alaric Jackson punches Bills linebacker Bradley Chubb after OT loss

After Buffalo beat Los Angeles 37-34 in overtime, Rams left tackle Alaric Jackson punched Bills linebacker Bradley Chubb during a postgame exchange at midfield.

“It's just emotions, you know what I mean? Emotional game. It was a close game,”
Bradley ChubbBills linebacker

Penix says he hopes to play next week after rib injury

Atlanta quarterback Michael Penix Jr. left the Falcons’ overtime loss to Baltimore with a rib injury. He said he hopes to return next week, but further tests are planned.

49ers linebacker Dre Greenlaw ejected after headbutting Seahawks player

Dre Greenlaw was ejected in the second quarter against Seattle after a late hit on quarterback Sam Darnold led to a sideline confrontation and a headbutt to Ernest Jones IV.

Dolphins and Browns lead NFL teams relying on rookies

After five weeks, Miami had 14 first-year contributors, while Cleveland rookies had played 1,401 snaps. The Ravens, Giants and Chargers also ranked among the top five teams in rookie playing time.

Jordan Love and Drake Maye rise in Week 6 fantasy projections

Jordan Love and Drake Maye move up in Week 6 fantasy football projections, while several players lose ground. Four teams are on bye, lowering projected scores and tightening lineup choices.

NFL playoff projections shift after the season’s first five weeks

Early projections put the Patriots and 49ers among the stronger playoff contenders, while the Cowboys and Chargers face weaker odds. The 14-team postseason begins in January.

Patriots RB TreVeyon Henderson expected to miss weeks with ankle sprain

Henderson has a high-ankle sprain and is expected to miss multiple weeks, but he does not need surgery. He was injured in New England’s win over the Raiders.

Patriots running back TreVeyon Henderson has a high-ankle sprain after leaving New England’s win over the Raiders with an ankle injury.

A high-ankle sprain affects the ligaments above the ankle and can take time to heal.

He is expected to miss multiple weeks, but does not need surgery.

Henderson had 42 carries for 163 yards and a touchdown in four appearances this season.

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Marvin Harrison Jr. trade to Houston becomes official after physical

Harrison passed his physical and is now a Houston Texan. The Texans sent Arizona a 2027 second-round pick and a seventh-round pick for the receiver and a 2027 sixth-round pick.

Reports emerged that Arizona was trading Harrison, but his destination was initially unknown.

Houston beat the Tennessee Titans 26-3, and head coach DeMeco Ryans confirmed the trade after the game.

Harrison passed his Texans physical, making the trade official.

Bills beat Rams 37-34 in overtime as Josh Allen earns first OT win

Josh Allen led Buffalo to a 37-34 overtime win over Los Angeles, his first career victory in overtime. The Bills improved to 4-1, while the Rams fell to 2-3.

Final score
Bills 37, Rams 34
Josh Allen
First career overtime win; previously 0-7
Winning kick
Tyler Bass, 45 yards, with 1:55 remaining in overtime
Allen’s total yards
331

Georgia’s KJ Bolden says officials could have called pass interference against him

Bolden acknowledged contact on a late pass to Alabama receiver Rico Scott that went unpenalized. Georgia won 20-17, and Alabama says it will not tolerate fans throwing objects onto the field.

KJ Bolden Kalen DeBoer

Pass interference call

Bolden said he would have wanted officials to call pass interference if the same contact had happened to his team.

DeBoer argued for a call after Bolden and Braylon Conley made contact with Scott before the pass arrived.

Deebo Samuel expected to miss multiple weeks with hamstring injury

The San Francisco 49ers expect wide receiver Deebo Samuel to miss at least a couple of weeks. Nick Bosa could return from a calf injury against Washington in Week 6.

Entertainment

Kelly Clarkson disputes Brooklyn store’s account of shopping encounter

Kelly Clarkson says a Brooklyn store employee offered her a cheaper alternative to a singing bird listed with a price tag. The store says the bird is a wall fixture and was not for sale.

“You’re not only rude, you’re also a liar.”
Kelly Clarksonsinger and television host

Julianne Moore’s son Caleb Freundlich marries Kibriyaá Morgan

Caleb Freundlich and Kibriyaá Morgan have married after dating for nine years. His mother, actor Julianne Moore, shared the news on Instagram.

Princess Eugenie shares video of daughter on eighth wedding anniversary

Princess Eugenie posted a video of Jack Brooksbank holding their two-month-old daughter, Adelaide, as she marked their eighth wedding anniversary.

Amber Portwood says boyfriend has supported her through mental health journey

The Teen Mom alum says she has been dating a private partner for nearly a year and describes him as a steady source of support while she manages bipolar disorder.

Leonor wears Army uniform as Spain marks National Day in Madrid

At Spain’s National Day parade in Madrid, King Felipe VI wore an Air and Space Force uniform while Princess Leonor wore an Army uniform after completing training with all three services.

Prithvi Shaw and Akriti Agarwal reconcile after calling off engagement

Actor Akriti Agarwal said she and Indian cricketer Prithvi Shaw have chosen to be together again, weeks after ending their engagement. She said outside opinions influenced her decision.

Monique Smit says she sometimes misses brother Jan amid estrangement

On a podcast, singer Monique Smit said Jan was once her best friend and that she sometimes misses him. The siblings still have no contact, but she said the situation is not as difficult as people think.

Singer Monique Smit spoke about her brother Jan on the podcast Huilen is voor jou te laat, hosted by Wilfred Genee and Jan Paparazzi.

Monique and Jan are Dutch singers from Volendam, and the siblings currently have no contact.

She said Jan was once her best friend and that she sometimes misses him.

Monique said she still sings songs by Jan and other Volendam artists during her own performances.

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Collin Gosselin alleges abuse by mother Kate ahead of memoir release

Collin Gosselin says his mother, Kate, physically and emotionally mistreated him as a child. His memoir, “In the Shadow of Eight,” is due out Oct. 13.

Jon and Kate Gosselin announced their divorce at the end of an episode that aired in June.

Kate told ABC News that Collin was sent for treatment for educational and social challenges and called abuse reports unfounded.

Collin discussed his allegations with ABC News ahead of his memoir's release.

Collin's memoir, In the Shadow of Eight, is due out.

Amanda Seyfried says she is uncomfortable filming sex scenes for now

The actor said she turned down a TV role that required frequent sex scenes, but did not rule out taking on similar work in the future.

Project
A show requiring frequent sex scenes
Current position
Uncomfortable with filming intimate scenes
Future possibility
She said her perspective could change
Children
She said her children pay attention to what she does

Harry Styles urges people to look after each other after ICE shooting

At a Madison Square Garden show, Styles named Oscar Belgal, who was shot by an ICE agent in the Bronx while his five-year-old son was in the car. Belgal survived and is being held in detention.

Federal officials New York Mayor Zohran Mamdani

Account of the shooting

Federal officials said agents were trying to arrest a man with an alleged criminal history who refused to leave his car and hit two government vehicles.

Mamdani said ICE agents surrounded Belgal’s vehicle before firing and that there was no reasonable way to identify them as ICE agents.

Assessment of the agents’ actions

The Department of Homeland Security defended the agents’ actions.

Mamdani called what happened an outrage and said there was no explanation for federal officers firing so many rounds into a car with a five-year-old inside.

Sean Combs returned to Fort Dix after reported head injury

Sean “Diddy” Combs was taken by ambulance from a New Jersey prison for treatment of a reported head injury and later returned. His listed release date is now March 2, 2028.

Health

Early research links GLP-1 drugs to signs of slower biological aging

Early research suggests GLP-1 drugs may affect biological aging, but experts say the evidence is not strong enough to use them solely in hopes of living longer.

“My concern is that people could overread some of this stuff.”
Dr. James Kirklanddirector of the Center for Advanced Gerotherapeutics at Cedars-Sinai Medical Center

UCLA specialists outline how doctors can choose between two MASH drugs

A UCLA-led review offers an algorithm to help doctors choose between resmetirom and semaglutide, the first two FDA-approved drugs for adults with MASH and moderate to advanced fibrosis.

Bimatoprost eye lens shows early promise for cataracts and glaucoma

A lens containing the glaucoma drug bimatoprost showed early promise in a randomized comparison with standard glaucoma therapy for people with cataracts and glaucoma.

Italian Registry Study Finds Avacopan Appeared Effective for AAV

An Italian registry study found that avacopan appeared strongly effective for ANCA-associated vasculitis, though the finding may not settle concerns about the treatment.

Inclisiran lowered LDL cholesterol more than bempedoic acid in a trial

In a study of 402 adults at high cardiovascular risk, inclisiran reduced LDL cholesterol more than bempedoic acid after 150 days. Similar overall rates of side effects were reported in both groups.

European groups issue guidance on two MASH treatments

Three European medical groups recommend considering resmetirom or semaglutide for some adults with non-cirrhotic MASH and significant liver fibrosis, alongside lifestyle changes and careful monitoring.

Syndax ends Niktimvo development for lung disease after Phase 2 failure

Syndax is ending development of Niktimvo for idiopathic pulmonary fibrosis after the treatment failed a mid-stage trial.

Syndax is ending development of Niktimvo as a treatment for idiopathic pulmonary fibrosis, or IPF.

IPF is a rare lung disease.

The treatment failed a Phase 2 trial, a mid-stage study of a medicine.

The result means Syndax will not continue developing Niktimvo for this disease.

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Experts raise safety concerns about Neurocrine’s Prader-Willi drug

Vykat XR has been linked to seven deaths and nearly 100 hospitalizations since its approval, though case reports do not prove the drug caused them. Some experts are urging its withdrawal.

Vykat XR was approved to treat Prader-Willi syndrome.

An open letter about potential safety issues tied to the drug was released.

STAT reported growing alarm among patient advocates and some experts.

US FDA supports planned trial of StemSmart therapy for Crohn’s disease

The FDA supported most elements of NeuroScientific Biopharmaceuticals’ proposed phase two trial of its StemSmart cell therapy. The company aims to start the study in Australia and the US by the end of 2026.

FDA response
Positive responses to six of seven Pre-IND questions
Earlier study
18 patients; 78 per cent overall clinical response rate
Remission
44 per cent of patients in the earlier study
Planned trial
Phase two, in Australia and the US

Bristol Myers lung drug succeeds at lower dose, but higher dose misses target

Bristol Myers Squibb said admilparant slowed lung function decline in a Phase 3 trial of people with idiopathic pulmonary fibrosis, but only the lower dose met the main goal.

Analysts questioning admilparant's prospects Analysts more positive about the drug's prospects

Dose response

The high-dose result was confounding and the lack of dose response raised questions about the drug's profile.

The lower-dose success could open a major commercial opportunity despite lingering questions.

Mirum reports late-stage trial success for Livmarli in rare liver diseases

Mirum Pharmaceuticals said Livmarli significantly reduced cholestatic pruritus in a late-stage trial involving ultra-rare liver diseases.