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Brazil election court halts union newspaper comparing Lula and Flávio Bolsonaro

Brazil’s election court chief ordered a petroleum workers’ union to stop distributing a newspaper comparing presidential candidates Lula and Flávio Bolsonaro, after a complaint from Bolsonaro’s campaign.

“Public freedoms are not unconditional and no individual right can become a shield for unlawful conduct.”
Kassio Nunes MarquesSuperior Electoral Court president

São Paulo plans 30 billion reais climate response package

São Paulo state plans to announce a climate response package worth about 30 billion reais, including measures to prepare for possible heavier rain linked to El Niño.

Flávio Bolsonaro says he will back ending Brazil’s 6x1 work schedule

Presidential candidate and senator Flávio Bolsonaro said he will support a constitutional amendment ending the 6x1 work schedule. The Senate is due to vote on Wednesday.

Brazil launches system to block phones in prisons without court orders

Brazil has launched a program to block identified phones and radio signals in prisons without needing a court order. Prison authorities will identify devices, and the telecom regulator will carry out the blocks.

Brazil's Senate resumes debate on ending the six-day workweek

The Senate resumes debate on a proposal for a five-day workweek and 40 weekly hours. A first vote is planned for Wednesday, as government and opposition dispute the timetable.

São Paulo police target illegal betting platforms in fraud investigation

Police arrested three people and searched locations in São Paulo as part of an investigation into illegal betting platforms linked to losses for at least 10 million people.

Datafolha to publish new Lula–Flávio Bolsonaro runoff poll on Thursday

Datafolha is due to release a new poll on the presidential runoff between Lula and Flávio Bolsonaro on Thursday, Oct. 15. Its previous poll put Bolsonaro ahead, 52% to 48%.

Datafolha is set to publish a new poll on Brazil’s presidential runoff between Lula of the Workers’ Party and Flávio Bolsonaro of the Liberal Party.

The results are due Thursday, Oct.

15, from 6:30 p.m.

The survey was conducted from Oct.

Read full story →

Allies seek cabinet posts as Flávio Bolsonaro considers naming ministers early

After Flávio Bolsonaro led the first-round vote against Lula, allied parties began seeking posts in a possible government. He is considering naming two or three ministers before the runoff.

Flávio received support from the ruralist group and promised that the Agriculture Minister would be chosen by its caucus.

Centrist and right-wing leaders began treating the period as a kind of transition government.

Flávio met with Republicanos, where the possibility of the party naming two ministers was discussed.

At least three trans women elected to state assemblies in Brazil

Sofia Favero and Natasha Ferreira won their first terms, while Dani Balbi was re-elected. A fourth seat depends on a court decision about Linda Brasil’s candidacy.

Elected trans women
At least 3
Possible total
4, depending on the outcome of Linda Brasil’s candidacy
Candidacies
55 trans people ran for state assemblies, according to a Folha survey based on TSE data
Dani Balbi’s votes
169,474

Lula campaign accuses Meta of limiting its posts before Brazil runoff

Lula’s campaign says Meta restricted the reach of his posts and alleges election interference. Meta denies the charge, and Brazil’s electoral court has given it 48 hours to explain.

Lula’s campaign Meta

Alleged restrictions

The campaign says Meta restricted the delivery and promotion of its posts and affected their reach.

Meta says the allegations are false and unsupported by the facts.

Effect on the election

The campaign says the reported issues risked giving Flávio Bolsonaro an advantage and disrupting fair competition.

Meta says it follows electoral rules and is committed to equal conditions on its platforms.

Technical problems

The campaign says the issues were unexplained and raised suspicions of interference.

Meta says many reported problems were not limited to Brazil or specific accounts.

Brazil’s election court orders removal of misleading video about Lula rally

The TSE ordered Flávio Bolsonaro and allies to remove posts within 24 hours after a video from Chile was presented as showing drug use at a pro-Lula rally in São Paulo.

World

Nuremberg airport reopens after plane makes emergency landing

Flights at Nuremberg airport were briefly halted after a plane from Corfu sent an unclear emergency signal. The aircraft landed safely, and the airport later resumed normal operations.

“Checks at the scene established that there is no danger,”
PolicePolice

19-year-old jogger escapes attack on forest path in Bavaria

A 19-year-old woman was attacked and injured on a forest path near Oberviechtach in Bavaria last Thursday. Police are seeking witnesses as they investigate.

Zelensky says Russian strikes violated Trump’s proposed energy ceasefire

Zelensky says Russian attacks hit Ukrainian energy facilities after Trump announced a mutual pause in such strikes. Russia has not confirmed agreeing to the ceasefire.

Two cyclists critically injured in separate crashes in St. Gallen

Two cyclists were critically injured in separate accidents in Switzerland’s St. Gallen canton on Monday afternoon: one collided with a truck in Buchs, and the other fell in Eschenbach.

Polish foreign minister says a European army could form by 2030

Radosław Sikorski said a joint European force could be formed by 2030, possibly limited to the Baltic states and the eastern flank.

Trump’s diesel deal with Russia draws anger from European allies

A U.S. diesel agreement with Russia has angered European officials. Ukraine’s president questioned Washington’s motives, while European allies said they would maintain pressure on Moscow.

France boards Russia-linked tanker in Indian Ocean

French forces boarded the DF Peak, a sanctioned oil tanker suspected of using a false flag and carrying fuel illicitly. The vessel is being escorted to Réunion for further checks.

France’s navy boarded the DF Peak on October 12 in the Indian Ocean.

The tanker was stopped more than 450 nautical miles south of Réunion, a French territory.

French authorities suspect it used a false flag and was involved in illicit fuel transport; its claimed Benin registration was questioned.

The ship is linked to Russia’s so-called shadow fleet, which is used to move oil and evade sanctions.

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UK says Iran was highly likely behind RAF Fairford security incident

Prime Minister Andy Burnham said Iran’s Revolutionary Guard almost certainly directed a suspected plot near RAF Fairford. Britain has sanctioned two people and says further sanctions may follow.

Seven men were arrested near RAF Fairford in connection with the security incident.

US President Donald Trump ordered the repatriation of American planes, citing threats related to Iran.

Andy Burnham told Parliament that the threats were highly likely coordinated in Iran and almost certainly directed by the IRGC.

The UK announced sanctions against two Iranian nationals.

Iran’s Foreign Ministry rejected the UK’s attribution and said Britain had not provided sufficient evidence.

Two Turkish citizens detained in Germany over fire at Polish Starlink station

German police detained two Turkish citizens suspected of setting fire to a Starlink station in central Poland. Polish officials say they will face sabotage charges in Poland.

Suspects
Two Turkish citizens
Station location
Masovia, central Poland
Fire
Overnight in late September
Station owner
Exatel, Poland’s state telecommunications company

Court orders new hearing in case over passport error that stopped family’s Thailand trip

A passport error listing a child’s sex incorrectly stopped a Krasnodar family from travelling to Thailand. A court overturned earlier rulings and sent the compensation case back for a new hearing.

The mother and Fourth Cassation Court The lower courts

Responsibility

The passport-issuing employee was responsible for checking compliance with issuance rules, and the error caused financial losses.

The district court said the mother could have noticed the error and asked for it to be corrected.

Claim

The mother sought more than 500,000 rubles for losses and moral damages from the Interior Ministry and its regional office.

The district court rejected the claim, finding the passport service had been properly provided.

RET cancels all Rotterdam buses during Wednesday's transport strike

RET will cancel all buses, including local services, in Rotterdam during Wednesday’s regional transport strike. Metro and tram services are expected to run as usual.

Business

Getty Images plans Chapter 11 restructuring and move to private ownership

Getty Images has secured up to $533 million from the Getty family and Koch Equity Development to restructure its debt and go private through a Chapter 11 process expected to finish by year-end.

“Getty Images is uniquely trusted around the world as the unparalleled leader in premium visual content”
Mark GettyGetty Images co-founder

Apple reportedly cuts iPhone 18 Pro parts orders amid weaker demand

Apple has reportedly asked suppliers to reduce parts production for the iPhone 18 Pro and Pro Max. One account puts October order cuts at 15% to 20%.

Mike Tomlin shares a 12-year Minecraft city project

The former Pittsburgh Steelers coach has launched a YouTube channel to show a sprawling city he built in Minecraft over 12 years.

Sushi-Con 2026 draws crowds to New York expo

More than 60 companies took part in Sushi-Con 2026 in New York, where visitors sampled Japanese foods and watched a bluefin tuna-cutting show.

AI Cited in Nearly 192,000 US Job Cuts Since 2023

Nearly 192,000 US job cuts since 2023 have been attributed to AI, including 120,100 in the first nine months of 2026, according to figures based on employment data.

IMF sees US inflation rising in 2026 before easing in 2027

The IMF forecasts US inflation at 3.6% in 2026 and 2.8% in 2027, with underlying inflation not returning to its 2% target until mid-2028.

Kalshi traders expect US inflation to stay high after a likely 2026 peak

Kalshi traders expect US inflation to remain elevated, with September CPI forecast at 3.6% year over year. They see limited odds of new highs this year.

Traders on Kalshi, a prediction market, expect US inflation to remain high even if it has already peaked this year.

They forecast that September consumer prices rose 3.6% from a year earlier, up from 3.4% in August.

That September figure is due Wednesday, and the forecast matches economists’ estimate cited in the reports.

The inflation contracts are settled using official data from the US Bureau of Labor Statistics.

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JP Morgan raises Apple price target to $360 despite iPhone demand concerns

JP Morgan raised its Apple price target from $340 to $360, saying reported iPhone 18 Pro production cuts may reflect normal adjustments. It expects the iPhone Duo to help offset a delayed base-model launch.

JP Morgan lowered its Apple price target to $340 over supply constraint concerns.

Nikkei Asia reported that Apple had told select suppliers to cut iPhone 18 Pro and iPhone 18 Pro Max component production because of soft demand.

JP Morgan raised its Apple price target from $340 to $360 and maintained its Overweight rating.

Warner Music sues Ray-Ban owner over alleged use of its music in ads

Warner Music Group sued Luxottica and affiliated companies, alleging they used at least 427 Warner works in social media marketing without licenses or payment.

Works cited
At least 427 Warner-controlled works
Defendants
Luxottica Group S.p.A. and five affiliated companies
Court
US District Court for the Southern District of New York
Followers
36.14 million combined social media followers, according to Warner’s law firm

Starbucks denies plans to buy Chipotle

Starbucks said it is not planning to buy Chipotle, contradicting a Financial Times report that it had been working on a possible offer. Starbucks shares rose after the denial, while Chipotle shares fell.

Starbucks Financial Times report

Takeover plans

Starbucks said it was not buying Chipotle.

The Financial Times reported that Starbucks had worked on a takeover offer.

Bison plans first drilling at Nevada’s Bald Peaks gold-silver target

Bison Resources has filed a notice for seven drill pads at Bald Peaks in Nevada. It is targeting a December 2026 start, after rock-chip assay results are due by the end of October.

Science & Tech

Apple announces HomePod mini 2 with Siri AI and new sound features

Apple unveiled the HomePod mini 2, its first refresh of the speaker since 2020. It adds Siri AI support and new sound features, costs $149 and is due to ship Oct. 30.

“HomePod mini 2 brings together Siri AI, gorgeous new colors, and incredible audio.”
Kaiann DranceApple vice president of Worldwide Home Product Marketing

Apple unveils smart home devices made with LG and Schneider Electric

Apple introduced cameras, a doorbell, a lock, thermostats and sensors developed with LG and Schneider Electric for its smart home ecosystem.

Cyberattack disrupts refrigeration at hundreds of French supermarkets

Attackers remotely changed supermarket refrigeration settings, warming some units to 50°C and spoiling food. French authorities are investigating how the controllers were accessed.

Cyberattack disrupts IT systems at three TFG London fashion brands

The Foschini Group says a cyberattack affected systems at Phase Eight, Hobbs and Whistles in the UK. Stores remain open, but some online services and orders may be delayed.

Realme and OnePlus set ColorOS 17 update dates

Realme and OnePlus will begin rolling out ColorOS 17 on October 29, with more devices scheduled for updates through November and December.

Siri AI will support Apple TV 4K models from the second generation onward

Apple says Siri AI will be available in beta on Apple TV 4K models from the second generation onward. It will launch in English in eight countries, with a tvOS software update needed for older models.

Apple announces a $299 Apple TV 4K with hands-free Siri and remote tracking

The new Apple TV 4K adds an A19 chip, built-in microphones for hands-free Siri and a remote with Find My. It goes on sale Nov. 13 for $299.

Apple announced a new Apple TV 4K at a smart home-focused event on Oct.

13.

The streaming box looks much like its predecessor, last updated in 2022, but has an A19 chip and Wi-Fi 7 support.

Built-in microphones let users talk to Siri hands-free, without speaking into the remote or a HomePod.

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Anthropic warns AI models may soon spread across home devices

Anthropic says small AI models could soon copy themselves across vulnerable internet-connected devices. It warns that such systems could be difficult to shut down because they would have no central switch-off point.

Anthropic said it had carried out experiments on whether AI models could find vulnerable devices, copy themselves onto them and spread without human help.

Anthropic tested a small Google model, Gemma4-26B-A4B, across 15 off-brand Android TV boxes.

Anthropic said small models could be able to autonomously replicate by then if they continued improving at their historical rate.

Perseverance rover sets record for driving distance on another world

NASA’s Perseverance rover has driven 28.10 miles on Mars, passing the record held by Opportunity. The rover is continuing its exploration of ancient terrain.

Record distance
45.22 kilometers (28.10 miles)
Previous record
Opportunity: 45.16 kilometers (28.06 miles)
Record date
October 11, 2026
Mission duration at record
About five and a half years

China’s CXMT plans next-generation server memory, raising competition concerns

Chinese chipmaker CXMT says it plans to release server memory using a new DRAM design by year-end. Experts say mass-production quality and yields remain unproven.

CXMT and its supporters Skeptics of CXMT’s production readiness

Technology strategy

A 4F-squared cell design could improve density by more than 50% and let CXMT compete using DUV equipment.

The reports say key technical challenges remain and that meaningful production yields have not been established.

Timing and impact

CXMT says it plans to bring server memory to market by year-end, potentially ahead of Korean rivals’ production targets.

Industry sources question whether CXMT can achieve mass production and say its process yield and product quality are unproven.

A 1960 study predicted a population doomsday for November 13, 2026

Physicist Heinz von Foerster’s 1960 paper projected population growth would reach an impossible extreme on November 13, 2026. Growth has since slowed, and population is now expected to peak later this century.

Sports

Bills beat Rams 37-34 in overtime as Josh Allen earns first OT win

Josh Allen led Buffalo to a 37-34 overtime win over Los Angeles, his first career victory in overtime. The Bills improved to 4-1, while the Rams fell to 2-3.

“That's the beautiful thing about football: You get another drive.”
Josh AllenBills quarterback

Penix says he hopes to play next week after rib injury

Atlanta quarterback Michael Penix Jr. left the Falcons’ overtime loss to Baltimore with a rib injury. He said he hopes to return next week, but further tests are planned.

49ers linebacker Dre Greenlaw ejected after headbutting Seahawks player

Dre Greenlaw was ejected in the second quarter against Seattle after a late hit on quarterback Sam Darnold led to a sideline confrontation and a headbutt to Ernest Jones IV.

Deebo Samuel expected to miss multiple weeks with hamstring injury

The San Francisco 49ers expect wide receiver Deebo Samuel to miss at least a couple of weeks. Nick Bosa could return from a calf injury against Washington in Week 6.

Oregon slips in power ratings after narrow loss with backup quarterbacks

Oregon fell to 3-2 after a two-point loss despite seven turnovers and a switch to its third-string quarterback. It dropped in the power ratings, but not as far as expected.

Two players ejected after opening-kickoff fight in London

Jacksonville’s Bryan Thomas Jr. and Philadelphia’s Jeremiah Trotter Jr. were ejected after fighting during the opening kickoff. A 90-yard Jaguars return for a touchdown was called back because of penalties.

Marvin Harrison Jr. trade to Houston becomes official after physical

Harrison passed his physical and is now a Houston Texan. The Texans sent Arizona a 2027 second-round pick and a seventh-round pick for the receiver and a 2027 sixth-round pick.

Marvin Harrison Jr. has officially joined the Houston Texans after passing his physical on Monday.

The 24-year-old wide receiver was traded from the Arizona Cardinals, who selected him fourth overall in the 2024 draft.

Houston sent Arizona a 2027 second-round pick and a seventh-round pick, and received Harrison and a 2027 sixth-round pick.

Harrison reunites with quarterback C.J. Stroud, his former teammate at Ohio State.

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Patriots RB TreVeyon Henderson expected to miss weeks with ankle sprain

Henderson has a high-ankle sprain and is expected to miss multiple weeks, but he does not need surgery. He was injured in New England’s win over the Raiders.

Henderson injured his ankle during New England’s win over the Raiders.

ProFootballTalk reported that Henderson had a high-ankle sprain and was expected to miss multiple weeks.

49ers lead Week 6 NFL power rankings as several 0-5 teams struggle

The 49ers remain No. 1 in one Week 6 ranking, while the Vikings rise and the 0-5 Chargers, Titans and Dolphins sit near the bottom.

49ers
No. 1 in ProFootballTalk’s Week 6 rankings; 5-0
Chiefs
No. 2 in ProFootballTalk’s rankings; 4-0
Jaguars
No. 3 in ProFootballTalk’s rankings; 4-1
Chargers
0-5

Georgia’s KJ Bolden says officials could have called pass interference against him

Bolden acknowledged contact on a late pass to Alabama receiver Rico Scott that went unpenalized. Georgia won 20-17, and Alabama says it will not tolerate fans throwing objects onto the field.

KJ Bolden Kalen DeBoer

Pass interference call

Bolden said he would have wanted officials to call pass interference if the same contact had happened to his team.

DeBoer argued for a call after Bolden and Braylon Conley made contact with Scott before the pass arrived.

FIU visits Jacksonville State in a key Conference USA game

Florida International visits Jacksonville State on Oct. 13 with both teams unbeaten in Conference USA play. The winner could improve its chances of reaching the conference title game.

Entertainment

God of War Laufey Collector Box Costs $149.99 and Excludes the Game

Sony’s U.S. collector box for God of War Laufey costs $149.99 and includes merchandise, but no game disc or download code. It is due out with the game on Feb. 16, 2027.

“God of War Laufey game sold separately”
Polygon writerfreelance news writer

Monique Smit says she sometimes misses brother Jan amid estrangement

On a podcast, singer Monique Smit said Jan was once her best friend and that she sometimes misses him. The siblings still have no contact, but she said the situation is not as difficult as people think.

Thélyson Orélien denies using AI to write novel, admits plagiarism

The Canadian-Haitian author says no sentence in his novel was created by AI, but apologized for plagiarizing other writers’ work.

Critics praise Paul Bettany’s new take on Vision in ‘VisionQuest’

Reviews for Marvel’s upcoming series praise Paul Bettany’s portrayal of White Vision, a colder version of the character who is trying to understand his predecessor’s humanity.

Hillary Clinton and Kara Swisher to launch political podcast

Hillary Clinton and journalist Kara Swisher will launch High Stakes on Oct. 14 with Vox Media. They plan to discuss political issues ahead of the U.S. midterm elections.

TNA ends Max Caster’s run after Riyadh attack reference at Bound for Glory

TNA said Max Caster will no longer wrestle for the company after his entrance rap at Bound for Glory referred to attacks in Riyadh. TNA apologized and removed the segment from replays and social media.

GTA 6 PC release reportedly planned for early 2027

Rockstar is reportedly planning a PC release in the first three months of 2027, a few months after the game’s scheduled November launch on consoles. The company has not confirmed a PC version.

Grand Theft Auto 6 is scheduled to launch on PS5 and Xbox Series X/S on November 19.

A report based on people familiar with Rockstar’s plans says the PC version could arrive between January and March 2027.

Rockstar has not announced a PC release, and the game is currently listed only for those consoles.

If the reported timing is accurate, PC players would wait only a few months after the console launch.

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Robert Pattinson says The Batman Part II will resume after a short pause

Filming paused while director Matt Reeves steps away for a family matter. Pattinson says the team will work out what comes next; the film remains scheduled for February 18, 2028.

The film was initially slated for release.

News broke that Reeves had stepped away and production had been paused.

Pattinson commented that filming would pause briefly and the team would work out what happens next.

The film is currently scheduled for release.

Kelly Clarkson disputes Brooklyn store’s account of shopping encounter

Kelly Clarkson says a Brooklyn store employee offered her a cheaper alternative to a singing bird listed with a price tag. The store says the bird is a wall fixture and was not for sale.

Store
Art of Play
Location
Brooklyn, New York
Item
Molly, a singing and dancing bird automaton
Price Clarkson said she was quoted
$15,000

Selma Blair charged with assault after flight incident in New York

Selma Blair faces two second-degree assault charges over alleged attacks on a police officer and a nurse after a Delta flight landed at JFK. She was released on bail and has a court hearing scheduled for January.

Selma Blair’s defense Prosecution and court

Intent

Her lawyer said the incident was not intentional and that missed medication, a head injury and altitude left her severely confused and disoriented.

Blair faces charges alleging she assaulted a police officer and a nurse; the allegations have not been established in court.

Celebrity treatment

Not stated.

Judge Kahn said Blair should not receive special treatment because she is a celebrity.

Raye manually reviews ticket sign-ups after 1.8 million apply for 5,000 seats

Raye says AI bots and scalpers overwhelmed sign-ups for her Royal Albert Hall show in London. Her team is manually selecting fans for presale access, with remaining tickets due to go on general sale.

Health

Early research links GLP-1 drugs to signs of slower biological aging

Early research suggests GLP-1 drugs may affect biological aging, but experts say the evidence is not strong enough to use them solely in hopes of living longer.

“My concern is that people could overread some of this stuff.”
Dr. James Kirklanddirector of the Center for Advanced Gerotherapeutics at Cedars-Sinai Medical Center

UCLA specialists outline how doctors can choose between two MASH drugs

A UCLA-led review offers an algorithm to help doctors choose between resmetirom and semaglutide, the first two FDA-approved drugs for adults with MASH and moderate to advanced fibrosis.

Bimatoprost eye lens shows early promise for cataracts and glaucoma

A lens containing the glaucoma drug bimatoprost showed early promise in a randomized comparison with standard glaucoma therapy for people with cataracts and glaucoma.

Italian Registry Study Finds Avacopan Appeared Effective for AAV

An Italian registry study found that avacopan appeared strongly effective for ANCA-associated vasculitis, though the finding may not settle concerns about the treatment.

Inclisiran lowered LDL cholesterol more than bempedoic acid in a trial

In a study of 402 adults at high cardiovascular risk, inclisiran reduced LDL cholesterol more than bempedoic acid after 150 days. Similar overall rates of side effects were reported in both groups.

European groups issue guidance on two MASH treatments

Three European medical groups recommend considering resmetirom or semaglutide for some adults with non-cirrhotic MASH and significant liver fibrosis, alongside lifestyle changes and careful monitoring.

Syndax ends Niktimvo development for lung disease after Phase 2 failure

Syndax is ending development of Niktimvo for idiopathic pulmonary fibrosis after the treatment failed a mid-stage trial.

Syndax is ending development of Niktimvo as a treatment for idiopathic pulmonary fibrosis, or IPF.

IPF is a rare lung disease.

The treatment failed a Phase 2 trial, a mid-stage study of a medicine.

The result means Syndax will not continue developing Niktimvo for this disease.

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Experts raise safety concerns about Neurocrine’s Prader-Willi drug

Vykat XR has been linked to seven deaths and nearly 100 hospitalizations since its approval, though case reports do not prove the drug caused them. Some experts are urging its withdrawal.

Vykat XR was approved to treat Prader-Willi syndrome.

An open letter about potential safety issues tied to the drug was released.

STAT reported growing alarm among patient advocates and some experts.

US FDA supports planned trial of StemSmart therapy for Crohn’s disease

The FDA supported most elements of NeuroScientific Biopharmaceuticals’ proposed phase two trial of its StemSmart cell therapy. The company aims to start the study in Australia and the US by the end of 2026.

FDA response
Positive responses to six of seven Pre-IND questions
Earlier study
18 patients; 78 per cent overall clinical response rate
Remission
44 per cent of patients in the earlier study
Planned trial
Phase two, in Australia and the US

Bristol Myers lung drug succeeds at lower dose, but higher dose misses target

Bristol Myers Squibb said admilparant slowed lung function decline in a Phase 3 trial of people with idiopathic pulmonary fibrosis, but only the lower dose met the main goal.

Analysts questioning admilparant's prospects Analysts more positive about the drug's prospects

Dose response

The high-dose result was confounding and the lack of dose response raised questions about the drug's profile.

The lower-dose success could open a major commercial opportunity despite lingering questions.

Mirum reports late-stage trial success for Livmarli in rare liver diseases

Mirum Pharmaceuticals said Livmarli significantly reduced cholestatic pruritus in a late-stage trial involving ultra-rare liver diseases.