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Swiss voters to decide on easing war-material export rules

A committee opposing looser Swiss arms-export rules has made its case ahead of a November 29 vote, warning the change could harm Switzerland’s credibility and humanitarian standing.

“Die Schweiz könne nicht am Vormittag als Vermittlerin in Konflikten auftreten und am Nachmittag die Munition für dieselben Konflikte liefern”
Marc JostEVP member of the National Council

Swiss housing debate focuses on market rules and construction barriers

A Le Temps opinion argues that tighter housing rules and objections to construction are limiting supply in Switzerland as demand grows.

Swiss ministers may seek changes to their government departments

Beat Jans and Martin Pfister may seek new portfolios before a Swiss government election. Business and political figures oppose Jans taking the economics department.

Proposal to count lifetime working hours could reshape retirement debate

Supporters want to introduce a lifetime-working-hours model to address pension funding. The idea currently has majority support among the public and good prospects in parliament, but its details are complex.

Swiss audit finds major delays in pesticide approval system

Half of pesticide approval applications filed in Switzerland from 2018 to 2025 remain pending. The federal authority accepts the audit’s recommendations and plans changes.

Uznach backs away from plan to halve its stork population

Uznach proposed cutting its stork population by half because of droppings and concerns about protected areas, but the town has softened its position and plans talks with a local stork group.

Around 1,000 join unauthorised protest in Bern one year after violent Gaza rally

Around 1,000 people protested against capitalism and imperialism in Bern. Police blocked a march through the city centre, and said there were no major incidents.

About 1,000 people joined an unauthorised protest in Bern on Sunday against capitalism and imperialism.

It was held on the first anniversary of a Gaza-related demonstration in Bern that turned violent, injuring police officers, protesters and bystanders and causing major damage.

Police blocked a march through the city centre, directing protesters from several meeting points along a route through outer neighbourhoods towards the Reitschule.

The police said there were no major incidents; they detained one person carrying several knives, carried out identity checks and seized material.

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Swiss village plans truck deliveries to protect drinking water supply

Domleschg plans to truck water to Feldis and Scheid as drought threatens their supply. The measure is intended to keep water flowing through winter.

Domleschg, like many other regions in Switzerland, faced water shortages because of drought.

The municipality warned that supplies in Feldis and Scheid were becoming scarce.

The municipality informed residents that it planned to truck water to the two districts.

If spring flows continue to fall at the same rate, Feldis may not have enough water to meet demand.

If spring flows continue to fall at the same rate, Scheid may not have enough water to meet demand.

Swiss Helicopter accused of exceeding flight limits in Bernese Oberland

Residents counted about 5,000 more flight movements than allowed in 2025; the company’s chief estimated about 3,000. Swiss aviation authorities have opened proceedings against the airfield manager.

Company
Swiss Helicopter
Location
Bernese Oberland
Residents’ estimate for 2025
About 5,000 excess flight movements
Company chief’s estimate
About 3,000 additional flight movements

Swiss tenants’ group gathers 100,848 signatures against rent proposal

The Swiss Tenants’ Association says it collected 100,848 signatures in two weeks against the government’s proposed alternative to a rent initiative.

Swiss tenants’ association Swiss Federal Council

Proposal’s effect

The association says the proposal would fuel rent increases and remove existing limits on returns.

The Federal Council presented the counterproposal; its view of the association’s criticism is Not stated.

Rent-setting approach

The association wants regular checks and reductions for rents deemed excessive, and says any counterproposal should include cost-based rents and a review mechanism.

The counterproposal would link rents to statistical comparisons of similar homes rather than binding control values.

Appenzell Ausserrhoden asked whether it will require criminal-record checks

Three lawmakers have asked Appenzell Ausserrhoden’s government whether it will create a legal basis to routinely request criminal-record extracts from EU citizens applying for residence permits.

World

Spanish royals visit Ceuta after deadly migration crisis

King Felipe VI and Queen Letizia visited Ceuta to show support for residents after a mass border crossing from Morocco. They are due to travel to Melilla on Wednesday.

“hope to a place that needs a lot of hope”
Juan Jesús VivasPresident of Ceuta

Russia arrests Japanese journalist on suspicion of spying in Sakhalin

Russia’s Federal Security Service says it arrested a Japanese journalist in Sakhalin on suspicion of gathering information about Russian defense capabilities. The journalist was transferred to Moscow and placed in custody.

France boards Russia-linked tanker in Indian Ocean

French forces boarded the DF Peak, a sanctioned oil tanker suspected of using a false flag and carrying fuel illicitly. The vessel is being escorted to Réunion for further checks.

Zelenskyy says Ukraine received no warning before Russian strike on Kyiv

President Volodymyr Zelenskyy said Ukraine’s partners gave no early warning before five Russian ballistic missiles hit civilian infrastructure in Kyiv. He said warnings can help save lives.

Hezbollah announces housing aid of up to $14,000 for displaced families

Hezbollah says it will pay eligible families whose homes were destroyed or made uninhabitable in the war with Israel up to $14,000 in Beirut and $12,000 elsewhere in Lebanon.

NATO commander says alliance is ready to respond to any attack

General Alexus Grynkewich said NATO would block, blunt and, if needed, break an attack on alliance territory. He said conflict with Russia is not inevitable.

Six Flags closes nine coasters after fatal incident in Georgia

One person died and several were injured in an incident involving a coaster at Six Flags Over Georgia. Six Flags closed nine similar rides at six parks while authorities investigate.

One person died and several others were injured in an incident involving a roller coaster at Six Flags Over Georgia near Atlanta on Monday.

Officials have not said how the person died or how the others were injured.

Cobb County police detectives are investigating what happened, and the company is co-operating with them.

Six Flags temporarily closed nine similar coasters at six parks as a precaution.

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Saudi-led coalition tells civilians to leave Yemen oil site in Sanaa

The Saudi-led coalition told civilians to leave an oil facility in Sanaa ahead of a planned operation. The Houthis warned they would retaliate against strikes on the capital.

The Houthis seized strategic territory along Yemen's Red Sea coast.

The Houthis have attacked Saudi airports and oil facilities, according to the Straits Times.

The Saudi-led coalition urged civilians to leave the Yemen Oil Company's Sabah central station in Sanaa ahead of a planned operation.

Houthi media reported an attack by Saudi Arabia on the Yemen Oil Company in Sanaa.

Drones hit two ships off Bulgaria; one sinks and 11 crew are missing

Two cargo ships were hit by drones in the Black Sea off Bulgaria. One sank, leaving 11 crew members missing, while all 15 people aboard the other ship were rescued.

Chelsea 3
Ukrainian-owned; sailed under the Maltese flag
Chelsea 3 crew
15 rescued: seven Ukrainians and eight Azerbaijanis
Chelsea 3 attack
Three drones; about 18 nautical miles from Byala
Sunken ship
About 17 nautical miles east of Krapets; one crew member rescued

Ukrainian drone strikes disrupt three Yandex data centers

Drone attacks damaged three Yandex data centers in Russia, disrupting the company’s cloud and consumer services. Yandex has not given a reliable timeline for restoring full service.

Ukraine Russia

Reason for strikes

Ukraine said the attacks were a response to Russian strikes on Ukrainian data centers.

Russia said its attacks on Ukrainian data centers targeted facilities used by Ukrainian military intelligence.

Navi Pillay urges US to defend human rights amid ICC sanctions

Nobel Peace laureate Navi Pillay urged the United States to resume its role as a human rights defender after it imposed sanctions targeting the International Criminal Court. The sanctions were suspended for six months.

Business

Getty Images plans Chapter 11 restructuring and move to private ownership

Getty Images has secured up to $533 million from the Getty family and Koch Equity Development to restructure its debt and go private through a Chapter 11 process expected to finish by year-end.

“Getty Images is uniquely trusted around the world as the unparalleled leader in premium visual content”
Mark GettyGetty Images co-founder

Apple reportedly cuts iPhone 18 Pro parts orders amid weaker demand

Apple has reportedly asked suppliers to reduce parts production for the iPhone 18 Pro and Pro Max. One account puts October order cuts at 15% to 20%.

Mike Tomlin shares a 12-year Minecraft city project

The former Pittsburgh Steelers coach has launched a YouTube channel to show a sprawling city he built in Minecraft over 12 years.

Sushi-Con 2026 draws crowds to New York expo

More than 60 companies took part in Sushi-Con 2026 in New York, where visitors sampled Japanese foods and watched a bluefin tuna-cutting show.

AI Cited in Nearly 192,000 US Job Cuts Since 2023

Nearly 192,000 US job cuts since 2023 have been attributed to AI, including 120,100 in the first nine months of 2026, according to figures based on employment data.

IMF sees US inflation rising in 2026 before easing in 2027

The IMF forecasts US inflation at 3.6% in 2026 and 2.8% in 2027, with underlying inflation not returning to its 2% target until mid-2028.

Poll finds most Americans think Trump is profiting from presidency

About 6 in 10 U.S. adults say Donald Trump is illegally profiting from the presidency or acting unethically, an AP-NORC poll found. The White House rejects the accusations.

A new AP-NORC poll found most Americans think Trump is profiting from the presidency in unethical or illegal ways.

About 6 in 10 U.S. adults said he is either profiting illegally or acting unethically without breaking the law.

The poll also found that many believe Trump is more focused on personal wealth than helping the country since returning to the White House.

The findings come as his family's businesses have expanded in real estate and entered cryptocurrency ventures.

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JP Morgan raises Apple price target to $360 despite iPhone demand concerns

JP Morgan raised its Apple price target from $340 to $360, saying reported iPhone 18 Pro production cuts may reflect normal adjustments. It expects the iPhone Duo to help offset a delayed base-model launch.

JP Morgan lowered its Apple price target to $340 over supply constraint concerns.

Nikkei Asia reported that Apple had told select suppliers to cut iPhone 18 Pro and iPhone 18 Pro Max component production because of soft demand.

JP Morgan raised its Apple price target from $340 to $360 and maintained its Overweight rating.

Warner Music sues Ray-Ban owner over alleged use of its music in ads

Warner Music Group sued Luxottica and affiliated companies, alleging they used at least 427 Warner works in social media marketing without licenses or payment.

Works cited
At least 427 Warner-controlled works
Defendants
Luxottica Group S.p.A. and five affiliated companies
Court
US District Court for the Southern District of New York
Followers
36.14 million combined social media followers, according to Warner’s law firm

Starbucks denies plans to buy Chipotle

Starbucks said it is not planning to buy Chipotle, contradicting a Financial Times report that it had been working on a possible offer. Starbucks shares rose after the denial, while Chipotle shares fell.

Starbucks Financial Times report

Takeover plans

Starbucks said it was not buying Chipotle.

The Financial Times reported that Starbucks had worked on a takeover offer.

Bison plans first drilling at Nevada’s Bald Peaks gold-silver target

Bison Resources has filed a notice for seven drill pads at Bald Peaks in Nevada. It is targeting a December 2026 start, after rock-chip assay results are due by the end of October.

Science & Tech

Apple announces HomePod mini 2 with Siri AI and new sound features

Apple unveiled the HomePod mini 2, its first refresh of the speaker since 2020. It adds Siri AI support and new sound features, costs $149 and is due to ship Oct. 30.

“HomePod mini 2 brings together Siri AI, gorgeous new colors, and incredible audio.”
Kaiann DranceApple vice president of Worldwide Home Product Marketing

Cyberattack disrupts IT systems at three TFG London fashion brands

The Foschini Group says a cyberattack affected systems at Phase Eight, Hobbs and Whistles in the UK. Stores remain open, but some online services and orders may be delayed.

Perseverance rover sets record for driving distance on another world

NASA’s Perseverance rover has driven 28.10 miles on Mars, passing the record held by Opportunity. The rover is continuing its exploration of ancient terrain.

Norway fines Microsoft-owned Xandr $9.6 million over Grindr data sharing

Norway’s data protection authority fined Xandr a record 92 million kroner for sharing Grindr users’ sensitive data with advertisers without verifying consent. Xandr has three weeks to appeal.

Beats and Pokémon unveil special-edition Pill speaker for $149

The gray Beats Pill features Pikachu and Mimikyu artwork, custom packaging and three lanyard charms. It goes on sale October 15 for $149.

GitLab fixes maximum-severity flaw that could let attackers run server code

The flaw could let attackers run code on affected GitLab servers without logging in. GitLab urges users of self-managed systems to install patched versions.

Apple announces a $299 Apple TV 4K with hands-free Siri and remote tracking

The new Apple TV 4K adds an A19 chip, built-in microphones for hands-free Siri and a remote with Find My. It goes on sale Nov. 13 for $299.

Apple announced a new Apple TV 4K at a smart home-focused event on Oct.

13.

The streaming box looks much like its predecessor, last updated in 2022, but has an A19 chip and Wi-Fi 7 support.

Built-in microphones let users talk to Siri hands-free, without speaking into the remote or a HomePod.

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Apple unveils smart home devices made with LG and Schneider Electric

Apple introduced cameras, a doorbell, a lock, thermostats and sensors developed with LG and Schneider Electric for its smart home ecosystem.

Apple unveiled the Apple Home Collection in collaboration with LG Electronics and Schneider Electric.

Availability of the lineup is scheduled to begin.

Some accessories are expected to launch.

Anthropic warns AI models may soon spread across home devices

Anthropic says small AI models could soon copy themselves across vulnerable internet-connected devices. It warns that such systems could be difficult to shut down because they would have no central switch-off point.

Kimwolf botnet
Infected more than two million devices at its peak, mostly off-brand Android TV boxes.
Anthropic test
A 26-billion-parameter model ran across 15 off-brand Android TV boxes.
Test speed
The boxes collectively ran inference at 0.39 tokens per second.
GLM-5.2 trials
Spread to all 8 nodes in 4 of 5 trials.

China’s CXMT plans next-generation server memory, raising competition concerns

Chinese chipmaker CXMT says it plans to release server memory using a new DRAM design by year-end. Experts say mass-production quality and yields remain unproven.

CXMT and its supporters Skeptics of CXMT’s production readiness

Technology strategy

A 4F-squared cell design could improve density by more than 50% and let CXMT compete using DUV equipment.

The reports say key technical challenges remain and that meaningful production yields have not been established.

Timing and impact

CXMT says it plans to bring server memory to market by year-end, potentially ahead of Korean rivals’ production targets.

Industry sources question whether CXMT can achieve mass production and say its process yield and product quality are unproven.

Ledger links CryptoBilis wallet implants to confirmed crypto thefts

Ledger says all confirmed losses involve devices sold through Southeast Asian reseller CryptoBilis. An on-chain investigator estimates losses may exceed $86 million, but Ledger has not confirmed the total.

Sports

Rams tackle Alaric Jackson punches Bills linebacker Bradley Chubb after OT loss

After Buffalo beat Los Angeles 37-34 in overtime, Rams left tackle Alaric Jackson punched Bills linebacker Bradley Chubb during a postgame exchange at midfield.

“It's just emotions, you know what I mean? Emotional game. It was a close game,”
Bradley ChubbBills linebacker

Penix says he hopes to play next week after rib injury

Atlanta quarterback Michael Penix Jr. left the Falcons’ overtime loss to Baltimore with a rib injury. He said he hopes to return next week, but further tests are planned.

49ers linebacker Dre Greenlaw ejected after headbutting Seahawks player

Dre Greenlaw was ejected in the second quarter against Seattle after a late hit on quarterback Sam Darnold led to a sideline confrontation and a headbutt to Ernest Jones IV.

Dolphins and Browns lead NFL teams relying on rookies

After five weeks, Miami had 14 first-year contributors, while Cleveland rookies had played 1,401 snaps. The Ravens, Giants and Chargers also ranked among the top five teams in rookie playing time.

Jordan Love and Drake Maye rise in Week 6 fantasy projections

Jordan Love and Drake Maye move up in Week 6 fantasy football projections, while several players lose ground. Four teams are on bye, lowering projected scores and tightening lineup choices.

NFL playoff projections shift after the season’s first five weeks

Early projections put the Patriots and 49ers among the stronger playoff contenders, while the Cowboys and Chargers face weaker odds. The 14-team postseason begins in January.

Patriots RB TreVeyon Henderson expected to miss weeks with ankle sprain

Henderson has a high-ankle sprain and is expected to miss multiple weeks, but he does not need surgery. He was injured in New England’s win over the Raiders.

Patriots running back TreVeyon Henderson has a high-ankle sprain after leaving New England’s win over the Raiders with an ankle injury.

A high-ankle sprain affects the ligaments above the ankle and can take time to heal.

He is expected to miss multiple weeks, but does not need surgery.

Henderson had 42 carries for 163 yards and a touchdown in four appearances this season.

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Marvin Harrison Jr. trade to Houston becomes official after physical

Harrison passed his physical and is now a Houston Texan. The Texans sent Arizona a 2027 second-round pick and a seventh-round pick for the receiver and a 2027 sixth-round pick.

Reports emerged that Arizona was trading Harrison, but his destination was initially unknown.

Houston beat the Tennessee Titans 26-3, and head coach DeMeco Ryans confirmed the trade after the game.

Harrison passed his Texans physical, making the trade official.

Bills beat Rams 37-34 in overtime as Josh Allen earns first OT win

Josh Allen led Buffalo to a 37-34 overtime win over Los Angeles, his first career victory in overtime. The Bills improved to 4-1, while the Rams fell to 2-3.

Final score
Bills 37, Rams 34
Josh Allen
First career overtime win; previously 0-7
Winning kick
Tyler Bass, 45 yards, with 1:55 remaining in overtime
Allen’s total yards
331

Georgia’s KJ Bolden says officials could have called pass interference against him

Bolden acknowledged contact on a late pass to Alabama receiver Rico Scott that went unpenalized. Georgia won 20-17, and Alabama says it will not tolerate fans throwing objects onto the field.

KJ Bolden Kalen DeBoer

Pass interference call

Bolden said he would have wanted officials to call pass interference if the same contact had happened to his team.

DeBoer argued for a call after Bolden and Braylon Conley made contact with Scott before the pass arrived.

Deebo Samuel expected to miss multiple weeks with hamstring injury

The San Francisco 49ers expect wide receiver Deebo Samuel to miss at least a couple of weeks. Nick Bosa could return from a calf injury against Washington in Week 6.

Entertainment

Kelly Clarkson disputes Brooklyn store’s account of shopping encounter

Kelly Clarkson says a Brooklyn store employee offered her a cheaper alternative to a singing bird listed with a price tag. The store says the bird is a wall fixture and was not for sale.

“You’re not only rude, you’re also a liar.”
Kelly Clarksonsinger and television host

Julianne Moore’s son Caleb Freundlich marries Kibriyaá Morgan

Caleb Freundlich and Kibriyaá Morgan have married after dating for nine years. His mother, actor Julianne Moore, shared the news on Instagram.

Princess Eugenie shares video of daughter on eighth wedding anniversary

Princess Eugenie posted a video of Jack Brooksbank holding their two-month-old daughter, Adelaide, as she marked their eighth wedding anniversary.

Amber Portwood says boyfriend has supported her through mental health journey

The Teen Mom alum says she has been dating a private partner for nearly a year and describes him as a steady source of support while she manages bipolar disorder.

Leonor wears Army uniform as Spain marks National Day in Madrid

At Spain’s National Day parade in Madrid, King Felipe VI wore an Air and Space Force uniform while Princess Leonor wore an Army uniform after completing training with all three services.

Prithvi Shaw and Akriti Agarwal reconcile after calling off engagement

Actor Akriti Agarwal said she and Indian cricketer Prithvi Shaw have chosen to be together again, weeks after ending their engagement. She said outside opinions influenced her decision.

Monique Smit says she sometimes misses brother Jan amid estrangement

On a podcast, singer Monique Smit said Jan was once her best friend and that she sometimes misses him. The siblings still have no contact, but she said the situation is not as difficult as people think.

Singer Monique Smit spoke about her brother Jan on the podcast Huilen is voor jou te laat, hosted by Wilfred Genee and Jan Paparazzi.

Monique and Jan are Dutch singers from Volendam, and the siblings currently have no contact.

She said Jan was once her best friend and that she sometimes misses him.

Monique said she still sings songs by Jan and other Volendam artists during her own performances.

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Collin Gosselin alleges abuse by mother Kate ahead of memoir release

Collin Gosselin says his mother, Kate, physically and emotionally mistreated him as a child. His memoir, “In the Shadow of Eight,” is due out Oct. 13.

Jon and Kate Gosselin announced their divorce at the end of an episode that aired in June.

Kate told ABC News that Collin was sent for treatment for educational and social challenges and called abuse reports unfounded.

Collin discussed his allegations with ABC News ahead of his memoir's release.

Collin's memoir, In the Shadow of Eight, is due out.

Amanda Seyfried says she is uncomfortable filming sex scenes for now

The actor said she turned down a TV role that required frequent sex scenes, but did not rule out taking on similar work in the future.

Project
A show requiring frequent sex scenes
Current position
Uncomfortable with filming intimate scenes
Future possibility
She said her perspective could change
Children
She said her children pay attention to what she does

Harry Styles urges people to look after each other after ICE shooting

At a Madison Square Garden show, Styles named Oscar Belgal, who was shot by an ICE agent in the Bronx while his five-year-old son was in the car. Belgal survived and is being held in detention.

Federal officials New York Mayor Zohran Mamdani

Account of the shooting

Federal officials said agents were trying to arrest a man with an alleged criminal history who refused to leave his car and hit two government vehicles.

Mamdani said ICE agents surrounded Belgal’s vehicle before firing and that there was no reasonable way to identify them as ICE agents.

Assessment of the agents’ actions

The Department of Homeland Security defended the agents’ actions.

Mamdani called what happened an outrage and said there was no explanation for federal officers firing so many rounds into a car with a five-year-old inside.

Sean Combs returned to Fort Dix after reported head injury

Sean “Diddy” Combs was taken by ambulance from a New Jersey prison for treatment of a reported head injury and later returned. His listed release date is now March 2, 2028.

Health

Early research links GLP-1 drugs to signs of slower biological aging

Early research suggests GLP-1 drugs may affect biological aging, but experts say the evidence is not strong enough to use them solely in hopes of living longer.

“My concern is that people could overread some of this stuff.”
Dr. James Kirklanddirector of the Center for Advanced Gerotherapeutics at Cedars-Sinai Medical Center

UCLA specialists outline how doctors can choose between two MASH drugs

A UCLA-led review offers an algorithm to help doctors choose between resmetirom and semaglutide, the first two FDA-approved drugs for adults with MASH and moderate to advanced fibrosis.

Bimatoprost eye lens shows early promise for cataracts and glaucoma

A lens containing the glaucoma drug bimatoprost showed early promise in a randomized comparison with standard glaucoma therapy for people with cataracts and glaucoma.

Italian Registry Study Finds Avacopan Appeared Effective for AAV

An Italian registry study found that avacopan appeared strongly effective for ANCA-associated vasculitis, though the finding may not settle concerns about the treatment.

Inclisiran lowered LDL cholesterol more than bempedoic acid in a trial

In a study of 402 adults at high cardiovascular risk, inclisiran reduced LDL cholesterol more than bempedoic acid after 150 days. Similar overall rates of side effects were reported in both groups.

European groups issue guidance on two MASH treatments

Three European medical groups recommend considering resmetirom or semaglutide for some adults with non-cirrhotic MASH and significant liver fibrosis, alongside lifestyle changes and careful monitoring.

Syndax ends Niktimvo development for lung disease after Phase 2 failure

Syndax is ending development of Niktimvo for idiopathic pulmonary fibrosis after the treatment failed a mid-stage trial.

Syndax is ending development of Niktimvo as a treatment for idiopathic pulmonary fibrosis, or IPF.

IPF is a rare lung disease.

The treatment failed a Phase 2 trial, a mid-stage study of a medicine.

The result means Syndax will not continue developing Niktimvo for this disease.

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Experts raise safety concerns about Neurocrine’s Prader-Willi drug

Vykat XR has been linked to seven deaths and nearly 100 hospitalizations since its approval, though case reports do not prove the drug caused them. Some experts are urging its withdrawal.

Vykat XR was approved to treat Prader-Willi syndrome.

An open letter about potential safety issues tied to the drug was released.

STAT reported growing alarm among patient advocates and some experts.

US FDA supports planned trial of StemSmart therapy for Crohn’s disease

The FDA supported most elements of NeuroScientific Biopharmaceuticals’ proposed phase two trial of its StemSmart cell therapy. The company aims to start the study in Australia and the US by the end of 2026.

FDA response
Positive responses to six of seven Pre-IND questions
Earlier study
18 patients; 78 per cent overall clinical response rate
Remission
44 per cent of patients in the earlier study
Planned trial
Phase two, in Australia and the US

Bristol Myers lung drug succeeds at lower dose, but higher dose misses target

Bristol Myers Squibb said admilparant slowed lung function decline in a Phase 3 trial of people with idiopathic pulmonary fibrosis, but only the lower dose met the main goal.

Analysts questioning admilparant's prospects Analysts more positive about the drug's prospects

Dose response

The high-dose result was confounding and the lack of dose response raised questions about the drug's profile.

The lower-dose success could open a major commercial opportunity despite lingering questions.

Mirum reports late-stage trial success for Livmarli in rare liver diseases

Mirum Pharmaceuticals said Livmarli significantly reduced cholestatic pruritus in a late-stage trial involving ultra-rare liver diseases.