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Apple unveils $299 HomeView smart home hub
Apple unveiled HomeView, a smart home hub with a display for device controls, calls and media. Pre-orders begin today, and it goes on sale November 13.
SpaceX lists CRS-35 mission
SpaceX published a page titled “CRS-35 Mission.” It provides no further details.
Six Flags closes nine coasters after fatal incident in Georgia
One person died and several were injured in an incident involving a coaster at Six Flags Over Georgia. Six Flags closed nine similar rides at six parks while authorities investigate.
“We are deeply saddened by the guest incident at our park today”
Diddy Taken Out of Prison After Medical Emergency
Diddy was rushed out of prison after a medical emergency. No further details were provided.
Questions raised about presidential runs by Rubio, Ossoff and Ocasio-Cortez
A headline asks whether Rubio, Ossoff and Ocasio-Cortez will run for president. It gives no answer or further details.
Social Security’s 2027 cost-of-living increase forecast at 3.5%
A forecast puts Social Security’s 2027 cost-of-living adjustment at 3.5%, which would add about $68 a month to the average retiree’s benefit. The official figure is due Oct. 14.
Japan and US to review off-duty rules after Okinawa killing
Japan and the United States will review rules for US troops’ off-base conduct after a Marine was arrested on suspicion of killing a woman in Okinawa.
A US Marine was arrested on suspicion of killing an Okinawan woman at a hotel in Naha, the prefectural capital.
He has denied the allegations, and the case remains under investigation.
Japan and the United States have begun talks to review rules for troops off base and consider ways to prevent similar incidents.
The discussions will cover the military’s liberty policy, education and joint patrols by US forces and Japanese police.
Rays look to level ALCS against Guardians in Game 2
Cleveland beat Tampa Bay 7-3 in Game 1 of the ALCS. The Rays host Game 2 on Tuesday, with Freddy Peralta set to start.
Cleveland beat Tampa Bay 7-3 in Game 1 of the ALCS.
The teams are scheduled to meet in Game 2 at 8 p.m. ET.
Hailee Steinfeld Shares Update on Baby Harper Before Bills-Rams Game
Hailee Steinfeld shared a photo and details about baby Harper’s milestones in her newsletter ahead of the Buffalo Bills’ game against the Los Angeles Rams.
- Daughter
- Harper Haize Allen
- Newsletter
- Beau Society
- Newsletter date
- October 9
- New food
- Harper had started solids and liked them except for sweet potato.
Trump’s diesel deal with Russia draws anger from European allies
A U.S. diesel agreement with Russia has angered European officials. Ukraine’s president questioned Washington’s motives, while European allies said they would maintain pressure on Moscow.
Agreement
The U.S. reached a diesel agreement with Russia.
European officials recoiled from the agreement, and Ukraine called it “a gift” to Putin.
Response to Moscow
Not stated.
Allies vowed to keep pressure on Moscow.
Rwanda signs 10-year deal to bring Formula 1 back to Africa
Formula 1 has agreed a 10-year deal for Rwanda to host the African Grand Prix in the early 2030s. A new circuit in Bugesera must be built and meet FIA requirements first.
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27 mins agoPolitics
Trump’s Russian diesel deal draws bipartisan criticism in Congress
Trump says he struck a deal with Putin to import Russian diesel to lower U.S. fuel prices. Lawmakers say it could support Russia’s war in Ukraine and violate U.S. law.
“The harm to the Ukrainians is real”
Los Angeles moves to make some nitrous oxide sales a crime
The Los Angeles City Council unanimously approved a ban on cannabis and tobacco retailers selling or distributing nitrous oxide. The mayor plans to sign it, and violations could bring jail time.
Katie Zacharia begins term as White House press secretary
Katie Zacharia is starting her term as White House press secretary. President Trump said she will hold an introductory news conference Tuesday at 9:30 a.m.
Trump’s plan to import Russian diesel draws bipartisan criticism
Trump says Russia will supply diesel to help ease high fuel prices, but seven senators say the plan conflicts with a 2022 ban on Russian energy imports.
Judge orders halt to taxpayer-funded ads promoting Trump
A federal judge temporarily barred the Trump administration from airing taxpayer-funded ads promoting the president and ordered it to cancel the remaining advertising purchase.
Trump says he may meet North Korea's Kim in November
Trump said he may meet Kim Jong Un during a November trip to Asia, which includes stops in Manila and Shenzhen. No meeting has been confirmed.
Federal agents search Ilhan Omar’s Washington home
Agents searched the home of Democratic Rep. Ilhan Omar as part of an ongoing criminal investigation. Omar called the search political intimidation; no charges against her were announced.
Federal agents searched the Washington home of Ilhan Omar, a Democratic member of Congress from Minnesota.
The Justice Department said the search was carried out under a court-authorised warrant as part of an ongoing criminal investigation, but did not name Omar or explain the investigation.
News reports linked the search to a fraud inquiry about immigration paperwork filed by Omar’s late father when she was a child; officials have not confirmed that link.
Omar, who came to the United States from Somalia as a child, said the search was an attempt to target political opponents.
Elon Musk gives more than $276 million to Republican groups since July
Musk has donated more than $276 million to Republican groups since July, making him the biggest known donor of the 2026 midterm elections. The largest share went to a group backing Republican Senate candidates.
Musk said he planned to do less political spending in the future.
Musk gave more than $276 million to Republican groups.
News outlets reported the newly disclosed donations, ahead of a federal filing deadline.
Political committees are due to report their third-quarter finances.
Republicans face elections as they seek to hold their congressional majorities.
Former DOGE staff raise at least $500 million for private firms
At least two dozen former DOGE staff have moved into private businesses, and firms they co-founded or invested in have raised at least $500 million.
- Funding raised
- At least $500 million
- Former staffers identified
- At least two dozen
- DOGE operating period
- January 20 to July 4, 2025
- DOGE claimed savings
- $215 billion
US archbishop urges Catholic soldiers to avoid planned Hasan execution
Archbishop Timothy Broglio told Catholic service members to seek exemption from the planned firing squad execution of Nidal Hasan, which the Pentagon wants to livestream in December.
Purpose of public broadcast
Broglio questioned the value of broadcasting the execution and said it could harm the military’s reputation.
Hegseth said making the event public would help people understand the serious consequences of such acts.
Participation by Catholic service members
Broglio urged Catholics assigned to the firing squad to request exemption because participation would violate Church teaching.
Hegseth described using military members to carry out the execution; the sources do not state his view on religious exemptions.
Tillis says Trump’s Russian diesel deal may break the law
Senator Thom Tillis says Trump’s decision to ease sanctions on Russian diesel may violate US law. Tillis says the move could affect his support for year-end funding.
Poll finds most Americans see Trump as profiting unethically or illegally
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Federal agents search Ilhan Omar’s Washington home in immigration paperwork probe
18 hrs ago
Johnson says he would stay on as House GOP leader if party loses majority
22 hrs ago
Poll puts Democrats 7 points ahead on generic congressional ballot
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Fort Hood families oppose plan to livestream Hasan’s execution
11 hrs ago
Appeals court confirms Justice owes nearly $30 million to bond provider
4 hrs agoWorld
Emergency response for Christa Pike delayed by confusion after failed execution
911 recordings show more than half an hour passed before Tennessee prison officials confirmed a call for medical help after Christa Pike survived a lethal injection attempt.
“Per supervisors here at the DEC (Department of Emergency Communications) we have been informed it is a false call”
Coroner's inquest to examine death of Toronto woman who fell from balcony
A coroner's inquest is set to begin examining the death of a Toronto woman who fell from a balcony.
Inquest opens into Toronto woman’s 2020 death during police response
A 14-day coroner’s inquest is examining how Regis Korchinski-Paquet died after falling from a Toronto apartment balcony while police were in her home in 2020.
A timeline of key events in the Regis Korchinski-Paquet case
The story is about key events in the Regis Korchinski-Paquet case, but the available text does not describe those events.
Carney says U.S.-Russia diesel deal undermines efforts to end Ukraine war
Mark Carney told Volodymyr Zelenskyy that a new Russian diesel supply deal with the U.S. would give Russia revenue and work against efforts to end the war.
Sheinbaum invokes Mexican sovereignty amid U.S. security and trade tensions
Mexico’s president criticized a U.S. ambassador’s visit to a police academy project, as she balances security co-operation with defending Mexican sovereignty and seeking tariff relief.
Duane Davis faces life sentence for Tupac Shakur murder
Duane Davis, convicted of first-degree murder for orchestrating Tupac Shakur’s 1996 killing, was due to be sentenced in Las Vegas. He faces life in prison without parole and says he will appeal.
Duane “Keffe D” Davis was due to be sentenced in Las Vegas on Tuesday after being found guilty of first-degree murder in August.
The 63-year-old former gang leader faces a maximum sentence of life in prison without parole for his role in the 1996 killing of rapper Tupac Shakur.
Prosecutors said Davis orchestrated the shooting after a casino fight in which Shakur and his entourage beat Davis’s nephew.
Shakur was shot while riding in a car with record executive Marion “Suge” Knight and died in hospital six days later.
Trump-Putin diesel deal draws Ukraine’s criticism as experts doubt price impact
The US temporarily eased sanctions on Russian diesel sales after Trump and Putin agreed to supply fuel. Analysts say the shipments are unlikely to bring down prices soon.
Putin rejected the idea of an energy truce, saying that stopping strikes alone would not solve high diesel prices unless sanctions on Russia were lifted.
Trump announced the diesel deal after a phone call with Putin.
Ukrainian and US delegations were reportedly meeting in Miami as talks on ending the war resumed.
The US Treasury authorization permits transactions involving Russian-origin diesel.
More Canadian snowbirds are choosing destinations outside the U.S
Canadian retirees are swapping winter stays in Florida for places including Mexico and the Caribbean, citing safety concerns, costs and the weak Canadian dollar.
- U.S. winter plans
- 12.5 per cent of surveyed Canadian snowbird respondents
- Previous-year U.S. plans
- Roughly a quarter of respondents
- Delutises’ home
- Waterloo, Ontario
- Planned Dominican Republic stay
- Six weeks
Navi Pillay urges US to defend human rights amid ICC sanctions
Nobel Peace Prize winner Navi Pillay urged the United States to resume its role as a defender of human rights. She also voiced support for the International Criminal Court after the US announced sanctions against it.
Role of the ICC
Pillay expressed solidarity with the court’s work promoting international criminal justice.
The US has imposed sanctions targeting the ICC and says it will not allow the court to prosecute Americans.
US leadership
Pillay urged the US to return to a role as a defender of human rights and a liberator for the rest of the world.
Rubio called the ICC a “rogue court.
Canada’s Wonderland closes two coasters after fatal incident in Georgia
Canada’s Wonderland temporarily closed the Behemoth and Leviathan after a person died and several were injured on a similar ride at Six Flags Over Georgia. There is no reopening timeline.
DNA identifies former Chicago detective as killer in 1960 child murder
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Florida mother mourns two children found dead with their father
16 hrs agoBusiness
IMF forecasts Saudi economy to grow 7.9% in 2027
The IMF expects Saudi Arabia’s economy to contract 3.3% in 2026, then grow 7.9% in 2027 as energy production and trade recover.
“Saudi Arabia is somewhat less affected, as an economy with more diversified export routes, with a projected contraction of 3.3 percent in 2026 and growth of 7.9 percent in 2027”
Saudi Aramco targets 80% growth in gas sales by 2030
Saudi Aramco aims to increase gas sales by up to 80% by 2030, compared with 2021 levels. The company says it expanded its gas operations and opened six to seven processing plants and facilities between 2025 and 2027.
Saudi Arabia sets anti-dumping duties on Chinese aluminum can lids
Saudi Arabia will impose anti-dumping duties of 15.8% to 38.7% on imports of certain Chinese aluminum beverage-can lids for five years.
Saudi energy ministry pavilion traces oil history and future in nine sections
At the World Petroleum Congress in Riyadh, Saudi Arabia’s energy ministry is presenting a nine-section exhibit on the country’s oil history, energy products and sustainability efforts.
Delta delays Atlanta–Riyadh flights until March 2027 after airport attacks
Delta postponed its planned Oct. 23 launch of nonstop flights between Atlanta and Riyadh after deadly attacks and aviation safety warnings. The airline says it expects to begin service in March 2027.
Saudi Arabia says foreign investment in emerging sectors rose 162%
Investment Minister Fahad Al-Saif said foreign direct investment in emerging economic sectors rose 162% over five years. He said Saudi Arabia will now focus on investment quality and productivity.
Saudi Cultural Fund support reaches 2.5 billion riyals
The Saudi Cultural Fund says it provided 2.5 billion riyals to cultural projects and activities from its 2021 launch through the third quarter of 2026.
The Saudi Cultural Fund has provided 2.5 billion riyals to cultural projects and activities since it was established in 2021, through the end of the third quarter of 2026.
The support involves cultural projects across Saudi Arabia, with the private sector contributing about 1.6 billion riyals, or 64% of the total, and the fund contributing 904 million riyals.
The fund says supported projects are expected to add 5.3 billion riyals to GDP and create more than 13,800 jobs.
These are estimates of the projects’ expected impact, not reported results.
Saudi mortgage refinancing firm issues locally rated mortgage-backed securities
The Saudi Real Estate Refinance Company issued its second residential mortgage-backed securities deal, supported by a 420 million riyal portfolio and rated by Moody’s and Fitch.
SRC launched its first residential mortgage-backed securities issue, establishing a local securitization model.
Al Eqtisadiah reported that SRC had launched its second issue, with local-scale ratings from Fitch and Moody’s.
ACWA chairman says AI offers opportunity despite challenges
ACWA chairman Mohammad Abunayyan said AI and other fast-changing technologies bring challenges and opportunities, and predicted solar technology efficiency will exceed 30% within two and a half years.
- Solar technology efficiency forecast
- More than 30% within two and a half years
- Saudi electricity target
- Half of electricity needs from renewable sources by 2030
- ACWA’s Chinese projects
- More than one gigawatt of capacity
- Chinese wind acquisition agreements
- One operating 250-megawatt site and four projects under construction totalling 1,000 megawatts
IMF sees Saudi Arabia leading G20 growth in 2027
The IMF expects Saudi Arabia’s economy to contract 3.3% in 2026, then grow 7.9% in 2027, the fastest rate among G20 economies.
2027 growth forecast
The IMF projects growth of 7.9%.
The ministry forecasts growth of 12.8%.
Saudi Arabia plans to raise East-West Pipeline capacity to 10 million barrels a day
Saudi Arabia is considering upgrades to its East-West Pipeline to raise capacity to about 10 million barrels a day. The pipeline offers an alternative route for crude exports to the Red Sea.
SALIC transfers National Grain Co. ownership to SABIL in Saudi Arabia
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Foreign direct investment flows reported up 160%
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Aramco studies additional routes for oil exports
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Abdulaziz bin Salman says oil pipeline capacity will reach 10 million barrels a day
14 hrs agoScience & Tech
Apple announces HomePod mini 2 with Siri AI and new sound features
Apple unveiled the HomePod mini 2, its first refresh of the speaker since 2020. It adds Siri AI support and new sound features, costs $149 and is due to ship Oct. 30.
“HomePod mini 2 brings together Siri AI, gorgeous new colors, and incredible audio”
Apple reportedly plans HomeView smart home hub for November
Apple is expected to unveil its Siri-focused HomeView display on October 13 and begin shipping it around mid-November. A new Apple TV and HomePod mini are also expected.
GitLab fixes maximum-severity flaw that could let attackers run server code
The flaw could let attackers run code on affected GitLab servers without logging in. GitLab urges users of self-managed systems to install patched versions.
Ledger links CryptoBilis wallet implants to confirmed crypto thefts
Ledger says all confirmed losses involve devices sold through Southeast Asian reseller CryptoBilis. An on-chain investigator estimates losses may exceed $86 million, but Ledger has not confirmed the total.
NASA’s Perseverance rover sets record with 45.2km driven on Mars
Perseverance has driven 45.2km on Mars, surpassing the previous record held by NASA’s Opportunity rover. NASA says the rover’s autonomous navigation system handles more than 90% of its driving.
Scientists call for stronger safeguards against AI hacking
An international group of scientists, including dozens of Canadians, is urging stronger safeguards for AI models after several reported hacking incidents.
Apple announces a $299 Apple TV 4K with hands-free Siri and remote tracking
The new Apple TV 4K adds an A19 chip, built-in microphones for hands-free Siri and a remote with Find My. It goes on sale Nov. 13 for $299.
Apple announced a new Apple TV 4K at a smart home-focused event on Oct.
13.
The streaming box looks much like its predecessor, last updated in 2022, but has an A19 chip and Wi-Fi 7 support.
Built-in microphones let users talk to Siri hands-free, without speaking into the remote or a HomePod.
Apple unveils smart home devices made with LG and Schneider Electric
Apple introduced cameras, a doorbell, a lock, thermostats and sensors developed with LG and Schneider Electric for its smart home ecosystem.
Apple unveiled the Apple Home Collection in collaboration with LG Electronics and Schneider Electric.
Availability of the lineup is scheduled to begin.
Some accessories are expected to launch.
Cyberattack disrupts IT systems at three TFG London fashion brands
The Foschini Group says a cyberattack affected systems at Phase Eight, Hobbs and Whistles in the UK. Stores remain open, but some online services and orders may be delayed.
- Affected brands
- Phase Eight, Hobbs and Whistles
- Incident identified
- Sunday, 11 October 2026
- Stores
- Remained open
- Other UK brands
- Inside Story and White Stuff were unaffected
Honeybee stingers keep pumping venom after detaching from the insect
Researchers at Macquarie University filmed detached honeybee stingers pumping venom into a gel that mimics skin. Their findings reveal how the stinger’s tiny valves and lancets keep the venom flowing.
Sony Announces Japan-Only Midnight Black PlayStation 5
Sony will release a matte-black PS5 Digital Edition in Japan on Nov. 19 for ¥55,000. Buyers will need a separate disc drive to play physical games.
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A 1960 study predicted a population doomsday for November 13, 2026
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Bills beat Rams 37-34 in overtime for Josh Allen’s first OT win
Buffalo beat Los Angeles 37-34 in overtime after Josh Allen led a late drive and Tyler Bass kicked the winning field goal. It was Allen’s first career overtime victory.
“Guys kept chipping away, defense kept going out there making plays, special teams was big tonight”
Dolphins and Browns lead NFL teams relying on rookies
After five weeks, Miami had 14 first-year contributors, while Cleveland rookies had played 1,401 snaps. The Ravens, Giants and Chargers also ranked among the top five teams in rookie playing time.
Titans stick with Cam Ward as they face a 2027 quarterback decision
Tennessee coach Robert Saleh says Cam Ward will not be benched after the Titans fell to 0-5. His early numbers raise questions about whether the team may draft another quarterback in 2027.
Marvin Harrison Jr. trade to Houston becomes official after physical
Harrison passed his physical and is now a Houston Texan. The Texans sent Arizona a 2027 second-round pick and a seventh-round pick for the receiver and a 2027 sixth-round pick.
Rams lose to Bills and look to reset before facing Cardinals
The Rams lost 37-34 to the Bills, leaving them 2-3 despite gaining 454 yards. Puka Nacua said the team must regroup and define its identity before hosting Arizona.
Penix says he hopes to play next week after rib injury
Atlanta quarterback Michael Penix Jr. left the Falcons’ overtime loss to Baltimore with a rib injury. He said he hopes to return next week, but further tests are planned.
49ers lead Week 6 NFL power rankings as several 0-5 teams struggle
The 49ers remain No. 1 in one Week 6 ranking, while the Vikings rise and the 0-5 Chargers, Titans and Dolphins sit near the bottom.
Two Week 6 rankings assess the NFL after five weeks of the 2026 season.
One list keeps the San Francisco 49ers at No.
1, with the Kansas City Chiefs second and the Jacksonville Jaguars third.
The other ranking also puts the 49ers at the top and highlights the strength of the NFC West.
Jaguars left tackle Anton Harrison to have knee surgery
Anton Harrison will have arthroscopic surgery on his right knee after an injury against Philadelphia. His absence could last three to five weeks or the rest of the regular season.
Harrison injured his knee during Jacksonville’s 19-17 win over Philadelphia in London.
Reports said Harrison was set to have arthroscopic knee surgery, with his recovery timeline still uncertain.
Harrison is expected to have surgery when the Jaguars return from London.
The Jaguars are scheduled to play Houston at Wembley Stadium, with Walker Little expected to start at left tackle.
49ers linebacker Dre Greenlaw ejected after headbutting Seahawks player
Dre Greenlaw was ejected in the second quarter against Seattle after a late hit on quarterback Sam Darnold led to a sideline confrontation and a headbutt to Ernest Jones IV.
- Suspension
- One game without pay
- Teams
- San Francisco 49ers and Seattle Seahawks
- Players involved
- Dre Greenlaw and Ernest Jones IV
- Game result
- San Francisco won 32-29
Rams' limited investment in special teams faces renewed scrutiny
After another overtime loss, coach Sean McVay again criticized the Rams' special teams. The team has ranked near the bottom in several measures of investment in that unit.
Two players ejected after opening-kickoff fight in London
Jacksonville’s Bryan Thomas Jr. and Philadelphia’s Jeremiah Trotter Jr. were ejected after fighting during the opening kickoff. A 90-yard Jaguars return for a touchdown was called back because of penalties.
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Selma Blair charged with assault after flight incident in New York
Selma Blair faces two second-degree assault charges over alleged attacks on a police officer and a nurse after a Delta flight landed at JFK. She was released on bail and has a court hearing scheduled for January.
“This was not an intentional assault.”
God of War Laufey Collector Box Costs $149.99 and Excludes the Game
Sony’s U.S. collector box for God of War Laufey costs $149.99 and includes merchandise, but no game disc or download code. It is due out with the game on Feb. 16, 2027.
IDFA to open with film following Myanmar resistance recruits
The 39th International Documentary Film Festival Amsterdam will open with “White Tiger Column,” following young recruits as they train with Myanmar’s resistance movement. The festival runs Nov. 12 to 22.
The Social Reckoning opens to $5.5 million, far below its predecessor
Aaron Sorkin’s follow-up to The Social Network took in $5.5 million in its domestic opening weekend, against a reported production budget of about $30 million to $42 million.
Bryan Cranston mourns Breaking Bad co-star RJ Mitte, who died at 34
Cranston paid tribute to Mitte, who played his son on Breaking Bad, remembering his acting and disability advocacy. Accounts differ on whether his death was officially confirmed as suicide.
RimWorld moves to its own engine, with faster performance and saves intact
Update 1.7 moves RimWorld from Unity to Ludeon Studios’ Waylith Engine. The studio says it runs two to four times faster, and existing saves and most mods still work.
Thélyson Orélien denies using AI to write novel, admits plagiarism
The Canadian-Haitian author says no sentence in his novel was created by AI, but apologized for plagiarizing other writers’ work.
Thélyson Orélien denies that AI wrote any sentence of his novel, “C’était ça ou mourir.”
The Canadian-Haitian writer says he used tools for research but wrote the book himself.
He apologized and accepted responsibility for plagiarizing texts by established authors after moving to Canada.
He says he began writing the novel in Quebec in 2017 and finished a first draft in 2019.
TNA ends Max Caster’s run after Riyadh attack reference at Bound for Glory
TNA said Max Caster will no longer wrestle for the company after his entrance rap at Bound for Glory referred to attacks in Riyadh. TNA apologized and removed the segment from replays and social media.
Wrestling Observer dated the attack at King Khalid International Airport in Riyadh to this day.
Caster performed an entrance rap referencing the Riyadh attacks before his match against Moose at Bound for Glory.
TNA announced Caster would no longer wrestle for the promotion and said it had removed the segment from replays and social media.
Raye manually reviews ticket sign-ups after 1.8 million apply for 5,000 seats
Raye says AI bots and scalpers overwhelmed sign-ups for her Royal Albert Hall show in London. Her team is manually selecting fans for presale access, with remaining tickets due to go on general sale.
- Sign-ups
- 1.8 million
- Venue capacity
- 5,000 seats
- Venue
- Royal Albert Hall, London
- Show date
- 23 October 2026
Collin Gosselin alleges abuse by mother Kate ahead of memoir release
Collin Gosselin says his mother, Kate, physically and emotionally mistreated him as a child. His memoir, “In the Shadow of Eight,” is due out Oct. 13.
Alleged treatment
Collin says his mother dragged him by the ear and mistreated him and his siblings.
Kate previously said reports of abuse were unfounded.
His placement in an institution
Collin says he was removed from the home and placed in an institution, with little contact with his family.
Kate said he was sent for treatment for educational and social challenges and that the decision was the best thing she could do for him.
Julianne Moore’s son Caleb Freundlich marries Kibriyaá Morgan
Caleb Freundlich and Kibriyaá Morgan have married after dating for nine years. His mother, actor Julianne Moore, shared the news on Instagram.
Amanda Seyfried says she is uncomfortable filming sex scenes for now
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Taylor Swift’s ‘Patient Zero’ holds the No. 1 spot on the Hot 100
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God of War Laufey Collector’s Box Will Not Include the Game
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RTL removes Unter Uns morning reruns ahead of planned end
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48 mins agoHealth
Early research links GLP-1 drugs to signs of slower biological aging
Early research suggests GLP-1 drugs may affect biological aging, but experts say the evidence is not strong enough to use them solely in hopes of living longer.
“My concern is that people could overread some of this stuff.”
UCLA specialists outline how doctors can choose between two MASH drugs
A UCLA-led review offers an algorithm to help doctors choose between resmetirom and semaglutide, the first two FDA-approved drugs for adults with MASH and moderate to advanced fibrosis.
Bimatoprost eye lens shows early promise for cataracts and glaucoma
A lens containing the glaucoma drug bimatoprost showed early promise in a randomized comparison with standard glaucoma therapy for people with cataracts and glaucoma.
Italian Registry Study Finds Avacopan Appeared Effective for AAV
An Italian registry study found that avacopan appeared strongly effective for ANCA-associated vasculitis, though the finding may not settle concerns about the treatment.
Inclisiran lowered LDL cholesterol more than bempedoic acid in a trial
In a study of 402 adults at high cardiovascular risk, inclisiran reduced LDL cholesterol more than bempedoic acid after 150 days. Similar overall rates of side effects were reported in both groups.
European groups issue guidance on two MASH treatments
Three European medical groups recommend considering resmetirom or semaglutide for some adults with non-cirrhotic MASH and significant liver fibrosis, alongside lifestyle changes and careful monitoring.
Syndax ends Niktimvo development for lung disease after Phase 2 failure
Syndax is ending development of Niktimvo for idiopathic pulmonary fibrosis after the treatment failed a mid-stage trial.
Syndax is ending development of Niktimvo as a treatment for idiopathic pulmonary fibrosis, or IPF.
IPF is a rare lung disease.
The treatment failed a Phase 2 trial, a mid-stage study of a medicine.
The result means Syndax will not continue developing Niktimvo for this disease.
Experts raise safety concerns about Neurocrine’s Prader-Willi drug
Vykat XR has been linked to seven deaths and nearly 100 hospitalizations since its approval, though case reports do not prove the drug caused them. Some experts are urging its withdrawal.
Vykat XR was approved to treat Prader-Willi syndrome.
An open letter about potential safety issues tied to the drug was released.
STAT reported growing alarm among patient advocates and some experts.
US FDA supports planned trial of StemSmart therapy for Crohn’s disease
The FDA supported most elements of NeuroScientific Biopharmaceuticals’ proposed phase two trial of its StemSmart cell therapy. The company aims to start the study in Australia and the US by the end of 2026.
- FDA response
- Positive responses to six of seven Pre-IND questions
- Earlier study
- 18 patients; 78 per cent overall clinical response rate
- Remission
- 44 per cent of patients in the earlier study
- Planned trial
- Phase two, in Australia and the US
Bristol Myers lung drug succeeds at lower dose, but higher dose misses target
Bristol Myers Squibb said admilparant slowed lung function decline in a Phase 3 trial of people with idiopathic pulmonary fibrosis, but only the lower dose met the main goal.
Dose response
The high-dose result was confounding and the lack of dose response raised questions about the drug's profile.
The lower-dose success could open a major commercial opportunity despite lingering questions.
Mirum reports late-stage trial success for Livmarli in rare liver diseases
Mirum Pharmaceuticals said Livmarli significantly reduced cholestatic pruritus in a late-stage trial involving ultra-rare liver diseases.
Bristol Myers reports two Phase 3 trial successes
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