Explore

Jump to a category

Politics

Trump’s plan to import Russian diesel draws bipartisan criticism

Trump says the U.S. will import Russian diesel to ease fuel prices. Lawmakers from both parties say the plan could help finance Russia’s war in Ukraine and may violate U.S. law.

“it’s illegal, immoral, wrong”
Angus KingU.S. senator from Maine

Former DOGE staff raise at least $500 million for private firms

At least two dozen former DOGE staff have moved into private businesses, and firms they co-founded or invested in have raised at least $500 million.

Katie Zacharia begins term as White House press secretary

Katie Zacharia is starting her term as White House press secretary. President Trump said she will hold an introductory news conference Tuesday at 9:30 a.m.

Supreme Court to hear Trump’s dispute with watchdog group over DOGE

The Supreme Court is set to hear Donald Trump’s dispute with a watchdog group over DOGE. No details of the case or hearing date are provided.

Supreme Court to hear DOGE’s bid to withhold internal documents

The Supreme Court will hear DOGE’s bid to avoid turning over its internal documents.

Judge orders halt to taxpayer-funded ads promoting Trump

A federal judge temporarily barred the Trump administration from airing taxpayer-funded ads promoting the president and ordered it to cancel the remaining advertising purchase.

Federal agents search Ilhan Omar’s Washington home

Agents searched the home of Democratic Rep. Ilhan Omar as part of an ongoing criminal investigation. Omar called the search political intimidation; no charges against her were announced.

Federal agents searched the Washington home of Ilhan Omar, a Democratic member of Congress from Minnesota.

The Justice Department said the search was carried out under a court-authorised warrant as part of an ongoing criminal investigation, but did not name Omar or explain the investigation.

News reports linked the search to a fraud inquiry about immigration paperwork filed by Omar’s late father when she was a child; officials have not confirmed that link.

Omar, who came to the United States from Somalia as a child, said the search was an attempt to target political opponents.

Read full story →

Elon Musk gives more than $276 million to Republican groups since July

Musk has donated more than $276 million to Republican groups since July, making him the biggest known donor of the 2026 midterm elections. The largest share went to a group backing Republican Senate candidates.

Musk said he planned to do less political spending in the future.

Musk gave more than $276 million to Republican groups.

News outlets reported the newly disclosed donations, ahead of a federal filing deadline.

Political committees are due to report their third-quarter finances.

Republicans face elections as they seek to hold their congressional majorities.

Los Angeles moves to make some nitrous oxide sales a crime

The Los Angeles City Council unanimously approved a ban on cannabis and tobacco retailers selling or distributing nitrous oxide. The mayor plans to sign it, and violations could bring jail time.

Council vote
Unanimous approval
Penalty
Up to $1,000 fine, six months in jail, or both
Ordinance sponsors
Imelda Padilla and Eunisses Hernandez
State legislation
SB 758 and SB 936

US archbishop urges Catholic soldiers to avoid planned Hasan execution

Archbishop Timothy Broglio told Catholic service members to seek exemption from the planned firing squad execution of Nidal Hasan, which the Pentagon wants to livestream in December.

Archbishop Timothy Broglio Defense Secretary Pete Hegseth

Purpose of public broadcast

Broglio questioned the value of broadcasting the execution and said it could harm the military’s reputation.

Hegseth said making the event public would help people understand the serious consequences of such acts.

Participation by Catholic service members

Broglio urged Catholics assigned to the firing squad to request exemption because participation would violate Church teaching.

Hegseth described using military members to carry out the execution; the sources do not state his view on religious exemptions.

Tillis says Trump’s Russian diesel deal may break the law

Senator Thom Tillis says Trump’s decision to ease sanctions on Russian diesel may violate US law. Tillis says the move could affect his support for year-end funding.

World

Simon and Rachel leave five dead and six missing in Mexico

Storms Simon and Rachel caused deaths and flooding along Mexico’s Pacific coast. Simon remained offshore, with heavy rain and possible flooding still forecast.

“We heard a loud noise that sounded like ocean waves, but really loud,”
Johana NuriuluEnsenada resident

Storms threaten south-central Brazil with winds of up to 90 km/h

Storms are expected across parts of south-central Brazil on Tuesday, with winds reaching up to 90 km/h and heavy rain forecast in Paraná.

Teenager wakes in coffin during family wake in Guatemala

Yuleidy Ixcotoyac, 15, began moving during her wake in El Jocote, Guatemala, after her family believed she had died. She had not been examined by a doctor.

Hurricane Simon weakens to Category 3 but threatens Mexico’s Pacific coast

Simon weakened from Category 4 to Category 3 as it moved parallel to Mexico’s Pacific coast, bringing heavy rain, strong winds and flooding. Authorities issued high alerts and closed Puerto Vallarta’s airport temporarily.

Brazilian law allows protective orders based on a woman’s account

Brazil’s Maria da Penha Law allows women seeking urgent protection from property-related abuse to request protective measures without first presenting a full set of evidence or hiring a lawyer.

10-year-old girl dies after drowning at water park in Ceará

A 10-year-old girl died after drowning at a water park in the interior of Ceará on Sunday. Staff treated her at the site and took her to hospital, where she died.

Hurricane Simón forecast to reach Sinaloa as a Category 1 storm

Simón is forecast to reach the Mazatlán area on Thursday as a Category 1 hurricane. Authorities have issued alerts as it moves toward Sinaloa and Nayarit.

Hurricane Simón is moving northwest across the Pacific coast of Mexico and was a Category 3 storm near Jalisco on Monday, October 12.

The National Meteorological Service forecasts that it will weaken and reach the Mazatlán area in Sinaloa as a Category 1 hurricane around midnight on Thursday, October 15.

Heavy rain and dangerous waves are expected in southern Sinaloa and northern Nayarit on Wednesday.

The storm has already caused damage in Guerrero and Colima, including flooding, landslides and damage to homes and businesses.

Read full story →

Gang kidnaps three officials in Morelos to secure member's release

Pueblos Unidos seized three officials in Morelos after authorities detained a senior gang member. Officials released the suspect, and the gang later freed the three employees.

The attorney-general’s office arrested a Pueblos Unidos member in a raid targeting extortion.

Pueblos Unidos seized three office employees and held them hostage.

The office released the detained suspect to protect its staff.

The gang released all three employees; one was taken to hospital with a gunshot wound and was stable.

Argentina asks international tribunal to halt UK-authorized oil activity near Falklands

Argentina has asked an international tribunal to halt British-authorized hydrocarbon activity near the Falkland Islands, which Britain controls and Argentina claims.

Tribunal
International Tribunal for the Law of the Sea
Filing date
October 13, 2026
Target area
Northern Falklands Basin continental shelf
Territory
The UK controls the Falkland Islands, which Argentina claims

China sanctions ministers from Paraguay and Belize over Taiwan ties

China imposed sanctions on Paraguay’s communications minister and Belize’s foreign minister for supporting their countries’ diplomatic ties with Taiwan. The measures include asset freezes and entry bans.

China Taiwan government

Taiwan's status

China says Taiwan is one of its provinces and has no right to the trappings of a state.

Taiwan's government strongly rejects China's view.

Diplomatic ties

China sanctioned the ministers over support for Paraguay's and Belize's diplomatic ties with Taiwan.

Paraguay and Belize maintain formal diplomatic relations with Taiwan.

South Korea plans $300,000 in aid for quake-hit Panama

South Korea plans to provide Panama with $300,000 in humanitarian aid after a magnitude 7.7 earthquake damaged homes, schools and health facilities.

Business

JP Morgan raises Apple price target to $360 despite iPhone demand concerns

JP Morgan raised its Apple price target from $340 to $360, saying reported iPhone 18 Pro production cuts may reflect normal adjustments. It expects the iPhone Duo to help offset a delayed base-model launch.

“there is nothing beyond the typical production adjustments Apple makes every year.”
JP Morgan analystsAnalysts

Apple reportedly cuts iPhone 18 Pro parts orders amid weaker demand

Apple has reportedly asked suppliers to reduce parts production for the iPhone 18 Pro and Pro Max. One account puts October order cuts at 15% to 20%.

Mike Tomlin shares a 12-year Minecraft city project

The former Pittsburgh Steelers coach has launched a YouTube channel to show a sprawling city he built in Minecraft over 12 years.

Sushi-Con 2026 draws crowds to New York expo

More than 60 companies took part in Sushi-Con 2026 in New York, where visitors sampled Japanese foods and watched a bluefin tuna-cutting show.

AI Cited in Nearly 192,000 US Job Cuts Since 2023

Nearly 192,000 US job cuts since 2023 have been attributed to AI, including 120,100 in the first nine months of 2026, according to figures based on employment data.

IMF sees US inflation rising in 2026 before easing in 2027

The IMF forecasts US inflation at 3.6% in 2026 and 2.8% in 2027, with underlying inflation not returning to its 2% target until mid-2028.

UnitedHealth raises its profit forecast again as turnaround efforts advance

UnitedHealth raised its profit forecast again as its turnaround efforts gathered pace. No forecast figure or further details were provided.

UnitedHealth has raised its profit forecast again.

The company’s turnaround efforts are gathering pace, according to the headline.

A profit forecast is an estimate of how much profit a company expects to make.

The headline gives no new forecast figure or details about the changes behind the increase.

Read full story →

Bumble reportedly in advanced talks for a $1bn takeover

Bumble shares rose almost 50% after a report that technology holding company Ithaca is in advanced talks to buy the dating app firm for around $1bn.

Whitney Wolfe Herd launched Bumble.

Bumble listed on Nasdaq and later reached a market value of more than $14bn.

A report said Bumble was in advanced takeover talks, and its shares rose almost 50%.

Ithaca could announce a deal to buy Bumble, according to the Wall Street Journal report cited by the BBC.

Warner Music sues Ray-Ban owner over alleged use of its music in ads

Warner Music Group sued Luxottica and affiliated companies, alleging they used at least 427 Warner works in social media marketing without licenses or payment.

Works cited
At least 427 Warner-controlled works
Defendants
Luxottica Group S.p.A. and five affiliated companies
Court
US District Court for the Southern District of New York
Followers
36.14 million combined social media followers, according to Warner’s law firm

Starbucks denies plans to buy Chipotle

Starbucks said it is not planning to buy Chipotle, contradicting a Financial Times report that it had been working on a possible offer. Starbucks shares rose after the denial, while Chipotle shares fell.

Starbucks Financial Times report

Takeover plans

Starbucks said it was not buying Chipotle.

The Financial Times reported that Starbucks had worked on a takeover offer.

Bison plans first drilling at Nevada’s Bald Peaks gold-silver target

Bison Resources has filed a notice for seven drill pads at Bald Peaks in Nevada. It is targeting a December 2026 start, after rock-chip assay results are due by the end of October.

Science & Tech

Apple announces HomePod mini 2 with Siri AI and new sound features

Apple unveiled the HomePod mini 2, its first refresh of the speaker since 2020. It adds Siri AI support and new sound features, costs $149 and is due to ship Oct. 30.

“HomePod mini 2 brings together Siri AI, gorgeous new colors, and incredible audio”
Kaiann DranceApple's vice president of Worldwide Home Product Marketing

Anthropic warns AI models may soon spread across home devices

Anthropic says small AI models could soon copy themselves across vulnerable internet-connected devices. It warns that such systems could be difficult to shut down because they would have no central switch-off point.

GitLab fixes maximum-severity flaw that could let attackers run server code

The flaw could let attackers run code on affected GitLab servers without logging in. GitLab urges users of self-managed systems to install patched versions.

Ledger links CryptoBilis wallet implants to confirmed crypto thefts

Ledger says all confirmed losses involve devices sold through Southeast Asian reseller CryptoBilis. An on-chain investigator estimates losses may exceed $86 million, but Ledger has not confirmed the total.

Scientists call for stronger safeguards against AI hacking

An international group of scientists, including dozens of Canadians, is urging stronger safeguards for AI models after several reported hacking incidents.

Honeybee stingers keep pumping venom after detaching from the insect

Researchers at Macquarie University filmed detached honeybee stingers pumping venom into a gel that mimics skin. Their findings reveal how the stinger’s tiny valves and lancets keep the venom flowing.

Apple announces a $299 Apple TV 4K with hands-free Siri and remote tracking

The new Apple TV 4K adds an A19 chip, built-in microphones for hands-free Siri and a remote with Find My. It goes on sale Nov. 13 for $299.

Apple announced a new Apple TV 4K at a smart home-focused event on Oct.

13.

The streaming box looks much like its predecessor, last updated in 2022, but has an A19 chip and Wi-Fi 7 support.

Built-in microphones let users talk to Siri hands-free, without speaking into the remote or a HomePod.

Read full story →

Apple unveils smart home devices made with LG and Schneider Electric

Apple introduced cameras, a doorbell, a lock, thermostats and sensors developed with LG and Schneider Electric for its smart home ecosystem.

Apple unveiled the Apple Home Collection in collaboration with LG Electronics and Schneider Electric.

Availability of the lineup is scheduled to begin.

Some accessories are expected to launch.

Cyberattack disrupts IT systems at three TFG London fashion brands

The Foschini Group says a cyberattack affected systems at Phase Eight, Hobbs and Whistles in the UK. Stores remain open, but some online services and orders may be delayed.

Affected brands
Phase Eight, Hobbs and Whistles
Incident identified
Sunday, 11 October 2026
Stores
Remained open
Other UK brands
Inside Story and White Stuff were unaffected

China’s CXMT plans next-generation server memory, raising competition concerns

Chinese chipmaker CXMT says it plans to release server memory using a new DRAM design by year-end. Experts say mass-production quality and yields remain unproven.

CXMT and its supporters Skeptics of CXMT’s production readiness

Technology strategy

A 4F-squared cell design could improve density by more than 50% and let CXMT compete using DUV equipment.

The reports say key technical challenges remain and that meaningful production yields have not been established.

Timing and impact

CXMT says it plans to bring server memory to market by year-end, potentially ahead of Korean rivals’ production targets.

Industry sources question whether CXMT can achieve mass production and say its process yield and product quality are unproven.

Sony Announces Japan-Only Midnight Black PlayStation 5

Sony will release a matte-black PS5 Digital Edition in Japan on Nov. 19 for ¥55,000. Buyers will need a separate disc drive to play physical games.

Sports

Rwanda signs 10-year deal to bring Formula 1 back to Africa

Formula 1 has agreed a 10-year deal for Rwanda to host the African Grand Prix in the early 2030s. A new circuit in Bugesera must be built and meet FIA requirements first.

“Today belongs to Africa. For more than three decades, the world's premier motorsport championship has raced without this continent.”
Paul KagameRwanda’s president

Litton century gives Bangladesh a 479-run lead over Afghanistan

Litton Das scored 102 as Bangladesh set Afghanistan a target of 479 in Abu Dhabi. Sediqullah Atal later made his maiden century, keeping Afghanistan's hopes alive.

Ayush Mhatre suffers Grade 4 hamstring tear

Mumbai vice-captain Ayush Mhatre tore his right hamstring while batting against Chandigarh in the Ranji Trophy. He is expected to be out for about a month.

Dodgers Weigh Benching Ohtani for NLCS Game 3

After losing Game 2 to Milwaukee, Los Angeles is considering sitting Shohei Ohtani for Game 3. Manager Dave Roberts plans to discuss the decision with Ohtani before the game.

Australia need six wickets to beat South Africa in Durban Test

South Africa begin day five at 102 for four, chasing 421 against Australia. Steve Smith is being assessed for a possible concussion after a blow to the helmet.

Five Clockwork Carnage qualifiers set for AEW’s October 14 show

AEW has announced five qualifying matches for its October 14 Dynamite and Collision programming. The winners will join Will Ospreay, Samoa Joe and Mike Bailey in the Clockwork Carnage match at WrestleDream.

Alexander Zverev guaranteed to finish 2026 as year-end world No. 1

Carlos Alcaraz’s defeat at the Shanghai Masters and Jannik Sinner’s season-ending knee injury mean Zverev cannot be caught in the rankings. He will be the first German man to finish a season at No. 1.

Alexander Zverev is guaranteed to finish 2026 as the world’s top-ranked men’s tennis player.

Carlos Alcaraz’s loss to Belgium’s Zizou Bergs in the Shanghai Masters third round removed his chance of catching Zverev.

Jannik Sinner, who currently holds the top ranking, is out for the rest of the season with a knee injury.

Zverev will be the first German man to end a season at No.

Read full story →

Bethell returns as England name four uncapped players for Australia tour

Jacob Bethell is fit to return for England’s white-ball tour of Australia, while four uncapped players are named for the T20 squad. The tour runs from 13 November to 2 December.

Bethell suffered a knee injury during the ODI series against India.

England are due to begin the ODI series against Australia in Perth.

The five-match T20 series is due to begin in Melbourne.

The tour is due to end with the final T20 in Canberra.

Bills beat Rams 37-34 in overtime as Josh Allen earns first OT win

Josh Allen led Buffalo to a 37-34 overtime win over Los Angeles, his first career victory in overtime. The Bills improved to 4-1, while the Rams fell to 2-3.

Final score
Bills 37, Rams 34
Josh Allen
First career overtime win; previously 0-7
Winning kick
Tyler Bass, 45 yards, with 1:55 remaining in overtime
Allen’s total yards
331

Ollie Pope withdraws from Afghanistan Premier League draft

England batter Ollie Pope has withdrawn from the draft for the inaugural Afghanistan Premier League, amid debate over the Taliban’s treatment of women and girls. David Willey and Will Smeed have also pulled out, according to reports.

Rob Key Dawid Malan

Participation

Key said he would not play in the league and called participation a moral judgement for players.

Malan said he was willing to play if the boards approved it, citing the need to earn a living.

Responsibility

Key said players had to be prepared to take the right moral stance.

Malan said players take guidance from the ICC and cricket boards, and questioned why individuals faced the choice when England still plays Afghanistan in global tournaments.

Australia ends South Africa’s unbeaten Test run in Durban

Australia beat South Africa in Durban, ending the hosts’ unbeaten run. Captain Temba Bavuma said the team would focus on its response and on areas it could improve.

Entertainment

Monique Smit says she sometimes misses brother Jan amid estrangement

On a podcast, singer Monique Smit said Jan was once her best friend and that she sometimes misses him. The siblings still have no contact, but she said the situation is not as difficult as people think.

“Jan was my very best friend.”
Monique SmitSinger

Raye manually reviews ticket sign-ups after 1.8 million apply for 5,000 seats

Raye says AI bots and scalpers overwhelmed sign-ups for her Royal Albert Hall show in London. Her team is manually selecting fans for presale access, with remaining tickets due to go on general sale.

Ego Nwodim mocks Shane Gillis’s joke about women’s gym clothes

After Shane Gillis joked that women at the gym “dress like whores” on SNL, former cast member Ego Nwodim responded with a gym selfie and a pointed caption.

Bryan Cranston mourns Breaking Bad co-star RJ Mitte, who died at 34

Cranston paid tribute to Mitte, who played his son on Breaking Bad, remembering his acting and disability advocacy. Accounts differ on whether his death was officially confirmed as suicide.

The Social Reckoning opens to $5.5 million, far below its predecessor

Aaron Sorkin’s follow-up to The Social Network took in $5.5 million in its domestic opening weekend, against a reported production budget of about $30 million to $42 million.

IDFA to open with film following Myanmar resistance recruits

The 39th International Documentary Film Festival Amsterdam will open with “White Tiger Column,” following young recruits as they train with Myanmar’s resistance movement. The festival runs Nov. 12 to 22.

Selma Blair charged with assault after flight incident in New York

Selma Blair faces two second-degree assault charges over alleged attacks on a police officer and a nurse after a Delta flight landed at JFK. She was released on bail and has a court hearing scheduled for January.

Actor Selma Blair faces two assault charges after an incident on a Delta flight from Los Angeles to New York.

The charges say she allegedly kicked a police officer taking her to hospital and later kicked a nurse in Queens.

She was arraigned in Queens on two counts of second-degree assault and has pleaded not guilty, according to one account.

A judge set bail at $20,000 cash or a $60,000 bond, and she was released.

Read full story →

Thélyson Orélien denies using AI to write novel, admits plagiarism

The Canadian-Haitian author says no sentence in his novel was created by AI, but apologized for plagiarizing other writers’ work.

Orélien says he began writing the novel in Quebec.

Orélien says he completed a first draft.

Orélien was in France for a promotional tour.

Orélien returned to Canada, interrupting the tour.

He denied that AI created any sentence in the novel and acknowledged responsibility for plagiarism.

TNA ends Max Caster’s run after Riyadh attack reference at Bound for Glory

TNA said Max Caster will no longer wrestle for the company after his entrance rap at Bound for Glory referred to attacks in Riyadh. TNA apologized and removed the segment from replays and social media.

Promotion
TNA
Wrestler
Max Caster
Event
Bound for Glory 2026
Opponent
Moose

Collin Gosselin alleges abuse by mother Kate ahead of memoir release

Collin Gosselin says his mother, Kate, physically and emotionally mistreated him as a child. His memoir, “In the Shadow of Eight,” is due out Oct. 13.

Collin Gosselin Kate Gosselin

Alleged treatment

Collin says his mother dragged him by the ear and mistreated him and his siblings.

Kate previously said reports of abuse were unfounded.

His placement in an institution

Collin says he was removed from the home and placed in an institution, with little contact with his family.

Kate said he was sent for treatment for educational and social challenges and that the decision was the best thing she could do for him.

RimWorld moves to its own engine, with faster performance and saves intact

Update 1.7 moves RimWorld from Unity to Ludeon Studios’ Waylith Engine. The studio says it runs two to four times faster, and existing saves and most mods still work.

Health

Early research links GLP-1 drugs to signs of slower biological aging

Early research suggests GLP-1 drugs may affect biological aging, but experts say the evidence is not strong enough to use them solely in hopes of living longer.

“My concern is that people could overread some of this stuff.”
Dr. James Kirklanddirector of the Center for Advanced Gerotherapeutics at Cedars-Sinai Medical Center

UCLA specialists outline how doctors can choose between two MASH drugs

A UCLA-led review offers an algorithm to help doctors choose between resmetirom and semaglutide, the first two FDA-approved drugs for adults with MASH and moderate to advanced fibrosis.

Bimatoprost eye lens shows early promise for cataracts and glaucoma

A lens containing the glaucoma drug bimatoprost showed early promise in a randomized comparison with standard glaucoma therapy for people with cataracts and glaucoma.

Italian Registry Study Finds Avacopan Appeared Effective for AAV

An Italian registry study found that avacopan appeared strongly effective for ANCA-associated vasculitis, though the finding may not settle concerns about the treatment.

Inclisiran lowered LDL cholesterol more than bempedoic acid in a trial

In a study of 402 adults at high cardiovascular risk, inclisiran reduced LDL cholesterol more than bempedoic acid after 150 days. Similar overall rates of side effects were reported in both groups.

European groups issue guidance on two MASH treatments

Three European medical groups recommend considering resmetirom or semaglutide for some adults with non-cirrhotic MASH and significant liver fibrosis, alongside lifestyle changes and careful monitoring.

Syndax ends Niktimvo development for lung disease after Phase 2 failure

Syndax is ending development of Niktimvo for idiopathic pulmonary fibrosis after the treatment failed a mid-stage trial.

Syndax is ending development of Niktimvo as a treatment for idiopathic pulmonary fibrosis, or IPF.

IPF is a rare lung disease.

The treatment failed a Phase 2 trial, a mid-stage study of a medicine.

The result means Syndax will not continue developing Niktimvo for this disease.

Read full story →

Experts raise safety concerns about Neurocrine’s Prader-Willi drug

Vykat XR has been linked to seven deaths and nearly 100 hospitalizations since its approval, though case reports do not prove the drug caused them. Some experts are urging its withdrawal.

Vykat XR was approved to treat Prader-Willi syndrome.

An open letter about potential safety issues tied to the drug was released.

STAT reported growing alarm among patient advocates and some experts.

US FDA supports planned trial of StemSmart therapy for Crohn’s disease

The FDA supported most elements of NeuroScientific Biopharmaceuticals’ proposed phase two trial of its StemSmart cell therapy. The company aims to start the study in Australia and the US by the end of 2026.

FDA response
Positive responses to six of seven Pre-IND questions
Earlier study
18 patients; 78 per cent overall clinical response rate
Remission
44 per cent of patients in the earlier study
Planned trial
Phase two, in Australia and the US

Bristol Myers lung drug succeeds at lower dose, but higher dose misses target

Bristol Myers Squibb said admilparant slowed lung function decline in a Phase 3 trial of people with idiopathic pulmonary fibrosis, but only the lower dose met the main goal.

Analysts questioning admilparant's prospects Analysts more positive about the drug's prospects

Dose response

The high-dose result was confounding and the lack of dose response raised questions about the drug's profile.

The lower-dose success could open a major commercial opportunity despite lingering questions.

Mirum reports late-stage trial success for Livmarli in rare liver diseases

Mirum Pharmaceuticals said Livmarli significantly reduced cholestatic pruritus in a late-stage trial involving ultra-rare liver diseases.