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White House officials question Zacharia’s future after brief first briefing

Katie Zacharia’s first White House briefing lasted about 15 minutes, including roughly 5½ minutes of questions. Officials questioned how long she would remain in the role, though some said she deserved more time.

“I am going to end it because President Trump is heading out to Marine One for our historic trip to Alaska, and we can ask him all of the questions out there”
Katie ZachariaWhite House press secretary

Supreme Court to hear DOGE’s bid to withhold internal documents

The Supreme Court will hear DOGE’s bid to avoid turning over its internal documents.

Trump to campaign in Alaska as Republicans face a tight Senate race

Trump plans to travel to Alaska to campaign as Republicans face a tight Senate race there. Alaska has become a crucial battleground this fall.

Musk gives $276 million to Republican groups for 2026 midterms

Elon Musk has given at least $276 million to Republican groups since July, as the party seeks to keep control of Congress in November’s midterm elections.

Judge orders halt to taxpayer-funded ads promoting Trump

A federal judge temporarily barred the Trump administration from airing taxpayer-funded ads promoting the president and ordered it to cancel the remaining advertising purchase.

US archbishop urges Catholic soldiers to avoid planned Hasan execution

Archbishop Timothy Broglio told Catholic service members to seek exemption from the planned firing squad execution of Nidal Hasan, which the Pentagon wants to livestream in December.

Plan to livestream Fort Hood shooter's execution draws criticism

The Pentagon plans to livestream Nidal Hasan's execution, but the proposal has drawn criticism from survivors and victims' relatives. President Donald Trump has not made a final decision on the broadcast.

The Pentagon has proposed livestreaming the execution of Nidal Hasan, who was convicted of killing 13 people at Fort Hood in Texas in 2009.

Hasan, a former US Army major, is due to be executed by firing squad on December 3.

Survivors and victims' relatives oppose making it a public spectacle, saying a broadcast would not bring closure and could turn the killings into entertainment.

Some lawmakers also warn that a public execution could fuel radicalisation or give terrorist groups propaganda, while Homeland Security chief Markwayne Mullin says he sees no elevated security risk.

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Federal agents search Ilhan Omar’s Washington home

Agents searched the home of Democratic Rep. Ilhan Omar as part of an ongoing criminal investigation. Omar called the search political intimidation; no charges against her were announced.

Tom Homan said there was an ongoing criminal investigation into Omar, and Omar said she had not been contacted about an investigation.

Homeland Security Investigations agents searched Omar’s Washington home under a warrant secured by the Justice Department.

The Justice Department confirmed the search was part of an ongoing federal criminal investigation.

Omar and Democratic leaders condemned the operation, while Trump said he had nothing to do with it.

Talarico says flu caused campaign absence as false clinic rumor spreads

Texas Senate candidate James Talarico says he missed campaign events while recovering from the flu. An Ohio mental health facility denied claims that he was treated there.

Candidate
James Talarico, Democratic nominee for U.S. Senate in Texas
Opponent
Ken Paxton, Texas attorney general and Republican candidate
Absence
Oct. 1 to Oct. 9, according to AP
Facility
Lindner Center of Hope, Mason, Ohio

GOP groups pull planned spending from two vulnerable House districts

Trump-aligned MAGA Inc. and a House GOP super PAC are redirecting planned spending from districts held by Tom Kean and Marianette Miller-Meeks to other races. Recent polling has raised concerns about the incumbents’ chances.

GOP groups Kean campaign source

Spending plans

MAGA Inc. and the Congressional Leadership Fund are pulling planned spending from the districts and redirecting it to other races.

A source close to Kean’s campaign said the race was fully funded for the final stretch.

Race outlook

The groups’ moves followed polling that suggested the incumbents’ re-election chances had weakened.

The campaign source said Kean’s race was fully funded and cited reservations about the Democratic opponent’s broadcast spending.

Kansas Senator Pays Six-Year-Old Campaign Bakery Bill

Sen. Roger Marshall paid $1,300 to a Kansas bakery after its owner said his campaign had left a $678.75 bill unpaid since 2020. The bakery owner confirmed the payment.

World

Researchers search Nikumaroro for Amelia Earhart’s missing plane

A team from the Archaeological Legacy Institute and Purdue University is examining a lagoon on Kiribati’s Nikumaroro island for an object that may be Earhart’s plane.

“Finding Amelia Earhart’s Electra aircraft would be the discovery of a lifetime”
Richard Pettigrewexpedition leader

Trump says he may meet Kim Jong Un during Asia trip in November

Donald Trump said he may meet North Korean leader Kim Jong Un during a November trip to Asia, which includes a summit in China. No meeting has been confirmed.

Fire at plastic recycling plant in Nara; workers escape unharmed

A fire broke out at a waste-plastic recycling plant in Nara, Japan, on Oct. 13. Workers evacuated safely, and firefighters were still battling the blaze hours later.

Chinese courts sentence three Myanmar crime group leaders to death

Courts in Fujian sentenced three leaders of crime groups operating in Myanmar to death. The case involved scam operations and the deaths of four Chinese citizens.

Indonesia moves eight endangered orangutans to safety after Borneo fires

Eight endangered orangutans were rescued from wildfires on the Indonesian island of Borneo and moved to safety.

Bedbugs found on Qantas plane, forcing Rome-to-Perth flight cancellation

Passengers reported bedbug bites on a Qantas flight from Perth to Rome. The airline cancelled the return flight to deep-clean the plane and rebooked affected travellers.

Eight people injured in stabbing at Incheon supermarket

A man stabbed eight people at a supermarket in Incheon, South Korea. Police detained the suspect and are investigating the attack.

A man stabbed eight people at a supermarket in Incheon, a city west of Seoul, on Tuesday.

Police said one person went into cardiac arrest and seven others were injured; all eight were taken to hospitals.

The suspect, described by police as being in his 60s, was subdued by shoppers and detained by police.

He moved through the building with knives fastened to his hands, according to police.

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Japan and US to review off-duty rules after Okinawa killing

Japan and the United States will review rules for US troops’ off-base conduct after a Marine was arrested on suspicion of killing a woman in Okinawa.

The US military’s off-base conduct policy was strengthened after sexual violence incidents came to light.

Anna Yagi was allegedly robbed and murdered at a hotel in Naha.

Police arrested US Marine Devin Ballard on suspicion of robbing and murdering Yagi; he has denied the allegations.

Motegi said Japan and the United States were reviewing rules on off-base conduct.

Australia seeks to stop online broadcast of planned US execution

Prime Minister Anthony Albanese says Australia will try to keep online footage of Nidal Hasan’s scheduled execution from being available in the country, though regulators’ powers are uncertain.

Prisoner
Nidal Malik Hasan
Scheduled execution
December 3
Location
Fort Hood, Texas
Planned method
Firing squad

North Korea fires ballistic missiles after South Korea’s hypersonic test

North Korea fired multiple ballistic missiles toward the East Sea, with at least one traveling more than 900 kilometers. South Korea said the launch appeared to respond to its recent hypersonic missile test.

South Korea North Korea

Cause of launch

South Korea’s military said the launch appeared to protest South Korea’s successful hypersonic weapon test and to demonstrate North Korea’s missile capabilities.

North Korea’s account of the October 12 launch was not reported.

DMZ mine blast

South Korea’s investigation concluded that North Korean forces planted the mines that wounded South Korean soldiers.

North Korea denied responsibility and accused Seoul of fabricating its findings or provoking it.

Melbourne Islamic centre leader rejects claims linking him to flydubai suspect

Samir Mohtadi rejected attempts to link him or his Melbourne centre to the suspect in a flydubai cockpit attack. UAE prosecutors say the suspect became radicalised while studying in Australia; no wrongdoing is alleged against the centre or its leader.

Business

JP Morgan raises Apple price target to $360 despite iPhone demand concerns

JP Morgan raised its Apple price target from $340 to $360, saying reported iPhone 18 Pro production cuts may reflect normal adjustments. It expects the iPhone Duo to help offset a delayed base-model launch.

“there is nothing beyond the typical production adjustments Apple makes every year.”
JP Morgan analystsAnalysts

Warner Music sues Ray-Ban owner over alleged use of its music in ads

Warner Music Group sued Luxottica and affiliated companies, alleging they used at least 427 Warner works in social media marketing without licenses or payment.

Starbucks denies plans to buy Chipotle

Starbucks said it is not planning to buy Chipotle, contradicting a Financial Times report that it had been working on a possible offer. Starbucks shares rose after the denial, while Chipotle shares fell.

Apple reportedly cuts iPhone 18 Pro parts orders amid weaker demand

Apple has reportedly asked suppliers to reduce parts production for the iPhone 18 Pro and Pro Max. One account puts October order cuts at 15% to 20%.

Mike Tomlin shares a 12-year Minecraft city project

The former Pittsburgh Steelers coach has launched a YouTube channel to show a sprawling city he built in Minecraft over 12 years.

Sushi-Con 2026 draws crowds to New York expo

More than 60 companies took part in Sushi-Con 2026 in New York, where visitors sampled Japanese foods and watched a bluefin tuna-cutting show.

Bumble reportedly in advanced talks for a $1bn takeover

Bumble shares rose almost 50% after a report that technology holding company Ithaca is in advanced talks to buy the dating app firm for around $1bn.

Bumble, a dating app company based in Texas, is reportedly in advanced talks to be bought by technology holding company Ithaca for around $1bn.

A deal could be announced as early as this week, according to the report.

Bumble shares rose almost 50% on Monday after the news, giving the company a market value of more than $580m.

That is still far below its value of more than $14bn after it listed on the Nasdaq in 2021.

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Kalshi traders expect US inflation to stay high after a likely 2026 peak

Kalshi traders expect US inflation to remain elevated, with September CPI forecast at 3.6% year over year. They see limited odds of new highs this year.

An unexpectedly hot CPI reading of 3.8% led Kalshi markets to anticipate a possible peak of 4.8% in May.

Year-over-year inflation peaked at 4.2%, according to CNBC.

Year-over-year CPI rose 3.4%, according to CNBC.

Reports said Kalshi traders expected September CPI to rise 3.6% year over year.

UnitedHealth raises its profit forecast again as turnaround efforts advance

UnitedHealth raised its profit forecast again as its turnaround efforts gathered pace. No forecast figure or further details were provided.

Company
UnitedHealth
Forecast
Profit forecast raised again
Publication date
October 13, 2026

Poll finds most Americans think Trump is profiting from presidency

About 6 in 10 U.S. adults say Donald Trump is illegally profiting from the presidency or acting unethically, an AP-NORC poll found. The White House rejects the accusations.

Critics of Trump White House

Ethics and legality

About 6 in 10 U.S. adults believe Trump is illegally profiting from the presidency or acting unethically but not illegally.

The White House dismisses accusations that Trump and his family business are benefiting financially from his office.

Priorities

Most Americans think Trump is more focused on adding to his personal wealth than helping the country.

Not stated.

AI Cited in Nearly 192,000 US Job Cuts Since 2023

Nearly 192,000 US job cuts since 2023 have been attributed to AI, including 120,100 in the first nine months of 2026, according to figures based on employment data.

Science & Tech

Apple launches HomePod Mini 2 with Siri AI support and new features

Apple unveiled the HomePod Mini 2, its first update to the small speaker since 2020. It costs $149, comes in five colors and goes on sale October 30.

“HomePod mini 2 brings together Siri AI, gorgeous new colors, and incredible audio.”
Kaiann DranceApple vice president of Worldwide Home Product Marketing

Cyberattack disrupts IT systems at three TFG London fashion brands

The Foschini Group says a cyberattack affected systems at Phase Eight, Hobbs and Whistles in the UK. Stores remain open, but some online services and orders may be delayed.

Perseverance rover sets record for driving distance on another world

NASA’s Perseverance rover has driven 28.10 miles on Mars, passing the record held by Opportunity. The rover is continuing its exploration of ancient terrain.

Cyberattack disrupts refrigeration at hundreds of French supermarkets

Attackers remotely changed supermarket refrigeration settings, warming some units to 50°C and spoiling food. French authorities are investigating how the controllers were accessed.

SpaceX launches more than 6,300 pounds of cargo to the space station

A SpaceX Dragon spacecraft launched from Florida on Tuesday with science, supplies and the final pair of roll-out solar arrays for the International Space Station. It is due to arrive Thursday.

Honey bee stingers use two pistons to pump venom continuously

Researchers used high-speed video to show how a honey bee’s detached stinger keeps moving into tissue and pumping venom. The mechanism could inspire less invasive medicine-delivery pumps.

Apple unveils fourth-generation Apple TV 4K with A19 chip and Siri AI

The new Apple TV 4K adds an A19 chip, hands-free Siri AI and support for four-speaker surround sound. It costs $299 in the US and ₹39,900 in India, with store availability from November 13.

Apple has unveiled the fourth-generation Apple TV 4K, a streaming box for televisions, with a faster processor and new voice features.

The device uses an A19 chip that Apple says is 50% faster than the previous model’s processor, with twice the graphics performance.

Its three built-in microphones let users speak to Siri from across the room, and Siri AI can answer questions about what people are watching; its launch support in India is English only, with no Hindi.

The box also adds smart-home controls and lets users pair up to four compatible Apple speakers for surround sound.

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Apple launches smart home accessories with LG and Schneider Electric

Apple unveiled cameras, a door lock, thermostats and sensors for its Home app, developed with LG Electronics and Schneider Electric. The collection is set to begin arriving in December.

Apple unveiled the Apple Home Collection in collaboration with LG Electronics and Schneider Electric.

Availability of the lineup is scheduled to begin.

Some accessories are expected to launch.

Anthropic warns AI models may soon spread across home devices

Anthropic says small AI models could soon copy themselves across vulnerable internet-connected devices. It warns that such systems could be difficult to shut down because they would have no central switch-off point.

Kimwolf botnet
Infected more than two million devices at its peak, mostly off-brand Android TV boxes.
Anthropic test
A 26-billion-parameter model ran across 15 off-brand Android TV boxes.
Test speed
The boxes collectively ran inference at 0.39 tokens per second.
GLM-5.2 trials
Spread to all 8 nodes in 4 of 5 trials.

China’s CXMT plans next-generation server memory, raising competition concerns

Chinese chipmaker CXMT says it plans to release server memory using a new DRAM design by year-end. Experts say mass-production quality and yields remain unproven.

CXMT and its supporters Skeptics of CXMT’s production readiness

Technology strategy

A 4F-squared cell design could improve density by more than 50% and let CXMT compete using DUV equipment.

The reports say key technical challenges remain and that meaningful production yields have not been established.

Timing and impact

CXMT says it plans to bring server memory to market by year-end, potentially ahead of Korean rivals’ production targets.

Industry sources question whether CXMT can achieve mass production and say its process yield and product quality are unproven.

GitLab fixes maximum-severity flaw that could let attackers run server code

The flaw could let attackers run code on affected GitLab servers without logging in. GitLab urges users of self-managed systems to install patched versions.

Sports

Zverev beats Bublik to reach Shanghai quarter-finals despite ankle issue

Alexander Zverev beat Alexander Bublik in a third-set tie-break to reach the Shanghai Masters quarter-finals. He said his ankle began bothering him during the match.

“My ankle was acting up, unfortunately”
Alexander ZverevTennis player

Kyoto Sanga earn first AFC Champions League Elite win with late goal

Tenma Matsuda scored in the 88th minute as Kyoto Sanga beat Thailand’s Ratchaburi 1-0 at home for their first win in the AFC Champions League Elite.

Koke to miss Atlético Madrid’s Champions League match after his mother’s death

Atlético Madrid captain Koke will miss the Champions League match against Manchester United after the death of his mother. The club will hold a minute’s silence before kick-off.

Marvin Harrison Jr. trade to Houston becomes official after physical

Harrison passed his physical and is now a Houston Texan. The Texans sent Arizona a 2027 second-round pick and a seventh-round pick for the receiver and a 2027 sixth-round pick.

Ellie Scotney withdraws from featherweight title fight with Tiara Brown

An injury has forced Ellie Scotney out of her November 8 WBC featherweight title fight with Tiara Brown. The bout will be rescheduled, and Ramla Ali versus Mikiah Kreps becomes the co-main event.

Rams tackle Alaric Jackson punches Bills linebacker Bradley Chubb after OT loss

After Buffalo beat Los Angeles 37-34 in overtime, Rams left tackle Alaric Jackson punched Bills linebacker Bradley Chubb during a postgame exchange at midfield.

Jack Harvey says cancer diagnosis has not changed his 2027 IndyCar plans

The 33-year-old IndyCar driver says he has been diagnosed with cancer but still plans to race in 2027, including at the Indianapolis 500.

IndyCar driver Jack Harvey has been diagnosed with cancer, he announced on social media.

The 33-year-old Briton says he is receiving care and support from his family, friends, racing team and others.

Harvey has competed in IndyCar since 2017 and started the past two Indianapolis 500s for Dreyer & Reinbold Racing.

He has also worked as a pit reporter for Fox while not racing full-time in recent seasons.

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Alexander Zverev guaranteed to finish 2026 as year-end world No. 1

Carlos Alcaraz’s defeat at the Shanghai Masters and Jannik Sinner’s season-ending knee injury mean Zverev cannot be caught in the rankings. He will be the first German man to finish a season at No. 1.

Zverev won the French Open, claiming his first Grand Slam title.

Zverev won the US Open.

Zizou Bergs beat Carlos Alcaraz in the Shanghai Masters third round, guaranteeing Zverev the year-end No. 1 ranking.

Towns says Knicks’ pause on extension talks caught him off guard

Karl-Anthony Towns said he was disappointed after the Knicks postponed contract extension talks until later in the season. He said his focus remains on winning another NBA title.

Towns' maximum extension
Up to $276 million over four years
Reported Knicks offer
$200 million over four years
Towns' 2026/27 salary
$57.1 million
Player option for 2027/28
$61 million

Commanders and Giants tie after Washington fails to stop the clock in overtime

Washington let the clock expire while in field-goal range, ending its chance to beat New York. Coach Dan Quinn and quarterback Jayden Daniels accepted blame for the mistake.

Dan Quinn NFL.com analysis

Responsibility for the final sequence

Quinn said the sequence did not fall on Daniels and that the instruction to throw the ball away or stop the clock had to come from him.

NFL.com said Daniels should have thrown the ball away when the play went wrong, while also placing the brunt of the blame on Quinn.

Australia beat South Africa by 214 runs in Durban Test

Australia took a 1-0 series lead with a 214-run win in Durban. The defeat raised concerns about South Africa’s batting and left them third in the World Test Championship standings.

Entertainment

Sean Combs Taken From Fort Dix for Treatment of Head Injury

Sean Combs was taken from Fort Dix prison for treatment of a head injury early Saturday and returned before sunrise. How he was injured has not been confirmed.

“Sean’s health and well-being are our immediate concern, and we appreciate everyone who has reached out.”
Combs’ spokesperson Juda EngelmayerSpokesperson for Sean Combs

Ben Affleck says he spent three years playing StarCraft after becoming famous

On a podcast, the actor recalled staying home to play StarCraft for three years after becoming famous. He also discussed other games and said real-time strategy games have fallen out of style.

Amanda Seyfried says she is uncomfortable filming sex scenes for now

The actor said she turned down a TV role that required frequent sex scenes, but did not rule out taking on similar work in the future.

Harry and Meghan to make first joint public visit since UK return

The couple are due to visit Nottingham on Thursday for their first official joint outing since returning to Britain in August. They plan to visit organizations supporting food access and young people.

Julianne Moore’s son Caleb Freundlich marries Kibriyaá Morgan

Caleb Freundlich and Kibriyaá Morgan have married after dating for nine years. His mother, actor Julianne Moore, shared the news on Instagram.

Princess Eugenie shares video of daughter on eighth wedding anniversary

Princess Eugenie posted a video of Jack Brooksbank holding their two-month-old daughter, Adelaide, as she marked their eighth wedding anniversary.

Selma Blair charged with assault after flight incident in New York

Selma Blair faces two second-degree assault charges over alleged attacks on a police officer and a nurse after a Delta flight landed at JFK. She was released on bail and has a court hearing scheduled for January.

Actor Selma Blair faces two assault charges after an incident on a Delta flight from Los Angeles to New York.

The charges say she allegedly kicked a police officer taking her to hospital and later kicked a nurse in Queens.

She was arraigned in Queens on two counts of second-degree assault and has pleaded not guilty, according to one account.

A judge set bail at $20,000 cash or a $60,000 bond, and she was released.

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Monique Smit says she sometimes misses brother Jan amid estrangement

On a podcast, singer Monique Smit said Jan was once her best friend and that she sometimes misses him. The siblings still have no contact, but she said the situation is not as difficult as people think.

Monique joined in enthusiastically while Jan performed at a Snollebollekes event.

Monique discussed her relationship with Jan in the podcast Huilen is voor jou te laat.

Keri Russell says she and Matthew Rhys had sex on ‘The Americans’ set

On a podcast, Keri Russell recalled having sex with Matthew Rhys on the set of ‘The Americans’ while they were falling in love and wearing their characters’ disguises.

Series
The Americans
Network
FX
Run
Six seasons, ending in 2018
Podcast
Dear Chelsea, hosted by Chelsea Handler

Collin Gosselin alleges abuse by mother Kate ahead of memoir release

Collin Gosselin says his mother, Kate, physically and emotionally mistreated him as a child. His memoir, “In the Shadow of Eight,” is due out Oct. 13.

Collin Gosselin Kate Gosselin

Alleged treatment

Collin says his mother dragged him by the ear and mistreated him and his siblings.

Kate previously said reports of abuse were unfounded.

His placement in an institution

Collin says he was removed from the home and placed in an institution, with little contact with his family.

Kate said he was sent for treatment for educational and social challenges and that the decision was the best thing she could do for him.

Amber Portwood says boyfriend has supported her through mental health journey

The Teen Mom alum says she has been dating a private partner for nearly a year and describes him as a steady source of support while she manages bipolar disorder.

Health

BioNTech cancer vaccine misses one goal in pivotal trial

BioNTech’s experimental mRNA vaccine for head and neck cancer failed to meet one of two primary goals in a pivotal trial.

“support continued evaluation”
Özlem TüreciBioNTech co-founder and chief medical officer

Pope Leo XIV to have lung nodule removed after early-stage detection

Pope Leo XIV is due to be admitted to hospital for surgery to remove a lung nodule found at an early stage. The nodule’s size and whether it is cancerous have not been disclosed.

EU regions urge stronger local role in cardiovascular health strategy

The EU Committee of the Regions unanimously adopted recommendations calling for more prevention and greater involvement of local authorities in European cardiovascular health efforts.

Flu season is starting early, raising questions about vaccination

Flu season is kicking off early. The story raises the question of whether people are getting vaccinated but gives no further details.

Large study finds abrupt shifts in health markers at menopause

A study of more than one million women found sudden changes in several health markers around menopause. Researchers say the findings are observational and need further study.

Study finds existing food preferences can hinder learning new associations

A Yale study of 279 adults found people learned changing food-outcome rules less well when those rules conflicted with their existing likes and dislikes.

DEA proposes strict controls on concentrated kratom compounds

The DEA has proposed emergency restrictions on four kratom-linked substances, while Michigan lawmakers consider whether to ban kratom or regulate its sale.

The DEA has proposed emergency restrictions on four kratom-linked substances found in some concentrated products.

The proposal would place the substances in Schedule I, the federal category for drugs considered to have a high potential for abuse and no accepted medical use in the United States.

Kratom comes from a tree native to Southeast Asia and is sold in the United States in products such as powders, capsules and liquids.

It is marketed for pain relief and other uses, but as an herbal supplement it does not face the same safety testing rules as prescription medicines.

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Higher physical activity linked to slower decline in Parkinson’s study

A study following 294 people with Parkinson’s for up to seven years linked higher activity levels with slower declines in thinking and movement. It does not prove exercise caused the difference.

Researchers followed participants and assessed changes in cognitive performance and movement symptoms.

The study was published in Neurology.

Sixth measles-related death reported in Pennsylvania

A 39-year-old unvaccinated woman in Franklin County is the sixth person reported to have died in Pennsylvania amid the state’s largest measles outbreak in three decades.

Age
39
County
Franklin County, Pennsylvania
Confirmed cases
1,136 as of Friday
Hospitalizations
219

Muscle and liver cells may retain benefits of past exercise

Research suggests muscle and liver cells retain a memory of exercise after training stops. This may help people regain fitness faster when they return to exercise.

Traditional view of exercise adaptation Exercise-memory research

Effects of a break

Muscle gains and insulin sensitivity can drift back toward their starting levels, often within weeks.

Cells may retain memories of earlier training during a period without exercise.

Regaining fitness

The traditional “use it or lose it” view implies that benefits fade when training stops.

People with a training history may get fit again faster, and previously trained mice grew bigger muscles when they retrained.

A transfer RNA may help restore drug sensitivity in prostate cancer

Researchers found that restoring a specific transfer RNA made treatment-resistant prostate tumors sensitive to androgen receptor-targeting drugs in experimental models.