2 hrs ago
Study Links Weight Loss Drugs To Genetic Hair Loss Risk
Scientists studied whether a body signal connected to some weight-loss medicines might also be linked to hair loss.
They looked at genes in men that affect GLP-1 receptors.
Men with certain versions of these genes were 7% more likely to have male-pattern hair loss.
The researchers checked other factors, including high blood pressure, insulin resistance and testosterone levels.
The link remained after those factors were considered.
This does not prove that medicines such as Ozempic directly cause permanent hair loss.
Some people lose hair after taking these medicines, possibly during rapid weight loss.
Hair growth may return after a person’s weight becomes stable.
More research is needed to understand the connection and see whether it affects women.
Researchers found a 7% higher risk of male-pattern hair loss associated with genetically higher GLP-1 receptor activity.
The study examined the GLP1R gene and genetic markers linked to androgenetic alopecia in men.
The association remained after researchers accounted for hypertension, insulin resistance and lower testosterone levels.
The findings do not establish that GLP-1 medicines directly cause hair loss or explain the biological mechanism involved.
Researchers said further studies are needed to confirm the link and determine whether it applies to women.
- Who
- Researchers led by Lynn Petukhova of NYU Langone Health studied genetic data from men, with collaborators from the University of Pennsylvania, King's College London and Columbia University.
- What
- A study identified an association between genetically higher GLP-1 receptor activity and a 7% increased risk of androgenetic alopecia in men.
- Where
- The research was led at NYU Langone Health and used publicly available genetic databases.
- When
- The study was published online on September 3; the article does not specify the year.
- Why
- Researchers investigated a suspected connection between GLP-1 activity and male-pattern hair loss and hope future studies could help identify people at higher risk.
Key facts
- Reported added risk
- 7% among men with genetically higher GLP-1 receptor activity
- Condition studied
- Androgenetic alopecia, or inherited male-pattern hair loss
- Gene examined
- GLP1R, which influences levels of GLP-1 receptor proteins
- Data sources
- The eQTLGen database included 31,684 mostly White men and women; another database included 205,327 mostly White men
- Publication
- Journal of Investigative Dermatology, published online September 3
- Study limitation
- The research did not establish a biological mechanism or prove that GLP-1 medicines directly cause hair loss
- Funding
- National Institutes of Health grants R01AR080796 and K01AR075111
Quotes
Lynn Petukhova
Senior investigator and assistant professor at NYU Grossman School of Medicine
“Our study provides the first genetic link between GLP-1 use and an increased risk of male-pattern hair loss from androgenetic alopecia, an association long suspected but until now not shown scientifically,”
NDTV
Sources
Related news
Study Links Ozempic-Like Drugs to Increased Hair Loss Risk
Hair Loss Drug Boom Sends Biotech Stocks Toward Next Ozempic
New Oral GLP-1 Pill Helps Adults Lose 12.1% Weight
Experimental Weight-Loss Drug Aims To Reduce Fat While Preserving Muscle
Doctors Warn Against Treating Ozempic as a Weight-Loss Shortcut
Nestle targets weight-loss drug users with AI-driven new products
Eli Lilly’s Mounjaro Approved to Reduce Cardiovascular Risks
