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Sildenafil Shows Promise Against Cancer Spread; Human Trials Still Needed

Sildenafil Shows Promise Against Cancer Spread; Human Trials Still Needed
Can a pill for erectile dysfunction cure cancer? Here's what the doctor says · firstpost.com

Scientists are studying a medicine called sildenafil, which is the main ingredient in a pill called Viagra.

Viagra is usually used to help people with a health problem called erectile dysfunction.

A new study from the Weizmann Institute of Science in Israel looked at how cancer works.

Cancer can spread through the body when cells break off from a tumor and travel to other parts of the body.

This spreading is called metastasis, and it is the most common reason people die from cancer.

The scientists found that sildenafil might stop cancer cells from using cholesterol, which they need to spread.

Cholesterol is like a fuel that helps cancer cells travel.

But this discovery was only made in a laboratory, not in real patients.

Doctors say we need more tests on humans before we know if it really works, or which cancers it might help.

Most importantly, doctors tell people not to take Viagra by themselves to try to fight cancer, because it can have side effects and be unsafe.

Key facts

Drug studied
Sildenafil, the active ingredient in Viagra
Research institution
Weizmann Institute of Science, Israel
Proposed mechanism
Interfering with how cancer cells use cholesterol
Stage of research
Laboratory and preclinical studies; not yet tested in humans
Relevance
Metastasis is the leading cause of cancer-related death
Expert quoted
Dr Saphalta Baghmar, Senior Consultant, Medical Oncology, Amrita Hospital, Faridabad
Expert advice
Patients should not take sildenafil for cancer prevention or treatment outside a clinical setting
Potential benefit
Drug repurposing could speed up access to therapies since safety profiles are often already understood

Quotes

Dr. Saphalta Baghmar

Senior Consultant, Medical Oncology, Amrita Hospital

“"These findings are scientifically exciting because they explore how an existing drug might affect cancer biology."”
firstpost.com
“"These results are promising, but they do not prove that sildenafil can prevent or treat cancer in patients."”
firstpost.com

Sources

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