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Moderna-Merck Cancer Vaccine Shows Breakthrough in Melanoma Trial

Moderna-Merck Cancer Vaccine Shows Breakthrough in Melanoma Trial
Moderna-Merck cancer vaccine marks breakthrough after 100 years of failed trials - Telegraph India · telegraphindia.com

Moderna and Merck are testing a vaccine made for each person’s cancer.

The vaccine studies mutations in a patient’s tumor and teaches the immune system what to attack.

It was tested in more than 1,000 people with melanoma whose tumors had been surgically removed.

The vaccine was used together with a medicine called Keytruda.

The companies said the treatment helped keep tumors from returning or spreading in the trial.

Earlier cancer vaccines had often failed because they targeted only a small number of cancer features.

This vaccine can target many features at once.

Scientists still need to publish the full results and test whether it works against other cancers.

U.S. approval could happen as soon as next year, according to the report.

Key facts

Vaccine
Intismeran autogene
Developers
Moderna and Merck
Cancer tested
Localized melanoma
Trial size
More than 1,000 patients
Treatment combination
Personalized mRNA vaccine plus Keytruda
Targets
Up to 34 patient-specific cancer targets, according to Merck’s Dean Li
Potential approval
U.S. approval could come as soon as next year

Quotes

Stephane Bancel

CEO of Moderna

“It was a moment that we'd worked really hard toward. We knew what was at stake for the planet with COVID”
telegraphindia.com
“We failed back then, and we failed for many years”
telegraphindia.com

Sources

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