4 days ago
Moderna-Merck Cancer Vaccine Shows Breakthrough in Melanoma Trial
Moderna and Merck are testing a vaccine made for each person’s cancer.
The vaccine studies mutations in a patient’s tumor and teaches the immune system what to attack.
It was tested in more than 1,000 people with melanoma whose tumors had been surgically removed.
The vaccine was used together with a medicine called Keytruda.
The companies said the treatment helped keep tumors from returning or spreading in the trial.
Earlier cancer vaccines had often failed because they targeted only a small number of cancer features.
This vaccine can target many features at once.
Scientists still need to publish the full results and test whether it works against other cancers.
U.S. approval could happen as soon as next year, according to the report.
Moderna and Merck reported that their personalized mRNA cancer vaccine met its goal in a late-stage trial.
The trial involved more than 1,000 patients with localized melanoma after tumor removal.
The vaccine, intismeran autogene, targets dozens of mutations unique to each patient’s tumor.
Researchers paired the vaccine with Merck’s Keytruda, which helps activate immune-system T-cells.
Full trial details are pending, while U.S. approval could come as soon as next year.
- Who
- Moderna and Merck developed and tested the personalized cancer vaccine with melanoma patients.
- What
- The mRNA vaccine intismeran autogene met its goal in a late-stage trial and helped prevent melanoma tumors from returning or spreading.
- Where
- The trial involved patients with localized melanoma; the article does not specify a single trial location.
- When
- The companies received the successful trial results late on August 13; the year is not specified in the article.
- Why
- The vaccine is designed to train the immune system to recognize and attack mutations unique to each patient’s cancer.
Key facts
- Vaccine
- Intismeran autogene
- Developers
- Moderna and Merck
- Cancer tested
- Localized melanoma
- Trial size
- More than 1,000 patients
- Treatment combination
- Personalized mRNA vaccine plus Keytruda
- Targets
- Up to 34 patient-specific cancer targets, according to Merck’s Dean Li
- Potential approval
- U.S. approval could come as soon as next year
Quotes
Stephane Bancel
CEO of Moderna
“It was a moment that we'd worked really hard toward. We knew what was at stake for the planet with COVID”
telegraphindia.com
“We failed back then, and we failed for many years”
telegraphindia.com







