Health · Medical Research · 3 hrs ago
Early-onset Alzheimer’s linked to different health problems than later-onset disease
A Finnish study found early-onset Alzheimer’s differs from the later-onset disease in the health problems people experience.
The study examined 407 people diagnosed before age 65 and compared their health records with those of more than 4,000 similar people without Alzheimer’s.
Several health problems became more common in the five years before diagnosis, including depression, dizziness, headaches, brain injuries, epilepsy and thyroid disorders.
Tinnitus and hearing loss were more common as early as six to ten years before diagnosis.
High blood pressure and high blood fats were not more common among the early-onset group than among the comparison group.
Healthcare visits rose sharply in the five years before diagnosis, with the biggest increase in the final year.
The findings suggest early-onset Alzheimer’s may involve processes that differ partly from those behind later-onset disease.
A study found that people with early-onset Alzheimer’s disease had different health problems from those with late-onset disease.
Early-onset disease was defined as diagnosis before age 65.
Several conditions, including depression, dizziness, headaches and traumatic brain injuries, were more common in the five years before diagnosis.
Tinnitus and hearing loss were more common six to ten years before diagnosis.
The study found no significant differences in morbidity 11 to 15 years before diagnosis.
- Who
- Researchers from the University of Oulu and the University of Eastern Finland studied people with early-onset Alzheimer’s disease.
- What
- The study found that their health problems differed from those associated with late-onset disease.
- When
- The study was published on October 13, 2026. It examined health records from the 15 years before diagnosis.
- Where
- The study used data from memory clinics at Oulu University Hospital and Kuopio University Hospital, combined with nationwide Finnish health register data.
- Why
- The researchers said the findings suggest early-onset Alzheimer’s may involve mechanisms that differ, at least in part, from those underlying late-onset disease.
This story does not have two clearly opposing sides.
The study found no significant differences in morbidity between people later diagnosed with early-onset Alzheimer’s and the comparison group.
Tinnitus and hearing loss were already more common among people later diagnosed with early-onset Alzheimer’s.
A range of health conditions, including depression, dizziness and headaches, were more common.
Healthcare visits rose most steeply.
- Early-onset definition
- Diagnosis before age 65
- Study group
- 407 people with early-onset Alzheimer’s disease
- Comparison group
- More than 4,000 age- and sex-matched people without the disease
- Study locations
- Oulu University Hospital and Kuopio University Hospital
- Health-record period
- 15 years before diagnosis
What people are saying
Our findings support the view that early-onset Alzheimer's disease is not simply a younger-age version of late-onset Alzheimer's disease.
EOAD (early onset Alzheimer's disease) patients had higher prevalence of vertigo, depression, headache, delirium, brain injuries, thyroid disorders, alcohol-related disorders, epilepsy, strokes, and otorhinolaryngologic diseases 1-5 years before diagnosis,











