2 months ago
Gut Signals Boost Memory via Vagus Nerve, Study Finds
Scientists studied rats to see how the food they eat affects their memory.
They found that when rats ate healthy food, a chemical called acetylcholine was released in a part of the brain that helps remember.
This release was helped by signals from the vagus nerve, which connects the gut to the brain.
If the vagus nerve was blocked, the rats had less acetylcholine and had trouble remembering where food was.
Eating a lot of sugary or fatty food made the rats remember better at first, but later it hurt their memory.
Even after switching to healthy food, the rats still had weaker memory.
The researchers think that stimulating the vagus nerve might help people with memory problems, like in Alzheimer’s disease.
Rats given nutritious food showed increased acetylcholine release in hippocampal neurons.
Blocking vagus nerve signals reduced acetylcholine and impaired food-location memory.
High‑fat/sugar diets enhanced short‑term memory but caused long‑term deficits.
Early‑life consumption of such diets weakened gut‑brain communication even after switching to healthy food.
Findings suggest vagus‑nerve stimulation could target memory decline in Alzheimer’s disease.
- Who
- Researchers from USC Dornsife College of Letters, Arts and Sciences, led by Scott Kanoski
- What
- Study on how gut signals via the vagus nerve influence memory in rats
- Where
- United States, California
- When
- Published 4 June 2024
- Why
- To understand diet’s role in memory and explore potential Alzheimer’s therapies
Key facts
- Study Published
- 4 June 2024
- Journal
- Nature Communications
- Lead Author
- Scott Kanoski
- Key Finding
- Vagus nerve signals boost acetylcholine in hippocampus
- Implication
- Vagus nerve stimulation could target memory decline in Alzheimer’s disease
Quotes
Scott Kanoski
Professor of biological sciences at USC Dornsife College
“"The disruption of acetylcholine signaling in the hippocampus is one of the earliest neurochemical changes in Alzheimer’s disease"”
theprint.in
“"We think the mechanism likely evolved to help animals remember vital information about food sources,"”
theprint.in
Study authors
Researchers from USC Dornsife College of Letters, Arts and Sciences
“"The study concludes that the signals sent through the vagus nerve can also help make memories"”
theprint.in





