Science & Tech · Science & Environment · 1 hr ago

Jonathan the tortoise’s gene switches may offer clues to long life

Jonathan the tortoise’s gene switches may offer clues to long life

Jonathan is an Aldabra giant tortoise thought to be about 194 years old, far older than the species’ estimated upper limit of about 94 years.

He has lived for much of his life on the South Atlantic island of St. Helena.

Researchers studied DNA from a mouth swab because the island government did not allow them to take blood.

They found that chemical tags near many of his genes had become disordered with age, but tags near a group of genes involved in cell energy stayed as orderly as those in a five-year-old tortoise.

The team also identified unusual gene variants that may relate to DNA repair, chromosome protection and control of tumors, but their effects have not been confirmed.

The findings could help scientists study how some animals live for an unusually long time.

Because the study examined one exceptionally old tortoise, it cannot show that these gene features caused Jonathan’s longevity.

What people are saying

Working with a really old giant tortoise is such a privilege: you get a sense of the tortoise being your collaborator, not your study subject
Justin GerlachCo-author and Peterhouse researchervia Earth.com

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