1 hr ago
Scientists Reveal How DNA Molecules Overcome Repulsion to Pair
DNA molecules normally push away from each other because both carry negative charges.
However, they sometimes need to join together for important jobs inside cells.
Scientists from the University of Sheffield and the University of York watched two DNA molecules pair up.
They used a powerful microscope and computer simulations.
The scientists found that positively charged metal ions can connect the two DNA molecules.
These ions fit into grooves in the DNA and hold both strands at the same time.
This makes the molecules line up like the teeth of a zipper.
The discovery confirms an idea called the DNA zipper model.
It may help scientists understand genetic changes, cancer and future DNA-based technology.
Researchers at the Universities of Sheffield and York directly visualised two DNA molecules pairing for the first time.
High-powered atomic force microscopy and computer simulations were used to study the process.
Nickel, magnesium and calcium ions act as molecular bridges between the negatively charged DNA strands.
The findings support the DNA zipper model proposed more than two decades ago.
The research could improve understanding of genetic processes, cancer development and DNA-based biotechnology.
- Who
- Researchers from the University of Sheffield and the University of York, including Thomas Catley and Agnes Noy.
- What
- They directly visualised two DNA molecules pairing and found that divalent metal ions help hold them together.
- Where
- At research teams associated with the University of Sheffield and the University of York.
- When
- The study is reported as published in Nucleic Acids Research; the articles do not provide a publication date.
- Why
- To explain how DNA molecules overcome their natural negative-charge repulsion during biological processes.
Key facts
- Institutions
- University of Sheffield and University of York
- Research method
- High-powered atomic force microscopy combined with computer simulations
- Molecular helpers
- Nickel, magnesium and calcium ions
- Mechanism
- Divalent ions bridge the DNA strands across their grooves
- Model confirmed
- The DNA zipper model
- Applications
- Understanding genetic recombination, gene silencing, chromosome packaging, cancer development and DNA origami
- Publication
- Nucleic Acids Research
Quotes
Thomas Catley
Co-lead author from the University of Sheffield’s School of Chemical Materials and Biological Engineering
“This discovery could help researchers identify regions of the genome especially involved in DNA pairing. These regions may become particularly important when mutations disrupt normal cellular processes and contribute to cancer.”
rediff.com
“Hopefully, these programmable interactions could eventually help engineers design custom DNA structures for future biotechnology, such as DNA origami and shed light on how DNA is actually packaged inside cells.”
rediff.com










