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Scientists Reveal How DNA Molecules Overcome Repulsion to Pair

Scientists Reveal How DNA Molecules Overcome Repulsion to Pair
How DNA Molecules Overcome Repulsion To Pair Up · rediff.com

DNA molecules normally push away from each other because both carry negative charges.

However, they sometimes need to join together for important jobs inside cells.

Scientists from the University of Sheffield and the University of York watched two DNA molecules pair up.

They used a powerful microscope and computer simulations.

The scientists found that positively charged metal ions can connect the two DNA molecules.

These ions fit into grooves in the DNA and hold both strands at the same time.

This makes the molecules line up like the teeth of a zipper.

The discovery confirms an idea called the DNA zipper model.

It may help scientists understand genetic changes, cancer and future DNA-based technology.

Key facts

Institutions
University of Sheffield and University of York
Research method
High-powered atomic force microscopy combined with computer simulations
Molecular helpers
Nickel, magnesium and calcium ions
Mechanism
Divalent ions bridge the DNA strands across their grooves
Model confirmed
The DNA zipper model
Applications
Understanding genetic recombination, gene silencing, chromosome packaging, cancer development and DNA origami
Publication
Nucleic Acids Research

Quotes

Thomas Catley

Co-lead author from the University of Sheffield’s School of Chemical Materials and Biological Engineering

“This discovery could help researchers identify regions of the genome especially involved in DNA pairing. These regions may become particularly important when mutations disrupt normal cellular processes and contribute to cancer.”
rediff.com
“Hopefully, these programmable interactions could eventually help engineers design custom DNA structures for future biotechnology, such as DNA origami and shed light on how DNA is actually packaged inside cells.”
rediff.com

Sources

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