Health · Medical Research · 11 hrs ago
Pantethine shows promise against psoriasis in early research
Researchers in China found pantethine may ease psoriasis, an inflammatory condition linked to an overactive immune response.
The team studied dendritic cells, which help direct the body’s defenses but can also drive inflammation when they become too active.
They found that enzymes called Vanins can lower pantethine levels in these cells, increasing cholesterol production and immune activity.
Pantethine reduced excessive immune activity and psoriasis in mice, according to the study.
In a small trial involving 24 people with psoriasis, the researchers reported improved symptoms; all participants also received a topical ointment.
The findings suggest a link between cholesterol production and psoriasis, but they do not establish pantethine as a proven treatment.
Further research is needed to assess its benefits for people, and the study does not say what happens next.
Researchers in China found that pantethine, a supplement derived from vitamin B5, reduced psoriasis symptoms in mice and in a small human trial.
The study involved 24 people with psoriasis, all of whom received a topical ointment containing calcipotriene/betamethasone.
The researchers found that pantethine reduced cholesterol accumulation in dendritic cells and helped limit their excessive immune activity.
The findings were published October 27 in the Journal of Experimental Medicine.
The research suggests pantethine may offer a new approach to psoriasis, but the human trial was small.
- Who
- Researchers led by Wei-Na Zhang and colleagues in China. The study also involved 24 people with psoriasis.
- What
- Researchers investigated pantethine as a possible treatment for psoriasis. They reported benefits in mice and improved symptoms in a small human trial.
- When
- The findings were published October 27. The year is not stated in the article text.
- Where
- The research was conducted by scientists in China, including researchers in Beijing.
- Why
- Researchers investigated whether pantethine could reduce excessive immune activity linked to psoriasis. They found that it reduced cholesterol accumulation in dendritic cells.
This story does not have two clearly opposing sides.
This story does not have a timeline yet.
- Human trial
- 24 patients with psoriasis
- Publication date
- October 27
- Journal
- Journal of Experimental Medicine
- Study location
- China
- Treatment investigated
- Pantethine, a supplement derived from vitamin B5
What people are saying
We found that pantethine administration effectively alleviated psoriasis in mice, suggesting that insufficient pantethine levels may be the crucial contributor to hyperactivation of dendritic cells and autoimmune inflammation following the up-regulation of Vanins
Emerging evidence highlights that metabolic pathways and their associated metabolites play vital roles in regulating immune cell function and autoimmune progression