9 months ago
Indian Researchers Develop Green Tea-Based Nanoparticle Therapy for Alzheimer's
Scientists in India have created a new treatment for Alzheimer's Disease using tiny particles called nanoparticles.
These nanoparticles are made with ingredients from green tea, a mood-boosting chemical, and an important building block for cells.
The treatment is special because it can do many things at once: it can break up harmful protein clumps in the brain, reduce stress and inflammation, and even help brain cells grow.
In experiments with mice, these nanoparticles helped improve memory and learning.
The researchers hope this new treatment can help people with Alzheimer's Disease by working on multiple levels to slow down the disease and support brain health.
Researchers at INST, Mohali developed a nanoparticle therapy for Alzheimer's Disease using green tea's antioxidant, dopamine, and tryptophan.
The therapy targets multiple pathological hallmarks: amyloid aggregation, oxidative stress, inflammation, and neuronal degeneration.
The nanoparticles, called EDTNPs, were functionalized with BDNF to enhance neuroprotective potential, creating B-EDTNPs.
Lab experiments and mouse models showed the nanoparticles disassembled toxic plaques, reduced inflammation, and improved memory and learning.
The research was supported by Dr. Ashok Kumar Datusalia and Dr. Nisha Singh, and published in the journal Small.
- Who
- Researchers at the Institute of Nano Science and Technology (INST), Mohali
- What
- Developed a green tea-based nanoparticle therapy for Alzheimer's Disease
- Where
- Institute of Nano Science and Technology (INST), Mohali, India
- When
- Research findings published in the journal Small
- Why
- To target multiple pathological hallmarks of Alzheimer's Disease simultaneously
Key facts
- Researchers
- Institute of Nano Science and Technology (INST), Mohali
- Therapy Components
- Epigallocatechin-3-gallate (EGCG), dopamine, tryptophan, Brain-Derived Neurotrophic Factor (BDNF)
- Targeted Pathological Hallmarks
- Amyloid aggregation, oxidative stress, inflammation, neuronal degeneration
- Research Support
- Dr. Ashok Kumar Datusalia (NIPER Raebareli), Dr. Nisha Singh (Gujarat Biotechnology University)
- Publication Journal
- Small
- Experimental Results
- Disassembled toxic plaques, reduced inflammation, restored brain cell balance, improved memory and learning in mouse models
Quotes
Researchers at the Institute of Nano Science and Technology (INST)
Research team at the Institute of Nano Science and Technology (INST), Mohali
“Incorporation of Brain-Derived Neurotrophic Factor (BDNF) -- a protein crucial for the survival, growth, and function of neurons onto EDTNPs (B-EDTNPs) creates a dual-action nanoplatform that not only clears neurotoxic Amyloid Beta aggregates (protein clumps that disrupt neural function and drive Alzheimer's disease pathology) but also enhances neuronal regeneration.”
NDTV
“The research could help people with Alzheimer's disease by offering a treatment that works on multiple levels. The nanoparticles not only remove harmful protein plaques but also reduce brain stress, inflammation, and help nerve cells grow through BDNF.”
NDTV
