Archive · 1 Dec 2025
Indian Scientists Discover Oral Cancer Gene Mutations in Women
Indian scientists have found special changes in genes that cause oral cancer in women.
They studied women in a part of India where many chew tobacco.
Using advanced technology, they found two important genes, CASP8 and TP53, that are different in women compared to men.
This discovery helps doctors understand why oral cancer is more aggressive in women and how to treat it better.
The team used computers to analyze the cancer tissues and found two groups of women with different immune responses.
This research is important because oral cancer is very common in India, especially among women who chew tobacco.
Indian scientists identified unique gene mutations in oral cancer among women in Kolar, Karnataka.
The study focused on women with a specific tobacco-chewing habit, revealing CASP8 as a novel driver mutation.
Two key genes, CASP8 and TP53, were found to be highly mutated, suggesting a more aggressive cancer form in women.
Researchers used whole-exome sequencing and AI to analyze tumor tissues, identifying two distinct patient groups.
The findings were published in the Clinical and Translational Medicine Journal, aiming to improve treatment for women with oral cancer.
- Who
- Indian scientists from JNCASR, NIBMG, and SDUAHER
- What
- Discovered unique gene mutations in oral cancer among women
- When
- Not specified
- Where
- Kolar, Karnataka, India
- Why
- To understand and better treat oral cancer in women with unique tobacco chewing habits
- Research Team
- JNCASR, NIBMG, SDUAHER
- Study Focus
- Oral cancer in women with unique tobacco chewing habits
- Key Genes Identified
- CASP8, TP53
- Study Location
- Kolar, Karnataka
- Journal
- Clinical and Translational Medicine
- Research Method
- Whole-exome sequencing and AI analysis
- Unique Mutation
- CASP8 as a driver mutation
