Archive · 25 Jun 2025
Mice Born From Two Fathers Reproduce, a Scientific First
Scientists have successfully made baby mice from two male parents.
They used a special method called epigenome editing to change how the sperm's DNA behaved.
This allowed the embryos to grow and even have babies of their own.
Although this is exciting, scientists say it's too risky and complicated to try in humans.
This is because they would need a lot of eggs and surrogate mothers, and the chances of success are very low.
Scientists in China created mice from two fathers, which then reproduced.
The process involved combining sperm from two male mice and reprogramming the DNA.
Epigenome editing was used to allow the embryos to develop correctly.
Out of 259 embryos, two mice survived and had offspring.
Experts caution against applying this technique to humans due to risks and complexity.
- Who
- Researchers from Shanghai Jiao Tong University in China
- What
- Scientists produced fertile mice from two male parents.
- When
- Published June 2025
- Where
- Shanghai Jiao Tong University in China
- Why
- To advance reproductive science and understand genomic imprinting.
Potential of Epigenetic Programming
Challenges and Limitations
Efficacy and Safety
Potential of Epigenetic Programming
Could provide a new approach for same-sex reproduction in mammals.
Challenges and Limitations
Current success rates are low, and there are potential health concerns.
Human Applicability
Potential of Epigenetic Programming
Provides an insight into genomic imprinting.
Challenges and Limitations
Cannot be translated to humans due to the low success rate and the need for a large number of eggs and surrogates.
- Publication Date
- June 25, 2025
- Technique
- Epigenome Editing
- Success Rate
- 2 out of 259 embryos
- Genomic Imprinting
- Key barrier in same-sex reproduction