Archive · 8 Aug 2025
Study Identifies New Genomic Risk Factors for Uterine Cancer
Scientists have found new parts of our DNA that can increase the risk of getting cancer in the lining of the uterus, a common type of cancer in women.
They found 5 new spots in our genes that might cause this cancer.
They also looked closely at a gene called NAV3, which seems to stop cells from growing too fast in the uterus.
When NAV3 isn't working correctly, cells can grow out of control and become cancerous.
These findings could help doctors better predict who might get this type of cancer and help create new ways to prevent and treat it.
Researchers have identified new genomic risk factors for uterine cancer.
The study increased the number of known genomic risk factors from 16 to 21.
Common risk factors include obesity, diabetes, and high oestrogen levels.
The team examined the NAV3 gene, which appeared to limit cell growth.
The research may aid in the development of preventative strategies and therapies.
- Who
- An international team of researchers, including those from Hannover Medical School (MHH).
- What
- Researchers identified new genomic risk factors for uterine cancer.
- When
- The findings were published in the journal eBioMedicine.
- Where
- The research was conducted by an international team, with researchers at Hannover Medical School (MHH) in Germany.
- Why
- The research aims to improve prediction of uterine cancer risk and develop new treatments.
- Cancer Type
- Endometrial cancer (lining of the uterus)
- Global Diagnoses
- Around 400,000 women annually
- Global Deaths
- Around 100,000 annually
- Known Risk Factors
- Obesity, diabetes, high oestrogen
- Genetic Predisposition
- Around 5% of cases
- New Risk Genes Identified
- 5
- Total Genomic Risk Factors
- 21