Archive · 24 Jul 2025
CCMB Researchers Discover Bacterial Proofreader Enzyme
Imagine bacteria have a wall to protect them, made of special bricks.
Sometimes, the wrong bricks get put in, making the wall weak.
Scientists found an enzyme in bacteria, like a little worker, that checks the wall and fixes mistakes.
This worker removes the wrong bricks, so the wall stays strong.
This is important because it could help create new medicines to fight bacteria.
Also, a similar worker exists in humans.
If this human worker doesn't work right, it can cause the body to attack itself, leading to illnesses.
This discovery opens up a possibility for new treatments for human diseases.
CCMB researchers discovered a bacterial enzyme that acts like a proofreader, fixing mistakes in cell walls.
The enzyme, PgeF, removes incorrect amino acids like L-serine or glycine, which weaken the cell wall.
This proofreading ensures the strength and integrity of the bacterial cell wall.
The discovery could lead to better antibiotics by targeting cell wall vulnerabilities.
A human enzyme, LACC1, has a homolog to PgeF, with defects linked to autoinflammatory disorders.
- Who
- Scientists led by Dr. Manjula Reddy at CSIR-CCMB.
- What
- Researchers discovered a bacterial enzyme that corrects mistakes in cell walls.
- When
- Findings were published in the PNAS journal.
- Where
- Research conducted at CSIR-CCMB in Hyderabad.
- Why
- To find new ways of blocking bacterial growth and understand immune-related diseases.
- Research Institute
- CSIR-CCMB
- Lead Scientist
- Dr. Manjula Reddy
- Enzyme Name
- PgeF
- Enzyme Function
- Corrects amino acid mistakes in cell walls
- Journal
- PNAS
- Human Enzyme Homolog
- LACC1
- LACC1 Association
- Autoinflammatory disorders