Archive · 2 Jan 2026
Study Challenges Habit Loop Theory for Compulsive Behaviors
Scientists studied rats to understand why people sometimes do things repeatedly even when they know it's bad, like washing hands too much or gambling.
They used to think this was because of a 'habit loop' that makes it hard to stop.
But this new study found that it might actually be because of inflammation in a part of the brain called the striatum.
This inflammation makes special star-shaped cells in the brain, called astrocytes, multiply and mess with the brain's ability to make decisions.
The rats in the study became more careful and thoughtful in their actions instead of just doing things out of habit.
The scientists think that maybe treating this inflammation with special drugs or even just exercising more and sleeping better could help people who struggle with these kinds of behaviors.
A new study in rats challenges the 'habit loop' theory of compulsive behaviors, suggesting inflammation in the striatum as an alternative explanation.
The study found that inducing inflammation in the striatum led to more goal-directed, deliberate behavior in rats, rather than habitual behavior.
Astrocytes, star-shaped cells in the brain, were found to multiply due to inflammation and interfere with decision-making processes.
The researchers suggest that drugs targeting astrocytes and reducing neuroinflammation, as well as broader anti-inflammatory measures like exercise and better sleep, could offer new treatment avenues.
The study was published in the journal Neuropsychopharmacology and was led by Laura Bradfield, a behavioural neuroscientist at the University of Technology Sydney.
- Who
- Researchers led by Laura Bradfield, a behavioural neuroscientist at the University of Technology Sydney
- What
- A study challenging the 'habit loop' theory of compulsive behaviors, suggesting inflammation in the striatum as an alternative explanation
- When
- The study was published in the journal Neuropsychopharmacology (exact date not specified)
- Where
- The research was conducted at the University of Technology Sydney, Australia, and involved rats
- Why
- To understand the mechanisms behind compulsive behaviors and explore potential new treatments
- Study Subject
- Rats
- Brain Region Studied
- Striatum
- Key Finding
- Inflammation in the striatum leads to more goal-directed behavior
- Cells Involved
- Astrocytes
- Potential Treatments
- Drugs targeting astrocytes, anti-inflammatory measures like exercise and better sleep
- Journal
- Neuropsychopharmacology