Archive · 29 May 2025
Scientists Discover Fat Cells Retain Weight Gain "Memory"
Scientists have discovered that fat cells have a kind of memory of when you were obese.
This means that even after losing weight, your fat cells might try to make you gain it back.
Researchers found this by studying mice and people who had weight loss surgery.
The fat cells in these people still showed changes that made them likely to regain weight.
These changes happen because of shifts in how your genes work, not in your genes themselves.
This may explain why it can be so hard to keep weight off after you lose it.
The scientists think that if they can figure out how to change these fat cells, it might help people stay slim for good.
Study indicates fat cells hold a "memory" of obesity, hindering weight loss.
Swiss scientists led the research, published in Nature.
Fat cells in formerly obese mice showed persistent changes even after weight loss.
Epigenetic changes in fat cells seem to drive the body's tendency to regain weight.
Research suggests targeting epigenetic changes in fat cells could help long-term weight management.
- Who
- Swiss scientists
- What
- A study on fat cells and their role in weight regain.
- When
- Not explicitly stated
- Where
- Research conducted on mice and humans.
- Why
- To understand why weight regain is common and explore potential solutions.
Differing Perspectives on Treatment
Current Research
Targeting Epigenetic Changes
Differing Perspectives on Treatment
Targeting epigenetic changes in fat cells could offer a new approach to keep weight off for good.
Current Research
The research is preliminary, further studies are needed.
- Lead Researchers
- Swiss Scientists
- Publication
- Nature
- Diet used in study
- High-fat diets
- Subjects
- Mice and humans
- Cause of 'obesogenic memory'
- Epigenetic changes