Archive · 25 Dec 2025
Alzheimer's Disease Reversed in Animal Studies
Scientists in the US have made a big discovery about Alzheimer's disease, a condition that affects the brain and is usually thought to be permanent.
They found that by keeping a special molecule called NAD+ balanced, they could not only stop Alzheimer's from getting worse but also reverse it in mice.
NAD+ is like a tiny energy booster in our cells.
The researchers used a special medicine called P7C3-A20 to keep NAD+ levels healthy.
They tested this on mice that had been changed in the lab to have the same genetic problems that cause Alzheimer's in people.
Amazingly, the mice got better and could think clearly again.
This gives hope that one day, similar treatments might help people with Alzheimer's too.
US researchers found Alzheimer's disease can be reversed in animal studies.
Maintaining NAD+ balance can prevent and reverse Alzheimer's.
NAD+ levels decline severely in Alzheimer's-affected brains.
Treatment with P7C3-A20 restored cognitive function in mice.
Results were observed in two different mouse models with advanced Alzheimer's.
- Who
- Researchers led by Andrew A. Pieper
- What
- Alzheimer's disease reversal in animal studies
- When
- Not specified
- Where
- United States
- Why
- To challenge the notion that Alzheimer's is irreversible and find potential treatments
- Study Focus
- Alzheimer's disease reversal in animal models
- Key Molecule
- NAD+ (Nicotinamide adenine dinucleotide)
- Research Method
- Preclinical mouse models and human Alzheimer's brains
- Treatment Used
- P7C3-A20 (pharmacological agent)
- Outcome
- Restoration of cognitive function in mice
- Study Publication
- Cell Reports Medicine
- Lead Researcher
- Andrew A. Pieper