Archive · 6 Jan 2026
Study Reveals Why Infections Relapse Despite Proper Antibiotics
Doctors and patients often face a frustrating problem: an infection that seems to go away with antibiotics comes back.
A new study explains that this can happen because some bacteria enter a survival mode that makes them invisible to antibiotics.
These bacteria can later wake up and cause the infection to return.
The study found two different ways bacteria can survive antibiotics: one is a controlled shutdown where they become dormant, and the other is a chaotic shutdown where they become unstable.
Understanding these survival modes could help doctors develop better treatments and reduce the chances of infections coming back.
A new study from Hebrew University of Jerusalem reveals that infections can relapse due to antibiotic persistence, not just resistance.
Persistence involves bacteria entering a temporary survival state that shields them from antibiotics.
Researchers identified two distinct bacterial shutdown modes: regulated growth arrest (dormancy) and disrupted growth arrest (dysregulated survival).
Understanding these mechanisms could lead to tailored therapies and better diagnostic tools for chronic infections.
The study suggests that targeting both types of persister cells could reduce relapse rates and improve antibiotic effectiveness.
- Who
- Researchers from Hebrew University of Jerusalem
- What
- Study on why infections relapse despite proper antibiotic treatment
- When
- Published in Science Advances
- Where
- Hebrew University of Jerusalem
- Why
- To understand and address the phenomenon of antibiotic persistence
- Study Institution
- Hebrew University of Jerusalem
- Researchers
- Prof. Nathalie Balaban and PhD student Adi Rotem
- Journal
- Science Advances
- Persistence Phenomenon
- Bacterial cells survive antibiotics by entering a temporary survival state
- Two Shutdown Modes
- Regulated growth arrest (dormancy) and disrupted growth arrest (dysregulated survival)
- Clinical Implications
- Potential for tailored therapies and better diagnostic tools