Archive · 16 Sep 2025
Study: Obesity's Variable Effects Linked to Genetics
Some people with obesity are healthy, while others get sick.
Scientists studied the genes of many people to find out why.
They found that some genes make people more likely to be obese, but less likely to get diabetes or heart disease.
This is because fat cells behave differently in different people.
These protective genes are even active in children, who may become obese, but not experience metabolic disease.
The researchers hope this information will help doctors predict who is at risk and develop new treatments, which might start in childhood.
Researchers analyzed genetic data from nearly half a million people.
They identified 205 genetic regions linked to higher body fat but better metabolic health.
A genetic risk score was developed to assess the impact of these variants.
Kids with protective variants were more likely to develop obesity, but not diseases.
The findings may help doctors predict and prevent obesity complications.
- Who
- Researchers from Mount Sinai and the University of Copenhagen.
- What
- Analyzed genetic data to understand why obesity affects individuals differently.
- When
- The study was recently published.
- Where
- The study was conducted in Denmark and the UK.
- Why
- To identify genetic factors that explain the varied health outcomes associated with obesity and to personalize care.
- Study Participants
- 452,768 individuals
- Lead Researchers
- Icahn School of Medicine at Mount Sinai, University of Copenhagen
- Genetic Regions Found
- 205 regions linked to higher body fat
- Key Finding
- Certain genetic variants can lead to obesity without related health complications.
- Published In
- Nature Medicine
- Study Focus
- UK Biobank participants of European ancestry