Archive · 25 Nov 2025
Long Pepper Compound Shows Promise in Colon Cancer Treatment
Scientists in India found that a natural compound called Piperlongumine, which comes from long pepper, can help fight colon cancer.
Colon cancer is when cells in the large intestine grow out of control and form tumors.
It's a common type of cancer worldwide.
The scientists did experiments and found that Piperlongumine can kill colon cancer cells without harming healthy cells.
This is important because regular treatments like chemotherapy can be painful and have bad side effects.
The compound works by making the cancer cells stressed to the point where they destroy themselves, while normal cells can handle this stress.
Long pepper is cheap and easy to grow, so this could be a low-cost and effective treatment, especially in countries where cancer treatments are very expensive.
The scientists published their findings in a journal called BioFactors and are now looking into using Piperlongumine with other cancer drugs to make treatments even better.
Piperlongumine, a compound in long pepper, selectively kills colon cancer cells while leaving healthy cells unharmed.
The compound increases oxidative stress in cancer cells, causing them to self-destruct.
Long pepper is inexpensive and easily cultivated, making Piperlongumine a low-cost therapeutic alternative.
The findings were published in the journal BioFactors, with researchers planning to investigate its use alongside chemotherapeutic drugs.
Colon cancer is a common and deadly disease, with nearly 1.9 million new cases and 900,000 deaths reported in 2022.
- Who
- Researchers at the National Institute of Technology Rourkela (NIT Rourkela)
- What
- Discovered that Piperlongumine, a compound in long pepper, can selectively kill colon cancer cells
- When
- Published on November 25, 2025
- Where
- National Institute of Technology Rourkela, India
- Why
- To find a cost-efficient and less harmful alternative to chemotherapy for colon cancer treatment
- Compound
- Piperlongumine
- Source
- Long pepper (pippali/thippili/maghaun)
- Target
- Colon cancer cells
- Effect
- Selectively kills cancer cells, minimal side effects
- Publication
- BioFactors journal
- Researchers
- NIT Rourkela team led by Prof. Bijesh Kumar Biswal
- Potential Benefit
- Low-cost, green therapeutic alternative
- Next Steps
- Investigating combination with chemotherapeutic drugs