Archive · 27 Oct 2025
New Non-Hormonal Pill Approved to Treat Menopause Hot Flashes
Many women experience hot flashes and night sweats during menopause.
A new, non-hormonal pill called Elinzanetant (Lynkuet) has been approved in the US to help.
It works by blocking brain chemicals that trigger hot flashes.
In clinical trials, the pill significantly reduced hot flashes and improved sleep.
This drug provides a new option for women who can't or don't want to use hormone therapy.
It is to be taken daily.
Some women reported side effects like headaches.
It's an alternative to hormone therapy and other previous treatments.
The FDA has approved the non-hormonal drug elinzanetant (Lynkuet) to treat menopausal hot flashes.
The pill is an alternative to hormone replacement therapy.
Clinical trials showed a significant reduction in the frequency of hot flashes.
Elinzanetant works by blocking brain chemicals related to hot flashes and night sweats.
Some patients reported side effects such as headaches and sleepiness.
- Who
- Menopausal women
- What
- Non-hormonal pill (Elinzanetant) to treat hot flashes and night sweats
- When
- Available in the US from November; trials showed benefits at 12 and 26 weeks
- Where
- US, also approved in Australia, Canada, Britain and Switzerland
- Why
- To provide an alternative for women experiencing menopausal symptoms, especially those who cannot or choose not to use hormone therapy
- Drug Name
- Elinzanetant (Lynkuet)
- Drug Type
- Non-hormonal pill
- Primary Use
- Treat moderate-to-severe hot flashes and night sweats
- FDA Approval
- Yes, in the US
- Reported Hot Flash Reduction (Elinzanetant)
- 73% after 12 weeks; >80% reported at least a 50% reduction at 26 weeks
- Side Effects
- Headaches, sleepiness, fatigue, joint pain
