Archive · 11 Aug 2025
IIT Roorkee Develops Drug to Fight Superbug Resistance
Imagine tiny bugs called bacteria getting really good at ignoring the medicines doctors give us.
This is called antibiotic resistance, and it's becoming a big problem.
Scientists at IIT Roorkee made a new medicine, Compound 3b, to help with this.
Compound 3b works with an existing medicine called Meropenem.
This combination is designed to fight a dangerous superbug, Klebsiella pneumoniae.
The new medicine helps the old medicine work again by stopping the bacteria from destroying it.
Tests show this new medicine is safe and works well, offering a promising solution to a growing health threat and helping keep us healthy.
IIT Roorkee researchers developed a new drug candidate, Compound 3b, to combat antibiotic resistance.
Compound 3b works with Meropenem to treat infections caused by the superbug Klebsiella pneumoniae.
The compound neutralizes the resistance mechanism, showing therapeutic results in preclinical models.
The study found Compound 3b to be specific, safe for human cells, and effective in animal tests.
This discovery offers a strategic solution to the global health challenge of rising antibiotic resistance.
- Who
- Researchers led by Prof. Ranjana Pathania from IIT Roorkee, in collaboration with researchers from UiT Tromso in Norway.
- What
- Development of Compound 3b to restore the effectiveness of antibiotics against drug-resistant bacteria.
- When
- The findings have been published in the Journal of Medicinal Chemistry.
- Where
- At the Indian Institute of Technology Roorkee (IIT Roorkee).
- Why
- To combat the global rise of antibiotic resistance and safeguard public health.
- Drug Name
- Compound 3b
- Target Pathogen
- Klebsiella pneumoniae
- Primary Antibiotic
- Meropenem
- Research Lead
- Prof. Ranjana Pathania
- Institution
- IIT Roorkee
- Journal Published
- Journal of Medicinal Chemistry