Archive · 28 Nov 2025
Bird Flu Threatens Humans with Fever Resistance
Scientists found that bird flu viruses can grow even when the body temperature is high, like during a fever.
Normally, a fever helps stop human flu viruses.
But bird flu viruses can survive and make people very sick.
This is because bird flu viruses like higher temperatures, which are found in the lungs and guts of their natural hosts like ducks and seagulls.
The researchers used mice to study this.
They found that a part of the virus called the PB1 gene helps the virus survive high temperatures.
This is important because bird flu can be very dangerous to humans, with high death rates in some cases.
Understanding this helps us prepare for possible outbreaks.
Bird flu viruses can replicate at temperatures higher than a typical fever, unlike human flu viruses.
Fever is less effective against bird flu viruses due to their ability to thrive at higher temperatures.
The PB1 gene in bird flu viruses plays a key role in their temperature resistance.
Bird flu viruses tend to infect the lower respiratory tract and gut, where temperatures are higher.
Historically, bird flu has had high fatality rates in humans, such as over 40% in H5N1 infections.
- Who
- Researchers from the universities of Cambridge and Glasgow, UK
- What
- Bird flu viruses can replicate at higher temperatures, posing a greater threat to humans
- When
- The study was published in the journal Science
- Where
- Research conducted in the UK using mice models
- Why
- To understand how fever affects bird flu viruses and their potential danger to humans
- Study Focus
- Bird flu virus replication at higher temperatures
- Researchers
- Universities of Cambridge and Glasgow, UK
- Key Finding
- Bird flu viruses can replicate at higher temperatures than human flu viruses
- PB1 Gene
- Plays a key role in temperature sensitivity of bird flu viruses
- Fatality Rate
- Historically high, e.g., over 40% in H5N1 infections
- Research Method
- In vivo models using mice infected with influenza viruses
- Journal
- Science
- Natural Hosts
- Ducks and seagulls
- Infection Sites
- Lower respiratory tract and gut