Archive · 29 Jan 2026
Keto Diet Linked to Fatty Liver Disease in Mice Study
A new study found that mice on a keto diet, which is high in fats and low in carbs, gained less weight but developed fatty liver disease.
This condition is a early stage of chronic liver disease.
The study also found that the keto diet affected how the mice regulated blood sugar.
After a few months, the mice had low blood sugar and insulin levels, but when carbs were reintroduced, their blood sugar spiked.
The researchers suggest that people considering a keto diet should talk to their doctor, monitor their liver function, and avoid extreme versions of the diet.
They also suggest that a balanced diet might be safer and more sustainable.
A new study found that mice on a keto diet developed fatty liver disease despite preventing weight gain.
The keto diet also disrupted blood sugar regulation in the mice.
Male mice showed more severe fat accumulation in the liver than females.
Some metabolic dysregulation improved after the mice were removed from the keto diet.
Experts recommend discussing long-term keto diet plans with a healthcare provider and monitoring liver function regularly.
- Who
- Researchers at University of Utah Health
- What
- A study on the long-term effects of the ketogenic diet on liver health in mice
- When
- The study was published in Science Advances
- Where
- The research was conducted at University of Utah Health
- Why
- To understand the potential metabolic risks of prolonged keto dieting
- Study Type
- Long-term experiment with mice
- Duration
- Nine months
- Key Finding
- Keto diet led to fatty liver disease in mice
- Gender Difference
- Male mice showed more severe fat accumulation
- Blood Sugar Impact
- Keto diet disrupted blood sugar regulation
- Reversibility
- Some metabolic dysregulation improved after stopping keto diet
- Expert Advice
- Consult healthcare provider before long-term keto diet