Archive · 7 Dec 2025
Laughing Gas Shows Promise for Depression Relief
Scientists found that laughing gas, also known as nitrous oxide, can help people feeling very sad, called depression.
They gave a small amount of this gas to people and saw that it made them feel better quickly, within a day.
This is exciting because some people with depression don't get better with usual treatments.
The gas works by helping the brain work better.
It can cause some small problems like feeling sick or dizzy, but these go away.
The scientists think this could be a new way to help people with depression, but they need to do more research to make sure it's safe and works well.
A single dose of 50% nitrous oxide can reduce depressive symptoms within 24 hours.
Repeated doses over several weeks led to more durable improvements.
Side effects were generally mild and temporary, including nausea, dizziness, and headaches.
Researchers believe nitrous oxide targets glutamate receptors in the brain, similar to ketamine.
Further studies are needed to determine optimal dosing and long-term integration into treatment pathways.
- Who
- Researchers from the University of Birmingham and University of Oxford
- What
- A study on the effects of nitrous oxide on depression
- When
- Recently published in eBioMedicine
- Where
- UK
- Why
- To find new treatments for severe depression
- Study Subject
- Depression treatment with nitrous oxide
- Key Finding
- Single dose reduces symptoms within 24 hours
- Participants
- 247 across 7 clinical trials
- Dose
- 50% nitrous oxide
- Side Effects
- Mild and temporary (nausea, dizziness, headaches)
- Researchers
- University of Birmingham and University of Oxford
- Publication
- eBioMedicine