Archive · 14 Jan 2026
KAIST Develops In-Body Immune Cell Reprogramming for Cancer
Scientists at KAIST have found a new way to fight cancer by changing immune cells already in tumours.
They made a special drug that turns these immune cells into cancer fighters.
This drug is injected right into the tumour, where immune cells called macrophages absorb it.
The drug tells these macrophages to recognize and attack cancer cells.
It also helps nearby immune cells join the fight.
In tests with animals, this method slowed down tumour growth and made the immune system stronger against cancer.
This could be a big step forward in treating cancers that are hard to fight, like those in the stomach, lungs, or liver.
The best part is that this method doesn't need to take cells out of the body and change them in a lab.
It does everything right inside the body, making it faster and easier.
KAIST researchers developed a method to reprogram immune cells inside tumours to fight cancer
A drug injected into the tumour is absorbed by macrophages, turning them into cancer-fighting cells
This approach avoids the need for lab-based cell extraction and modification
In animal models, the treatment significantly slowed tumour growth and enhanced immune response
The method uses lipid nanoparticles loaded with mRNA and an immune-activating compound
- Who
- KAIST researchers led by Professor Ji-Ho Park
- What
- Developed a method to reprogram immune cells inside tumours to fight cancer
- When
- Study published on November 18, 2026
- Where
- KAIST, South Korea
- Why
- To overcome limitations of current CAR-macrophage therapies and improve treatment of solid tumours
- Institution
- KAIST (Korea Advanced Institute of Science and Technology)
- Lead Researcher
- Professor Ji-Ho Park
- Method
- Lipid nanoparticles with mRNA and immune-activating compound
- Target Cells
- Tumour-associated macrophages
- Outcome
- Significant tumour growth suppression in animal models
- Publication
- ACS Nano (November 18)
- Funding
- National Research Foundation of Korea