Archive · 21 Jun 2025
Longevity Drugs Explored: Do Rapamycin and Metformin Work?
Scientists are looking for ways to help people live longer, and one way is to study how fasting works.
They've found that some drugs, like rapamycin and metformin, might have similar effects.
Rapamycin seems to work in animal studies, but metformin doesn't.
The study has found that eating healthy, exercising, and avoiding smoking may also help in living a long and healthy life.
Research explores chemical alternatives to fasting for extending lifespan.
Rapamycin and metformin are investigated for their potential to slow aging.
Animal studies show that calorie restriction and rapamycin are effective, but metformin is not.
The TAME trial for metformin is delayed due to funding issues.
Side effects led to one individual ceasing rapamycin use despite potential benefits.
- Who
- Researchers are investigating rapamycin and metformin, alongside other methods like fasting.
- What
- Research on longevity drugs is reviewed.
- When
- A paper summarizing animal research on longevity drugs was published.
- Where
- The research was conducted in various locations.
- Why
- To find effective methods to extend lifespan.
Those who support
Those who are against
Drug Choice
Those who support
Advocates of using Metformin for longevity.
Those who are against
Those who have chosen Rapamycin for life extension.
Belief in Longevity
Those who support
Belief in Rapamycin's potential, despite its side effects.
Those who are against
Those who chose Rapamycin.
- Drugs Studied
- Rapamycin, Metformin
- mTOR Pathway
- Inhibited by Rapamycin and fasting, overactivation linked to aging.
- TAME Trial
- A trial for Metformin delayed due to lack of funds
- PEARL Trial
- Trial for Rapamycin that started in July 2020, found no strong evidence of success
- Main Suggestion
- Eat wisely, drink moderately, exercise regularly, and sleep well.