Archive · 18 Sep 2025
CCMB Team Uncovers White Blood Cell's Shape-Shifting Mechanism
Imagine tiny white blood cells chasing bad germs in your body.
These cells change shape really fast to catch them!
Scientists at CCMB have figured out how they do this.
They found a protein called SPIN90 that works with another complex called Arp2/3.
This duo builds tiny frameworks inside the cell.
These frameworks help the cell push out and change shape quickly, like building a new shape.
This helps the cells move and attack.
Understanding this could help scientists learn about diseases, like cancer, immune disorders, and how wounds heal.
Scientists investigated white blood cell shape-shifting.
CCMB team discovered the molecular mechanism.
Findings published in Nature Structural & Molecular Biology.
SPIN90 protein plays a central role in the process.
Research used a cryogenic electron microscope.
- Who
- Scientists at CCMB
- What
- Discovered the molecular mechanism behind white blood cell shape-shifting.
- When
- Findings published in Nature Structural & Molecular Biology.
- Where
- CSIR–Centre for Cellular and Molecular Biology (CCMB) in Hyderabad.
- Why
- To understand how cells remodel themselves in health and disease.
- Research Institution
- CSIR–Centre for Cellular and Molecular Biology (CCMB)
- Published In
- Nature Structural & Molecular Biology
- Lead Researcher
- Dr. Saikat Chowdhury
- Key Protein
- SPIN90
- Methodology
- Cryogenic electron microscope