Archive · 17 Dec 2025
Study Finds Immune and Vascular Disruptions in Chronic Fatigue Syndrome
Scientists studied blood from people with chronic fatigue syndrome (CFS) and found that their immune and blood vessel systems are not working properly.
They discovered that the white blood cells of CFS patients have less energy, which is important for the body to function well.
The researchers also found that certain immune cells are less mature in CFS patients and that there are higher levels of proteins related to blood vessel activation.
This study helps us understand why CFS is such a complex condition and why it affects people in different ways.
The findings were published in a scientific journal called Cell Reports Medicine.
Study found disruptions in vascular and immune systems in chronic fatigue syndrome (CFS) patients.
White blood cells in CFS patients show reduced energy generation, indicated by higher AMP and ADP levels.
Immune cells in CFS patients are less mature, including T-lymphocytes, dendritic cells, and natural killer cells.
Higher levels of proteins associated with endothelial activation and lower levels of immunoglobulin-related proteins were found.
Research highlights the biological complexity of CFS, with abnormalities across multiple systems.
- Who
- Researchers led by Macquarie University in Australia
- What
- Disruptions in vascular and immune systems in chronic fatigue syndrome patients
- When
- Study published in Cell Reports Medicine
- Where
- Macquarie University, Australia
- Why
- To understand the biological complexity of chronic fatigue syndrome
- Study Focus
- Blood proteins in chronic fatigue syndrome (CFS) patients
- Key Finding
- Disruptions in vascular and immune system balance
- Energy Generation
- Reduced ATP generation in white blood cells
- Immune Cells
- Less mature T-lymphocytes, dendritic cells, and natural killer cells
- Endothelial Activation
- Higher levels of proteins associated with endothelial activation
- Immunoglobulin Proteins
- Lower levels of circulating immunoglobulin-related proteins
- Research Team
- Led by Macquarie University, Australia
- Journal
- Cell Reports Medicine