Archive · 26 Jun 2025
Study: Inflammation Persists Despite Asthma Treatment
Scientists looked at how a type of medicine called biologics affects the immune cells in people with severe asthma.
They studied blood samples from patients before and during treatment.
Surprisingly, some inflammation-causing immune cells increased.
This might explain why asthma symptoms sometimes return when treatment stops.
The research team used special methods to study these cells more closely.
They are working to understand the long-term effects of these medicines and why they don't always eliminate all inflammatory cells.
Study reveals inflammatory cells persist in blood despite severe asthma treatment with biologics.
Researchers analyzed blood samples from 40 asthma patients before and during biologic treatment.
Certain immune cells associated with asthma inflammation increased during treatment.
Findings may explain why airway inflammation often returns after treatment cessation.
Researchers used flow cytometry and single cell sequencing to study immune cells.
- Who
- Researchers from Karolinska Institutet in Sweden conducted the study on 40 patients.
- What
- Study found that inflammatory cells in the blood of severe asthma patients increased during biologic treatment.
- When
- The research was published in the journal Allergy.
- Where
- The research was conducted at the Karolinska Institutet in Sweden.
- Why
- To understand the long-term immunological effects of biologic drugs used to treat severe asthma.
Current Understanding
Study Implications
Effectiveness of Biologics
Current Understanding
Biologics improve life and reduce inflammation.
Study Implications
Study suggests treatment doesn't eradicate all inflammatory cells.
- Study Focus
- Effect of biologics on immune cells in severe asthma patients.
- Research Institution
- Karolinska Institutet
- Journal
- Allergy
- Key Finding
- Inflammatory cells increased during treatment.
- Patient Count
- 40
- Treatment type
- Biologics (e.g., mepolizumab, dupilumab)
