Archive · 24 Nov 2025
Study Finds Heart Attack Risk Underestimated in 45% of People
A new study found that the tools doctors use to check if someone might have a heart attack miss almost half of the people who are actually at risk.
The researchers looked at data from 474 patients and found that if these patients had been checked just two days before their heart attack, nearly half would have been told they were at low risk and not given preventive treatment.
The study suggests that symptoms like chest pain often appear too late to help.
Instead, the researchers think doctors should use special scans to find early signs of heart disease before it becomes a big problem.
Current heart attack screening tools may miss 45% of people at actual risk.
The study analyzed data from 474 patients under age 66 with no known coronary artery disease.
Nearly half of the patients would not have been recommended for preventive therapy by the ASCVD risk score.
More than half of the patients would not have been recommended for preventive therapy by the newer PREVENT calculator.
60% of patients developed symptoms less than two days before their cardiac event.
- Who
- Mount Sinai researchers led by Amir Ahmadi
- What
- A study finding that current heart attack screening tools may miss 45% of people at risk
- When
- Published in JACC: Advances, reported on November 24
- Where
- United States
- Why
- To assess the accuracy of current screening tools and propose better methods for early detection
- Study Lead
- Mount Sinai researchers in the US
- Publication
- JACC: Advances
- Sample Size
- 474 patients under age 66 with no known coronary artery disease
- ASCVD Risk Score
- 45% of patients would not have been recommended for preventive therapy
- PREVENT Calculator
- 61% of patients would not have been recommended for preventive therapy
- Symptom Onset
- 60% of patients developed symptoms less than two days before their cardiac event
- Key Finding
- Current screening tools may miss 45% of people at actual risk of heart attacks
- Proposed Solution
- Atherosclerosis imaging to identify silent plaque before it ruptures