Archive · 28 Nov 2025
Alzheimer's Gene Linked to Delirium Risk
Scientists found that a gene called APOE, which is known to increase the risk of Alzheimer's disease, also directly increases the risk of delirium.
Delirium is a state of confusion that often happens in hospitalized patients.
The study looked at over a million people and found that the APOE gene affects delirium risk even in people who don't have dementia.
This means the gene has a separate role in causing delirium.
The researchers also found proteins that can predict delirium risk years before symptoms appear.
This discovery could help us understand how delirium is linked to future dementia risk.
The APOE gene is directly linked to delirium risk independently of Alzheimer's disease.
Study analyzed data from over 1 million people in the UK, Finland, and the US.
APOE gene's effect on delirium risk was evident even after adjusting for dementia.
Researchers identified proteins that can predict delirium risk years before symptoms appear.
Findings suggest brain vulnerability and inflammation may play important roles in delirium.
- Who
- Researchers from the University of Edinburgh
- What
- Linked the APOE gene to delirium risk independently of Alzheimer's disease
- When
- Study findings published in Nature Ageing
- Where
- UK, Finland, and US
- Why
- To understand the genetic components of delirium and its link to dementia
- Gene
- APOE
- Gene Variant
- APOE e4
- Study Participants
- Over 1 million from UK, Finland, and US
- Study Findings
- APOE gene directly linked to delirium risk independently of Alzheimer's
- Research Institution
- University of Edinburgh
- Journal
- Nature Ageing
- Key Researchers
- Vasilis Raptis, Albert Tenesa