Archive · 5 Jan 2026
CAR T-Cell Therapy Revitalizes Aging Intestines
Scientists have found a new way to help old intestines heal themselves.
They used a special treatment called CAR T-cell therapy, which targets old cells that stick around and cause problems.
In mice, this treatment made their guts work better, reduced swelling, and helped them absorb food more easily.
It even protected their guts from damage caused by radiation.
The good effects lasted for up to a year.
The scientists also saw promising results in human gut cells, which means this treatment might one day help older people and cancer patients have healthier guts.
CAR T-cell therapy targets senescent cells in aging intestines, boosting gut regeneration in mice.
Treatment reduced inflammation, improved nutrient absorption, and protected against radiation damage.
Benefits lasted up to a year in mice, with potential applications for aging adults and cancer patients.
Researchers observed similar positive effects in human intestinal and colorectal cells.
The study was conducted by scientists at Cold Spring Harbor Laboratory.
- Who
- Researchers at Cold Spring Harbor Laboratory
- What
- Discovered a method to help aging intestines heal using CAR T-cell therapy
- When
- Recent discovery, exact date not specified
- Where
- Washington, conducted at Cold Spring Harbor Laboratory
- Why
- To improve gut health in older adults and cancer patients
- Treatment
- CAR T-cell therapy
- Target
- Senescent cells
- Subjects
- Mice and human intestinal cells
- Benefits
- Improved nutrient absorption, reduced inflammation, faster healing
- Duration of Effects
- Up to one year in mice
- Potential Applications
- Aging adults and cancer patients
- Research Institution
- Cold Spring Harbor Laboratory