Archive · 10 Dec 2025
MDR Found in Liver Transplant Patients
A big study by the South Asian Liver Institute found that many people who get liver transplants in India have bacteria that don't respond to common medicines.
Out of 67 patients, 24% had infections, mostly from a type of bacteria called gram-negative.
Almost all of these infections didn't get better with regular antibiotics, and some didn't even respond to the strongest medicines.
Surprisingly, more than half of the infected patients already had these tough bacteria before their surgery.
Doctors say infections are the main reason liver-transplant patients die, but knowing about these infections early helps them use the right medicines and keep problems under control.
A 26-month study by the South Asian Liver Institute found a 24% incidence of bacterial infections in 67 liver-transplant patients.
94% of the infections were resistant to first- and second-line antibiotics, with some resistant even to last-resort antibiotics like oxazolidinones.
56% of the infected patients tested positive for MDR organisms before surgery.
Infections remain the leading cause of death among liver-transplant patients nationwide.
Early detection and appropriate antibiotic use helped control complications during the procedure.
- Who
- Liver transplant patients in India, including those from Tier-2 towns
- What
- Prevalence of multi-drug antimicrobial resistance (MDR) among liver-transplant patients
- When
- Over a 26-month period
- Where
- Semi-rural setting in India
- Why
- To understand the incidence and resistance patterns of bacterial infections in liver-transplant patients
- Study Duration
- 26 months
- Patients Studied
- 67
- Infection Incidence
- 24%
- Resistance to First-Line Antibiotics
- 94%
- Pre-Surgery Infections
- 56%
- Infections During Procedure
- 30%