Archive · 9 Dec 2025
WHO reports 2,501 mpox cases, 12 deaths in October
The World Health Organization (WHO) reported that in October 2025, there were 2,501 new confirmed cases of mpox, also known as monkeypox, and 12 deaths from 44 countries.
All types of the mpox virus are still spreading.
In Africa, 21 countries had active mpox cases, with the most cases in the Democratic Republic of Congo, Liberia, Ghana, Kenya, and Uganda.
Mali reported mpox for the first time.
New cases of a specific type of mpox virus, clade Ib MPXV, were found in travelers in Belgium, Germany, Greece, and the UK.
Some of these cases showed that the virus is spreading locally in countries like Italy, Malaysia, the Netherlands, Portugal, Spain, and the US.
Half of the cases were among men who have sex with men.
The WHO says the risk to the general public is low, but it's moderate for men who have sex with multiple partners.
WHO reported 2,501 new mpox cases and 12 deaths in October 2025 from 44 countries.
All clades of the monkeypox virus continue to circulate globally.
21 African countries reported active mpox transmission, with the highest cases in the Democratic Republic of Congo, Liberia, Ghana, Kenya, and Uganda.
New clade Ib MPXV cases were reported in travelers in Belgium, Germany, Greece, and the UK, with local transmission in Italy, Malaysia, the Netherlands, Portugal, Spain, and the US.
Half of the clade Ib MPXV cases were among men who have sex with men, with the WHO assessing the public health risk as moderate for this group and low for the general population.
- Who
- World Health Organization (WHO)
- What
- Report on mpox cases and deaths in October 2025
- When
- October 2025
- Where
- 44 countries across all WHO regions
- Why
- To provide an update on the multi-country outbreak of mpox
- Total new confirmed cases
- 2,501
- Total deaths
- 12
- Case fatality ratio
- 0.5%
- Countries reporting cases
- 44
- Countries in Africa with active transmission
- 21
- Countries reporting clade Ib MPXV cases
- 6
- Countries with community transmission of clade Ib MPXV
- 6
- Cases among men who have sex with men
- 22