Archive · 17 Dec 2025
Oral Bacteria May Help Reduce Nicotine Dependence
Scientists found that using smokeless tobacco for a long time changes the bacteria in your mouth.
Some of these bacteria can break down nicotine, the addictive part of tobacco.
This discovery might help people quit tobacco because these bacteria could reduce how much nicotine gets into the body.
The researchers collected saliva samples and used special tools to study the bacteria.
They found that these bacteria not only survive in nicotine but also break it down.
This could lead to new ways to help people stop using tobacco, like using good bacteria as a treatment.
However, more research is needed before this can be used to help people quit tobacco.
Prolonged smokeless tobacco use alters the oral microbiome, promoting 'nicotinophilic' bacteria that metabolize nicotine.
Researchers identified these bacteria using advanced techniques like 16S rRNA gene sequencing and MALDI-TOF mass spectrometry.
Nicotinophilic bacteria were found to actively break down nicotine, reducing its presence in the body.
This discovery could lead to new tobacco cessation strategies, such as microbiome-based interventions or targeted oral probiotics.
Further studies and clinical trials are needed before these findings can be translated into practical treatments.
- Who
- Dr. Nishant Mehta and his research team at PGIMER, Chandigarh
- What
- Oral bacteria that can break down nicotine in smokeless tobacco users
- When
- Presented at the 29th IAPHD National Conference (NATCON 2025)
- Where
- Mangaluru, India
- Why
- To explore new possibilities for tobacco cessation strategies
- Researcher
- Dr. Nishant Mehta, PGIMER, Chandigarh
- Conference
- 29th IAPHD National Conference (NATCON 2025), Mangaluru
- Methodology
- 16S rRNA gene sequencing, MALDI-TOF mass spectrometry, UV-visible spectroscopy
- Key Finding
- Nicotinophilic bacteria can metabolize nicotine
- Potential Application
- Microbiome-based interventions for tobacco cessation
- Current Status
- Early research, clinical trials needed